PubRank

Myles H Akabas

Author PubWeight™ 49.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs. Acad Med 2010 6.51
2 Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 2006 4.84
3 Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci 2005 2.91
4 Defining the propofol binding site location on the GABAA receptor. Mol Pharmacol 2004 1.77
5 Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. Am J Physiol Cell Physiol 2007 1.52
6 GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site. J Neurosci 2009 1.50
7 Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop. J Gen Physiol 2008 1.49
8 The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol 2008 1.48
9 State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments. J Neurosci 2006 1.44
10 A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors. J Neurosci 2005 1.33
11 Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility. J Biol Chem 2011 1.33
12 Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Mol Biochem Parasitol 2009 1.20
13 GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating. J Biol Chem 2002 1.18
14 The location of a closed channel gate in the GABAA receptor channel. J Gen Physiol 2007 1.18
15 Balance of activity between LN(v)s and glutamatergic dorsal clock neurons promotes robust circadian rhythms in Drosophila. Neuron 2012 1.09
16 Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment. J Biol Chem 2004 1.08
17 Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum. J Biol Chem 2008 1.06
18 Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1. Mol Biochem Parasitol 2009 1.01
19 Structural evidence that propofol stabilizes different GABA(A) receptor states at potentiating and activating concentrations. J Neurosci 2002 0.99
20 Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation. J Biol Chem 2004 0.97
21 Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment. Biophys J 2007 0.97
22 Drosophila pacemaker neurons require g protein signaling and GABAergic inputs to generate twenty-four hour behavioral rhythms. Neuron 2010 0.93
23 Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms. Mol Biochem Parasitol 2006 0.92
24 Differential protein mobility of the gamma-aminobutyric acid, type A, receptor alpha and beta subunit channel-lining segments. J Biol Chem 2004 0.91
25 Spontaneous thermal motion of the GABA(A) receptor M2 channel-lining segments. J Biol Chem 2005 0.91
26 Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain. J Biol Chem 2012 0.90
27 Length and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitization. PLoS One 2012 0.90
28 Transmembrane segment 11 appears to line the purine permeation pathway of the Plasmodium falciparum equilibrative nucleoside transporter 1 (PfENT1). J Biol Chem 2010 0.89
29 5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals. J Gen Physiol 2011 0.88
30 Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site. J Med Chem 2008 0.85
31 Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity. Biochem J 2012 0.85
32 Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites. ACS Chem Biol 2015 0.79
33 UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. J Biol Chem 2013 0.79
34 Purine import into malaria parasites as a target for antimalarial drug development. Ann N Y Acad Sci 2014 0.78
35 Taking Charge: Feeding Malaria via Anion Channels. Cell 2011 0.75
36 Ion channels: Manipulating the munchies in mice. Nat Chem Biol 2011 0.75
37 Channels: Rotamers affect ion conductance. Nat Chem Biol 2012 0.75
38 History and Outcomes of 50 Years of Physician-Scientist Training in Medical Scientist Training Programs. Acad Med 2017 0.75
39 Watching single protons bind. Nat Chem Biol 2006 0.75