Published in Cochrane Database Syst Rev on January 24, 2007
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet (2009) 4.38
Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons. Mol Ther (2009) 3.33
Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression. Nat Biotechnol (2014) 2.99
Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch (2010) 2.83
Amyotrophic lateral sclerosis. Orphanet J Rare Dis (2009) 2.76
Prognostic factors in ALS: A critical review. Amyotroph Lateral Scler (2009) 2.63
Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial. Int J Neuropsychopharmacol (2009) 2.33
A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell (2013) 2.14
NMDA receptors in clinical neurology: excitatory times ahead. Lancet Neurol (2008) 2.13
Clinical diagnosis and management of amyotrophic lateral sclerosis. Nat Rev Neurol (2011) 2.08
Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study. Brain (2008) 1.72
Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment. Pharmacol Ther (2011) 1.71
The molecular basis of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum. Ann Med (2012) 1.66
Beta-band intermuscular coherence: a novel biomarker of upper motor neuron dysfunction in motor neuron disease. Brain (2012) 1.52
Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis. Brain (2008) 1.40
Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Research in Japanese Patients. PLoS One (2016) 1.39
Clinical and experimental applications of sodium phenylbutyrate. Drugs R D (2011) 1.32
SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments. Mamm Genome (2011) 1.17
Diagnosis and management of motor neurone disease. BMJ (2008) 1.16
A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and preliminary efficacy of riluzole in patients with traumatic spinal cord injury. J Neurotrauma (2013) 1.13
Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand? Front Neurosci (2010) 1.12
Cystatin C: a candidate biomarker for amyotrophic lateral sclerosis. PLoS One (2010) 1.08
The complex molecular biology of amyotrophic lateral sclerosis (ALS). Prog Mol Biol Transl Sci (2012) 1.05
Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. Oncogene (2012) 1.01
Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells. Cell Mol Life Sci (2010) 1.01
The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials. Amyotroph Lateral Scler (2010) 0.99
Intrathecal delivery of mesenchymal stromal cells protects the structure of altered perineuronal nets in SOD1 rats and amends the course of ALS. Stem Cells (2014) 0.96
G-CSF prevents the progression of structural disintegration of white matter tracts in amyotrophic lateral sclerosis: a pilot trial. PLoS One (2011) 0.95
An imbalance between excitatory and inhibitory neurotransmitters in amyotrophic lateral sclerosis revealed by use of 3-T proton magnetic resonance spectroscopy. JAMA Neurol (2013) 0.92
Amyotrophic lateral sclerosis: update and new developments. Degener Neurol Neuromuscul Dis (2012) 0.91
Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis. PLoS One (2012) 0.90
Chronic riluzole treatment increases glucose metabolism in rat prefrontal cortex and hippocampus. J Cereb Blood Flow Metab (2008) 0.90
Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium. Future Neurol (2010) 0.89
Riluzole in psychiatry: a systematic review of the literature. Expert Opin Drug Metab Toxicol (2008) 0.89
p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration. Cell Death Differ (2016) 0.88
Therapeutic neuroprotective agents for amyotrophic lateral sclerosis. Cell Mol Life Sci (2013) 0.88
Emerging therapies for acute traumatic spinal cord injury. CMAJ (2012) 0.88
Plasma neurofilament heavy chain levels correlate to markers of late stage disease progression and treatment response in SOD1(G93A) mice that model ALS. PLoS One (2012) 0.86
Redox regulation in amyotrophic lateral sclerosis. Oxid Med Cell Longev (2013) 0.86
Being PRO-ACTive: What can a Clinical Trial Database Reveal About ALS? Neurotherapeutics (2015) 0.86
Vitamin D(3) at 50x AI attenuates the decline in paw grip endurance, but not disease outcomes, in the G93A mouse model of ALS, and is toxic in females. PLoS One (2013) 0.85
Decline in daily running distance presages disease onset in a mouse model of ALS. Neuromolecular Med (2009) 0.84
Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model. PLoS One (2014) 0.83
Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic lateral sclerosis (LiCALS) [Eudract number: 2008-006891-31]. BMC Neurol (2011) 0.83
The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis. PLoS One (2013) 0.83
Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders. Int J Mol Sci (2009) 0.82
Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application. EPMA J (2010) 0.81
Current and emerging treatments for amyotrophic lateral sclerosis. Neuropsychiatr Dis Treat (2009) 0.81
Human TBK1: A Gatekeeper of Neuroinflammation. Trends Mol Med (2016) 0.80
Amyotrophic Lateral Sclerosis: New Perpectives and Update. Neurol Int (2015) 0.80
A novel acylaminoimidazole derivative, WN1316, alleviates disease progression via suppression of glial inflammation in ALS mouse model. PLoS One (2014) 0.80
Need for a paradigm shift in therapeutic approaches to CNS injury. Expert Rev Neurother (2012) 0.80
Metal-deficient aggregates and diminished copper found in cells expressing SOD1 mutations that cause ALS. Front Aging Neurosci (2014) 0.80
Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis. J Med Chem (2014) 0.80
Progress in therapy development for amyotrophic lateral sclerosis. Neurol Res Int (2012) 0.79
Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis. Biomed Res Int (2014) 0.79
A Novel Mathematical Approach to Define the Genes/SNPs Conferring Risk or Protection in Sporadic Amyotrophic Lateral Sclerosis Based on Auto Contractive Map Neural Networks and Graph Theory. Neurol Res Int (2012) 0.78
Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis? Neural Regen Res (2016) 0.78
Speech in ALS: Longitudinal Changes in Lips and Jaw Movements and Vowel Acoustics. J Med Speech Lang Pathol (2013) 0.77
The fraction of activated N-methyl-D-aspartate receptors during synaptic transmission remains constant in the presence of the glutamate release inhibitor riluzole. J Neural Transm (Vienna) (2008) 0.77
Novel Neuroprotective Multicomponent Therapy for Amyotrophic Lateral Sclerosis Designed by Networked Systems. PLoS One (2016) 0.76
Proteomic analysis of cerebrospinal fluid in amyotrophic lateral sclerosis. Exp Ther Med (2016) 0.76
The preclinical discovery of amyotrophic lateral sclerosis drugs. Expert Opin Drug Discov (2011) 0.76
Stronger is not always better: could a bodybuilding dietary supplement lead to ALS? Exp Neurol (2010) 0.76
Current Perspective of Stem Cell Therapy in Neurodegenerative and Metabolic Diseases. Mol Neurobiol (2016) 0.76
A three-groups model for high-throughput survival screens. Biometrics (2016) 0.75
Model systems of motor neuron diseases as a platform for studying pathogenic mechanisms and searching for therapeutic agents. Acta Naturae (2015) 0.75
Statistical insights into major human muscular diseases. Hum Mol Genet (2014) 0.75
MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis. PLoS One (2016) 0.75
ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment? Front Aging Neurosci (2017) 0.75
Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer's and Amyotrophic Lateral Sclerosis Brains. Neurosci J (2016) 0.75
Autologous bone marrow mononuclear cells as neuroprotective treatment of amyotrophic lateral sclerosis. Neural Regen Res (2016) 0.75
Amyotrophic lateral sclerosis presenting as upper limb weakness in a 35 year old female: a case report. J Can Chiropr Assoc (2011) 0.75
High Content Analysis in Amyotrophic Lateral Sclerosis. Mol Cell Neurosci (2016) 0.75
A Cystine-Rich Whey Supplement (Immunocal(®)) Delays Disease Onset and Prevents Spinal Cord Glutathione Depletion in the hSOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis. Antioxidants (Basel) (2014) 0.75
Multidisciplinary Interventions in Motor Neuron Disease. J Neurodegener Dis (2014) 0.75
The role of solvent exclusion in the interaction between D124 and the metal site in SOD1: implications for ALS. J Biol Inorg Chem (2013) 0.75
Effectiveness of Riluzole as a pharmacotherapeutic treatment option for early cervical myelopathy: a double-blinded, placebo-controlled randomised controlled trial. Eur Spine J (2015) 0.75
FRACTIONATION OF SERUM PROTEINS IN HYPERPROTEINEMIA, WITH SPECIAL REFERENCE TO MULTIPLE MYELOMA. J Clin Invest (1941) 11.64
Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst (1992) 8.69
THE RELATION OF CEPHALIN FLOCCULATION AND COLLOIDAL GOLD REACTIONS TO THE SERUM PROTEINS. J Clin Invest (1943) 7.05
AN ELECTROPHORETIC STUDY OF THE PROTEIN COMPONENTS IN CEREBROSPINAL FLUID AND THEIR RELATIONSHIP TO THE SERUM PROTEINS. J Clin Invest (1942) 6.90
MECHANISM OF THE POSITIVE CEPHALIN-CHOLESTEROL FLOCCULATION REACTION IN HEPATITIS. J Clin Invest (1945) 5.81
Tumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma. J Natl Cancer Inst (1995) 3.96
DNA content and DNA-based centromeric index of the 24 human chromosomes. Science (1973) 3.08
Structure and function of heparan sulphate proteoglycans. Biochem J (1986) 2.78
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev (2012) 2.49
Chromosome measurement and sorting by flow systems. Proc Natl Acad Sci U S A (1975) 2.37
Phase II screening trial of lithium carbonate in amyotrophic lateral sclerosis: examining a more efficient trial design. Neurology (2011) 2.28
Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology (2001) 2.27
SIGNIFICANCE OF CEPHALIN-CHOLESTEROL FLOCCULATION TEST IN MALARIAL FEVER. J Clin Invest (1945) 2.26
Helicobacter pylori infection in children: potential clues to pathogenesis. J Pediatr Gastroenterol Nutr (1993) 2.25
Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues. J Neurol Neurosurg Psychiatry (2008) 2.24
A prospective controlled trial of early postoperative oral intake following major abdominal gynecologic surgery. Gynecol Oncol (1997) 2.23
Common properties of the oncogenic RNA viruses (oncornaviruses). Virology (1970) 2.20
Search for a human breast cancer virus. Nature (1971) 2.14
Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping. Cancer Res (1996) 2.04
Mammary tumor viruses. Adv Cancer Res (1979) 2.03
Endometriosis and ovulatory disorder: reduced fertilisation in vitro compared with tubal and unexplained infertility. Lancet (1985) 2.00
Chromosomal alterations in ductal carcinomas in situ and their in situ recurrences. J Natl Cancer Inst (2000) 1.99
The liver to abdominal area ratio (LAAR): a novel imaging score for prognostication in cirrhosis. Aliment Pharmacol Ther (2013) 1.98
Correlation of Ki-67 antigen expression with mitotic figure index and tumor grade in breast carcinomas using the novel "paraffin"-reactive MIB1 antibody. Hum Pathol (1994) 1.89
Murine mammary tumor virus: characterization of infection of nonmurine cells. J Virol (1976) 1.87
Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis. Cancer Res (2000) 1.82
An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer. Cancer Res (2000) 1.81
Nucleic acid splicing events occur frequently during macronuclear development in the protozoan Oxytricha nova and involve the elimination of unique DNA. Genes Dev (1987) 1.72
The relationship between maternal age and uterine dysfunction: a continuous effect throughout reproductive life. Am J Obstet Gynecol (2000) 1.72
Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin. Cancer Res (2000) 1.67
Ultrastructural comparison of a virus from a Rhesus-monkey mammary carcinoma with four oncogenic RNA viruses. Proc Natl Acad Sci U S A (1971) 1.67
Chromosomal alterations in ulcerative colitis-related neoplastic progression. Gastroenterology (1997) 1.66
Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis. Neurology (2004) 1.60
Endocan or endothelial cell specific molecule-1 (ESM-1): a potential novel endothelial cell marker and a new target for cancer therapy. Biochim Biophys Acta (2005) 1.56
The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse. J Biol Chem (2001) 1.55
Isolation of the mouse mammary tumor virus: chemical and morphological studies. J Natl Cancer Inst (1965) 1.51
Homology between human breast tumour RNA and mouse mammary tumour virus genome. Nature (1974) 1.51
Chronic expanding hematoma of the thorax. AJR Am J Roentgenol (2003) 1.50
The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutat Res (1995) 1.50
Analysis of Bax and Bcl-2 expression in p53-immunopositive breast cancers. Clin Cancer Res (1997) 1.48
Helical nucleocapsid structure of the oncogenic ribonucleic acid viruses (oncornaviruses). J Virol (1971) 1.48
The fate of the ovaries after radical hysterectomy and ovarian transposition. Gynecol Oncol (1995) 1.47
The overexpression of RHAMM, a hyaluronan-binding protein that regulates ras signaling, correlates with overexpression of mitogen-activated protein kinase and is a significant parameter in breast cancer progression. Clin Cancer Res (1998) 1.41
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Amyotroph Lateral Scler Other Motor Neuron Disord (2003) 1.41
Neutralization of murine mammary tumour virus by sera of women with breast cancer. Nature (1971) 1.40
Violence research. Science (1994) 1.40
Fine structure of Haemobartonella muris as compared with Eperythrozoon coccoides and Mycoplasma pulmonis. J Bacteriol (1965) 1.38
Analysis of somatic cell mutations at the glycophorin A locus in atomic bomb survivors: a comparative study of assay methods. Radiat Res (1993) 1.38
A VISCOUS PROTEIN OBTAINED IN LARGE AMOUNT FROM THE SERUM OF A PATIENT WITH MULTIPLE MYELOMA. J Clin Invest (1943) 1.38
Measures of cell turnover (proliferation and apoptosis) and their association with survival in breast cancer. Clin Cancer Res (2001) 1.37
Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia. Am J Pathol (1999) 1.35
Electron microscopy of the nucleic acid of mouse mammary tumor virus. J Virol (1970) 1.32
Preoperative chemo-radiation for carcinoma of the vulva with N2/N3 nodes: a gynecologic oncology group study. Int J Radiat Oncol Biol Phys (2000) 1.30
Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity. J Biol Chem (2001) 1.28
Detection of high-molecular-weight RNA in particles from human milk. Science (1972) 1.27
The prognostic value of proliferation indices: a study with in vivo bromodeoxyuridine and Ki-67. Breast Cancer Res Treat (2000) 1.27
Experimental infection of a cat kidney cell line with the mouse mammary tumor virus. Cancer Res (1976) 1.27
Highly sensitive sequencing of the sulfated domains of heparan sulfate. J Biol Chem (1999) 1.27
Psychiatric diagnoses in adolescents seropositive for the human immunodeficiency virus. Arch Pediatr Adolesc Med (2000) 1.26
Comparison of mitotic index, in vitro bromodeoxyuridine labeling, and MIB-1 assays to quantitate proliferation in breast cancer. J Clin Oncol (1999) 1.24
Tumor angiogenesis correlates with lymph node metastases in invasive bladder cancer. J Urol (1995) 1.22
Invasive micropapillary carcinoma of the breast: a prognostic study. Hum Pathol (1999) 1.22
The functional relationship between in vivo bromodeoxyuridine labeling index and Ki-67 proliferation index in human breast cancer. Breast Cancer Res Treat (1998) 1.21
Patterns of sulphation in heparan sulphate: polymorphism based on a common structural theme. Int J Biochem (1992) 1.21
A preliminary evaluation of a prospective study of pulmonary function studies and symptoms of hypoventilation in ALS/MND patients. J Neurol Sci (2001) 1.19
Characteristics of the structural components of the mouse mammary tumor virus. I. Morphological and biochemical studies. Virology (1971) 1.18
Three-dimensional reconstruction of ventricular septal defects: validation studies and in vivo feasibility. J Am Coll Cardiol (1994) 1.17
A temperature-sensitive mutation of Crygs in the murine Opj cataract. J Biol Chem (2000) 1.16
THE USE OF INFRA-RED FILM FOR ELECTROPHORETIC AND ULTRACENTRIFUGAL ANALYSES. Science (1941) 1.15
Diagnostic accuracy of fine-needle aspiration biopsy is determined by physician training in sampling technique. Cancer (2001) 1.14
Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro. J Biol Chem (1998) 1.14
The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer. Anticancer Res (1998) 1.13
Molecular cloning of the major cell surface heparan sulfate proteoglycan from rat liver. J Biol Chem (1992) 1.13
Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains. J Mol Biol (2007) 1.12
Serologic evidence for reactivation of cryptococcosis in solid-organ transplant recipients. Clin Vaccine Immunol (2007) 1.11
A study of age group track and field records to relate age and running speed. Nature (1975) 1.11
The DNA-based human karyotype. Cytometry (1984) 1.11
Reverse transcriptase and high molecular weight RNA in particles from mouse and human milk. J Natl Cancer Inst (1972) 1.10
Oxidative stress pathways highlighted in tumor cell immortalization: association with breast cancer outcome. Oncogene (2007) 1.10
Analyses of brain tumor cell lines confirm a simple model of relationships among fluorescence in situ hybridization, DNA index, and comparative genomic hybridization. Genes Chromosomes Cancer (1997) 1.10
Fibroblast growth factor-2 stimulation of p42/44MAPK phosphorylation and IkappaB degradation is regulated by heparan sulfate/heparin in rat mammary fibroblasts. J Biol Chem (2000) 1.10
Sulphated proteoglycan is required for collecting duct growth and branching but not nephron formation during kidney development. Development (1995) 1.09
ATTEMPTS AT PURIFICATION OF A MURINE STRAIN OF HUMAN POLIOMYELITIS VIRUS. Science (1942) 1.08
Toxicity of wheat gliadin fractions in coeliac disease. Lancet (1973) 1.07
Mutagenic activity in nipple aspirates of human breast fluid. Cancer Res (1980) 1.07
A soluble antigen of the mammary tumor virus. Virology (1967) 1.07
Phase II study of paclitaxel and valspodar (PSC 833) in refractory ovarian carcinoma: a gynecologic oncology group study. J Clin Oncol (2001) 1.07
Norethisterone treatment to control timing of the IVF cycle. Hum Reprod (1986) 1.06
Outcomes associated with cesarean section versus vaginal breech delivery at a university hospital. J Perinatol (2006) 1.06
Effect of cooking time and temperature on the heterocyclic amine content of fried beef patties. Food Chem Toxicol (1994) 1.05
The localization of vestibular efferent neurons in the kitten with horseradish peroxidase. Acta Otolaryngol (1974) 1.05
Identification of an extended N-acetylated sequence adjacent to the protein-linkage region of fibroblast heparan sulphate. Biochem J (1987) 1.03
Effect of intraoperative blood transfusion on patient outcome in hepatic transplantation. Arch Surg (1999) 1.03
Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancers. Clin Cancer Res (2001) 1.03
Do homologous chromosomes differ? Two statistical tests. Cytogenet Cell Genet (1973) 1.03
Separation of B and C type virions by centrifugation in gentle density gradients. J Virol (1974) 1.02
Proteoglycans: pericellular and cell surface multireceptors that integrate external stimuli in the mammary gland. J Mammary Gland Biol Neoplasia (2001) 1.02
Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade. Genes Chromosomes Cancer (1998) 1.01