PubRank

Manfred Gessler

Author PubWeight™ 67.22‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev 2004 4.41
2 Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet 2008 4.28
3 Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity 2008 2.62
4 Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res 2007 2.51
5 Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest 2010 2.42
6 Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell 2009 2.11
7 Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res 2007 2.05
8 Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney. J Pathol 2012 1.88
9 Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet 2013 1.86
10 Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res 2006 1.77
11 Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development 2006 1.67
12 Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice. Circ Res 2007 1.48
13 1q gain is a frequent finding in preoperatively treated Wilms tumors, but of limited prognostic value for risk stratification in the SIOP2001/GPOH trial. Genes Chromosomes Cancer 2014 1.47
14 Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol 2005 1.46
15 Hey genes in cardiovascular development. Trends Cardiovasc Med 2003 1.35
16 Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila. Dev Dyn 2005 1.21
17 Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain. Gene Expr Patterns 2004 1.16
18 Target genes of the WNT/beta-catenin pathway in Wilms tumors. Genes Chromosomes Cancer 2006 1.12
19 Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Gene 2004 1.07
20 New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors. Genes Chromosomes Cancer 2008 1.03
21 Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet 2012 1.02
22 Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3. Cancer Res 2014 1.02
23 Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development. Gene Expr Patterns 2003 1.02
24 Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor. Clin Cancer Res 2010 0.99
25 Identification of the human homolog of the imprinted mouse Air non-coding RNA. Genomics 2008 0.99
26 Characterization of hey bHLH genes in teleost fish. Dev Genes Evol 2003 0.95
27 Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain. Dev Dyn 2005 0.95
28 Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Glia 2009 0.95
29 Developmental expression and biochemical characterization of Emu family members. Dev Biol 2002 0.94
30 Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases. Gene Expr Patterns 2005 0.94
31 Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet 2012 0.94
32 Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome. Mamm Genome 2004 0.93
33 Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562. Clin Cancer Res 2009 0.92
34 All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo. Oncogene 2005 0.92
35 COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1. J Cell Sci 2013 0.92
36 WTX inactivation is a frequent, but late event in Wilms tumors without apparent clinical impact. Genes Chromosomes Cancer 2009 0.91
37 Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis. Genes Chromosomes Cancer 2007 0.91
38 The rodent Four-jointed ortholog Fjx1 regulates dendrite extension. Dev Biol 2007 0.89
39 Hey bHLH factors in cardiovascular development. Pediatr Cardiol 2009 0.87
40 Treatment-independent miRNA signature in blood of Wilms tumor patients. BMC Genomics 2012 0.86
41 Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo. Nat Genet 2002 0.85
42 Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse. Dev Dyn 2003 0.85
43 Characterization of primary Wilms tumor cultures as an in vitro model. Genes Chromosomes Cancer 2011 0.85
44 Novel familial WT1 read-through mutation associated with Wilms tumor and slow progressive nephropathy. Am J Kidney Dis 2005 0.85
45 Cloning and expression analysis of the mouse stroma marker Snep encoding a novel nidogen domain protein. Dev Dyn 2004 0.84
46 Retinoic acid pathway activity in Wilms tumors and characterization of biological responses in vitro. Mol Cancer 2011 0.82
47 her7 and hey1, but not lunatic fringe show dynamic expression during somitogenesis in medaka (Oryzias latipes). Gene Expr Patterns 2004 0.81
48 Autoantibody signature differentiates Wilms tumor patients from neuroblastoma patients. PLoS One 2011 0.79
49 Expression patterns of the mouse Spir-2 actin nucleator. Gene Expr Patterns 2010 0.77
50 Chibby, a novel antagonist of the Wnt pathway, is not involved in Wilms tumor development. Cancer Lett 2005 0.77
51 Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human. Chromosome Res 2014 0.77
52 Multicenter study identified molecular blood-born protein signatures for Wilms Tumor. Int J Cancer 2011 0.76
53 Identification of limited regions of genetic aberrations in patients affected with Wilms' tumor using a tiling-path chromosome 22 array. Int J Cancer 2006 0.76