PubRank

Leo E Otterbein

Author PubWeight™ 96.63‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The therapeutic potential of carbon monoxide. Nat Rev Drug Discov 2010 3.03
2 The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab 2012 2.36
3 Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Mol Cell Biochem 2002 2.16
4 Autoantibodies in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007 1.94
5 Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. J Clin Invest 2006 1.91
6 Carbon monoxide in biology and medicine. Bioessays 2004 1.91
7 Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J Exp Med 2005 1.90
8 Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem 2003 1.83
9 Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation. Am J Pathol 2013 1.73
10 Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus. Crit Care Med 2005 1.73
11 Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning. Proc Natl Acad Sci U S A 2007 1.61
12 Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species. FASEB J 2007 1.60
13 Heme oxygenase and carbon monoxide initiate homeostatic signaling. J Mol Med (Berl) 2007 1.60
14 Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation. Circulation 2005 1.60
15 Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine. Gastroenterology 2003 1.59
16 Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem 2002 1.52
17 Biliverdin administration protects against endotoxin-induced acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol 2005 1.49
18 Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation. Thromb Haemost 2014 1.48
19 Carbon monoxide orchestrates a protective response through PPARgamma. Immunity 2006 1.47
20 Carbon monoxide inhalation protects rat intestinal grafts from ischemia/reperfusion injury. Am J Pathol 2003 1.47
21 Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. Am J Pathol 2003 1.43
22 Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury. FASEB J 2003 1.42
23 Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways. PLoS One 2013 1.40
24 Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. J Exp Med 2003 1.39
25 Biliverdin protects the functional integrity of a transplanted syngeneic small bowel. Gastroenterology 2004 1.39
26 Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury. FASEB J 2004 1.38
27 Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both. Am J Transplant 2005 1.36
28 Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide. Am J Physiol Renal Physiol 2004 1.33
29 An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis. J Immunol 2011 1.31
30 Carbon monoxide modulates endotoxin-induced production of granulocyte macrophage colony-stimulating factor in macrophages. Am J Respir Cell Mol Biol 2002 1.27
31 Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma. Endocrinology 2008 1.20
32 Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt. J Biol Chem 2009 1.20
33 Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver. FASEB J 2004 1.19
34 Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury. FASEB J 2006 1.18
35 Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. J Natl Cancer Inst 2008 1.18
36 Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation. Shock 2005 1.15
37 Carbon monoxide reverses established pulmonary hypertension. J Exp Med 2006 1.14
38 Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells. FASEB J 2007 1.14
39 Toll-like receptor 4 suppression leads to islet allograft survival. FASEB J 2007 1.12
40 Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth. Cancer Res 2013 1.12
41 Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells. J Biol Chem 2004 1.10
42 Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen-activated protein kinase pathway. Am J Respir Cell Mol Biol 2002 1.09
43 Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One 2010 1.09
44 Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules. J Biol Chem 2012 1.05
45 The social network of carbon monoxide in medicine. Trends Mol Med 2012 1.05
46 Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs. FASEB J 2004 1.04
47 Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury. Circulation 2010 1.04
48 Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase. Proc Natl Acad Sci U S A 2011 1.02
49 Carbon monoxide protects against the development of experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 2005 1.01
50 Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation. J Clin Invest 2014 1.00
51 Heme oxygenase-1: a metabolic nike. Antioxid Redox Signal 2014 1.00
52 Emerging role of carbon monoxide in physiologic and pathophysiologic states. Antioxid Redox Signal 2002 0.99
53 Go green: the anti-inflammatory effects of biliverdin reductase. Front Pharmacol 2012 0.99
54 Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. Gastroenterology 2012 0.98
55 Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts. Surgery 2003 0.98
56 Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice. Am J Physiol Lung Cell Mol Physiol 2003 0.97
57 Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway. J Immunol 2004 0.96
58 Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol 2007 0.95
59 Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation. Endocrinology 2014 0.94
60 Carbon monoxide enhances early liver regeneration in mice after hepatectomy. Hepatology 2011 0.94
61 Low-dose carbon monoxide reduces airway hyperresponsiveness in mice. Am J Physiol Lung Cell Mol Physiol 2003 0.93
62 Restoring HOmeostasis: is heme oxygenase-1 ready for the clinic? Trends Pharmacol Sci 2007 0.92
63 Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1. J Clin Invest 2015 0.92
64 Inhaled carbon monoxide inhibits intimal hyperplasia and provides added benefit with nitric oxide. J Vasc Surg 2006 0.87
65 Regulation of IL-1beta -induced GM-CSF production in human airway smooth muscle cells by carbon monoxide. Am J Physiol Lung Cell Mol Physiol 2002 0.87
66 Carbon monoxide is a poison... to microbes! CO as a bactericidal molecule. Curr Opin Pharmacol 2009 0.86
67 Carbon Monoxide and the brain: time to rethink the dogma. Curr Pharm Des 2013 0.85
68 Induction of protective genes leads to islet survival and function. J Transplant 2011 0.85
69 Carbon monoxide abrogates ischemic insult to neuronal cells via the soluble guanylate cyclase-cGMP pathway. PLoS One 2013 0.84
70 Inhaled carbon monoxide provides cerebral cytoprotection in pigs. PLoS One 2012 0.83
71 'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity. Biol Chem 2004 0.82
72 Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion. FASEB J 2004 0.81
73 Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages. PLoS One 2011 0.81
74 Inhaled carbon monoxide prevents graft-induced intimal hyperplasia in swine. J Surg Res 2006 0.80
75 Carbon monoxide protects against hemorrhagic shock and resuscitation-induced microcirculatory injury and tissue injury. Shock 2015 0.79
76 Biliverdin protects against liver ischemia reperfusion injury in swine. PLoS One 2013 0.79
77 Differential modulation by exogenous carbon monoxide of TNF-alpha stimulated mitogen-activated protein kinases in rat pulmonary artery endothelial cells. Antioxid Redox Signal 2002 0.79
78 Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics. Dalton Trans 2013 0.79
79 Inhale to survive, cycle or die? Carbon monoxide and cellular proliferation. Cell Cycle 2008 0.77
80 Carbon monoxide induces chromatin remodelling to facilitate endothelial cell migration. Thromb Haemost 2014 0.77
81 Intratracheal instillation of neutrophils rescues bacterial overgrowth initiated by trauma damage-associated molecular patterns. J Trauma Acute Care Surg 2017 0.75
82 Activation of peroxisome proliferator-activated receptor γ prolongs islet allograft survival. Cell Transplant 2012 0.75