1
|
Mutations of the BRAF gene in human cancer.
|
Nature
|
2002
|
65.42
|
2
|
Patterns of somatic mutation in human cancer genomes.
|
Nature
|
2007
|
38.41
|
3
|
Lung cancer: intragenic ERBB2 kinase mutations in tumours.
|
Nature
|
2004
|
8.35
|
4
|
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.
|
Nat Genet
|
2009
|
8.30
|
5
|
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
Nat Genet
|
2013
|
8.24
|
6
|
Somatic mutations of the protein kinase gene family in human lung cancer.
|
Cancer Res
|
2005
|
7.66
|
7
|
Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing.
|
Proc Natl Acad Sci U S A
|
2008
|
7.22
|
8
|
A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.
|
Cancer Res
|
2006
|
6.91
|
9
|
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.
|
Nat Genet
|
2005
|
6.70
|
10
|
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
|
Nat Genet
|
2013
|
5.58
|
11
|
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.
|
Nat Genet
|
2009
|
4.38
|
12
|
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
|
Nat Genet
|
2013
|
4.35
|
13
|
RNA editing of human microRNAs.
|
Genome Biol
|
2006
|
4.16
|
14
|
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
|
Mol Cancer Ther
|
2006
|
4.09
|
15
|
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
Nat Genet
|
2013
|
3.81
|
16
|
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
Nat Genet
|
2013
|
3.42
|
17
|
Genome-wide association analysis identifies three new breast cancer susceptibility loci.
|
Nat Genet
|
2012
|
3.20
|
18
|
Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults.
|
Genes Chromosomes Cancer
|
2006
|
2.50
|
19
|
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
|
PLoS Genet
|
2013
|
2.39
|
20
|
Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation.
|
Nat Genet
|
2007
|
2.35
|
21
|
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.
|
Am J Hum Genet
|
2013
|
2.24
|
22
|
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.
|
Am J Hum Genet
|
2007
|
2.07
|
23
|
X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment.
|
Nat Genet
|
2008
|
1.95
|
24
|
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk.
|
PLoS Genet
|
2013
|
1.88
|
25
|
Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation.
|
Am J Hum Genet
|
2006
|
1.85
|
26
|
Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.
|
Hum Mol Genet
|
2013
|
1.78
|
27
|
Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus.
|
Am J Hum Genet
|
2007
|
1.73
|
28
|
A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.
|
Hum Mol Genet
|
2013
|
1.52
|
29
|
Fine scale mapping of the breast cancer 16q12 locus.
|
Hum Mol Genet
|
2010
|
1.39
|
30
|
Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly.
|
Am J Hum Genet
|
2007
|
1.26
|
31
|
High throughput DNA sequence variant detection by conformation sensitive capillary electrophoresis and automated peak comparison.
|
Genomics
|
2006
|
1.08
|
32
|
Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.
|
Hum Genet
|
2013
|
0.99
|
33
|
Ovarian cancer familial relative risks by tumour subtypes and by known ovarian cancer genetic susceptibility variants.
|
J Med Genet
|
2013
|
0.95
|
34
|
Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.
|
Mol Nutr Food Res
|
2014
|
0.77
|