Published in Trends Biochem Sci on August 01, 2005
TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity. J Biol Chem (2008) 1.67
Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione. J Neurochem (2008) 1.58
Oxidative stress as a mediator of cardiovascular disease. Oxid Med Cell Longev (2010) 1.58
Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation. Cancer Res (2008) 1.52
Deducing in vivo toxicity of combustion-derived nanoparticles from a cell-free oxidative potency assay and metabolic activation of organic compounds. Environ Health Perspect (2008) 1.32
Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose. Biochim Biophys Acta (2010) 1.25
Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione. J Biol Chem (2008) 1.22
Role of oxidative stress in epileptic seizures. Neurochem Int (2011) 1.20
Protein misfolding disorders: pathogenesis and intervention. J Inherit Metab Dis (2006) 1.17
Hydrolase regulates NAD+ metabolites and modulates cellular redox. J Biol Chem (2009) 1.13
Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo. Genome Biol (2007) 1.13
Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic Biol Med (2013) 1.09
Apoptotic signals induce specific degradation of ribosomal RNA in yeast. Nucleic Acids Res (2008) 1.08
Immuno-spin trapping analyses of DNA radicals. Nat Protoc (2007) 1.04
In vitro acute exposure to DEHP affects oocyte meiotic maturation, energy and oxidative stress parameters in a large animal model. PLoS One (2011) 0.98
Regulation of a glutamyl-tRNA synthetase by the heme status. Proc Natl Acad Sci U S A (2007) 0.95
Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography. J Biol Chem (2010) 0.93
Use of comparative proteomics to identify potential resistance mechanisms in cancer treatment. Cancer Treat Rev (2007) 0.92
Schisandrin B prevents doxorubicin-induced chronic cardiotoxicity and enhances its anticancer activity in vivo. PLoS One (2011) 0.91
Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes. J Neurochem (2011) 0.91
Glutathionylation of the pro-apoptotic protein p53 in Alzheimer's disease brain: implications for AD pathogenesis. Neurochem Res (2009) 0.91
Autoantibodies to posttranslational modifications in rheumatoid arthritis. Mediators Inflamm (2014) 0.86
The redox sensor TXNL1 plays a regulatory role in fluid phase endocytosis. PLoS One (2007) 0.86
Channel regulation by extracellular redox protein. Channels (Austin) (2008) 0.84
The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response. Cell Death Dis (2014) 0.83
Plausible antioxidant biomechanics and anticonvulsant pharmacological activity of brain-targeted β-carotene nanoparticles. Int J Nanomedicine (2012) 0.83
Oxidative stress associated with neuronal apoptosis in experimental models of epilepsy. Oxid Med Cell Longev (2014) 0.81
The "Gln-Type" Thiol Dioxygenase from Azotobacter vinelandii Is a 3-Mercaptopropionic Acid Dioxygenase. Biochemistry (2015) 0.80
Prooxidant effects of verbascoside, a bioactive compound from olive oil mill wastewater, on in vitro developmental potential of ovine prepubertal oocytes and bioenergetic/oxidative stress parameters of fresh and vitrified oocytes. Biomed Res Int (2014) 0.80
Vitrification preserves chromatin integrity, bioenergy potential and oxidative parameters in mouse embryos. Reprod Biol Endocrinol (2013) 0.80
Breaking the light and heavy chain linkage of human immunoglobulin G1 (IgG1) by radical reactions. J Biol Chem (2011) 0.79
Relevance of the glutathione system in temporal lobe epilepsy: evidence in human and experimental models. Oxid Med Cell Longev (2014) 0.78
Effects of single exposure of sodium fluoride on lipid peroxidation and antioxidant enzymes in salivary glands of rats. Oxid Med Cell Longev (2013) 0.77
Identification and functional characterization of Leishmania donovani secretory peroxidase: delineating its role in NRAMP1 regulation. PLoS One (2013) 0.76
Increased oxidant status in children with breath-holding spells. Childs Nerv Syst (2012) 0.76
Non-chemical proton-dependent steps prior to O2-activation limit Azotobacter vinelandii 3-mercaptopropionic acid dioxygenase (MDO) catalysis. Arch Biochem Biophys (2016) 0.76
Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress. EMBO J (2016) 0.75
Different chromatin and energy/redox responses of mouse morulae and blastocysts to slow freezing and vitrification. Reprod Biol Endocrinol (2015) 0.75
Confocal fluorescence assessment of bioenergy/redox status of dromedary camel (Camelus dromedarius) oocytes before and after in vitro maturation. Reprod Biol Endocrinol (2014) 0.75
Manipulation of inflammation in ARDS: achievable goal or distant target? Thorax (2006) 0.75
Thiol dioxygenase turnover yields benzothiazole products from 2-mercaptoaniline and O2-dependent oxidation of primary alcohols. Arch Biochem Biophys (2017) 0.75
Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain. Redox Biol (2017) 0.75
Leishmania donovani-specific 25- and 28-kDa urinary proteins activate macrophage effector functions, lymphocyte proliferation and Th1 cytokines production. Parasitol Res (2013) 0.75
Metal and redox modulation of cysteine protein function. Chem Biol (2003) 1.52
From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides. Angew Chem Int Ed Engl (2007) 1.31
Multiple roles of cysteine in biocatalysis. Biochem Biophys Res Commun (2003) 1.22
Reactive sulfur species: an emerging concept in oxidative stress. Biol Chem (2002) 1.13
The diazo route to diazonamide A. Studies on the indole bis-oxazole fragment. J Org Chem (2005) 1.12
Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential. Org Biomol Chem (2007) 1.05
Polysulfides as biologically active ingredients of garlic. Org Biomol Chem (2007) 1.05
Rapid access to α-alkoxy and α-amino acid derivatives through safe continuous-flow generation of diazoesters. Chemistry (2011) 1.02
Natural products containing a diazo group. Nat Prod Rep (2011) 1.01
Tellurium: an element with great biological potency and potential. Org Biomol Chem (2010) 1.00
A fungal metallothionein is required for pathogenicity of Magnaporthe grisea. Plant Cell (2004) 0.99
Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells. Biochemistry (2007) 0.97
Potential of the dietary antioxidants resveratrol and curcumin in prevention and treatment of hematologic malignancies. Molecules (2010) 0.96
Asymmetric synthesis of the central tryptophan residue of stephanotic acid. Org Biomol Chem (2004) 0.96
Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chem Biol (2006) 0.96
The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product. Nat Prod Rep (2008) 0.96
Heat shock protein 90 controls HIV-1 reactivation from latency. Proc Natl Acad Sci U S A (2014) 0.95
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem (2013) 0.94
Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling. Mol Pharmacol (2011) 0.93
5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo. Mol Cancer Ther (2006) 0.92
Rhodium carbene routes to oxazoles and thiazoles. Catalyst effects in the synthesis of oxazole and thiazole carboxylates, phosphonates, and sulfones. J Org Chem (2010) 0.92
Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target. Mol Pharmacol (2009) 0.91
Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds. Anticancer Agents Med Chem (2011) 0.90
Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1). Bioorg Med Chem (2004) 0.90
A short synthesis of the triazolopyrimidine antibiotic essramycin. J Nat Prod (2010) 0.90
Synthesis of 3-(carboxyarylalkyl)imidazo[2,1-f][1,2,4]triazines as potential inhibitors of AMP deaminase. Org Biomol Chem (2008) 0.89
Biomimetic synthesis of the apoptosis-inducing thiazinoquinone thiaplidiaquinone A. J Org Chem (2012) 0.88
Oxidative rearrangement of indoles: a new approach to the EFHG-tetracyclic core of diazonamide A. J Org Chem (2007) 0.88
Synthesis of the reported structure of crassiflorone, a naturally occurring quinone isolated from the African ebony Diospyros crassiflora, and regioisomeric pentacyclic furocoumarin naphthoquinones. Org Biomol Chem (2011) 0.88
Keap calm, and carry on covalently. J Med Chem (2013) 0.87
Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity. J Med Chem (2007) 0.87
Metal trafficking: from maintaining the metal homeostasis to future drug design. Metallomics (2009) 0.87
ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis. Carcinogenesis (2012) 0.86
Allicin disrupts the cell's electrochemical potential and induces apoptosis in yeast. Free Radic Biol Med (2010) 0.86
Microwave-mediated Claisen rearrangement followed by phenol oxidation: a simple route to naturally occurring 1,4-benzoquinones. The first syntheses of verapliquinones A and B and panicein A. J Org Chem (2005) 0.86
Sensor/effector drug design with potential relevance to cancer. Curr Pharm Des (2006) 0.86
Nucleophilic fluorination of β-ketoester derivatives with HBF4. Chem Commun (Camb) (2012) 0.86
A two step route to indoles from haloarenes--a versatile variation on the Fischer indole synthesis. Chem Commun (Camb) (2010) 0.86
Total synthesis of stephanotic acid methyl ester. Org Lett (2006) 0.85
Total synthesis of the thiopeptide amythiamicin D. Chem Commun (Camb) (2004) 0.85
Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems. Mol Pharmacol (2003) 0.85
Emerging approaches for histone deacetylase inhibitor drug discovery. Expert Opin Drug Discov (2015) 0.85
Inspired by Nature: The Use of Plant-derived Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ. Nat Prod Commun (2015) 0.84
Selective antimicrobial activity associated with sulfur nanoparticles. J Biomed Nanotechnol (2011) 0.84
Synthesis of indolequinones from bromoquinones and enamines mediated by Cu(OAc)2.H2O. J Org Chem (2010) 0.84
Reactive sulphur species: an in vitro investigation of the oxidation properties of disulphide S-oxides. Biochem J (2002) 0.84
Diallylpolysulfides induce growth arrest and apoptosis. Int J Oncol (2010) 0.84
Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90. J Org Chem (2013) 0.84
Synthesis of β-keto esters in-flow and rapid access to substituted pyrimidines. J Org Chem (2010) 0.83
The diazo route to diazonamide A: studies on the tyrosine-derived fragment. Org Biomol Chem (2005) 0.83
Synthesis of amino-1,4-benzoquinones and their use in Diels-Alder approaches to the aminonaphthoquinone antibiotics. J Org Chem (2011) 0.83
Total synthesis of the thiopeptide antibiotic amythiamicin D. J Am Chem Soc (2005) 0.82
Proanthocyanidins: oligomeric structures with unique biochemical properties and great therapeutic promise. Nat Prod Commun (2012) 0.82
Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles. Bioorg Med Chem Lett (2007) 0.82
Synthesis and selective anticancer activity of organochalcogen based redox catalysts. J Med Chem (2010) 0.82
Asymmetric synthesis of chiral alpha-ferrocenylalkylamines and their use in the preparation of chiral redox-active receptors. Org Lett (2002) 0.82
Amination of heteroaryl chlorides: palladium catalysis or SN Ar in green solvents? ChemSusChem (2013) 0.81
Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems. Biochemistry (2011) 0.81
An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration. Chem Commun (Camb) (2013) 0.81
Indolequinone antitumour agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Org Biomol Chem (2007) 0.81
Alkyl halide-free heteroatom alkylation and epoxidation facilitated by a recyclable polymer-supported oxidant for the in-flow preparation of diazo compounds. Chemistry (2015) 0.81
Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes. J Am Chem Soc (2010) 0.81
Cell cycle arrest in early mitosis and induction of caspase-dependent apoptosis in U937 cells by diallyltetrasulfide (Al2S4). Apoptosis (2009) 0.81
Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I. Bioorg Med Chem Lett (2003) 0.80
Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release. Biochem Pharmacol (2002) 0.80
Synthesis of spirotetramates via a Diels-Alder approach. Org Lett (2011) 0.80
The organotelluride catalyst (PHTE)₂NQ prevents HOCl-induced systemic sclerosis in mouse. J Invest Dermatol (2012) 0.79
Diverse trifluoromethyl heterocycles from a single precursor. J Org Chem (2012) 0.79
Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1. Org Biomol Chem (2007) 0.79
Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents. Org Biomol Chem (2009) 0.78
Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells. Chem Commun (Camb) (2009) 0.78
The remarkable effect of the 7-substituent in the diastereoselective oxidative rearrangement of indoles: asymmetric synthesis of 3,3-disubstituted oxindoles. Chem Commun (Camb) (2006) 0.78
Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents. Angiogenesis (2002) 0.78
Multifunctional redox catalysts as selective enhancers of oxidative stress. Org Biomol Chem (2005) 0.78
Total synthesis of siphonazole and its O-methyl derivative, structurally unusual bis-oxazole natural products. Org Biomol Chem (2008) 0.78
Synthesis of the oxepinochromone natural products ptaeroxylin (desoxykarenin), ptaeroxylinol, and eranthin. J Org Chem (2010) 0.78
Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential. Org Biomol Chem (2003) 0.78
Redox catalysts as sensitisers towards oxidative stress. FEBS Lett (2003) 0.78
Targeting the Hsp90 chaperone: synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90. Chemistry (2010) 0.78
Targeting the disturbed redox equilibrium in chronic lymphocytic leukemia by novel reactive oxygen species-catalytic 'sensor/effector' compounds. Leuk Lymphoma (2011) 0.78
Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases. Int J Oncol (2011) 0.78
A concise route to pyridines from hydrazides by metal carbene N-H insertion, 1,2,4-triazine formation, and Diels-Alder reaction. Org Lett (2009) 0.78
The total synthesis of siphonazole, a structurally unusual bis-oxazole natural product. Chem Commun (Camb) (2007) 0.78
Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90. Org Biomol Chem (2014) 0.78
Two approaches to the aromatic core of the aminonaphthoquinone antibiotics. J Org Chem (2013) 0.77
Regioselectivity of the Claisen rearrangement in meta-allyloxy aryl ketones: an experimental and computational study, and application in the synthesis of (R)-(-)-pestalotheol D. Chemistry (2011) 0.77
Synthesis of (+/-)-likonide B (smenochromene D) using a regioselective Claisen rearrangement, separation of the enantiomers and stereochemical assignment. Org Biomol Chem (2009) 0.77
Biomimetic approaches to diazonamide A. Direct synthesis of the indole bis-oxazole fragment by oxidation of a TyrValTrpTrp tetrapeptide. Chem Commun (Camb) (2006) 0.77
19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity. Mol Pharmacol (2014) 0.77
Selenium- and tellurium-containing multifunctional redox agents as biochemical redox modulators with selective cytotoxicity. Chemistry (2010) 0.77
Two-step route to indoles and analogues from haloarenes: a variation on the Fischer indole synthesis. J Org Chem (2011) 0.77
The rhodium carbene route to oxazoles: a remarkable catalyst effect. Chem Commun (Camb) (2009) 0.77
The natural organosulfur compound dipropyltetrasulfide prevents HOCl-induced systemic sclerosis in the mouse. Arthritis Res Ther (2013) 0.77
Quinones as dienophiles in the Diels-Alder reaction: history and applications in total synthesis. Angew Chem Int Ed Engl (2014) 0.77
Use of a substrate/alliinase combination to generate antifungal activity in situ. J Agric Food Chem (2005) 0.77
Copper(II)-Mediated Synthesis of Indolequinones from Bromoquinones and Enamines. European J Org Chem (2013) 0.77
Diallyl tetrasulfane activates both the eIF2α and Nrf2/HO-1 pathways. Biochim Biophys Acta (2012) 0.77
Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin. Org Biomol Chem (2007) 0.77