Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice.

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Published in J Clin Invest on February 16, 2006

Authors

John D Belcher1, Hemachandra Mahaseth, Thomas E Welch, Leo E Otterbein, Robert P Hebbel, Gregory M Vercellotti

Author Affiliations

1: Division of Hematology, Oncology, and Transplantation, Department of Medicine and Vascular Biology Center, University of Minnesota, Minneapolis, Minnesota 55455, USA. belcher@umn.edu

Associated clinical trials:

Phase 2 Study of MP4CO to Treat Vaso-occlusive Sickle Crisis | NCT01925001

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Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease. Am J Physiol Heart Circ Physiol (2009) 1.08

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice. Blood (2010) 1.07

Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules. J Biol Chem (2012) 1.05

Heme, heme oxygenase and ferritin in vascular endothelial cell injury. Mol Nutr Food Res (2005) 1.05

The social network of carbon monoxide in medicine. Trends Mol Med (2012) 1.05

Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs. FASEB J (2004) 1.04

Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury. Circulation (2010) 1.04

Nanoparticle preconditioning for enhanced thermal therapies in cancer. Nanomedicine (Lond) (2011) 1.03

Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction. Free Radic Biol Med (2006) 1.03

Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase. Proc Natl Acad Sci U S A (2011) 1.02

Establishment of outgrowth endothelial cells from peripheral blood. Nat Protoc (2012) 1.01

Carbon monoxide protects against the development of experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol (2005) 1.01

Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation. J Clin Invest (2014) 1.00