Published in Mol Pharmacol on January 31, 2007
Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action. Am J Psychiatry (2009) 1.71
Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J Pharmacol Exp Ther (2008) 1.31
Regulation of monoamine transporters: Role of transporter phosphorylation. Pharmacol Ther (2010) 1.30
Genetic contributions to avoidance-based decisions: striatal D2 receptor polymorphisms. Neuroscience (2009) 1.27
Mechanisms of dopamine transporter regulation in normal and disease states. Trends Pharmacol Sci (2013) 1.25
Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance. PLoS One (2010) 1.24
Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors. J Biol Chem (2010) 1.23
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors. Curr Opin Pharmacol (2009) 1.21
Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. J Neurosci (2010) 1.19
Human immunodeficiency virus (HIV) infection of human macrophages is increased by dopamine: a bridge between HIV-associated neurologic disorders and drug abuse. Am J Pathol (2009) 1.18
Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans. J Neurosci (2009) 1.18
A receptor mechanism for methamphetamine action in dopamine transporter regulation in brain. J Pharmacol Exp Ther (2009) 1.15
Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome. J Biol Chem (2012) 1.14
Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: live-cell imaging using total internal reflection fluorescence microscopy. J Neurosci (2009) 1.14
Trafficking of dopamine transporters in psychostimulant actions. Semin Cell Dev Biol (2009) 1.11
Prenatal stress induces increased striatal dopamine transporter binding in adult nonhuman primates. Biol Psychiatry (2013) 1.10
Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: a [11C] FLB-457 and PET study. Neurobiol Dis (2012) 1.05
Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse. CNS Neurol Disord Drug Targets (2008) 1.03
GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs. Proc Natl Acad Sci U S A (2007) 1.03
Vesicular and plasma membrane transporters for neurotransmitters. Cold Spring Harb Perspect Biol (2012) 1.02
The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. J Neurosci (2011) 1.00
Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. Eur J Neurosci (2013) 1.00
DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding. Schizophr Bull (2011) 0.98
Genetic complementation screen identifies a mitogen-activated protein kinase phosphatase, MKP3, as a regulator of dopamine transporter trafficking. Mol Biol Cell (2008) 0.97
Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters. J Neurochem (2009) 0.96
Drosophila Dopamine2-like receptors function as autoreceptors. ACS Chem Neurosci (2011) 0.95
Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction. Transl Psychiatry (2013) 0.94
Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats. Biochem Biophys Res Commun (2009) 0.91
Protein kinase Cβ is a modulator of the dopamine D2 autoreceptor-activated trafficking of the dopamine transporter. J Neurochem (2013) 0.91
Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A. Br J Pharmacol (2014) 0.89
A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum. ACS Chem Neurosci (2010) 0.89
Serotonin uptake is largely mediated by platelets versus lymphocytes in peripheral blood cells. ACS Chem Neurosci (2012) 0.89
PKCβ Inhibitors Attenuate Amphetamine-Stimulated Dopamine Efflux. ACS Chem Neurosci (2016) 0.89
Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism. Neuropharmacology (2014) 0.88
Dopamine transporter trafficking: rapid response on demand. Future Neurol (2010) 0.88
Rescue of dopamine transporter function in hypoinsulinemic rats by a D2 receptor-ERK-dependent mechanism. J Neurosci (2012) 0.88
4-(4-(dimethylamino)phenyl)-1-methylpyridinium (APP+) is a fluorescent substrate for the human serotonin transporter. J Biol Chem (2012) 0.87
Real-time, spatially resolved analysis of serotonin transporter activity and regulation using the fluorescent substrate, ASP+. J Neurochem (2010) 0.86
Inhibition of dopamine transporter activity by G protein βγ subunits. PLoS One (2013) 0.86
The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism. J Neurochem (2009) 0.85
α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter. J Biol Chem (2011) 0.85
Regulation of dopamine transporter activity by carboxypeptidase E. Mol Brain (2009) 0.85
Impaired dopamine release and uptake in R6/1 Huntington's disease model mice. Neurosci Lett (2011) 0.85
Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS Genet (2014) 0.84
mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission. J Neurosci (2015) 0.81
Cocaine up-regulation of the norepinephrine transporter requires threonine 30 phosphorylation by p38 mitogen-activated protein kinase. J Biol Chem (2011) 0.81
Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse. Adv Pharmacol (2014) 0.81
Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease. PLoS One (2011) 0.80
Ethanol potentiates dopamine uptake and increases cell surface distribution of dopamine transporters expressed in SK-N-SH and HEK-293 cells. Alcohol (2008) 0.80
Regulated norepinephrine transporter interaction with the neurokinin-1 receptor establishes transporter subcellular localization. J Biol Chem (2013) 0.79
Outside the box signaling: secreted factors modulate GnRH receptor-mediated gonadotropin regulation. Mol Cell Endocrinol (2013) 0.79
Striatal dopamine neurotransmission: regulation of release and uptake. Basal Ganglia (2016) 0.79
All aglow about presynaptic receptor regulation of neurotransmitter transporters. Mol Pharmacol (2007) 0.79
Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications. Neuropsychopharmacology (2010) 0.79
Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters. Pharmacol Rev (2016) 0.78
Low brain iron effects and reversibility on striatal dopamine dynamics. Exp Neurol (2014) 0.77
Analysis of synaptic proteins in the cerebrospinal fluid as a new tool in the study of inborn errors of neurotransmission. J Inherit Metab Dis (2011) 0.77
Protein kinase C beta regulates the D₂-like dopamine autoreceptor. Neuropharmacology (2015) 0.76
Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans. PLoS Genet (2014) 0.76
In vitro study methodologies to investigate genetic aspects and effects of drugs used in attention-deficit hyperactivity disorder. J Neural Transm (Vienna) (2012) 0.75
Dopamine D3 autoreceptor inhibition enhances cocaine potency at the dopamine transporter. J Neurochem (2016) 0.75
Acute Depletion of D2 Receptors from the Rat Substantia Nigra Alters Dopamine Kinetics in the Dorsal Striatum and Drug Responsivity. Front Behav Neurosci (2017) 0.75
A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine Reuptake. PLoS One (2015) 0.75
The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters Through a Rho-Dependent Mechanism. J Neurosci (2017) 0.75
Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther (2006) 7.03
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (2010) 5.86
The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site. Mol Cell (2008) 4.29
Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development. Immunity (2006) 3.62
A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Mol Pharmacol (2006) 3.23
A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia. Proc Natl Acad Sci U S A (2004) 3.00
Dopamine D2 receptors form higher order oligomers at physiological expression levels. EMBO J (2008) 2.99
Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nat Chem Biol (2009) 2.98
Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch. J Biol Chem (2002) 2.87
Cyanine fluorophore derivatives with enhanced photostability. Nat Methods (2011) 2.85
Origins and unconventional behavior of neutrophils in developing zebrafish. Blood (2007) 2.76
The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. J Biol Chem (2002) 2.75
The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci (2008) 2.72
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev (2007) 2.62
Single-molecule dynamics of gating in a neurotransmitter transporter homologue. Nature (2010) 2.41
Building a new conceptual framework for receptor heteromers. Nat Chem Biol (2009) 2.41
Live imaging of emerging hematopoietic stem cells and early thymus colonization. Blood (2007) 2.36
Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc Natl Acad Sci U S A (2005) 2.33
Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats. J Neurosci (2010) 2.33
Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proc Natl Acad Sci U S A (2006) 2.29
Monitoring the function of membrane transport proteins in detergent-solubilized form. Proc Natl Acad Sci U S A (2007) 2.27
The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop. Annu Rev Pharmacol Toxicol (2002) 2.27
Mechanism of chloride interaction with neurotransmitter:sodium symporters. Nature (2007) 2.25
Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci U S A (2009) 2.25
Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nat Struct Mol Biol (2010) 2.20
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature (2011) 2.18
The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice. Proc Natl Acad Sci U S A (2004) 2.10
An intracellular interaction network regulates conformational transitions in the dopamine transporter. J Biol Chem (2008) 2.07
State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. J Biol Chem (2006) 2.01
Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron (2006) 2.00
Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci U S A (2005) 1.98
Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A (2011) 1.98
N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux. PLoS Biol (2004) 1.94
mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol (2006) 1.93
Increased abundance of opioid receptor heteromers after chronic morphine administration. Sci Signal (2010) 1.90
Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers. FASEB J (2007) 1.89
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor. J Med Chem (2012) 1.87
Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy. Clin Infect Dis (2011) 1.82
G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacol Rev (2014) 1.82
Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action. Am J Psychiatry (2009) 1.71
Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters. J Biol Chem (2003) 1.70
Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc Natl Acad Sci U S A (2007) 1.70
The role of N-glycosylation in function and surface trafficking of the human dopamine transporter. J Biol Chem (2004) 1.70
Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism. J Biol Chem (2003) 1.69
The emerging functions of endocannabinoid signaling during CNS development. Trends Pharmacol Sci (2007) 1.68
PI 3-kinase regulation of dopamine uptake. J Neurochem (2002) 1.64
A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. J Neurosci (2005) 1.63
Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity. J Neurosci (2003) 1.63
Systems approach to explore components and interactions in the presynapse. Proteomics (2009) 1.61
Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. J Pharmacol Exp Ther (2002) 1.59
Distinctive rheumatic manifestations in 98 patients with human immunodeficiency virus infection in China. J Rheumatol (2007) 1.56
Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists. J Biol Chem (2009) 1.55
Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia. Proc Natl Acad Sci U S A (2002) 1.55
Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Proc Natl Acad Sci U S A (2005) 1.53
Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo. J Biol Chem (2008) 1.51
Cholinergic agonists as novel treatments for schizophrenia: the promise of rational drug development for psychiatry. Am J Psychiatry (2008) 1.49
Cocaine increases dopamine uptake and cell surface expression of dopamine transporters. Biochem Biophys Res Commun (2002) 1.49
Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proc Natl Acad Sci U S A (2012) 1.48
The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PLoS One (2011) 1.48
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding. J Biol Chem (2003) 1.45
Morphine administration alters the profile of hippocampal postsynaptic density-associated proteins: a proteomics study focusing on endocytic proteins. Mol Cell Proteomics (2006) 1.43
The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proc Natl Acad Sci U S A (2009) 1.43
Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Proc Natl Acad Sci U S A (2008) 1.42
Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat Neurosci (2011) 1.41
Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet (2003) 1.40
Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3. FASEB J (2008) 1.40
Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Mol Pharmacol (2008) 1.38
Receptor heteromerization and drug discovery. Trends Pharmacol Sci (2010) 1.37
N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization. J Biol Chem (2002) 1.37
Experimental conditions can obscure the second high-affinity site in LeuT. Nat Struct Mol Biol (2012) 1.37
Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure. J Neurosci (2003) 1.37
Conformation state-sensitive antibodies to G-protein-coupled receptors. J Biol Chem (2006) 1.37
Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching. Biochemistry (2007) 1.37
Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity. Proc Natl Acad Sci U S A (2013) 1.34
The human dopamine transporter forms a tetramer in the plasma membrane: cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs. J Biol Chem (2003) 1.33
Neural systems underlying opiate addiction. J Neurosci (2002) 1.33
Regulated internalization and phosphorylation of the native norepinephrine transporter in response to phorbol esters. Evidence for localization in lipid rafts and lipid raft-mediated internalization. J Biol Chem (2004) 1.32
Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J Biol Chem (2005) 1.32
Exploring a role for heteromerization in GPCR signalling specificity. Biochem J (2011) 1.31
Regulation of monoamine transporters: Role of transporter phosphorylation. Pharmacol Ther (2010) 1.30
Multiple actions of spinophilin regulate mu opioid receptor function. Neuron (2008) 1.30