Published in Cell on August 01, 1978
Isolation of a subclass of nuclear proteins responsible for conferring a DNase I-sensitive structure on globin chromatin. Proc Natl Acad Sci U S A (1979) 3.08
Control of expression of histocompatibility antigens (H-2) and beta 2-microglobulin in F9 teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 2.22
Tropomyosin is decreased in transformed cells. Proc Natl Acad Sci U S A (1981) 1.83
Non-nucleosomal packaging of a tandemly repeated DNA sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena. Proc Natl Acad Sci U S A (1981) 1.62
Vertebrate DNAs contain nucleotide sequences related to the transforming gene of avian myeloblastosis virus. J Virol (1981) 1.57
Activation of cellular genes by avian RNA tumor viruses. Proc Natl Acad Sci U S A (1980) 1.24
Chromatin conformation of integrated Moloney leukemia virus DNA sequences in tissues of BALB/Mo mice and in virus-infected cell lines. J Virol (1980) 1.20
Chromatin conformational changes accompany transcriptional activation of a glucose-repressed gene in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1982) 1.16
DNase I sensitivity of ribosomal genes in isolated nucleosome core particles. Nucleic Acids Res (1980) 1.02
Limited DNase I nicking as a probe of gene conformation. Proc Natl Acad Sci U S A (1980) 0.99
Condensation of chromatin into chromosomes preserves an open configuration but alters the DNase I hypersensitive cleavage sites of the transcribed gene. Nucleic Acids Res (1982) 0.95
Deoxyribonuclease I sensitivity of plasmid genomes in teratocarcinoma-derived stem and differentiated cells. Proc Natl Acad Sci U S A (1981) 0.88
The chromatin structure of Rous sarcoma proviruses is changed by factors that act in trans in cell hybrids. EMBO J (1985) 0.86
Retention or loss of v-mil sequences after propagation of MH2 virus in vivo or in vitro. J Virol (1987) 0.81
Virogenic BrdU and BrdU-sensitive DNA sequences are disproportionately concentrated in the template-active chromatin of rat embryo cells. Nucleic Acids Res (1979) 0.77
Distribution of proviral sequences in chromatin of embryonic fibroblasts infected by Rous sarcoma virus. Proc Natl Acad Sci U S A (1981) 0.75
Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell (1987) 22.17
The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell (1990) 15.36
Chromosomal subunits in active genes have an altered conformation. Science (1976) 14.63
Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNAase I. Cell (1980) 12.78
Transcriptional regulation of hemoglobin switching in chicken embryos. Mol Cell Biol (1981) 9.97
Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection. Science (1990) 9.54
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation. Cell (1990) 7.94
The detection of DNA-binding proteins by protein blotting. Nucleic Acids Res (1980) 7.84
Sequence-specific DNA binding by the c-Myc protein. Science (1990) 7.75
A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells. Nature (1986) 7.19
MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer. Cell (1989) 6.94
MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts. Science (1988) 6.78
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell (1991) 6.48
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev (1994) 6.42
Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science (1995) 6.25
Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line. Nature (1982) 6.11
An unwinding activity that covalently modifies its double-stranded RNA substrate. Cell (1988) 5.93
Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol Cell Biol (1995) 5.71
Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev (1997) 5.49
A developmentally stable chromatin structure in the human beta-globin gene cluster. Proc Natl Acad Sci U S A (1986) 5.47
Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids. Nucleic Acids Res (1987) 5.46
Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation. Nature (1981) 5.39
Inhibition of thymidine kinase gene expression by anti-sense RNA: a molecular approach to genetic analysis. Cell (1984) 5.22
Enhanced transcription of c-myc in bursal lymphoma cells requires continuous protein synthesis. Science (1985) 5.08
An altered DNA conformation detected by S1 nuclease occurs at specific regions in active chick globin chromatin. Cell (1982) 4.93
Hb switching in chickens. Cell (1980) 4.88
Xenopus embryos regulate the nuclear localization of XMyoD. Genes Dev (1994) 4.77
Looping versus linking: toward a model for long-distance gene activation. Genes Dev (1999) 4.63
Control of c-myc regulation in normal and neoplastic cells. Adv Cancer Res (1991) 4.60
The helix-loop-helix gene E2A is required for B cell formation. Cell (1994) 4.59
Assembly and propagation of repressed and depressed chromosomal states. Cell (1985) 4.55
Alpha-Globin-gene switching during the development of chicken embryos: expression and chromosome structure. Cell (1981) 4.47
Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature (1985) 4.35
Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation. Genes Dev (1995) 4.30
A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Genes Dev (1990) 4.30
Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature (1994) 4.28
Positive autoregulation of the myogenic determination gene MyoD1. Cell (1989) 4.28
The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region. Genes Dev (1992) 4.20
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci U S A (1996) 4.13
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev (1995) 4.11
Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol (1993) 4.08
Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus. Proc Natl Acad Sci U S A (1983) 4.05
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development (1994) 3.99
A developmentally regulated activity that unwinds RNA duplexes. Cell (1987) 3.79
Chromosomal proteins and chromatin structure. Annu Rev Biochem (1975) 3.74
Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature (1989) 3.73
Constitutive and conditional suppression of exogenous and endogenous genes by anti-sense RNA. Science (1985) 3.71
Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene. Cell (1983) 3.62
Functional antagonism between c-Jun and MyoD proteins: a direct physical association. Cell (1992) 3.55
A randomised controlled trial comparing two schedules of antenatal visits: the antenatal care project. BMJ (1996) 3.50
Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation. Cell (1994) 3.50
Expression of the c-myb proto-oncogene during cellular proliferation. Nature (1986) 3.45
Enhancers increase the probability but not the level of gene expression. Proc Natl Acad Sci U S A (1995) 3.44
Borrelia burgdorferi genes selectively expressed in the infected host. Proc Natl Acad Sci U S A (1995) 3.42
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev (1996) 3.40
Transcription elongation and eukaryotic gene regulation. Oncogene (1990) 3.34
Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts. Cell (1986) 3.34
A dominant role for DNA secondary structure in forming hypersensitive structures in chromatin. Cell (1983) 3.33
Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus. Genes Dev (2000) 3.27
Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins. Genes Dev (1992) 3.27
Molecular analysis of the human beta-globin locus activation region. Proc Natl Acad Sci U S A (1989) 3.17
The 1200 patients project: creating a new medical model system for clinical implementation of pharmacogenomics. Clin Pharmacol Ther (2012) 3.15
Isolation of a subclass of nuclear proteins responsible for conferring a DNase I-sensitive structure on globin chromatin. Proc Natl Acad Sci U S A (1979) 3.08
Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. Mol Cell (2000) 3.03
Transcription of DNA injected into Xenopus oocytes is influenced by template topology. Nature (1983) 3.02
Histones H2a, H2b, H3, and H4 form a tetrameric complex in solutions of high salt. Cell (1975) 2.98
Sequence requirements for premature termination of transcription in the human c-myc gene. Cell (1988) 2.87
UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J (2002) 2.77
Dissection of chromosome structure with trypsin and nucleases. Proc Natl Acad Sci U S A (1974) 2.74
B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol Cell Biol (1996) 2.70
CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis. Cell (1990) 2.61
Biased hypermutation of viral RNA genomes could be due to unwinding/modification of double-stranded RNA. Cell (1989) 2.54
Propagation of globin DNAase I-hypersensitive sites in absence of factors required for induction: a possible mechanism for determination. Cell (1982) 2.54
The burden of diabetes and impaired glucose tolerance in India using the WHO 1999 criteria: prevalence of diabetes in India study (PODIS). Diabetes Res Clin Pract (2004) 2.53
Neurophysiological correlates of age-related changes in human motor function. Neurology (2002) 2.52
Interaction of HMG 14 and 17 with actively transcribed genes. Cell (1980) 2.52
Expression of transfected DNA depends on DNA topology. Cell (1986) 2.47
Ten years' experience in zygomycosis at a tertiary care centre in India. J Infect (2001) 2.47
Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1. Cell (1989) 2.40
A model for chromatin based upon two symmetrically paired half-nucleosomes. Cell (1976) 2.39
Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A (1999) 2.39
Histone-H1-dependent chromatin superstructures and the suppression of gene activity. Cell (1984) 2.36
Nuclear compartmentalization and gene activity. Nat Rev Mol Cell Biol (2000) 2.36
Negative control of DNA replication in composite SV40-bovine papilloma virus plasmids. Cell (1986) 2.35
Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas. Mol Cell Biol (1986) 2.34
Methylation-specific PCR simplifies imprinting analysis. Nat Genet (1997) 2.33
The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus. Mol Cell (1998) 2.22
Participation of the human beta-globin locus control region in initiation of DNA replication. Science (1995) 2.18
Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3. Mol Cell Biol (1996) 2.17
The control of mammalian DNA replication: a brief history of space and timing. Cell (2001) 2.15
Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas. Int J Radiat Oncol Biol Phys (1996) 2.15
Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination. Proc Natl Acad Sci U S A (1993) 2.15
Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts. Proc Natl Acad Sci U S A (1994) 2.14