Endogenous TNFalpha lowers maximum peak bone mass and inhibits osteoblastic Smad activation through NF-kappaB.

PubWeight™: 1.42‹?› | Rank: Top 5%

🔗 View Article (PMID 17266397)

Published in J Bone Miner Res on May 01, 2007

Authors

Yan Li1, Aimin Li, Karen Strait, Hongying Zhang, Mark S Nanes, M Neale Weitzmann

Author Affiliations

1: Division of Endocrinology and Metabolism and Lipids, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Articles citing this

Role of T-cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss. Nat Commun (2015) 1.63

RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice. J Clin Invest (2008) 1.52

Role of NF-κB in the skeleton. Cell Res (2010) 1.45

Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins. J Biol Chem (2008) 1.41

Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand. Proc Natl Acad Sci U S A (2010) 1.33

Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem (2011) 1.32

Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha. J Bone Miner Res (2010) 1.25

Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB. J Biol Chem (2009) 1.24

HIV: inflammation and bone. Curr HIV/AIDS Rep (2012) 1.23

Functions of nuclear factor kappaB in bone. Ann N Y Acad Sci (2010) 1.21

The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis. Scientifica (Cairo) (2013) 1.20

Novel functions for NFκB: inhibition of bone formation. Nat Rev Rheumatol (2010) 1.19

Bone density, structure, and strength in juvenile idiopathic arthritis: importance of disease severity and muscle deficits. Arthritis Rheum (2008) 1.13

TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation. Bone Res (2015) 1.12

Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments. Cell Death Dis (2013) 1.02

LPS-stimulated inflammatory environment inhibits BMP-2-induced osteoblastic differentiation through crosstalk between TLR4/MyD88/NF-κB and BMP/Smad signaling. Stem Cells Dev (2013) 0.99

HDL cholesterol and bone mineral density: is there a genetic link? Bone (2012) 0.99

Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF. J Bone Miner Res (2010) 0.97

Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts, suppress bone-resorbing osteoclasts, and enhance bone mineral density in vivo. Nanomedicine (2011) 0.95

Direct bone formation during distraction osteogenesis does not require TNFalpha receptors and elevated serum TNFalpha fails to inhibit bone formation in TNFR1 deficient mice. Bone (2009) 0.93

Secondary osteoporosis in patients with juvenile idiopathic arthritis. J Osteoporos (2011) 0.88

Etanercept administration to neonatal SH3BP2 knock-in cherubism mice prevents TNF-α-induced inflammation and bone loss. J Bone Miner Res (2014) 0.88

Osteoclasts-Key Players in Skeletal Health and Disease. Microbiol Spectr (2016) 0.88

Novel adipokines and bone metabolism. Int J Endocrinol (2013) 0.87

Loss of Bone and Wnt10b Expression in Male Type 1 Diabetic Mice Is Blocked by the Probiotic Lactobacillus reuteri. Endocrinology (2015) 0.85

NF-κB RelB negatively regulates osteoblast differentiation and bone formation. J Bone Miner Res (2014) 0.85

Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia. J Cereb Blood Flow Metab (2015) 0.84

The current and future therapies of bone regeneration to repair bone defects. Int J Dent (2012) 0.84

Role of carotenoid β-cryptoxanthin in bone homeostasis. J Biomed Sci (2012) 0.82

Serum sclerostin in high-activity adult patients with juvenile idiopathic arthritis. Arthritis Res Ther (2014) 0.80

QCT Volumetric Bone Mineral Density and Vascular and Valvular Calcification: The Framingham Study. J Bone Miner Res (2015) 0.80

The Role of Bone Marrow Microenvironment in Governing the Balance between Osteoblastogenesis and Adipogenesis. Aging Dis (2015) 0.79

Bone disease in cystic fibrosis: new pathogenic insights opening novel therapies. Osteoporos Int (2015) 0.79

NF-κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases. Adv Protein Chem Struct Biol (2016) 0.78

Anti-cancer IAP antagonists promote bone metastasis: a cautionary tale. J Bone Miner Metab (2013) 0.78

Suppression of NF-κB activation by gentian violet promotes osteoblastogenesis and suppresses osteoclastogenesis. Curr Mol Med (2014) 0.77

Mitigative effect of erythromycin on PMMA challenged preosteoblastic MC3T3-E1 cells. ScientificWorldJournal (2014) 0.77

Manipulating bone disease in inflammatory bowel disease patients. Ann Gastroenterol (2013) 0.76

Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Mediators Inflamm (2016) 0.76

Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia. Am J Hum Genet (2016) 0.76

Bone status in adults with early-onset juvenile idiopathic arthritis following 1-year anti-TNFα therapy and discontinuation of glucocorticoids. Rheumatol Int (2013) 0.76

β-Caryophyllene promotes osteoblastic mineralization, and suppresses osteoclastogenesis and adipogenesis in mouse bone marrow cultures in vitro. Exp Ther Med (2016) 0.75

Neonatal High Bone Mass With First Mutation of the NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65). J Bone Miner Res (2015) 0.75

Bone histomorphometric changes in children with rheumatic disorders on chronic glucocorticoids. Pediatr Rheumatol Online J (2016) 0.75

Rocaglamide-A Potentiates Osteoblast Differentiation by Inhibiting NF-κB Signaling. Mol Cells (2015) 0.75

Gliotoxin potentiates osteoblast differentiation by inhibiting nuclear factor-κB signaling. Mol Med Rep (2015) 0.75

Modulation of osteoblastic/odontoblastic differentiation of adult mesenchymal stem cells through gene introduction: a brief review. J Korean Assoc Oral Maxillofac Surg (2013) 0.75

Bioactive silica nanoparticles reverse age-associated bone loss in mice. Nanomedicine (2015) 0.75

Strontium inhibits titanium particle-induced osteoclast activation and chronic inflammation via suppression of NF-κB pathway. Sci Rep (2016) 0.75

Articles by these authors

Genetic variability of human respiratory syncytial virus A strains circulating in Ontario: a novel genotype with a 72 nucleotide G gene duplication. PLoS One (2012) 2.21

B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood (2007) 2.16

IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest (2006) 2.15

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest (2008) 2.01

Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem (2001) 1.99

Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr (2008) 1.86

Mouse cone arrestin expression pattern: light induced translocation in cone photoreceptors. Mol Vis (2002) 1.78

Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator. Proc Natl Acad Sci U S A (2003) 1.75

A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner. Arthritis Rheum (2009) 1.70

Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH. Proc Natl Acad Sci U S A (2012) 1.68

GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina. J Neurosci (2003) 1.66

IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Proc Natl Acad Sci U S A (2002) 1.65

PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B. Am J Physiol Lung Cell Mol Physiol (2010) 1.60

Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer Cell (2009) 1.60

Characterization of waterborne outbreak-associated Campylobacter jejuni, Walkerton, Ontario. Emerg Infect Dis (2003) 1.59

beta2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis. Cancer Res (2006) 1.55

Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest (2010) 1.54

PTH expands short-term murine hemopoietic stem cells through T cells. Blood (2012) 1.53

The true role of mRECIST guideline: does it really estimate viable tumor or merely improve accuracy in hepatocellular carcinoma response evaluation? J BUON (2014) 1.44

TaSnRK2.4, an SNF1-type serine/threonine protein kinase of wheat (Triticum aestivum L.), confers enhanced multistress tolerance in Arabidopsis. J Exp Bot (2009) 1.41

Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats. Proc Natl Acad Sci U S A (2010) 1.38

Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways. J Biol Chem (2006) 1.37

Beta2-microglobulin promotes the growth of human renal cell carcinoma through the activation of the protein kinase A, cyclic AMP-responsive element-binding protein, and vascular endothelial growth factor axis. Clin Cancer Res (2006) 1.34

Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand. Proc Natl Acad Sci U S A (2010) 1.33

T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab (2009) 1.32

Estrogen prevents bone loss through transforming growth factor beta signaling in T cells. Proc Natl Acad Sci U S A (2004) 1.32

Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Proc Natl Acad Sci U S A (2007) 1.31

The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis. Am J Physiol Endocrinol Metab (2004) 1.29

T cells potentiate PTH-induced cortical bone loss through CD40L signaling. Cell Metab (2008) 1.28

TaNAC2, a NAC-type wheat transcription factor conferring enhanced multiple abiotic stress tolerances in Arabidopsis. J Exp Bot (2012) 1.26

Evaluation of vitamin D repletion regimens to correct vitamin D status in adults. Endocr Pract (2009) 1.24

HIV: inflammation and bone. Curr HIV/AIDS Rep (2012) 1.23

2 cm spatial-resolution and 2 km range Brillouin optical fiber sensor using a transient differential pulse pair. Appl Opt (2012) 1.20

Integration of the NfkappaB p65 subunit into the vitamin D receptor transcriptional complex: identification of p65 domains that inhibit 1,25-dihydroxyvitamin D3-stimulated transcription. J Cell Biochem (2004) 1.17

Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer. Cancer Res (2010) 1.15

An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency. Proc Natl Acad Sci U S A (2005) 1.13

The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1. Hum Mol Genet (2002) 1.12

Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis. Dev Biol (2009) 1.11

Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblasts. J Cell Biochem (2003) 1.07

Signaling via Alk5 controls the ontogeny of lung Clara cells. Development (2010) 1.07

Perivascular epithelioid cell neoplasm of the urinary bladder in an adolescent: a case report and review of the literature. Diagn Pathol (2012) 1.07

Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPK. J Biol Chem (2003) 1.05

HIV-1 infection and antiretroviral therapies: risk factors for osteoporosis and bone fracture. Curr Opin Endocrinol Diabetes Obes (2010) 1.05

Population structure and antimicrobial resistance of invasive serotype IV group B Streptococcus, Toronto, Ontario, Canada. Emerg Infect Dis (2015) 1.04

Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2. J Cell Physiol (2006) 1.03

Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss. PLoS One (2010) 1.03

Baicalin is anti-inflammatory in cigarette smoke-induced inflammatory models in vivo and in vitro: A possible role for HDAC2 activity. Int Immunopharmacol (2012) 1.02

NOTCH1 is required for regeneration of Clara cells during repair of airway injury. Stem Cells (2012) 1.02

Mesenchymal stem cells participating in ex vivo endothelium repair and its effect on vascular smooth muscle cells growth. Int J Cardiol (2005) 1.02

Evaluation of the flocculation performance of carboxymethyl chitosan-graft-polyacrylamide, a novel amphoteric chemically bonded composite flocculant. Water Res (2011) 1.01

Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation. Mol Cell Biochem (2011) 1.01

Transgenic expression of TaMYB2A confers enhanced tolerance to multiple abiotic stresses in Arabidopsis. Funct Integr Genomics (2011) 1.00

Characterization of invasive group B streptococcus strains from the greater Toronto area, Canada. J Clin Microbiol (2014) 0.99

An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1. J Biol Chem (2013) 0.99

High-resolution genomic mapping reveals consistent amplification of the fibroblast growth factor receptor substrate 2 gene in well-differentiated and dedifferentiated liposarcoma. Genes Chromosomes Cancer (2011) 0.99

PLEK: a tool for predicting long non-coding RNAs and messenger RNAs based on an improved k-mer scheme. BMC Bioinformatics (2014) 0.98

A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation. J Biol Chem (2011) 0.98

Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. J Cell Biochem (2004) 0.98

Metagenomic insights into chlorination effects on microbial antibiotic resistance in drinking water. Water Res (2012) 0.98

Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. Endocr Pract (2004) 0.97

CSK controls retinoic acid receptor (RAR) signaling: a RAR-c-SRC signaling axis is required for neuritogenic differentiation. Mol Cell Biol (2007) 0.96

The intact strontium ranelate complex stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation. Mol Cell Biochem (2011) 0.96

Bioactive silica nanoparticles promote osteoblast differentiation through stimulation of autophagy and direct association with LC3 and p62. ACS Nano (2014) 0.96

Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins. Exp Cell Res (2004) 0.96

Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons. Brain Res (2010) 0.95

Smad4 restoration leads to a suppression of Wnt/beta-catenin signaling activity and migration capacity in human colon carcinoma cells. Biochem Biophys Res Commun (2009) 0.95

Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts, suppress bone-resorbing osteoclasts, and enhance bone mineral density in vivo. Nanomedicine (2011) 0.95

HIV and bone metabolism. Discov Med (2011) 0.95

The estrogen 17beta-estradiol and phytoestrogen genistein mediate differential effects on osteoblastic NF-kappaB activity. Int J Mol Med (2009) 0.93

Characterization of evolution of mode coupling in a graded-index polymer optical fiber by using Brillouin optical time-domain analysis. Opt Express (2014) 0.93

Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor α action in osteoblast differentiation. J Bone Miner Res (2011) 0.93

Clinical, endoscopic and histological differentiations between Crohn's disease and intestinal tuberculosis. Digestion (2012) 0.93

Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Endocrinology (2003) 0.92

Tip30 deletion in MMTV-Neu mice leads to enhanced EGFR signaling and development of estrogen receptor-positive and progesterone receptor-negative mammary tumors. Cancer Res (2010) 0.92

Cloning and characterization of TaSnRK2.3, a novel SnRK2 gene in common wheat. J Exp Bot (2013) 0.92

Metagenomic profiling of antibiotic resistance genes and mobile genetic elements in a tannery wastewater treatment plant. PLoS One (2013) 0.91

Antiretroviral therapy induces a rapid increase in bone resorption that is positively associated with the magnitude of immune reconstitution in HIV infection. AIDS (2016) 0.91

Loss of Trop2 promotes carcinogenesis and features of epithelial to mesenchymal transition in squamous cell carcinoma. Mol Cancer Res (2011) 0.91

Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm. Stem Cells (2015) 0.90

Regulation of osterix (Osx, Sp7) and the Osx promoter by parathyroid hormone in osteoblasts. J Mol Endocrinol (2009) 0.90

Fracture assessment tool risk scores in bone density reports do not change physician prescribing behavior for osteoporosis. Am J Med Sci (2011) 0.90

Modulation of HOXA10 and other markers of endometrial receptivity by age and human chorionic gonadotropin in an endometrial explant model. Fertil Steril (2009) 0.89

Adsorption of divalent heavy metal ions onto IDA-chelating resins: simulation of physicochemical structures and elucidation of interaction mechanisms. Talanta (2009) 0.89

Nitric oxide donors inhibit luciferase expression in a promoter-independent fashion. J Biol Chem (2003) 0.88

Quercetin, a potent suppressor of NF-κB and Smad activation in osteoblasts. Int J Mol Med (2011) 0.88

Ovariectomy-induced bone loss occurs independently of B cells. J Cell Biochem (2007) 0.88

The sclerostin-independent bone anabolic activity of intermittent PTH treatment is mediated by T-cell-produced Wnt10b. J Bone Miner Res (2014) 0.88

Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone loss. Ann N Y Acad Sci (2010) 0.87

Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPase. J Biol Chem (2005) 0.87

FeCl3 and acetic acid co-catalyzed hydrolysis of corncob for improving furfural production and lignin removal from residue. Bioresour Technol (2012) 0.87

Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest (2012) 0.87

Flocculation of Escherichia coli using a quaternary ammonium salt grafted carboxymethyl chitosan flocculant. Environ Sci Technol (2014) 0.87

Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-κB activation. Int J Mol Med (2010) 0.87

CTLA-4Ig-induced T cell anergy promotes Wnt-10b production and bone formation in a mouse model. Arthritis Rheumatol (2014) 0.86

Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B. Blood (2013) 0.86

Sub-MHz ultrahigh-resolution optical spectrometry based on Brillouin dynamic gratings. Opt Lett (2014) 0.86