Published in Proc Natl Acad Sci U S A on December 18, 2002
Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest (2006) 3.45
Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev (2007) 2.82
Osteoimmunology: interactions of the bone and immune system. Endocr Rev (2008) 2.32
B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood (2007) 2.16
IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest (2006) 2.15
Cells of the synovium in rheumatoid arthritis. Macrophages. Arthritis Res Ther (2007) 1.83
Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation. Proc Natl Acad Sci U S A (2006) 1.64
The role of estrogen and androgen receptors in bone health and disease. Nat Rev Endocrinol (2013) 1.48
Estrogen prevents bone loss through transforming growth factor beta signaling in T cells. Proc Natl Acad Sci U S A (2004) 1.32
The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization. Proc Natl Acad Sci U S A (2004) 1.30
T cells potentiate PTH-induced cortical bone loss through CD40L signaling. Cell Metab (2008) 1.28
The Interplay between the bone and the immune system. Clin Dev Immunol (2013) 1.26
Interleukin-7 induced immunopathology in arthritis. Ann Rheum Dis (2006) 1.25
HIV: inflammation and bone. Curr HIV/AIDS Rep (2012) 1.23
The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis. Scientifica (Cairo) (2013) 1.20
The immune system and bone. Arch Biochem Biophys (2010) 1.19
Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis: comparison with IL1 beta and tumour necrosis factor alpha. Ann Rheum Dis (2004) 1.14
An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency. Proc Natl Acad Sci U S A (2005) 1.13
Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-alpha production. Infect Immun (2007) 1.12
Osteoimmunology: cytokines and the skeletal system. BMB Rep (2008) 1.04
T cells: critical bone regulators in health and disease. Bone (2010) 1.04
Dysregulated B cell expression of RANKL and OPG correlates with loss of bone mineral density in HIV infection. PLoS Pathog (2014) 1.03
Association between peripheral T-Lymphocyte activation and impaired bone mineral density in HIV-infected patients. J Transl Med (2013) 1.03
Regulation of bone by the adaptive immune system in arthritis. Arthritis Res Ther (2011) 1.00
In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis. J Bone Miner Res (2008) 1.00
Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts. Biochem Med (Zagreb) (2013) 0.97
IL-7 up-regulates TNF-alpha-dependent osteoclastogenesis in patients affected by solid tumor. PLoS One (2006) 0.95
The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis. J Immunol (2013) 0.95
Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts, suppress bone-resorbing osteoclasts, and enhance bone mineral density in vivo. Nanomedicine (2011) 0.95
Osteoblast-specific overexpression of human interleukin-7 rescues the bone mass phenotype of interleukin-7-deficient female mice. J Bone Miner Res (2012) 0.95
How B cells influence bone biology in health and disease. Bone (2010) 0.94
Interaction among cells of bone, immune system, and solid tumors leads to bone metastases. Clin Dev Immunol (2013) 0.94
Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases. J Immunol Res (2015) 0.93
Porphyromonas gingivalis infection-associated periodontal bone resorption is dependent on receptor activator of NF-κB ligand. Infect Immun (2013) 0.92
Bone invading NSCLC cells produce IL-7: mice model and human histologic data. BMC Cancer (2010) 0.90
Mechanisms modulating inflammatory osteolysis: a review with insights into therapeutic targets. Pathol Res Pract (2008) 0.89
Immune regulation of osteoclast function in postmenopausal osteoporosis: a critical interdisciplinary perspective. Int J Med Sci (2012) 0.88
Osteoclasts-Key Players in Skeletal Health and Disease. Microbiol Spectr (2016) 0.88
Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro. J Bone Miner Metab (2007) 0.87
CTLA-4Ig-induced T cell anergy promotes Wnt-10b production and bone formation in a mouse model. Arthritis Rheumatol (2014) 0.86
OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis. Proc Natl Acad Sci U S A (2014) 0.86
Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches. Semin Immunopathol (2008) 0.86
Pasteurella multocida toxin-stimulated osteoclast differentiation is B cell dependent. Infect Immun (2010) 0.85
Influence of intraarticular corticosteroid administration on serum cytokines in rheumatoid arthritis. Clin Rheumatol (2006) 0.85
T-cells and B-cells in osteoporosis. Curr Opin Endocrinol Diabetes Obes (2014) 0.84
Interactions between the immune system and bone. World J Orthop (2011) 0.83
Alpha1beta1 integrin and interleukin-7 receptor up-regulate the expression of RANKL in human T cells and enhance their osteoclastogenic function. Immunology (2008) 0.83
Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice. Bone (2013) 0.81
Estrogens and Androgens in Skeletal Physiology and Pathophysiology. Physiol Rev (2017) 0.81
Bone-immune cell crosstalk: bone diseases. J Immunol Res (2015) 0.80
T cells, osteoblasts, and osteocytes: interacting lineages key for the bone anabolic and catabolic activities of parathyroid hormone. Ann N Y Acad Sci (2015) 0.79
B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice. Open Bone J (2015) 0.79
Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds: successful suppression of bone destruction accompanied with adjuvant-induced arthritis in rats. Histochem Cell Biol (2005) 0.79
Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting. World J Gastroenterol (2006) 0.79
The role of the immune system in the physiopathology of osteoporosis. Clin Cases Miner Bone Metab (2012) 0.77
Immunoregulation of bone remodelling. Int J Crit Illn Inj Sci (2012) 0.77
A Special Ingredient (VtR) Containing Oligostilbenes Isolated from Vitis thunbergii Prevents Bone Loss in Ovariectomized Mice: In Vitro and In Vivo Study. Evid Based Complement Alternat Med (2013) 0.76
The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors. J Immunol Res (2015) 0.76
Does systemic inflammation and immune activation contribute to fracture risk in HIV? Curr Opin HIV AIDS (2016) 0.75
Tributyltin exposure alters cytokine levels in mouse serum. J Immunotoxicol (2016) 0.75
Hypersensitivity reactions to metal implants: laboratory options. BMC Musculoskelet Disord (2016) 0.75
Bioactive silica nanoparticles reverse age-associated bone loss in mice. Nanomedicine (2015) 0.75
Network-Based Meta-Analyses of Associations of Multiple Gene Expression Profiles with Bone Mineral Density Variations in Women. PLoS One (2016) 0.75
Markers in blood and saliva for prediction of orthodontically induced inflammatory root resorption: a retrospective case controlled-study. Prog Orthod (2017) 0.75
A preliminary investigation of short-term cytokine expression in gingival crevicular fluid secondary to high-level orthodontic forces and the associated root resorption: case series analytical study. Prog Orthod (2017) 0.75
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature (1999) 8.23
Rheumatoid arthritis. Cell (1996) 6.01
TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest (2000) 5.78
Minireview: the OPG/RANKL/RANK system. Endocrinology (2001) 4.47
Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest (2000) 3.15
Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo. Proc Natl Acad Sci U S A (2001) 2.56
Activated T lymphocytes support osteoclast formation in vitro. Biochem Biophys Res Commun (1999) 2.28
Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways. J Biol Chem (2001) 2.13
Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines. Blood (2000) 1.74
TNFalpha potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL. Endocrinology (2002) 1.72
Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum (1999) 1.60
Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency. Proc Natl Acad Sci U S A (1997) 1.51
Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrow. J Clin Invest (1994) 1.51
T cell activation induces human osteoclast formation via receptor activator of nuclear factor kappaB ligand-dependent and -independent mechanisms. J Bone Miner Res (2001) 1.43
Adoptive transfer of neonatal T lymphocytes rescues immunoglobulin production in mice with severe combined immune deficiency. J Exp Med (1991) 1.23
Connection between B lymphocyte and osteoclast differentiation pathways. J Immunol (2001) 1.22
Prostaglandin E2 induces expression of receptor activator of nuclear factor-kappa B ligand/osteoprotegrin ligand on pre-B cells: implications for accelerated osteoclastogenesis in estrogen deficiency. J Bone Miner Res (2000) 1.20
Generation of bone-resorbing osteoclasts from B220+ cells: its role in accelerated osteoclastogenesis due to estrogen deficiency. J Bone Miner Res (2001) 1.10
Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis. J Rheumatol (1995) 1.10
Effects of T cell adoptive transfer into nude mice on alveolar bone resorption induced by endotoxin. J Periodontal Res (1996) 1.08
A role for CD8+ T lymphocytes in osteoclast differentiation in vitro. Endocrinology (1996) 1.07
T-cell development in the absence of a thymus: the number, the phenotype, and the functional capacity of T lymphocytes in nude mice. Am J Anat (1984) 1.05
Osteoclast precursors as leukocytes: importance of the area code. Bone (1998) 0.93
Detection of cytokine mRNA in human, articular cartilage from patients with rheumatoid arthritis and osteoarthritis by reverse transcriptase-polymerase chain reaction. Scand J Rheumatol (1998) 0.93
T lymphocytes are not the target for estradiol-mediated suppression of DTH in reconstituted female severe combined immunodeficient (SCID) mice. Clin Exp Immunol (1998) 0.91
Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest (2006) 3.45
Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab (2003) 2.27
B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood (2007) 2.16
IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest (2006) 2.15
Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator. Proc Natl Acad Sci U S A (2003) 1.75
A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner. Arthritis Rheum (2009) 1.70
Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH. Proc Natl Acad Sci U S A (2012) 1.68
Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall. Circulation (2009) 1.63
beta2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis. Cancer Res (2006) 1.55
PTH expands short-term murine hemopoietic stem cells through T cells. Blood (2012) 1.53
The role of T lymphocytes in bone metabolism. Immunol Rev (2005) 1.53
Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest (2002) 1.47
Endogenous TNFalpha lowers maximum peak bone mass and inhibits osteoblastic Smad activation through NF-kappaB. J Bone Miner Res (2007) 1.42
Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats. Proc Natl Acad Sci U S A (2010) 1.38
Beta2-microglobulin promotes the growth of human renal cell carcinoma through the activation of the protein kinase A, cyclic AMP-responsive element-binding protein, and vascular endothelial growth factor axis. Clin Cancer Res (2006) 1.34
Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand. Proc Natl Acad Sci U S A (2010) 1.33
T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab (2009) 1.32
Estrogen prevents bone loss through transforming growth factor beta signaling in T cells. Proc Natl Acad Sci U S A (2004) 1.32
Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Proc Natl Acad Sci U S A (2007) 1.31
T cells potentiate PTH-induced cortical bone loss through CD40L signaling. Cell Metab (2008) 1.28
HIV: inflammation and bone. Curr HIV/AIDS Rep (2012) 1.23
An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency. Proc Natl Acad Sci U S A (2005) 1.13
Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblasts. J Cell Biochem (2003) 1.07
HIV-1 infection and antiretroviral therapies: risk factors for osteoporosis and bone fracture. Curr Opin Endocrinol Diabetes Obes (2010) 1.05
Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss. PLoS One (2010) 1.03
T cells: unexpected players in the bone loss induced by estrogen deficiency and in basal bone homeostasis. Ann N Y Acad Sci (2007) 1.01
Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation. Mol Cell Biochem (2011) 1.01
Estrogen regulation of immune cell bone interactions. Ann N Y Acad Sci (2006) 0.96
Bioactive silica nanoparticles promote osteoblast differentiation through stimulation of autophagy and direct association with LC3 and p62. ACS Nano (2014) 0.96
The intact strontium ranelate complex stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation. Mol Cell Biochem (2011) 0.96
Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts, suppress bone-resorbing osteoclasts, and enhance bone mineral density in vivo. Nanomedicine (2011) 0.95
HIV and bone metabolism. Discov Med (2011) 0.95
The estrogen 17beta-estradiol and phytoestrogen genistein mediate differential effects on osteoblastic NF-kappaB activity. Int J Mol Med (2009) 0.93
Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss. Curr Osteoporos Rep (2009) 0.91
Bone mass and metabolism in thalassemic children and adolescents treated with different iron-chelating drugs. J Bone Miner Metab (2004) 0.90
Ovariectomy-induced bone loss occurs independently of B cells. J Cell Biochem (2007) 0.88
Quercetin, a potent suppressor of NF-κB and Smad activation in osteoblasts. Int J Mol Med (2011) 0.88
The sclerostin-independent bone anabolic activity of intermittent PTH treatment is mediated by T-cell-produced Wnt10b. J Bone Miner Res (2014) 0.88
Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone loss. Ann N Y Acad Sci (2010) 0.87
Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-κB activation. Int J Mol Med (2010) 0.87
Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B. Blood (2013) 0.86
CTLA-4Ig-induced T cell anergy promotes Wnt-10b production and bone formation in a mouse model. Arthritis Rheumatol (2014) 0.86
Exogenous regucalcin suppresses osteoblastogenesis and stimulates adipogenesis in mouse bone marrow culture. Integr Biol (Camb) (2012) 0.83
Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturation. Cell Cycle (2015) 0.83
High dose 1,25(OH)2D3 inhibits osteoblast mineralization in vitro. Int J Mol Med (2012) 0.83
T cell-expressed CD40L potentiates the bone anabolic activity of intermittent PTH treatment. J Bone Miner Res (2015) 0.81
The bone anabolic carotenoid p-hydroxycinnamic acid promotes osteoblast mineralization and suppresses osteoclast differentiation by antagonizing NF-κB activation. Int J Mol Med (2012) 0.81
Honokiol stimulates osteoblastogenesis by suppressing NF-κB activation. Int J Mol Med (2011) 0.81
A new regulator of osteoclastogenesis: estrogen response element-binding protein in bone. J Bone Miner Res (2011) 0.81
The bone anabolic carotenoid beta-cryptoxanthin enhances transforming growth factor-beta1-induced SMAD activation in MC3T3 preosteoblasts. Int J Mol Med (2009) 0.81
Skeletal fluorosis from brewed tea. J Clin Endocrinol Metab (2011) 0.80
LONG-TERM MONITORING OF THE PHYSICOCHEMICAL PROPERTIES OF SILICA-BASED NANOPARTICLES ON THE RATE OF ENDOCYTOSIS AND EXOCYTOSIS AND CONSEQUENCES OF CELL DIVISION. Soft Mater (2013) 0.80
Suppression of NF-kappaB activation blocks osteoclastic bone resorption during estrogen deficiency. Int J Mol Med (2008) 0.80
Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. J Clin Invest (2016) 0.79
Link protein N-terminal peptide binds to bone morphogenetic protein (BMP) type II receptor and drives matrix protein expression in rabbit intervertebral disc cells. J Biol Chem (2013) 0.79
IL-7 drives T cell-mediated bone loss following ovariectomy. Ann N Y Acad Sci (2006) 0.79
Role of the immune system in postmenopausal bone loss. Curr Osteoporos Rep (2005) 0.79
Curcumin analog UBS109 prevents bone marrow osteoblastogenesis and osteoclastogenesis disordered by coculture with breast cancer MDA-MB-231 bone metastatic cells in vitro. Mol Cell Biochem (2014) 0.78
Age-associated changes in gene expression of goat oocytes. Theriogenology (2013) 0.78
The protease inhibitors and HIV-associated bone loss. Curr Opin HIV AIDS (2016) 0.78
Maternal diabetes causes abnormal dynamic changes of endoplasmic reticulum during mouse oocyte maturation and early embryo development. Reprod Biol Endocrinol (2013) 0.77
Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic rats. Pathog Dis (2014) 0.76
Differential CD4+ cell count increase and CD4+ : CD8+ ratio normalization with maraviroc compared with tenofovir. AIDS (2016) 0.75
Stability studies of principal illicit drugs in oral fluid: preparation of reference materials for external quality assessment schemes. Ther Drug Monit (2007) 0.75
Exogenous regucalcin stimulates osteoclastogenesis and suppresses osteoblastogenesis through NF-κB activation. Mol Cell Biochem (2011) 0.75