Patterns of somatic mutation in human cancer genomes.

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A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature (2009) 18.39

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature (2009) 18.08

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature (2010) 16.12

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Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature (2009) 13.45

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18

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Transcriptome sequencing to detect gene fusions in cancer. Nature (2009) 11.63

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The landscape of cancer genes and mutational processes in breast cancer. Nature (2012) 11.24

Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22

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Diverse somatic mutation patterns and pathway alterations in human cancers. Nature (2010) 10.83

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science (2010) 10.78

The life history of 21 breast cancers. Cell (2012) 10.59

The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature (2010) 10.04

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol (2011) 9.60

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Integrative analysis of the melanoma transcriptome. Genome Res (2010) 8.46

The genetic landscape of the childhood cancer medulloblastoma. Science (2010) 8.34

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Nat Genet (2009) 8.30

An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res (2008) 8.12

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med (2011) 7.89

Melanoma genome sequencing reveals frequent PREX2 mutations. Nature (2012) 7.77

Exome sequencing identifies GRIN2A as frequently mutated in melanoma. Nat Genet (2011) 7.31

Mutual exclusivity analysis identifies oncogenic network modules. Genome Res (2011) 7.22

Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing. Proc Natl Acad Sci U S A (2008) 7.22

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A (2012) 7.14

Genomic instability--an evolving hallmark of cancer. Nat Rev Mol Cell Biol (2010) 7.11

Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution. Genome Res (2007) 6.91

Clonal architecture of secondary acute myeloid leukemia. N Engl J Med (2012) 6.71

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet (2012) 6.65

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Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet (2011) 6.43

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med (2010) 6.39

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine. EMBO Mol Med (2010) 6.38

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet (2010) 6.10

Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet (2011) 6.06

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat Med (2013) 6.01

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73

Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat Genet (2011) 5.68

SomaticSniper: identification of somatic point mutations in whole genome sequencing data. Bioinformatics (2011) 5.62

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell (2008) 5.47

A dimerization-dependent mechanism drives RAF catalytic activation. Nature (2009) 5.39

Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer (2010) 5.26

APOBEC3B is an enzymatic source of mutation in breast cancer. Nature (2013) 5.18

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev (2011) 5.02

The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory. Bioessays (2011) 5.01

Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations. Cancer Res (2009) 4.92

TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol (2010) 4.92

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet (2012) 4.84

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nat Genet (2012) 4.82

Transcriptome sequencing of malignant pleural mesothelioma tumors. Proc Natl Acad Sci U S A (2008) 4.75

Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet (2013) 4.61

Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell (2008) 4.59

Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. Mol Cell (2012) 4.52

Accumulation of driver and passenger mutations during tumor progression. Proc Natl Acad Sci U S A (2010) 4.47

Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science (2013) 4.42

Translating insights from the cancer genome into clinical practice. Nature (2008) 4.37

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med (2011) 4.37

The impact of the unfolded protein response on human disease. J Cell Biol (2012) 4.36

Double indexing overcomes inaccuracies in multiplex sequencing on the Illumina platform. Nucleic Acids Res (2011) 4.33

Automated inference of molecular mechanisms of disease from amino acid substitutions. Bioinformatics (2009) 4.31

Functional copy-number alterations in cancer. PLoS One (2008) 4.27

Immunobiology of the TAM receptors. Nat Rev Immunol (2008) 4.26

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A (2008) 4.13

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet (2007) 3.95

Evidence for APOBEC3B mutagenesis in multiple human cancers. Nat Genet (2013) 3.94

Comprehensive identification of mutational cancer driver genes across 12 tumor types. Sci Rep (2013) 3.92

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood (2008) 3.89

Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell (2009) 3.85

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. Nat Genet (2009) 3.80

Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci U S A (2011) 3.80

The diverse and complex roles of NF-κB subunits in cancer. Nat Rev Cancer (2012) 3.75

Automated network analysis identifies core pathways in glioblastoma. PLoS One (2010) 3.64

Exome sequencing of liver fluke-associated cholangiocarcinoma. Nat Genet (2012) 3.63

Deciphering signatures of mutational processes operative in human cancer. Cell Rep (2013) 3.61

Janus kinases in immune cell signaling. Immunol Rev (2009) 3.60

Genetic progression and the waiting time to cancer. PLoS Comput Biol (2007) 3.57

Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1. Cancer Res (2009) 3.56

Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev (2012) 3.44

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood (2009) 3.40

Targeting the unfolded protein response in disease. Nat Rev Drug Discov (2013) 3.37

Tyrosine phosphorylation: thirty years and counting. Curr Opin Cell Biol (2009) 3.31

Breast cancer: origins and evolution. J Clin Invest (2007) 3.31

Mutations of the BRAF gene in human cancer. Nature (2002) 65.42

The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02

A census of human cancer genes. Nat Rev Cancer (2004) 36.20

The protein kinase complement of the human genome. Science (2002) 35.36

Reactome: a knowledgebase of biological pathways. Nucleic Acids Res (2005) 20.05

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell (2004) 19.51

ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06

The PANTHER database of protein families, subfamilies, functions and pathways. Nucleic Acids Res (2005) 13.37

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (1995) 13.15

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev (2001) 13.15

BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res (2002) 8.55

Targeted cancer therapy. Nature (2004) 7.81

Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res (2005) 7.66

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res (2002) 7.09

A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res (2006) 6.91

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet (2005) 6.70

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nat Genet (2006) 6.67

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet (2001) 6.36

Statistical analysis of pathogenicity of somatic mutations in cancer. Genetics (2006) 5.56

Mutational analysis of the tyrosine kinome in colorectal cancers. Science (2003) 5.43

Colorectal cancer: mutations in a signalling pathway. Nature (2005) 5.42

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Likelihood models of somatic mutation and codon substitution in cancer genes. Genetics (2003) 2.46

Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential. Biochim Biophys Acta (2004) 2.35

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Human mismatch repair, drug-induced DNA damage, and secondary cancer. Biochimie (2003) 2.03

Titin and its associated proteins: the third myofilament system of the sarcomere. Adv Protein Chem (2005) 2.00

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Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med (2004) 71.08

Mutations of the BRAF gene in human cancer. Nature (2002) 65.42

The Bioperl toolkit: Perl modules for the life sciences. Genome Res (2002) 58.63

The Pfam protein families database. Nucleic Acids Res (2002) 51.34

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The Pfam protein families database. Nucleic Acids Res (2011) 33.46

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature (2012) 31.78

Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res (2010) 25.55

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Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40

A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27

Origins and functional impact of copy number variation in the human genome. Nature (2009) 23.63

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Signatures of mutational processes in human cancer. Nature (2013) 21.63

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet (2005) 18.59

A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature (2009) 18.39

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell (2011) 16.72

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Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature (2012) 15.91

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Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet (2008) 15.43

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