Published in Nat Genet on February 11, 2007
Strong purifying selection in transmission of mammalian mitochondrial DNA. PLoS Biol (2008) 3.38
Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition. Cell (2012) 2.81
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New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice. PLoS Genet (2009) 1.26
Mitochondrial DNA variant discovery and evaluation in human Cardiomyopathies through next-generation sequencing. PLoS One (2010) 1.25
Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A. Nucleic Acids Res (2012) 1.21
High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects. PLoS One (2012) 1.21
Previous estimates of mitochondrial DNA mutation level variance did not account for sampling error: comparing the mtDNA genetic bottleneck in mice and humans. Am J Hum Genet (2010) 1.10
The causes of mutation accumulation in mitochondrial genomes. Proc Biol Sci (2009) 1.10
Transmission of mitochondrial DNA diseases and ways to prevent them. PLoS Genet (2010) 1.08
Mitochondrial DNA heteroplasmy in ovine fetuses and sheep cloned by somatic cell nuclear transfer. BMC Dev Biol (2007) 1.04
Two ways to make an mtDNA bottleneck. Nat Genet (2008) 1.04
Mitochondrial DNA transcription regulation and nucleoid organization. J Inherit Metab Dis (2011) 1.00
Mitochondrial DNA mutations may contribute to aging via cell death caused by peptides that induce cytochrome c release. Rejuvenation Res (2008) 1.00
Keeping mtDNA in shape between generations. PLoS Genet (2014) 0.98
Doubly uniparental inheritance of mitochondria as a model system for studying germ line formation. PLoS One (2011) 0.97
Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster. Nat Genet (2014) 0.95
Poor correlations in the levels of pathogenic mitochondrial DNA mutations in polar bodies versus oocytes and blastomeres in humans. Am J Hum Genet (2011) 0.90
Mitochondrial DNA disease and developmental implications for reproductive strategies. Mol Hum Reprod (2014) 0.90
High mutation rates in the mitochondrial genomes of Daphnia pulex. Mol Biol Evol (2011) 0.89
Maternal obesity, infertility and mitochondrial dysfunction: potential mechanisms emerging from mouse model systems. Mol Hum Reprod (2013) 0.89
Is the mitochondrial cloud the selection machinery for preferentially transmitting wild-type mtDNA between generations? Rewinding Müller's ratchet efficiently. Curr Genet (2010) 0.88
The strength and timing of the mitochondrial bottleneck in salmon suggests a conserved mechanism in vertebrates. PLoS One (2011) 0.87
A wide range of 3243A>G/tRNALeu(UUR) (MELAS) mutation loads may segregate in offspring through the female germline bottleneck. PLoS One (2014) 0.87
What cost mitochondria? The maintenance of functional mitochondrial DNA within and across generations. Philos Trans R Soc Lond B Biol Sci (2014) 0.87
DHEA-mediated inhibition of the pentose phosphate pathway alters oocyte lipid metabolism in mice. Endocrinology (2013) 0.85
Germline quality control: eEF2K stands guard to eliminate defective oocytes. Dev Cell (2014) 0.85
Controlling for contamination in re-sequencing studies with a reproducible web-based phylogenetic approach. Biotechniques (2014) 0.84
Enlightenment of yeast mitochondrial homoplasmy: diversified roles of gene conversion. Genes (Basel) (2011) 0.84
Endocrine disorders in mitochondrial disease. Mol Cell Endocrinol (2013) 0.83
Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNA(Lys) gene. Proc Natl Acad Sci U S A (2014) 0.83
Selection for Mitochondrial Quality Drives Evolution of the Germline. PLoS Biol (2016) 0.82
Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism. Elife (2015) 0.82
Biomarker Validation for Aging: Lessons from mtDNA Heteroplasmy Analyses in Early Cancer Detection. Biomark Insights (2009) 0.82
Oocyte mitochondrial function and reproduction. Curr Opin Obstet Gynecol (2015) 0.81
Does mtDNA nucleoid organization impact aging? Exp Gerontol (2009) 0.81
Real-Time PCR Quantification of Heteroplasmy in a Mouse Model with Mitochondrial DNA of C57BL/6 and NZB/BINJ Strains. PLoS One (2015) 0.80
Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans. PLoS One (2014) 0.80
Lack of Structural Variation but Extensive Length Polymorphisms and Heteroplasmic Length Variations in the Mitochondrial DNA Control Region of Highly Inbred Crested Ibis, Nipponia nippon. PLoS One (2013) 0.79
Exclusion of dysfunctional mitochondria from Balbiani body during early oogenesis of Thermobia. Cell Tissue Res (2016) 0.78
Closed-form stochastic solutions for non-equilibrium dynamics and inheritance of cellular components over many cell divisions. Proc Math Phys Eng Sci (2015) 0.78
Genetic manipulation for inherited neurodegenerative diseases: myth or reality? Br J Ophthalmol (2016) 0.77
Regulation of mitochondrial genome inheritance by autophagy and ubiquitin-proteasome system: implications for health, fitness, and fertility. Biomed Res Int (2014) 0.77
Single lymphocytes from two healthy individuals with mitochondrial point heteroplasmy are mainly homoplasmic. Int J Legal Med (2007) 0.77
Single-cell A3243G mitochondrial DNA mutation load assays for segregation analysis. J Histochem Cytochem (2007) 0.77
Segregation of point mutation heteroplasmy in the control region of dog mtDNA studied systematically in deep generation pedigrees. Int J Legal Med (2010) 0.77
Dynamic regulation of mitochondrial genome maintenance in germ cells. Reprod Med Biol (2013) 0.76
The mitochondrial brain: From mitochondrial genome to neurodegeneration. Biochim Biophys Acta (2009) 0.76
Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations. Am J Hum Genet (2016) 0.75
Can paternal leakage maintain sexually antagonistic polymorphism in the cytoplasm? J Evol Biol (2015) 0.75
Reactive oxygen species stimulate mitochondrial allele segregation toward homoplasmy in human cells. Mol Biol Cell (2016) 0.75
Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck. Genome Res (2016) 0.75
Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway. J Assist Reprod Genet (2016) 0.75
Regular bottlenecks and restrictions to somatic fusion prevent the accumulation of mitochondrial defects in Neurospora. Philos Trans R Soc Lond B Biol Sci (2014) 0.75
Maximizing signal-to-noise ratio in the random mutation capture assay. Nucleic Acids Res (2011) 0.75
Evolution: are the monkeys' typewriters rigged? R Soc Open Sci (2014) 0.75
Establishment of a heteroplasmic mouse strain with interspecific mitochondrial DNA haplotypes and improvement of a PCR-RFLP-based measurement system for estimation of mitochondrial DNA heteroplasmy. Transgenic Res (2017) 0.75
The molecular characterization of porcine egg precursor cells. Oncotarget (2017) 0.75
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science (2008) 5.54
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev (2006) 4.97
Depletion of definitive gut endoderm in Sox17-null mutant mice. Development (2002) 4.13
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells (2010) 2.91
Conserved role of nanos proteins in germ cell development. Science (2003) 2.86
Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin. Hum Mol Genet (2003) 2.37
Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer. Science (2010) 2.34
Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis. Am J Respir Crit Care Med (2007) 2.33
Identification and characterization of stem cells in prepubertal spermatogenesis in mice. Dev Biol (2003) 2.24
Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity (2005) 2.19
Interactions in the network of Usher syndrome type 1 proteins. Hum Mol Genet (2004) 2.16
Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Dev Biol (2004) 2.13
The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus. J Virol (2005) 2.13
Genetic differences among C57BL/6 substrains. Exp Anim (2009) 1.99
Stage-specific expression of microRNAs during Xenopus development. FEBS Lett (2005) 1.92
Disclosing hidden transcripts: mouse natural sense-antisense transcripts tend to be poly(A) negative and nuclear localized. Genome Res (2005) 1.85
Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation. Proc Natl Acad Sci U S A (2005) 1.82
A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci U S A (2008) 1.75
Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance. J Biol Chem (2007) 1.75
Island cells control temporal association memory. Science (2014) 1.71
Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Proc Natl Acad Sci U S A (2003) 1.69
Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest. Am J Physiol Heart Circ Physiol (2009) 1.66
X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genet (2007) 1.63
Reversible regulation of metastasis by ROS-generating mtDNA mutations. Mitochondrion (2008) 1.62
Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages. Curr Biol (2006) 1.61
Dicer is required for maintaining adult pancreas. PLoS One (2009) 1.59
Quantitative chemical composition of cortical GABAergic neurons revealed in transgenic venus-expressing rats. Cereb Cortex (2007) 1.58
Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. J Neurosci (2008) 1.58
One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation. Genomics (2007) 1.56
Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits. Genome Res (2008) 1.46
Mutations in a new scaffold protein Sans cause deafness in Jackson shaker mice. Hum Mol Genet (2003) 1.45
MuERV-L is one of the earliest transcribed genes in mouse one-cell embryos. Biol Reprod (2003) 1.43
Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells. Blood (2005) 1.41
Effect of hypothermia therapy after outpatient cardiac arrest due to ventricular fibrillation. Circ J (2009) 1.41
Analysis of the effect of surgical lung biopsy on serum KL-6 Levels in patients with interstitial pneumonia: surgical lung biopsy does not elevate serum KL-6 levels. Intern Med (2006) 1.39
Identification of Cis-regulatory elements in the mouse Pax9/Nkx2-9 genomic region: implication for evolutionary conserved synteny. Genetics (2003) 1.37
RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos. Proc Natl Acad Sci U S A (2011) 1.34
Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos. Blood (2003) 1.34
Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Nat Genet (2009) 1.33
Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells. Hum Mol Genet (2006) 1.32
Mitochondria-related male infertility. Proc Natl Acad Sci U S A (2006) 1.32
Dynamic changes in the epigenomic state and nuclear organization of differentiating mouse embryonic stem cells. Genes Cells (2007) 1.29
MeCP2-dependent repression of an imprinted miR-184 released by depolarization. Hum Mol Genet (2008) 1.29
Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/beta-catenin signaling in keratinocytes. FASEB J (2007) 1.29
New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice. PLoS Genet (2009) 1.26
Whirlin complexes with p55 at the stereocilia tip during hair cell development. Proc Natl Acad Sci U S A (2006) 1.26
Genetic variation of melatonin productivity in laboratory mice under domestication. Proc Natl Acad Sci U S A (2010) 1.24
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med (2005) 1.22
Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L. J Cell Sci (2008) 1.21
The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. Nat Commun (2011) 1.19
Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. J Biol Chem (2009) 1.19
Comparative expression analysis uncovers novel features of endogenous antisense transcription. Hum Mol Genet (2008) 1.18
Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells. FEBS Lett (2010) 1.18
Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice. J Biochem (2003) 1.17
Pathogenesis of hepatitis C virus infection in Tupaia belangeri. J Virol (2010) 1.17
Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos. Mech Dev (2004) 1.15
Malignant phyllodes tumor of the prostate: retrospective review of specimens obtained by sequential transurethral resection. Pathol Int (2002) 1.14
The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains. Genome Res (2013) 1.14
Unique inbred strain MSM/Ms established from the Japanese wild mouse. Exp Anim (2009) 1.13
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol (2006) 1.12
Origins of mouse inbred strains deduced from whole-genome scanning by polymorphic microsatellite loci. Mamm Genome (2005) 1.12
Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development. Mol Cell Biol (2002) 1.11
Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes. Mol Reprod Dev (2010) 1.11
Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a. Science (2013) 1.11
Phylogeny, recombination, and mechanisms of stepwise mitochondrial genome reorganization in mantellid frogs from Madagascar. Mol Biol Evol (2008) 1.11
Optimized beta-galactosidase staining method for simultaneous detection of endogenous gene expression in early mouse embryos. Genesis (2006) 1.10
Initiation of trophectoderm lineage specification in mouse embryos is independent of Cdx2. Development (2010) 1.10
Reprogramming events of mammalian somatic cells induced by Xenopus laevis egg extracts. Mol Reprod Dev (2007) 1.08
Normal embryonic and germ cell development in mice lacking alpha 1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1. Mol Cell Biol (2004) 1.08
Cell-free extracts from mammalian oocytes partially induce nuclear reprogramming in somatic cells. Biol Reprod (2009) 1.07
CXCL14 deficiency in mice attenuates obesity and inhibits feeding behavior in a novel environment. PLoS One (2010) 1.06
A novel murine gene, Sickle tail, linked to the Danforth's short tail locus, is required for normal development of the intervertebral disc. Genetics (2005) 1.06
Accumulation of pathogenic DeltamtDNA induced deafness but not diabetic phenotypes in mito-mice. Biochem Biophys Res Commun (2004) 1.06
Generation of transgenic rats expressing green fluorescent protein in S-100beta-producing pituitary folliculo-stellate cells and brain astrocytes. Endocrinology (2007) 1.05
HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan. Clin Cancer Res (2006) 1.05
Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis. Dev Biol (2009) 1.05
Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression. Development (2012) 1.04