Published in Mol Cell Endocrinol on December 16, 2006
Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2. Mol Cell Biol (2009) 0.92
Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease. Proc Natl Acad Sci U S A (2009) 0.89
Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands. Hum Gene Ther (2008) 0.89
Carboxypeptidase E cytoplasmic tail mediates localization of synaptic vesicles to the pre-active zone in hypothalamic pre-synaptic terminals. J Neurochem (2010) 0.87
Sorting of growth hormone-erythropoietin fusion proteins in rat salivary glands. Biochem Biophys Res Commun (2008) 0.84
γ-Adducin promotes process outgrowth and secretory protein exit from the Golgi apparatus. J Mol Neurosci (2012) 0.79
Cholesterol-enriched membrane rafts and insulin secretion. J Diabetes Investig (2012) 0.77
Exploring the membrane topology of prohormone convertase 1 in AtT20 Cells: in situ analysis by immunofluorescence microscopy. F1000Res (2012) 0.75
A human carboxypeptidase E/NF-α1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice. Transl Psychiatry (2016) 0.75
Constitutive and regulated secretion of proteins. Annu Rev Cell Biol (1987) 5.29
The proprotein convertases. Curr Opin Chem Biol (1998) 3.79
Membrane microdomains and caveolae. Curr Opin Cell Biol (1999) 3.34
The new enzymology of precursor processing endoproteases. J Biol Chem (1992) 3.26
Sorting and storage during secretory granule biogenesis: looking backward and looking forward. Biochem J (1998) 2.61
Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol Endocrinol (1991) 2.26
Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis. Cell (2001) 2.12
Eukaryotic protein processing: endoproteolysis of precursor proteins. Curr Opin Biotechnol (1997) 2.04
Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e. Neuron (2005) 1.69
Purification and characterization of the prohormone convertase PC1(PC3). J Biol Chem (1993) 1.46
Interaction of diphtheria toxin T domain with molten globule-like proteins and its implications for translocation. Science (1999) 1.32
The vesicle- and target-SNARE proteins that mediate Glut4 vesicle fusion are localized in detergent-insoluble lipid rafts present on distinct intracellular membranes. J Biol Chem (2002) 1.30
Structural elements that direct specific processing of different mammalian subtilisin-like prohormone convertases. J Biol Chem (1995) 1.16
Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells. Biochem J (1993) 1.16
Enzymatic properties of carboxyl-terminally truncated prohormone convertase 1 (PC1/SPC3) and evidence for autocatalytic conversion. J Biol Chem (1994) 1.16
Differential effects of temperature blockade on the proteolytic processing of three secretory granule-associated proteins. J Cell Sci (1994) 1.13
Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion. Biochemistry (2002) 1.13
Biogenesis of tail-anchored proteins. Biochem Soc Trans (2003) 1.10
Differences in pH optima and calcium requirements for maturation of the prohormone convertases PC2 and PC3 indicates different intracellular locations for these events. J Biol Chem (1995) 1.10
Two activation states of the prohormone convertase PC1 in the secretory pathway. J Biol Chem (1997) 0.97
Mutational analysis of PC1 (SPC3) in PC12 cells. 66-kDa PC1 is fully functional. J Biol Chem (1995) 0.94
The RGD motif and the C-terminal segment of proprotein convertase 1 are critical for its cellular trafficking but not for its intracellular binding to integrin alpha5beta1. J Biol Chem (1999) 0.94
The prohormone processing enzyme PC3 is a lipid raft-associated transmembrane protein. Biochemistry (2003) 0.92
Identification of kex2-related proteases in chromaffin granules by partial amino acid sequence analysis. J Biol Chem (1991) 0.90
Sorting of carboxypeptidase E to the regulated secretory pathway requires interaction of its transmembrane domain with lipid rafts. Biochem J (2003) 0.89
Carboxypeptidase E, a peripheral membrane protein implicated in the targeting of hormones to secretory granules, co-aggregates with granule content proteins at acidic pH. J Biol Chem (1998) 0.89
Comparison of the molecular forms of the Kex2/subtilisin-like serine proteases SPC2, SPC3, and furin in neuroendocrine secretory vesicles reveals differences in carboxyl-terminus truncation and membrane association. J Neurochem (1995) 0.89
Biogenesis of storage granules and vesicles. Curr Opin Cell Biol (1992) 0.88
A predicted alpha -helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway. J Biol Chem (2000) 0.88
Association of prohormone convertase 3 with membrane lipid rafts. J Mol Endocrinol (2001) 0.86
The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking. Biochem J (1997) 0.85
Identification of a novel prohormone sorting signal-binding site on carboxypeptidase E, a regulated secretory pathway-sorting receptor. Mol Endocrinol (1999) 0.84
Modulation of secretory granule-targeting efficiency by cis and trans compounding of sorting signals. J Biol Chem (2004) 0.84
The propeptide of prohormone convertase PC2 acts as a transferable aggregation and membrane-association signal. Eur J Biochem (1998) 0.82
Posttranslational maturation of the prohormone convertase SPC3 in vitro. J Neurochem (1997) 0.82
Proprotein convertase PC3 is not a transmembrane protein. Biochemistry (2005) 0.80
The Arg617-Arg618 cleavage site in the C-terminal domain of PC1 plays a major role in the processing and targeting of the enzyme within the regulated secretory pathway. J Neurochem (2003) 0.79
Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e. Neuron (2005) 1.69
Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics. Proc Natl Acad Sci U S A (2004) 1.64
Dense-core secretory granule biogenesis. Physiology (Bethesda) (2006) 1.62
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med (2009) 1.55
Crystal structures of the SAM-III/S(MK) riboswitch reveal the SAM-dependent translation inhibition mechanism. Nat Struct Mol Biol (2008) 1.54
Retracted The serine protease inhibitor neuroserpin regulates the growth and maturation of hippocampal neurons through a non-inhibitory mechanism. J Neurochem (2012) 1.47
The extended granin family: structure, function, and biomedical implications. Endocr Rev (2011) 1.43
The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. Endocrinology (2004) 1.33
New roles of carboxypeptidase E in endocrine and neural function and cancer. Endocr Rev (2012) 1.23
A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons. Mol Cell Neurosci (2008) 1.15
Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion. Biochemistry (2002) 1.13
Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones. Mol Endocrinol (2008) 1.10
Molecular basis of gene regulation by the THI-box riboswitch. Mol Microbiol (2007) 1.10
Tuning riboswitch regulation through conformational selection. J Mol Biol (2010) 1.06
Chromogranin A deficiency in transgenic mice leads to aberrant chromaffin granule biogenesis. J Neurosci (2005) 1.06
Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. Hippocampus (2008) 1.05
How peptide hormone vesicles are transported to the secretion site for exocytosis. Mol Endocrinol (2008) 1.04
Abnormal sterols in cholesterol-deficiency diseases cause secretory granule malformation and decreased membrane curvature. J Cell Sci (2006) 1.04
Carboxypeptidase E: elevated expression correlated with tumor growth and metastasis in pheochromocytomas and other cancers. Cell Mol Neurobiol (2010) 1.02
An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers. J Clin Invest (2011) 1.02
Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis. Biophys J (2004) 1.02
Carboxypeptidase E/NFα1: a new neurotrophic factor against oxidative stress-induced apoptotic cell death mediated by ERK and PI3-K/AKT pathways. PLoS One (2013) 1.02
Recycling of Raft-associated prohormone sorting receptor carboxypeptidase E requires interaction with ARF6. Mol Biol Cell (2003) 1.01
Carboxypeptidase E is required for normal synaptic transmission from photoreceptors to the inner retina. J Neurochem (2005) 1.00
Neuroprotective protein and carboxypeptidase E. J Mol Neurosci (2009) 0.99
Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation. Mol Biol Cell (2005) 0.98
The molecular profiles of neural stem cell niche in the adult subventricular zone. PLoS One (2012) 0.97
A new chromogranin A-dependent angiogenic switch activated by thrombin. Blood (2012) 0.96
Partial redirection of transgenic human growth hormone secretion from rat salivary glands. Hum Gene Ther (2005) 0.96
Secretory granule biogenesis and neuropeptide sorting to the regulated secretory pathway in neuroendocrine cells. J Mol Neurosci (2004) 0.95
Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density. Am J Physiol Endocrinol Metab (2010) 0.94
Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells. J Neurochem (2002) 0.94
Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells. Mol Endocrinol (2008) 0.93
The prohormone processing enzyme PC3 is a lipid raft-associated transmembrane protein. Biochemistry (2003) 0.92
Synaptic plasticity-associated proteases and protease inhibitors in the brain linked to the processing of extracellular matrix and cell adhesion molecules. Neuron Glia Biol (2009) 0.92
Variable sequences outside the SAM-binding core critically influence the conformational dynamics of the SAM-III/SMK box riboswitch. J Mol Biol (2011) 0.92
Biogenesis and transport of secretory granules to release site in neuroendocrine cells. J Mol Neurosci (2008) 0.91
Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland. Endocrinology (2010) 0.90
Disruption of a receptor-mediated mechanism for intracellular sorting of proinsulin in familial hyperproinsulinemia. Mol Endocrinol (2003) 0.89
Sorting of carboxypeptidase E to the regulated secretory pathway requires interaction of its transmembrane domain with lipid rafts. Biochem J (2003) 0.89
The C-terminus of prohormone convertase 2 is sufficient and necessary for Raft association and sorting to the regulated secretory pathway. Biochemistry (2004) 0.89
Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands. Hum Gene Ther (2008) 0.89
Carboxypeptidase E cytoplasmic tail mediates localization of synaptic vesicles to the pre-active zone in hypothalamic pre-synaptic terminals. J Neurochem (2010) 0.87
Efficacy and safety of en bloc ligation of renal hilum during laparoscopic nephrectomy. Urology (2007) 0.87
Carboxypeptidase E (NF-α1): a new trophic factor in neuroprotection. Neurosci Bull (2014) 0.87
Serpinin: a novel chromogranin A-derived, secreted peptide up-regulates protease nexin-1 expression and granule biogenesis in endocrine cells. Mol Endocrinol (2011) 0.86
The Leu34Phe ProCART mutation leads to cocaine- and amphetamine-regulated transcript (CART) deficiency: a possible cause for obesity in humans. Endocrinology (2005) 0.86
Carboxypeptidase E knockout mice exhibit abnormal dendritic arborization and spine morphology in central nervous system neurons. J Neurosci Res (2010) 0.86
Large dense-core secretory granule biogenesis is under the control of chromogranin A in neuroendocrine cells. Ann N Y Acad Sci (2002) 0.86
Nerve growth factor-dependent sorting of synaptotagmin IV protein to mature dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells. J Biol Chem (2002) 0.85
The novel chromogranin A-derived serpinin and pyroglutaminated serpinin peptides are positive cardiac β-adrenergic-like inotropes. FASEB J (2012) 0.85
A distinct trans-Golgi network subcompartment for sorting of synaptic and granule proteins in neurons and neuroendocrine cells. J Cell Sci (2011) 0.85
Neuroserpin regulates N-cadherin-mediated cell adhesion independently of its activity as an inhibitor of tissue plasminogen activator. J Neurosci Res (2008) 0.85
Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice. Endocrinology (2003) 0.85
Neuroserpin regulates the density of dendritic protrusions and dendritic spine shape in cultured hippocampal neurons. J Neurosci Res (2010) 0.85
Chromogranin A: a surprising link between granule biogenesis and hypertension. J Clin Invest (2005) 0.84
Sorting of growth hormone-erythropoietin fusion proteins in rat salivary glands. Biochem Biophys Res Commun (2008) 0.84
Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Food Chem (2012) 0.84
Cellular mechanisms for the biogenesis and transport of synaptic and dense-core vesicles. Int Rev Cell Mol Biol (2012) 0.83
Role of pGlu-serpinin, a novel chromogranin A-derived peptide in inhibition of cell death. J Mol Neurosci (2011) 0.82
Chemicals eluting from disposable plastic syringes and syringe filters alter neurite growth, axogenesis and the microtubule cytoskeleton in cultured hippocampal neurons. J Neurochem (2015) 0.82
Expression of the serine protease inhibitor neuroserpin in cells of the human myeloid lineage. Thromb Haemost (2007) 0.81
Chromogranin A: a new proposal for trafficking, processing and induction of granule biogenesis. Regul Pept (2009) 0.81
Visualization of peptide secretory vesicles in living nerve cells. Methods Mol Biol (2011) 0.80
Synthesis and characterization of the first potent inhibitor of yapsin 1. Implications for the study of yapsin-like enzymes. J Biol Chem (2002) 0.79
Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus. PLoS One (2013) 0.79
γ-Adducin promotes process outgrowth and secretory protein exit from the Golgi apparatus. J Mol Neurosci (2012) 0.79
Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Mol Nutr Food Res (2014) 0.78
Robotic ureteral reconstruction distal to the ureteropelvic junction: a large single institution clinical series with short-term follow up. J Endourol (2014) 0.78
Glucagon-like peptide-1 gene therapy. Exp Diabetes Res (2011) 0.78
Functional and immunocytochemical characterization of the creatine transporter in rat hippocampal neurons. J Neurochem (2010) 0.78
Expression and functional characterization of the serine protease inhibitor neuroserpin in endocrine cells. Ann N Y Acad Sci (2002) 0.77
Reprint of: Chromogranin A: a new proposal for trafficking, processing and induction of granule biogenesis. Regul Pept (2010) 0.77