Published in Bioorg Med Chem Lett on January 08, 2007
Human NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups. Biochemistry (2012) 0.82
Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays. Acta Biomater (2016) 0.79
Syntheses and Antibacterial Activity of N-Acylated Ciprofloxacin Derivatives Based on the Trimethyl Lock. ACS Med Chem Lett (2015) 0.79
Oxidative activation of antioxidant defence. Trends Biochem Sci (2005) 1.47
From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides. Angew Chem Int Ed Engl (2007) 1.31
Increased blood vessel density and endothelial cell proliferation in multiple sclerosis cerebral white matter. Neurosci Lett (2009) 1.17
The diazo route to diazonamide A. Studies on the indole bis-oxazole fragment. J Org Chem (2005) 1.12
Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential. Org Biomol Chem (2007) 1.05
Rapid access to α-alkoxy and α-amino acid derivatives through safe continuous-flow generation of diazoesters. Chemistry (2011) 1.02
Natural products containing a diazo group. Nat Prod Rep (2011) 1.01
Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells. Biochemistry (2007) 0.97
The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product. Nat Prod Rep (2008) 0.96
Asymmetric synthesis of the central tryptophan residue of stephanotic acid. Org Biomol Chem (2004) 0.96
Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chem Biol (2006) 0.96
Heat shock protein 90 controls HIV-1 reactivation from latency. Proc Natl Acad Sci U S A (2014) 0.95
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem (2013) 0.94
Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling. Mol Pharmacol (2011) 0.93
5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo. Mol Cancer Ther (2006) 0.92
Rhodium carbene routes to oxazoles and thiazoles. Catalyst effects in the synthesis of oxazole and thiazole carboxylates, phosphonates, and sulfones. J Org Chem (2010) 0.92
Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target. Mol Pharmacol (2009) 0.91
Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1). Bioorg Med Chem (2004) 0.90
A short synthesis of the triazolopyrimidine antibiotic essramycin. J Nat Prod (2010) 0.90
Synthesis of 3-(carboxyarylalkyl)imidazo[2,1-f][1,2,4]triazines as potential inhibitors of AMP deaminase. Org Biomol Chem (2008) 0.89
Oxidative rearrangement of indoles: a new approach to the EFHG-tetracyclic core of diazonamide A. J Org Chem (2007) 0.88
Biomimetic synthesis of the apoptosis-inducing thiazinoquinone thiaplidiaquinone A. J Org Chem (2012) 0.88
Synthesis of the reported structure of crassiflorone, a naturally occurring quinone isolated from the African ebony Diospyros crassiflora, and regioisomeric pentacyclic furocoumarin naphthoquinones. Org Biomol Chem (2011) 0.88
Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity. J Med Chem (2007) 0.87
Keap calm, and carry on covalently. J Med Chem (2013) 0.87
Microwave-mediated Claisen rearrangement followed by phenol oxidation: a simple route to naturally occurring 1,4-benzoquinones. The first syntheses of verapliquinones A and B and panicein A. J Org Chem (2005) 0.86
Nucleophilic fluorination of β-ketoester derivatives with HBF4. Chem Commun (Camb) (2012) 0.86
A two step route to indoles from haloarenes--a versatile variation on the Fischer indole synthesis. Chem Commun (Camb) (2010) 0.86
Total synthesis of the thiopeptide amythiamicin D. Chem Commun (Camb) (2004) 0.85
Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems. Mol Pharmacol (2003) 0.85
Total synthesis of stephanotic acid methyl ester. Org Lett (2006) 0.85
Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90. J Org Chem (2013) 0.84
Tetrahydroxanthones by sequential Pd-catalyzed C-O and C-C bond construction and use in the identification of the "antiausterity" pharmacophore of the kigamicins. Org Lett (2011) 0.84
Synthesis of indolequinones from bromoquinones and enamines mediated by Cu(OAc)2.H2O. J Org Chem (2010) 0.84
An improved and reliable method for isolation of microvascular endothelial cells from human omentum. Microcirculation (2011) 0.83
Synthesis of β-keto esters in-flow and rapid access to substituted pyrimidines. J Org Chem (2010) 0.83
The diazo route to diazonamide A: studies on the tyrosine-derived fragment. Org Biomol Chem (2005) 0.83
Synthesis of amino-1,4-benzoquinones and their use in Diels-Alder approaches to the aminonaphthoquinone antibiotics. J Org Chem (2011) 0.83
Total synthesis of the thiopeptide antibiotic amythiamicin D. J Am Chem Soc (2005) 0.82
Asymmetric synthesis of chiral alpha-ferrocenylalkylamines and their use in the preparation of chiral redox-active receptors. Org Lett (2002) 0.82
Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems. Biochemistry (2011) 0.81
Alkyl halide-free heteroatom alkylation and epoxidation facilitated by a recyclable polymer-supported oxidant for the in-flow preparation of diazo compounds. Chemistry (2015) 0.81
Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes. J Am Chem Soc (2010) 0.81
Indolequinone antitumour agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Org Biomol Chem (2007) 0.81
An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration. Chem Commun (Camb) (2013) 0.81
Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair Regen (2013) 0.81
Tenascin C induces a quiescent phenotype in cultured adult human astrocytes. Glia (2005) 0.81
Amination of heteroaryl chlorides: palladium catalysis or SN Ar in green solvents? ChemSusChem (2013) 0.81
Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Exp Cell Res (2011) 0.81
Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release. Biochem Pharmacol (2002) 0.80
Synthesis of spirotetramates via a Diels-Alder approach. Org Lett (2011) 0.80
Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I. Bioorg Med Chem Lett (2003) 0.80
Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1. Org Biomol Chem (2007) 0.79
Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea Hyperb Med (2013) 0.79
Diverse trifluoromethyl heterocycles from a single precursor. J Org Chem (2012) 0.79
Targeting the Hsp90 chaperone: synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90. Chemistry (2010) 0.78
The total synthesis of siphonazole, a structurally unusual bis-oxazole natural product. Chem Commun (Camb) (2007) 0.78
The remarkable effect of the 7-substituent in the diastereoselective oxidative rearrangement of indoles: asymmetric synthesis of 3,3-disubstituted oxindoles. Chem Commun (Camb) (2006) 0.78
Total synthesis of siphonazole and its O-methyl derivative, structurally unusual bis-oxazole natural products. Org Biomol Chem (2008) 0.78
A concise route to pyridines from hydrazides by metal carbene N-H insertion, 1,2,4-triazine formation, and Diels-Alder reaction. Org Lett (2009) 0.78
Synthesis of the oxepinochromone natural products ptaeroxylin (desoxykarenin), ptaeroxylinol, and eranthin. J Org Chem (2010) 0.78
Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents. Angiogenesis (2002) 0.78
Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90. Org Biomol Chem (2014) 0.78
19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity. Mol Pharmacol (2014) 0.77
Two approaches to the aromatic core of the aminonaphthoquinone antibiotics. J Org Chem (2013) 0.77
Studies toward the synthesis of luminacin D: assembly of simplified analogues devoid of the epoxide displaying antiangiogenic activity. Org Lett (2004) 0.77
Biomimetic approaches to diazonamide A. Direct synthesis of the indole bis-oxazole fragment by oxidation of a TyrValTrpTrp tetrapeptide. Chem Commun (Camb) (2006) 0.77
Quinones as dienophiles in the Diels-Alder reaction: history and applications in total synthesis. Angew Chem Int Ed Engl (2014) 0.77
The rhodium carbene route to oxazoles: a remarkable catalyst effect. Chem Commun (Camb) (2009) 0.77
Synthesis of (+/-)-likonide B (smenochromene D) using a regioselective Claisen rearrangement, separation of the enantiomers and stereochemical assignment. Org Biomol Chem (2009) 0.77
Two-step route to indoles and analogues from haloarenes: a variation on the Fischer indole synthesis. J Org Chem (2011) 0.77
Regioselectivity of the Claisen rearrangement in meta-allyloxy aryl ketones: an experimental and computational study, and application in the synthesis of (R)-(-)-pestalotheol D. Chemistry (2011) 0.77
Copper(II)-Mediated Synthesis of Indolequinones from Bromoquinones and Enamines. European J Org Chem (2013) 0.77
Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin. Org Biomol Chem (2007) 0.77
Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies. ACS Chem Biol (2011) 0.76
Solar photochemical oxidations of benzylic and allylic alcohols using catalytic organo-oxidation with DDQ: application to lignin models. Org Lett (2014) 0.76
Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1. Bioorg Med Chem (2013) 0.76
Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A. J Med Chem (2013) 0.76
Solution structures of thiopeptide antibiotics. Chem Commun (Camb) (2006) 0.76
Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies. Chemistry (2010) 0.76
Competition between planar and central chiral control elements in nucleophilic addition to ferrocenyl imine derivatives. Chem Commun (Camb) (2008) 0.76
Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells. Org Biomol Chem (2014) 0.75
Potassium N-iodo p-toluenesulfonamide (TsNIK, Iodamine-T): a new reagent for the oxidation of hydrazones to diazo compounds. Chemistry (2014) 0.75
Total synthesis of mevashuntin. Org Lett (2012) 0.75
A new route to α-carbolines based on 6π-electrocyclization of indole-3-alkenyl oximes. Org Lett (2013) 0.75
Carbene reactivity of 4-diazo-4H-imidazoles toward nucleophiles and aromatic compounds. J Org Chem (2009) 0.75
Toward the total synthesis of hygrocin B and divergolide C: construction of the naphthoquinone-azepinone core. Org Lett (2014) 0.75
Synthesis of parvistemin A via biomimetic oxidative dimerization. Org Lett (2011) 0.75
Total synthesis of (±)-distomadines A and B. Org Lett (2014) 0.75
Asymmetric synthesis of N-protected amino acids by the addition of organolithium carboxyl synthons to ROPHy/SOPHy-derived aldoximes and ketoximes. Org Biomol Chem (2003) 0.75
Synthesis of balsaminone A, a naturally occurring pentacyclic dinaphthofuran quinone. J Org Chem (2011) 0.75
Benzofuranquinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis and biological evaluation. Org Biomol Chem (2014) 0.75
Solar photochemical oxidation of alcohols using catalytic hydroquinone and copper nanoparticles under oxygen: oxidative cleavage of lignin models. J Org Chem (2014) 0.75
7-Deazapurine biosynthesis: NMR study of toyocamycin biosynthesis in Streptomyces rimosus using 2-13C-7-15N-adenine. Org Biomol Chem (2011) 0.75
Synthesis of an achiral isomer of lipoic acid as an anchor group for SAM formation on gold surfaces. J Org Chem (2010) 0.75