Published in Neuron on February 15, 2007
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain (2008) 2.55
The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. EMBO J (2008) 2.43
A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci (2010) 1.80
What causes cell death in Parkinson's disease? Ann Neurol (2008) 1.66
Sept4/ARTS is required for stem cell apoptosis and tumor suppression. Genes Dev (2010) 1.57
Molecular mechanisms of alpha-synuclein neurodegeneration. Biochim Biophys Acta (2008) 1.51
Forchlorfenuron alters mammalian septin assembly, organization, and dynamics. J Biol Chem (2008) 1.43
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. J Clin Invest (2009) 1.35
Integrating pathways of Parkinson's disease in a molecular interaction map. Mol Neurobiol (2013) 1.34
The emerging functions of septins in metazoans. EMBO Rep (2011) 1.34
Septins enforce morphogenetic events during sexual reproduction and contribute to virulence of Cryptococcus neoformans. Mol Microbiol (2009) 1.25
The role of DYRK1A in neurodegenerative diseases. FEBS J (2010) 1.23
Septins regulate bacterial entry into host cells. PLoS One (2009) 1.16
Regulation of distinct septin rings in a single cell by Elm1p and Gin4p kinases. Mol Biol Cell (2009) 1.13
Role of nucleotide binding in septin-septin interactions and septin localization in Saccharomyces cerevisiae. Mol Cell Biol (2008) 1.13
The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration. Neurobiol Dis (2010) 1.12
The septin cytoskeleton facilitates membrane retraction during motility and blebbing. J Cell Biol (2012) 1.11
Septin functions in organ system physiology and pathology. Biol Chem (2014) 1.10
Septin 14 is involved in cortical neuronal migration via interaction with Septin 4. Mol Biol Cell (2010) 1.07
Value of genetic models in understanding the cause and mechanisms of Parkinson's disease. Curr Neurol Neurosci Rep (2008) 1.06
Septin 11 is present in GABAergic synapses and plays a functional role in the cytoarchitecture of neurons and GABAergic synaptic connectivity. J Biol Chem (2009) 1.02
Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission. Mol Cell Biol (2008) 1.00
A role for septins in the interaction between the Listeria monocytogenes INVASION PROTEIN InlB and the Met receptor. Biophys J (2011) 0.98
Role of synucleins in Alzheimer's disease. Neurotox Res (2009) 0.98
Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Nat Commun (2013) 0.94
The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast. PLoS One (2012) 0.93
Septin ring size scaling and dynamics require the coiled-coil region of Shs1p. Mol Biol Cell (2012) 0.91
Application of in utero electroporation and live imaging in the analyses of neuronal migration during mouse brain development. Med Mol Morphol (2012) 0.91
The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice. PLoS One (2011) 0.89
Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner. Mol Biol Cell (2013) 0.87
Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome. J Neuropathol Exp Neurol (2011) 0.85
Septin phosphorylation and coiled-coil domains function in cell and septin ring morphology in the filamentous fungus Ashbya gossypii. Eukaryot Cell (2012) 0.85
IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours. Sci Rep (2014) 0.84
Emerging roles of sumoylation in the regulation of actin, microtubules, intermediate filaments, and septins. Cytoskeleton (Hoboken) (2015) 0.83
Synaptic dysfunction and septin protein family members in neurodegenerative diseases. Mol Neurodegener (2015) 0.82
Septin dynamics are essential for exocytosis. J Biol Chem (2015) 0.82
Dopamine and α-synuclein dysfunction in Smad3 null mice. Mol Neurodegener (2011) 0.81
Seeking truth on Monte Verita. Workshop on the molecular biology and biochemistry of septins and septin function. EMBO Rep (2007) 0.78
Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice. Mol Brain (2013) 0.78
LIN7A depletion disrupts cerebral cortex development, contributing to intellectual disability in 12q21-deletion syndrome. PLoS One (2014) 0.77
Septin 8 is an interaction partner and in vitro substrate of MK5. World J Biol Chem (2012) 0.77
Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development. Sci Rep (2016) 0.76
Climbing the scaffolds of Parkinson's disease pathogenesis. Neuron (2007) 0.76
A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. Nat Commun (2015) 0.76
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies. Nat Med (2017) 0.76
Specificity protein 1 transcription factor regulates human ARTS promoter activity through multiple binding sites. PLoS One (2015) 0.76
Septins: Regulators of Protein Stability. Front Cell Dev Biol (2016) 0.75
The Mammalian Septin Interactome. Front Cell Dev Biol (2017) 0.75
Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism. F1000Res (2015) 0.75
Localization of septin proteins in the mouse cochlea. Hear Res (2012) 0.75
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet (2009) 8.11
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol (2010) 7.62
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci (2008) 6.13
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature (2006) 4.80
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. JAMA (2006) 4.26
Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell (2009) 3.45
Entrapment of intracytosolic bacteria by septin cage-like structures. Cell Host Microbe (2010) 3.39
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study. Lancet Neurol (2011) 3.36
Mitochondrial genome variation in eastern Asia and the peopling of Japan. Genome Res (2004) 3.34
Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science (2014) 3.14
Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Ann Neurol (2008) 2.95
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells (2010) 2.91
Cell size and nucleoid organization of engineered Escherichia coli cells with a reduced genome. Mol Microbiol (2005) 2.77
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci Rep (2012) 2.60
Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro. J Biol Chem (2005) 2.60
Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neurons. Curr Biol (2007) 2.60
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain (2008) 2.55
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nat Commun (2012) 2.55
A mitotic septin scaffold required for Mammalian chromosome congression and segregation. Science (2005) 2.37
White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion. Stroke (2004) 2.29
Extensive genomic diversity in pathogenic Escherichia coli and Shigella Strains revealed by comparative genomic hybridization microarray. J Bacteriol (2004) 2.28
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. J Neurosci (2008) 2.27
Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells. Nat Neurosci (2009) 2.21
Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell (2005) 2.21
Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology (2012) 2.18
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain (2012) 2.18
Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder? Biol Psychiatry (2006) 2.11
LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res (2008) 2.09
Functional analysis of 1440 Escherichia coli genes using the combination of knock-out library and phenotype microarrays. Metab Eng (2005) 2.05
Genomic investigation of alpha-synuclein multiplication and parkinsonism. Ann Neurol (2008) 2.04
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. Hum Mol Genet (2004) 2.02
Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet (2012) 2.01
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain. EMBO Rep (2003) 2.01
Mutations for Gaucher disease confer high susceptibility to Parkinson disease. Arch Neurol (2009) 2.00
Gradient echo T2*-weighted magnetic resonance imaging revealing cerebral microbleeds in a patient with microscopic polyangiitis complicated by cerebrovascular disease. J Stroke Cerebrovasc Dis (2011) 1.99
Parkin stabilizes PINK1 through direct interaction. Biochem Biophys Res Commun (2009) 1.89
Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol (2008) 1.88
Non-redundant odor coding by sister mitral cells revealed by light addressable glomeruli in the mouse. Nat Neurosci (2010) 1.86
Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease. Hum Mol Genet (2006) 1.83
Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy (2011) 1.81
Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation. Cancer Cell (2009) 1.80
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy. FEBS Lett (2010) 1.79
Novel PINK1 mutations in early-onset parkinsonism. Ann Neurol (2004) 1.72
Diagnostic criteria for dyslipidemia. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb (2007) 1.70
Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. J Cell Biol (2005) 1.69
Mechanism and treatment of dropped head syndrome associated with parkinsonism. Parkinsonism Relat Disord (2008) 1.68
Fabrication, characterization, and application of boron-doped diamond microelectrodes for in vivo dopamine detection. Anal Chem (2007) 1.67
Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease. Ann Neurol (2006) 1.66
Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules. J Cell Biol (2008) 1.65
Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet (2007) 1.65
A combinatorial code for the interaction of alpha-synuclein with membranes. J Biol Chem (2005) 1.60
Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. J Cell Biol (2007) 1.60
A possible role for humoral immunity in the pathogenesis of Parkinson's disease. Brain (2005) 1.57
Dissection of hippocampal dentate gyrus from adult mouse. J Vis Exp (2009) 1.56
Reversible cerebral vasoconstriction syndrome presenting as subarachnoid hemorrhage, reversible posterior leukoencephalopathy, and cerebral infarction. Intern Med (2011) 1.55
UCHL1 is a Parkinson's disease susceptibility gene. Ann Neurol (2004) 1.54
Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Proc Natl Acad Sci U S A (2003) 1.54
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol (2002) 1.54
M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity. J Neurosci (2004) 1.53
Impact of early surgery in the active phase on long-term outcomes in left-sided native valve infective endocarditis. J Thorac Cardiovasc Surg (2011) 1.48
Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model. Neurobiol Aging (2013) 1.46
Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb (2007) 1.45
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice. Mol Brain (2009) 1.44
Clinical outcomes of medical therapy and timely operation in initially diagnosed type a aortic intramural hematoma: a 20-year experience. Circulation (2009) 1.43
Intramuscular transplantation of G-CSF-mobilized CD34(+) cells in patients with critical limb ischemia: a phase I/IIa, multicenter, single-blinded, dose-escalation clinical trial. Stem Cells (2009) 1.43
Hypersomnia caused by isolated angiitis of the CNS. Intern Med (2005) 1.42
Executive summary of the Japan Atherosclerosis Society (JAS) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan -2012 version. J Atheroscler Thromb (2013) 1.42
Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia. J Cereb Blood Flow Metab (2011) 1.40
[A case of status epilepticus with a possible therapeutic effect by dantrolene sodium]. Rinsho Shinkeigaku (2011) 1.40
Serotonergic modulation of odor input to the mammalian olfactory bulb. Nat Neurosci (2009) 1.39
Behavioral profiles of three C57BL/6 substrains. Front Behav Neurosci (2010) 1.39
Successful thrombus aspiration during primary percutaneous coronary intervention reduces infarct size and preserves myocardial viability: a cardiac magnetic resonance imaging study. J Invasive Cardiol (2011) 1.39
Elevated plus maze for mice. J Vis Exp (2008) 1.39
Impact of brain-behavior phenotypying of genetically-engineered mice on research of neuropsychiatric disorders. Neurosci Res (2007) 1.39
Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice. Mol Brain (2009) 1.37
Reversal of hippocampal neuronal maturation by serotonergic antidepressants. Proc Natl Acad Sci U S A (2010) 1.37
Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol Brain (2008) 1.35
The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. Clin Cancer Res (2004) 1.34
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol (2011) 1.34
Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion. Stroke (2007) 1.34
Siah-1 facilitates ubiquitination and degradation of synphilin-1. J Biol Chem (2003) 1.33
Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology (2013) 1.33
Light/dark transition test for mice. J Vis Exp (2006) 1.33
Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families. Mov Disord (2007) 1.32
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice. Proc Natl Acad Sci U S A (2005) 1.30
Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECK. Cancer Res (2004) 1.27
Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease. J Neurochem (2009) 1.27
A rotarod test for evaluation of motor skill learning. J Neurosci Methods (2010) 1.26