PubRank

M Groudine

Author PubWeight™ 274.04‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Chromosomal subunits in active genes have an altered conformation. Science 1976 14.63
2 Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNAase I. Cell 1980 12.78
3 A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells. Nature 1986 7.19
4 Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line. Nature 1982 6.11
5 Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev 1997 5.49
6 A developmentally stable chromatin structure in the human beta-globin gene cluster. Proc Natl Acad Sci U S A 1986 5.47
7 Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids. Nucleic Acids Res 1987 5.46
8 Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation. Nature 1981 5.39
9 Enhanced transcription of c-myc in bursal lymphoma cells requires continuous protein synthesis. Science 1985 5.08
10 Hb switching in chickens. Cell 1980 4.88
11 Looping versus linking: toward a model for long-distance gene activation. Genes Dev 1999 4.63
12 Control of c-myc regulation in normal and neoplastic cells. Adv Cancer Res 1991 4.60
13 Alpha-Globin-gene switching during the development of chicken embryos: expression and chromosome structure. Cell 1981 4.47
14 Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature 1985 4.35
15 Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation. Genes Dev 1995 4.30
16 A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Genes Dev 1990 4.30
17 The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region. Genes Dev 1992 4.20
18 Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev 1995 4.11
19 Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus. Proc Natl Acad Sci U S A 1983 4.05
20 Expression of the c-myb proto-oncogene during cellular proliferation. Nature 1986 3.45
21 Enhancers increase the probability but not the level of gene expression. Proc Natl Acad Sci U S A 1995 3.44
22 Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev 1996 3.40
23 Transcription elongation and eukaryotic gene regulation. Oncogene 1990 3.34
24 Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus. Genes Dev 2000 3.27
25 Molecular analysis of the human beta-globin locus activation region. Proc Natl Acad Sci U S A 1989 3.17
26 Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. Mol Cell 2000 3.03
27 Sequence requirements for premature termination of transcription in the human c-myc gene. Cell 1988 2.87
28 Propagation of globin DNAase I-hypersensitive sites in absence of factors required for induction: a possible mechanism for determination. Cell 1982 2.54
29 Interaction of HMG 14 and 17 with actively transcribed genes. Cell 1980 2.52
30 Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A 1999 2.39
31 Nuclear compartmentalization and gene activity. Nat Rev Mol Cell Biol 2000 2.36
32 Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas. Mol Cell Biol 1986 2.34
33 The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus. Mol Cell 1998 2.22
34 Participation of the human beta-globin locus control region in initiation of DNA replication. Science 1995 2.18
35 Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3. Mol Cell Biol 1996 2.17
36 The control of mammalian DNA replication: a brief history of space and timing. Cell 2001 2.15
37 Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts. Proc Natl Acad Sci U S A 1994 2.14
38 Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer. EMBO J 1998 2.13
39 A functional enhancer suppresses silencing of a transgene and prevents its localization close to centrometric heterochromatin. Cell 1999 2.12
40 Transcriptional enhancers act in cis to suppress position-effect variegation. Genes Dev 1996 2.09
41 Transcriptional regulation of the human cytomegalovirus major immediate-early gene is associated with induction of DNase I-hypersensitive sites. Mol Cell Biol 1986 2.05
42 Post-transcriptional regulation of the chicken thymidine kinase gene. Nucleic Acids Res 1984 2.02
43 The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells. Mol Cell Biol 1998 1.99
44 Genomic targeting of methylated DNA: influence of methylation on transcription, replication, chromatin structure, and histone acetylation. Mol Cell Biol 2000 1.98
45 Lineage-dependent transcription of globin genes. Cell 1974 1.97
46 Activation of beta-major globin gene transcription is associated with recruitment of NF-E2 to the beta-globin LCR and gene promoter. Proc Natl Acad Sci U S A 2001 1.94
47 Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev 1994 1.88
48 Accurate, TATA box-dependent polymerase III transcription from promoters of the c-myc gene in injected Xenopus oocytes. Genes Dev 1989 1.85
49 Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region. Genes Dev 1992 1.84
50 Activation of globin genes during chicken development. Cell 1981 1.83
51 Chromatin structure and de novo methylation of sperm DNA: implications for activation of the paternal genome. Science 1985 1.81
52 Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphoma. Science 1987 1.80
53 Regulation of beta-globin gene expression: straightening out the locus. Curr Opin Genet Dev 1996 1.76
54 Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. Mol Cell Biol 1997 1.75
55 Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. Proc Natl Acad Sci U S A 2000 1.74
56 Methylation-mediated proviral silencing is associated with MeCP2 recruitment and localized histone H3 deacetylation. Mol Cell Biol 2001 1.70
57 Description and targeted deletion of 5' hypersensitive site 5 and 6 of the mouse beta-globin locus control region. Blood 1998 1.68
58 Common mechanisms for the control of eukaryotic transcriptional elongation. Bioessays 1993 1.68
59 Dynamic analysis of proviral induction and De Novo methylation: implications for a histone deacetylase-independent, methylation density-dependent mechanism of transcriptional repression. Mol Cell Biol 2000 1.67
60 An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region. Proc Natl Acad Sci U S A 1993 1.60
61 Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells. Cancer Res 1995 1.59
62 Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast. Proc Natl Acad Sci U S A 1993 1.58
63 Alteration of c-myc chromatin structure by avian leukosis virus integration. Nature 1984 1.56
64 Temperature-sensitive changes in the structure of globin chromatin in lines of red cell precursors transformed by ts-AEV. Cell 1982 1.54
65 Long-distance control of origin choice and replication timing in the human beta-globin locus are independent of the locus control region. Mol Cell Biol 2000 1.53
66 DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructs. Biochemistry 1998 1.52
67 Rous sarcoma virus activates embryonic globin genes in chicken fibroblasts. Proc Natl Acad Sci U S A 1975 1.48
68 Role of methylation in the induced and spontaneous expression of the avian endogenous virus ev-1: DNA structure and gene products. Mol Cell Biol 1982 1.48
69 Genetic and physical analysis of the chicken tk gene. Mol Cell Biol 1984 1.47
70 Asynchronous DNA replication within the human beta-globin gene locus. Proc Natl Acad Sci U S A 1988 1.47
71 I-mf, a novel myogenic repressor, interacts with members of the MyoD family. Cell 1996 1.46
72 Requirement of the mouse I-mfa gene for placental development and skeletal patterning. EMBO J 1998 1.43
73 Nuclear relocation of a transactivator subunit precedes target gene activation. Proc Natl Acad Sci U S A 2001 1.42
74 The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes. Proc Natl Acad Sci U S A 2001 1.41
75 Regulation of expression and chromosomal subunit conformation of avian retrovirus genomes. Cell 1978 1.40
76 The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles. Genes Dev 1990 1.39
77 Tat-dependent adenosine-to-inosine modification of wild-type transactivation response RNA. Proc Natl Acad Sci U S A 1991 1.35
78 The generation and propagation of variegated chromosome structures. Cold Spring Harb Symp Quant Biol 1978 1.34
79 Targeted deletion of 5'HS1 and 5'HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites. Blood 2001 1.30
80 The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes. Mol Cell Biol 1998 1.28
81 Activation of cellular genes by avian RNA tumor viruses. Proc Natl Acad Sci U S A 1980 1.24
82 Transcription of three c-myc exons is enhanced in chicken bursal lymphoma cell lines. Proc Natl Acad Sci U S A 1985 1.23
83 Long-distance transcriptional enhancement by the histone acetyltransferase PCAF. Proc Natl Acad Sci U S A 1998 1.19
84 Expression of bcr and bcr-abl fusion transcripts in normal and leukemic cells. Mol Cell Biol 1987 1.16
85 Chromatin structure and developmental expression of the human alpha-globin cluster. Mol Cell Biol 1986 1.16
86 High-level beta-globin expression after retroviral transfer of locus activation region-containing human beta-globin gene derivatives into murine erythroleukemia cells. Proc Natl Acad Sci U S A 1990 1.12
87 Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis. Proc Natl Acad Sci U S A 1992 1.11
88 Inhibition of Tcf3 binding by I-mfa domain proteins. Mol Cell Biol 2001 1.10
89 Developmental aspects of chromatin structure and gene expression. Prog Clin Biol Res 1983 1.10
90 Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids. Nat Genet 1996 1.07
91 Varied interactions between proviruses and adjacent host chromatin. Mol Cell Biol 1986 1.07
92 Tissue-specific lability and expression of avian leukosis virus long terminal repeat enhancer-binding proteins. Mol Cell Biol 1989 1.05
93 Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region. Blood 2000 1.05
94 Expression of replication-dependent histone genes in avian spermatids involves an alternate pathway of mRNA 3'-end formation. Mol Cell Biol 1989 1.04
95 Polyadenylation and U7 snRNP-mediated cleavage: alternative modes of RNA 3' processing in two avian histone H1 genes. Genes Dev 1989 1.03
96 Sequences in the human c-myc P2 promoter affect the elongation and premature termination of transcripts initiated from the upstream P1 promoter. Mol Cell Biol 1992 1.02
97 Lability of leukosis virus enhancer-binding proteins in avian hematopoeitic cells. J Virol 1988 1.02
98 An upstream activator of transcription coordinately increases the level and epigenetic stability of gene expression. Proc Natl Acad Sci U S A 1996 1.01
99 Recombination in the avian oncoviruses as a model for the generation of defective transforming viruses. Cold Spring Harb Symp Quant Biol 1980 1.00
100 C(m)C(a/t)GG methylation: a new epigenetic mark in mammalian DNA? Proc Natl Acad Sci U S A 2001 1.00
101 Distinct properties of c-myc transcriptional elongation are revealed in Xenopus oocytes and mammalian cells and by template titration, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), and promoter mutagenesis. Mol Cell Biol 1993 0.99
102 Tumor suppression and transcription elongation: the dire consequences of changing partners. Science 1995 0.99
103 Analysis of mammalian cis-regulatory DNA elements by homologous recombination. Methods Enzymol 1999 0.97
104 What does the locus control region control? Curr Biol 1992 0.97
105 Translocation of an erythroid-specific hypersensitive site in deletion-type hereditary persistence of fetal hemoglobin. Mol Cell Biol 1990 0.97
106 Tumour-suppressor genes. Killer in search of a motive? Nature 1997 0.95
107 A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain. J Biol Chem 1997 0.94
108 In vivo footprinting of the human IL-2 gene reveals a nuclear factor bound to the transcription start site in T cells. Nucleic Acids Res 1993 0.92
109 Expression of a novel histone 2B during mouse spermiogenesis. Dev Biol 1989 0.91
110 Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection. Proc Natl Acad Sci U S A 1994 0.88
111 Regulation of amyloid A gene expression in cultured cells. Mol Cell Biol 1988 0.87
112 Cell cycle perturbations in acute myeloid leukemia samples following in vitro exposures to therapeutic agents. Leuk Res 1998 0.86
113 An alternative pathway of histone mRNA 3' end formation in mouse round spermatids. Nucleic Acids Res 1994 0.86
114 Molecular analysis of the c-myc transcription elongation block. Implications for the generation of Burkitt's lymphoma. Ann N Y Acad Sci 1990 0.85
115 Preferential radiosensitization of G1 checkpoint-deficient cells by methylxanthines. Int J Radiat Oncol Biol Phys 1996 0.84
116 Deletions within the mouse beta-globin locus control region preferentially reduce beta(min) globin gene expression. Genomics 2000 0.84
117 Reduced beta-globin gene expression in adult mice containing deletions of locus control region 5' HS-2 or 5' HS-3. Ann N Y Acad Sci 1998 0.82
118 Measurement of spontaneous and therapeutic agent-induced apoptosis with BCL-2 protein expression in acute myeloid leukemia. Blood 1997 0.82
119 Targeting silence: the use of site-specific recombination to introduce in vitro methylated DNA into the genome. Sci STKE 2001 0.81
120 The CDKN2A tumor-suppressor locus--a tale of two proteins. N Engl J Med 1998 0.80
121 Vitamin D(3) enhances the expression of I-mfa, an inhibitor of the MyoD family, in osteoblasts. Biochim Biophys Acta 2001 0.80
122 Deregulation of cell cycle control in hematologic malignancies. Curr Opin Hematol 1996 0.79
123 Pineal region tumors: results of radiation therapy and indications for elective spinal irradiation. Int J Radiat Oncol Biol Phys 1981 0.78
124 Chromatin structure and gene expression in germ line and somatic cells. Adv Exp Med Biol 1986 0.78
125 The modulation of Hb F synthesis in adult erythroid progenitor (burst-forming unit) cultures reflects changes in gamma-globin gene transcription and chromatin structure. Proc Natl Acad Sci U S A 1986 0.75
126 Unravelling immunoglobulin expression. Curr Biol 1991 0.75
127 Electron beam therapy of mycosis fungoides. Acta Radiol Oncol Radiat Phys Biol 1979 0.75
128 An evaluation of fast neutron beam teletherapy of metastatic cervical adenopathy from squamous cell carcinomas of the head and neck region. Cancer 1978 0.75