Single-molecule dynamics of gating in a neurotransmitter transporter homologue.

PubWeight™: 2.41‹?› | Rank: Top 2%

🔗 View Article (PMC 2940119)

Published in Nature on May 13, 2010

Authors

Yongfang Zhao1, Daniel Terry, Lei Shi, Harel Weinstein, Scott C Blanchard, Jonathan A Javitch

Author Affiliations

1: Center for Molecular Recognition, Columbia University College of Physicians and Surgeons, 630 W. 168th, New York, New York 10032, USA.

Articles citing this

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature (2012) 3.24

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature (2011) 2.18

Toward the fourth dimension of membrane protein structure: insight into dynamics from spin-labeling EPR spectroscopy. Structure (2011) 1.68

The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PLoS One (2011) 1.48

Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP. Nature (2012) 1.41

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat Struct Mol Biol (2012) 1.37

Ultra-stable organic fluorophores for single-molecule research. Chem Soc Rev (2014) 1.31

Ion-controlled conformational dynamics in the outward-open transition from an occluded state of LeuT. Biophys J (2012) 1.30

Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci U S A (2011) 1.29

Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanisms. Biophys J (2010) 1.27

A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters. Nat Struct Mol Biol (2014) 1.26

Transport dynamics in a glutamate transporter homologue. Nature (2013) 1.25

Modeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologue. PLoS Comput Biol (2010) 1.20

Conformational dynamics of ligand-dependent alternating access in LeuT. Nat Struct Mol Biol (2014) 1.19

Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters. Nature (2013) 1.17

The solute carrier 6 family of transporters. Br J Pharmacol (2012) 1.14

Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel. Elife (2014) 1.14

Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates. J Pharmacol Exp Ther (2013) 1.12

Chloride binding site of neurotransmitter sodium symporters. Proc Natl Acad Sci U S A (2013) 1.09

Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. J Biol Chem (2012) 1.09

Transport domain unlocking sets the uptake rate of an aspartate transporter. Nature (2015) 1.08

Substrate specificity and ion coupling in the Na+/betaine symporter BetP. EMBO J (2011) 1.07

The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. PLoS One (2011) 1.07

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue. EMBO Rep (2012) 1.05

Conformational dynamics of a class C G-protein-coupled receptor. Nature (2015) 1.03

The bright future of single-molecule fluorescence imaging. Curr Opin Chem Biol (2014) 1.03

The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine. Biol Chem (2011) 1.03

Vesicular and plasma membrane transporters for neurotransmitters. Cold Spring Harb Perspect Biol (2012) 1.02

Investigation of the sodium-binding sites in the sodium-coupled betaine transporter BetP. Proc Natl Acad Sci U S A (2012) 1.01

Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket. J Biol Chem (2012) 1.01

Insights into transport mechanism from LeuT engineered to transport tryptophan. EMBO J (2011) 1.00

Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release. PLoS Comput Biol (2011) 1.00

The molecular mechanism of ion-dependent gating in secondary transporters. PLoS Comput Biol (2013) 0.98

The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT. Chem Phys Lipids (2013) 0.96

Visualizing functional motions of membrane transporters with molecular dynamics simulations. Biochemistry (2013) 0.96

Molecular modeling and ligand docking for solute carrier (SLC) transporters. Curr Top Med Chem (2013) 0.95

High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach. J Biol Chem (2012) 0.94

Substrate-bound structure of the E. coli multidrug resistance transporter MdfA. Cell Res (2015) 0.93

Reconstructing a chloride-binding site in a bacterial neurotransmitter transporter homologue. J Biol Chem (2010) 0.93

Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling. Nat Commun (2014) 0.93

Cytoplasmic permeation pathway of neurotransmitter transporters. Biochemistry (2011) 0.92

Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2-Regulated Dynamics of the N-Terminus. ACS Chem Neurosci (2015) 0.91

NbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT. PLoS Comput Biol (2014) 0.91

Mutation of tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions. J Neuroimmune Pharmacol (2013) 0.90

LeuT conformational sampling utilizing accelerated molecular dynamics and principal component analysis. Biophys J (2012) 0.90

Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter. Biochemistry (2014) 0.90

Site-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transporters. Mol Pharmacol (2010) 0.89

GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters. Protein Sci (2016) 0.87

Computational characterization of structural dynamics underlying function in active membrane transporters. Curr Opin Struct Biol (2015) 0.87

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. J Biol Chem (2015) 0.87

Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter. J Biol Chem (2015) 0.86

Identification of novel serotonin transporter compounds by virtual screening. J Chem Inf Model (2014) 0.86

Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog. J Biol Chem (2015) 0.84

Neurotransmitter transporters: structure meets function. Structure (2013) 0.84

Identification of a second substrate-binding site in solute-sodium symporters. J Biol Chem (2014) 0.83

Properties of an inward-facing state of LeuT: conformational stability and substrate release. Biophys J (2015) 0.83

Computational approaches to detect allosteric pathways in transmembrane molecular machines. Biochim Biophys Acta (2016) 0.83

Insights from molecular dynamics: the binding site of cocaine in the dopamine transporter and permeation pathways of substrates in the leucine and dopamine transporters. J Mol Graph Model (2012) 0.83

Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins. Biophys J (2014) 0.82

Identification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) family. PLoS One (2012) 0.82

A comparative study of structures and structural transitions of secondary transporters with the LeuT fold. Eur Biophys J (2012) 0.82

Mapping membrane protein structure with fluorescence. Curr Opin Struct Biol (2012) 0.82

An N-terminal threonine mutation produces an efflux-favorable, sodium-primed conformation of the human dopamine transporter. Mol Pharmacol (2014) 0.81

A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter. J Biol Chem (2014) 0.81

Structural dynamics of potassium-channel gating revealed by single-molecule FRET. Nat Struct Mol Biol (2015) 0.81

Control of serotonin transporter phosphorylation by conformational state. Proc Natl Acad Sci U S A (2016) 0.80

Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies. J Am Chem Soc (2016) 0.80

Biophysical Approaches to the Study of LeuT, a Prokaryotic Homolog of Neurotransmitter Sodium Symporters. Methods Enzymol (2015) 0.80

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290. J Biol Chem (2016) 0.80

Mutations at tyrosine 88, lysine 92 and tyrosine 470 of human dopamine transporter result in an attenuation of HIV-1 Tat-induced inhibition of dopamine transport. J Neuroimmune Pharmacol (2015) 0.80

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter. Nat Commun (2016) 0.80

Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochem Int (2014) 0.79

Fast Step Transition and State Identification (STaSI) for Discrete Single-Molecule Data Analysis. J Phys Chem Lett (2014) 0.79

A steered molecular dynamics study of binding and translocation processes in the GABA transporter. PLoS One (2012) 0.78

Mapping conformational heterogeneity of mitochondrial nucleotide transporter in uninhibited states. Angew Chem Int Ed Engl (2015) 0.78

AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems. Entropy (Basel) (2015) 0.78

Navigating Membrane Protein Structure, Dynamics, and Energy Landscapes Using Spin Labeling and EPR Spectroscopy. Methods Enzymol (2015) 0.78

A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter. Sci Rep (2017) 0.78

Structural dynamics of the monoamine transporter homolog LeuT from accelerated conformational sampling and channel analysis. Proteins (2014) 0.77

Glu-311 in External Loop 4 of the Sodium/Proline Transporter PutP Is Crucial for External Gate Closure. J Biol Chem (2016) 0.77

A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study. Chem Sci (2015) 0.77

Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops. Biochim Biophys Acta (2015) 0.77

Application of fluorescence resonance energy transfer in protein studies. J Mol Struct (2014) 0.76

Substrate-modulated ADP/ATP-transporter dynamics revealed by NMR relaxation dispersion. Nat Struct Mol Biol (2015) 0.76

Conformational Changes in Two Inter-Helical Loops of Mhp1 Membrane Transporter. PLoS One (2015) 0.76

The Environment Shapes the Inner Vestibule of LeuT. PLoS Comput Biol (2016) 0.76

Probing molecular choreography through single-molecule biochemistry. Nat Struct Mol Biol (2015) 0.76

Membrane Phase-Dependent Occlusion of Intramolecular GLUT1 Cavities Demonstrated by Simulations. Biophys J (2017) 0.75

Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin. Nat Commun (2017) 0.75

Effect of Dimerization on the Dynamics of Neurotransmitter:Sodium Symporters. J Phys Chem B (2017) 0.75

Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport. Sci Rep (2016) 0.75

The Role of TM5 in Na2 Release and the Conformational Transition of Neurotransmitter:Sodium Symporters toward the Inward-Open State. J Biol Chem (2017) 0.75

Biophysics: Transporter in the spotlight. Nature (2010) 0.75

Core Transmembrane Domain 6 Plays a Pivotal Role in the Transport Cycle of the Sodium/Proline Symporter PutP. J Biol Chem (2016) 0.75

Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer. Proc Natl Acad Sci U S A (2017) 0.75

A Quick-responsive DNA Nanotechnology Device for Bio-molecular Homeostasis Regulation. Sci Rep (2016) 0.75

Single-molecule fluorescence resonance energy transfer in molecular biology. Nanoscale (2016) 0.75

Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter. Proc Natl Acad Sci U S A (2017) 0.75

Alternating access mechanisms of LeuT-fold transporters: trailblazing towards the promised energy landscapes. Curr Opin Struct Biol (2016) 0.75

Articles cited by this

A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal Biochem (1973) 31.32

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters. Nature (2005) 12.56

Evolutionarily conserved pathways of energetic connectivity in protein families. Science (1999) 9.12

A practical guide to single-molecule FRET. Nat Methods (2008) 8.62

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events. Biophys J (1996) 7.66

A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation. Protein Sci (1999) 6.05

tRNA dynamics on the ribosome during translation. Proc Natl Acad Sci U S A (2004) 5.38

A competitive inhibitor traps LeuT in an open-to-out conformation. Science (2008) 4.86

Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci (2003) 4.50

Protein folding studied by single-molecule FRET. Curr Opin Struct Biol (2008) 4.33

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature (2007) 4.29

The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site. Mol Cell (2008) 4.29

Following translation by single ribosomes one codon at a time. Nature (2008) 4.14

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science (2007) 4.08

Identification of two distinct hybrid state intermediates on the ribosome. Mol Cell (2007) 4.00

Cyanine dye labeling reagents: sulfoindocyanine succinimidyl esters. Bioconjug Chem (1995) 3.90

Translocation and unwinding mechanisms of RNA and DNA helicases. Annu Rev Biophys (2008) 3.86

Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling. Biophys J (2004) 3.42

Structure and mechanism of a Na+-independent amino acid transporter. Science (2009) 3.30

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Mol Pharmacol (2006) 3.23

Neurotransmitter transporters as molecular targets for addictive drugs. Drug Alcohol Depend (1998) 2.28

Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms. J Mol Biol (2008) 2.27

Monitoring the function of membrane transport proteins in detergent-solubilized form. Proc Natl Acad Sci U S A (2007) 2.27

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci U S A (2009) 2.25

Single-molecule FRET reveals sugar-induced conformational dynamics in LacY. Proc Natl Acad Sci U S A (2007) 2.24

Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat Struct Mol Biol (2009) 2.12

An intracellular interaction network regulates conformational transitions in the dopamine transporter. J Biol Chem (2008) 2.07

Mitigating unwanted photophysical processes for improved single-molecule fluorescence imaging. Biophys J (2009) 2.05

Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. J Biol Chem (1994) 2.01

Single-molecule RNA science. Annu Rev Biophys Biomol Struct (2005) 1.93

Single-molecule studies of RNA polymerase: motoring along. Annu Rev Biochem (2008) 1.80

Substrate binding and formation of an occluded state in the leucine transporter. Biophys J (2007) 1.77

Neurotransmitter transporters and their impact on the development of psychopharmacology. Br J Pharmacol (2006) 1.77

A survey of single-molecule techniques in chemical biology. ACS Chem Biol (2007) 1.68

Myosin V motor proteins: marching stepwise towards a mechanism. J Cell Biol (2003) 1.63

Single-molecule observations of ribosome function. Curr Opin Struct Biol (2009) 1.38

Molecular mechanism of ion-ion and ion-substrate coupling in the Na+-dependent leucine transporter LeuT. Biophys J (2008) 1.34

The Cys154-->Gly mutation in LacY causes constitutive opening of the hydrophilic periplasmic pathway. J Mol Biol (2008) 1.33

Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1. Mol Pharmacol (2005) 1.30

Single-molecule fluorescence spectroscopy and microscopy of biomolecular motors. Annu Rev Phys Chem (2004) 1.29

Mutation of arginine 44 of GAT-1, a (Na(+) + Cl(-))-coupled gamma-aminobutyric acid transporter from rat brain, impairs net flux but not exchange. J Biol Chem (2000) 1.23

How did the neurotransmitter cross the bilayer? A closer view. Curr Opin Neurobiol (2005) 1.20

Single-molecule fluorescence to study molecular motors. Q Rev Biophys (2007) 1.14

Molecular dynamics simulations of Na+/Cl(-)-dependent neurotransmitter transporters in a membrane-aqueous system. ChemMedChem (2007) 1.03

F1-ATPase: a highly efficient rotary ATP machine. Essays Biochem (2000) 1.02

Need for speed: mechanical regulation of a replicative helicase. Cell (2007) 0.81

Mechano-chemical coupling of molecular motors revealed by single molecule measurements. Curr Protein Pept Sci (2004) 0.80

Articles by these authors

Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther (2006) 7.03

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (2010) 5.86

The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site. Mol Cell (2008) 4.29

Identification of two distinct hybrid state intermediates on the ribosome. Mol Cell (2007) 4.00

Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet (2012) 3.34

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Mol Pharmacol (2006) 3.23

Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. Science (2011) 3.14

The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem (2008) 3.01

Dopamine D2 receptors form higher order oligomers at physiological expression levels. EMBO J (2008) 2.99

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nat Chem Biol (2009) 2.98

SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proc Natl Acad Sci U S A (2006) 2.89

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch. J Biol Chem (2002) 2.87

Cyanine fluorophore derivatives with enhanced photostability. Nat Methods (2011) 2.85

The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. J Biol Chem (2002) 2.75

The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci (2008) 2.72

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev (2007) 2.62

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A (2007) 2.60

PDZBase: a protein-protein interaction database for PDZ-domains. Bioinformatics (2004) 2.55

A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation (2012) 2.55

Building a new conceptual framework for receptor heteromers. Nat Chem Biol (2009) 2.41

Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc Natl Acad Sci U S A (2005) 2.33

Quantitative information management for the biochemical computation of cellular networks. Sci STKE (2004) 2.32

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci (2006) 2.30

D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism. Mol Pharmacol (2007) 2.28

Monitoring the function of membrane transport proteins in detergent-solubilized form. Proc Natl Acad Sci U S A (2007) 2.27

The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop. Annu Rev Pharmacol Toxicol (2002) 2.27

Twin-spot MARCM to reveal the developmental origin and identity of neurons. Nat Neurosci (2009) 2.26

Mechanism of chloride interaction with neurotransmitter:sodium symporters. Nature (2007) 2.25

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci U S A (2009) 2.25

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nat Struct Mol Biol (2010) 2.20

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature (2011) 2.18

The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice. Proc Natl Acad Sci U S A (2004) 2.10

Local resistance switching at grain and grain boundary surfaces of polycrystalline tungsten oxide films. Nanotechnology (2011) 2.09

An intracellular interaction network regulates conformational transitions in the dopamine transporter. J Biol Chem (2008) 2.07

Mitigating unwanted photophysical processes for improved single-molecule fluorescence imaging. Biophys J (2009) 2.05

Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia. Cancer Prev Res (Phila) (2008) 2.04

State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. J Biol Chem (2006) 2.01

Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron (2006) 2.00

Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci U S A (2005) 1.98

Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A (2011) 1.98

Site-specific labeling of the ribosome for single-molecule spectroscopy. Nucleic Acids Res (2005) 1.97

N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux. PLoS Biol (2004) 1.94

Additional support for a revised Gibbs analysis. Langmuir (2010) 1.94

Accommodation of aminoacyl-tRNA into the ribosome involves reversible excursions along multiple pathways. RNA (2010) 1.91

cAMP-dependent protein kinase A selects the excited state of the membrane substrate phospholamban. J Mol Biol (2011) 1.90

Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury. J Immunol (2005) 1.89

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor. J Med Chem (2012) 1.87

Conformational capture of the SAM-II riboswitch. Nat Chem Biol (2011) 1.84

Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach. Proc Natl Acad Sci U S A (2009) 1.79

Navigating the ribosome's metastable energy landscape. Trends Biochem Sci (2009) 1.74

Spontaneous formation of the unlocked state of the ribosome is a multistep process. Proc Natl Acad Sci U S A (2009) 1.71

Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action. Am J Psychiatry (2009) 1.71

Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters. J Biol Chem (2003) 1.70

The role of fluctuations in tRNA selection by the ribosome. Proc Natl Acad Sci U S A (2007) 1.69

Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J Immunol (2005) 1.69

Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism. J Biol Chem (2003) 1.69

Stress erythropoiesis: new signals and new stress progenitor cells. Curr Opin Hematol (2011) 1.68

NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers. Cancer Cell (2013) 1.67

Structural and dynamic basis of phospholamban and sarcolipin inhibition of Ca(2+)-ATPase. Biochemistry (2007) 1.66

Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proc Natl Acad Sci U S A (2011) 1.65

NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles. Biochemistry (2008) 1.65

PI 3-kinase regulation of dopamine uptake. J Neurochem (2002) 1.64

Synthesis, antiproliferative activity, and structure-activity relationships of 3-aryl-1H-quinolin-4-ones. ChemMedChem (2008) 1.64

Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity. J Neurosci (2003) 1.63

SABIO-RK--database for biochemical reaction kinetics. Nucleic Acids Res (2011) 1.63

Metronidazole-flavonoid derivatives as anti-Helicobacter pylori agents with potent inhibitory activity against HPE-induced interleukin-8 production by AGS cells. ChemMedChem (2007) 1.62

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell (2012) 1.61

HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Mol Cell (2011) 1.59

microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis (2010) 1.59

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol (2006) 1.59

A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus. J Virol (2005) 1.59

Rapid learning in cortical coding of visual scenes. Nat Neurosci (2007) 1.58

Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. Eur J Med Chem (2007) 1.57

Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method. Proc Natl Acad Sci U S A (2011) 1.57