Published in Circulation on January 08, 2007
Prevalence of the congenital long-QT syndrome. Circulation (2009) 4.32
The sudden infant death syndrome. N Engl J Med (2009) 3.97
Calmodulin mutations associated with recurrent cardiac arrest in infants. Circulation (2013) 2.66
Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation (2008) 2.56
Impact of genetics on the clinical management of channelopathies. J Am Coll Cardiol (2013) 2.30
Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Biochemistry (2008) 2.22
Population-based analysis of sudden death in children: The Oregon Sudden Unexpected Death Study. Heart Rhythm (2009) 2.12
Long QT syndrome-associated mutations in intrauterine fetal death. JAMA (2013) 2.00
A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors. Heart Rhythm (2007) 1.98
Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome. Heart Rhythm (2008) 1.87
Clinical implications for patients with long QT syndrome who experience a cardiac event during infancy. J Am Coll Cardiol (2009) 1.81
Epidemiologic, molecular, and functional evidence suggest A572D-SCN5A should not be considered an independent LQT3-susceptibility mutation. Heart Rhythm (2010) 1.76
Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. Heart Rhythm (2010) 1.72
Etiology of sudden death in the community: results of anatomical, metabolic, and genetic evaluation. Am Heart J (2010) 1.70
Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome. Circulation (2007) 1.64
Congenital long QT syndrome. Orphanet J Rare Dis (2008) 1.58
The molecular autopsy: should the evaluation continue after the funeral? Pediatr Cardiol (2012) 1.57
Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome. Circ Res (2008) 1.55
Malignant perinatal variant of long-QT syndrome caused by a profoundly dysfunctional cardiac sodium channel. Circ Arrhythm Electrophysiol (2008) 1.53
Part 10: Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation (2010) 1.50
Cardiac sodium channelopathies. Pflugers Arch (2009) 1.44
A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Na(v)1.5 and K(v)4.3 channel currents. Heart Rhythm (2011) 1.43
Genetic testing for potentially lethal, highly treatable inherited cardiomyopathies/channelopathies in clinical practice. Circulation (2011) 1.41
Structural models for the KCNQ1 voltage-gated potassium channel. Biochemistry (2007) 1.38
A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response. PLoS One (2007) 1.26
Common variants in cardiac ion channel genes are associated with sudden cardiac death. Circ Arrhythm Electrophysiol (2010) 1.22
Developmentally regulated SCN5A splice variant potentiates dysfunction of a novel mutation associated with severe fetal arrhythmia. Heart Rhythm (2011) 1.11
Arrhythmia phenotype during fetal life suggests long-QT syndrome genotype: risk stratification of perinatal long-QT syndrome. Circ Arrhythm Electrophysiol (2013) 1.11
A common SCN5A polymorphism modulates the biophysical defects of SCN5A mutations. Heart Rhythm (2010) 1.10
Structural heterogeneity promotes triggered activity, reflection and arrhythmogenesis in cardiomyocyte monolayers. J Physiol (2011) 1.08
Contribution of long-QT syndrome genes to sudden infant death syndrome: is it time to consider newborn electrocardiographic screening? Circulation (2007) 1.05
Sudden infant death syndrome in mice with an inherited mutation in RyR2. Circ Arrhythm Electrophysiol (2009) 1.04
A common single nucleotide polymorphism can exacerbate long-QT type 2 syndrome leading to sudden infant death. Circ Cardiovasc Genet (2010) 1.04
Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current. Circ Arrhythm Electrophysiol (2009) 1.02
Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death. Circulation (2011) 1.00
State of postmortem genetic testing known as the cardiac channel molecular autopsy in the forensic evaluation of unexplained sudden cardiac death in the young. Pacing Clin Electrophysiol (2009) 0.98
Prevalence and spectrum of large deletions or duplications in the major long QT syndrome-susceptibility genes and implications for long QT syndrome genetic testing. Am J Cardiol (2010) 0.97
Novel gene and mutation discovery in congenital long QT syndrome: let's keep looking where the street lamp standeth. Heart Rhythm (2008) 0.96
Cardiac potassium channel dysfunction in sudden infant death syndrome. J Mol Cell Cardiol (2007) 0.96
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Atrial fibrillation: the role of common and rare genetic variants. Eur J Hum Genet (2013) 0.92
Genomic risk factors in sudden infant death syndrome. Genome Med (2010) 0.90
Rationale and objectives for ECG screening in infancy. Heart Rhythm (2014) 0.90
Contribution of long-QT syndrome genetic variants in sudden infant death syndrome. Pediatr Cardiol (2009) 0.90
Genetic investigations of sudden unexpected deaths in infancy using next-generation sequencing of 100 genes associated with cardiac diseases. Eur J Hum Genet (2015) 0.89
Loss-of-function mutations in the KCNJ8-encoded Kir6.1 K(ATP) channel and sudden infant death syndrome. Circ Cardiovasc Genet (2011) 0.88
Torsades de pointes during complete atrioventricular block: Genetic factors and electrocardiogram correlates. Can J Cardiol (2010) 0.88
A mouse model to study the link between hypoxia, long QT interval and sudden infant death syndrome. Dis Model Mech (2012) 0.86
Opposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels. Front Pharmacol (2012) 0.86
Sudden infant death syndrome: do ion channels play a role? Heart Rhythm (2008) 0.85
Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations. BMC Evol Biol (2008) 0.85
Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Pediatrics (2010) 0.85
KCNE genetics and pharmacogenomics in cardiac arrhythmias: much ado about nothing? Expert Rev Clin Pharmacol (2013) 0.85
Cardiac ion channelopathies and the sudden infant death syndrome. ISRN Cardiol (2012) 0.84
Congenital short QT syndrome. Indian Pacing Electrophysiol J (2010) 0.83
Paralogue annotation identifies novel pathogenic variants in patients with Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia. J Med Genet (2013) 0.82
Serotonin gene variants are unlikely to play a significant role in the pathogenesis of the sudden infant death syndrome. Respir Physiol Neurobiol (2013) 0.82
Perceptions of an implantable cardioverter-defibrillator: A qualitative study of families with a history of sudden life-threatening cardiac events and recommendations to improve care. Einstein J Biol Med (2013) 0.81
Long QT interval in Turner syndrome--a high prevalence of LQTS gene mutations. PLoS One (2013) 0.81
QT interval prolongation in future SIDS victims: a polysomnographic study. Sleep (2008) 0.81
Common genetic variants in sudden cardiac death. Heart Rhythm (2009) 0.81
The Electrocardiogram Restitution Portrait Quantifying Dynamical Electrical Instability in Young Myocardium. Comput Cardiol (2007) 0.80
Hypoxia at the heart of sudden infant death syndrome? Pediatr Res (2013) 0.80
Comparison of formulas for calculation of the corrected QT interval in infants and young children. J Pediatr (2015) 0.80
Heterozygous nonsense SCN5A mutation W822X explains a simultaneous sudden infant death syndrome. Virchows Arch (2008) 0.79
Role of congenital long-QT syndrome in unexplained sudden infant death: proposal for an electrocardiographic screening in relatives. Eur J Pediatr (2009) 0.79
Potential of caveolae in the therapy of cardiovascular and neurological diseases. Front Physiol (2014) 0.78
Examining rare and low-frequency genetic variants previously associated with lone or familial forms of atrial fibrillation in an electronic medical record system: a cautionary note. Circ Cardiovasc Genet (2014) 0.78
Prenatal diagnosis and management of fetal Long QT syndrome. Pediatr Cardiol (2008) 0.78
Tox-database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition. BMC Pharmacol Toxicol (2012) 0.78
Sudden infant death syndrome caused by cardiac arrhythmias: only a matter of genes encoding ion channels? Int J Legal Med (2016) 0.77
Calmodulin 2 Mutation N98S Is Associated with Unexplained Cardiac Arrest in Infants Due to Low Clinical Penetrance Electrical Disorders. PLoS One (2016) 0.76
Mutations in Danish patients with long QT syndrome and the identification of a large founder family with p.F29L in KCNH2. BMC Med Genet (2014) 0.76
Arrhythmia pharmacogenomics: methodological considerations. Curr Pharm Des (2009) 0.76
Long QT molecular autopsy in sudden infant death syndrome. Arch Dis Child (2014) 0.76
Antenatal presentation of congenital long QT syndrome: A prenatal diagnosis not to be missed. Pediatr Cardiol (2008) 0.76
Hypothesis: holiday sudden cardiac death: food and alcohol inhibition of SULT1A enzymes as a precipitant. J Appl Toxicol (2012) 0.76
LQTS-associated mutation A257G in α1-syntrophin interacts with the intragenic variant P74L to modify its biophysical phenotype. Cardiogenetics (2011) 0.76
PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis. PLoS One (2016) 0.76
Management of survivors of cardiac arrest - the importance of genetic investigation. Nat Rev Cardiol (2016) 0.76
Correlation between seizure in children and prolonged QT interval. ARYA Atheroscler (2013) 0.75
Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A. Can J Physiol Pharmacol (2011) 0.75
Wild type and K897T polymorphisms of the hERG gene: modeling the APD in Caucasians. Bioinformation (2012) 0.75
Outcomes of heart transplantation using donor hearts from infants with sudden infant death syndrome. J Heart Lung Transplant (2010) 0.75
Risk stratification in young patients with channelopathies. Indian Pacing Electrophysiol J (2010) 0.75
Maternal cardiac arrhythmias during pregnancy and lactation. Obstet Med (2010) 0.75
Sudden infant death syndrome due to long QT syndrome: a brief review of the genetic substrate and prevalence. J Biol Res (Thessalon) (2017) 0.75
Underdiagnosis of Conditions Associated with Sudden Cardiac Death in Children - Is it the Absence of a Comprehensive Screening Program or a True Low Prevalence? Hawaii J Med Public Health (2016) 0.75
Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform. Heart Rhythm (2011) 0.75
The genomic load of deleterious mutations: relevance to death in infancy and childhood. Front Immunol (2015) 0.75
Infection: the neglected paradigm in SIDS research. Arch Dis Child (2017) 0.75
Sudden cardiac death in the young: how can disease recognition and prevention in family members be improved? Herzschrittmacherther Elektrophysiol (2012) 0.75
Sudden infant death syndrome and inherited cardiac conditions. Nat Rev Cardiol (2017) 0.75
Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell (2004) 7.45
Risk stratification in the long-QT syndrome. N Engl J Med (2003) 7.25
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med (2005) 5.05
Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med (2005) 4.85
Prevalence of the congenital long-QT syndrome. Circulation (2009) 4.32
PiggyBac transposon-mediated gene transfer in human cells. Mol Ther (2007) 4.07
Molecular basis of an inherited epilepsy. Neuron (2002) 3.77
Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice. JAMA (2005) 3.51
Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers. JAMA (2004) 3.24
Sudden infant death syndrome and unclassified sudden infant deaths: a definitional and diagnostic approach. Pediatrics (2004) 3.02
Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest (2003) 3.00
Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation (2002) 2.98
Long QT syndrome in adults. J Am Coll Cardiol (2007) 2.93
Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure. Eur Heart J (2010) 2.86
High efficacy of beta-blockers in long-QT syndrome type 1: contribution of noncompliance and QT-prolonging drugs to the occurrence of beta-blocker treatment "failures". Circulation (2008) 2.83
Two cases of sudden unexpected death in epilepsy in a GEFS+ family with an SCN1A mutation. Epilepsia (2008) 2.81
KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome. Circulation (2005) 2.78
Calmodulin mutations associated with recurrent cardiac arrest in infants. Circulation (2013) 2.66
The Jervell and Lange-Nielsen syndrome: natural history, molecular basis, and clinical outcome. Circulation (2006) 2.58
Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation (2008) 2.56
Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study. J Infect Dis (2005) 2.43
Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome. Circulation (2008) 2.40
Recommendations for interpretation of 12-lead electrocardiogram in the athlete. Eur Heart J (2009) 2.37
Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia. N Engl J Med (2008) 2.34
Impact of genetics on the clinical management of channelopathies. J Am Coll Cardiol (2013) 2.30
Cardiac sodium channel dysfunction in sudden infant death syndrome. Circulation (2007) 2.28
Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome. Heart Rhythm (2011) 2.26
Long-QT syndrome: from genetics to management. Circ Arrhythm Electrophysiol (2012) 2.24
Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Biochemistry (2008) 2.22
Modulating effects of age and gender on the clinical course of long QT syndrome by genotype. J Am Coll Cardiol (2003) 2.22
Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel. Circulation (2002) 2.20
Cost-effectiveness of neonatal ECG screening for the long QT syndrome. Eur Heart J (2006) 2.15
Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals. J Am Coll Cardiol (2011) 2.15
Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. J Am Soc Nephrol (2008) 2.04
Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women. Pharmacogenetics (2003) 2.03
Long QT syndrome-associated mutations in intrauterine fetal death. JAMA (2013) 2.00
NOS1AP is a genetic modifier of the long-QT syndrome. Circulation (2009) 2.00
Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Europace (2013) 1.97
Spectrum and prevalence of mutations involving BrS1- through BrS12-susceptibility genes in a cohort of unrelated patients referred for Brugada syndrome genetic testing: implications for genetic testing. J Am Coll Cardiol (2012) 1.97
Real-life observations of clinical outcomes with rhythm- and rate-control therapies for atrial fibrillation RECORDAF (Registry on Cardiac Rhythm Disorders Assessing the Control of Atrial Fibrillation). J Am Coll Cardiol (2011) 1.91
Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome. J Am Coll Cardiol (2008) 1.91
Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome. J Cardiovasc Electrophysiol (2003) 1.91
Cardiac ion channels. Annu Rev Physiol (2002) 1.90
Gain-of-function mutation S422L in the KCNJ8-encoded cardiac K(ATP) channel Kir6.1 as a pathogenic substrate for J-wave syndromes. Heart Rhythm (2010) 1.89
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet (2013) 1.86
Exercise-induced increase in baroreflex sensitivity predicts improved prognosis after myocardial infarction. Circulation (2002) 1.84
Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol. J Am Coll Cardiol (2012) 1.81
Clinical implications for patients with long QT syndrome who experience a cardiac event during infancy. J Am Coll Cardiol (2009) 1.81
Myotonia congenita. Adv Genet (2008) 1.80
Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A. J Neurosci (2003) 1.77
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Long-QT syndrome after age 40. Circulation (2008) 1.73
A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. Mol Cancer (2004) 1.72
Long QT syndrome and pregnancy. J Am Coll Cardiol (2007) 1.71
Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks). J Mol Cell Cardiol (2005) 1.70
The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. J Clin Invest (2008) 1.69
Polymorphic ventricular tachycardia and KCNJ2 mutations. Heart Rhythm (2004) 1.68
Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block. Circulation (2002) 1.65
Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy. Proc Natl Acad Sci U S A (2004) 1.65
Risk of death in the long QT syndrome when a sibling has died. Heart Rhythm (2008) 1.64
Excessive heart rate increase during mild mental stress in preparation for exercise predicts sudden death in the general population. Eur Heart J (2009) 1.61