Published in Int J Biochem Cell Biol on January 20, 2007
Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion. Cancer Res (2010) 2.01
Na Channel β Subunits: Overachievers of the Ion Channel Family. Front Pharmacol (2011) 1.69
An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers. Neuroscientist (2008) 1.43
Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration. Am J Physiol Cell Physiol (2011) 1.37
Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells. J Biol Chem (2009) 1.28
A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit. Int J Biochem Cell Biol (2008) 1.17
Ion channels as targets for cancer therapy. Int J Physiol Pathophysiol Pharmacol (2011) 1.10
Voltage-gated sodium channels and metastatic disease. Channels (Austin) (2012) 1.05
Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model. Dis Model Mech (2013) 1.02
Antimetastatic potential of amide-linked local anesthetics: inhibition of lung adenocarcinoma cell migration and inflammatory Src signaling independent of sodium channel blockade. Anesthesiology (2012) 1.02
Voltage-Gated Na+ Channels: Not Just for Conduction. Cold Spring Harb Perspect Biol (2016) 1.01
Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation. Philos Trans R Soc Lond B Biol Sci (2014) 0.98
The effects of anesthetics on tumor progression. Int J Physiol Pathophysiol Pharmacol (2013) 0.91
Ranolazine inhibits NaV1.5-mediated breast cancer cell invasiveness and lung colonization. Mol Cancer (2014) 0.90
Voltage-gated ion channels in cancer cell proliferation. Cancers (Basel) (2015) 0.89
Ion channel gene expression in lung adenocarcinoma: potential role in prognosis and diagnosis. PLoS One (2014) 0.87
Voltage-gated sodium channel as a target for metastatic risk reduction with re-purposed drugs. F1000Res (2015) 0.84
Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling. Sci Rep (2015) 0.81
T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines. J Exp Clin Cancer Res (2015) 0.80
Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo. Oncotarget (2015) 0.79
Voltage-gated sodium channels and cancer: is excitability their primary role? Front Pharmacol (2015) 0.78
Biochemical constitution of extracellular medium is critical for control of human breast cancer MDA-MB-231 cell motility. J Membr Biol (2008) 0.78
Requirement for chloride channel function during the hepatitis C virus life cycle. J Virol (2015) 0.77
Suppression of PPARβ, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities. Pflugers Arch (2014) 0.77
Expression of Voltage-Gated Sodium Channel Nav1.8 in Human Prostate Cancer is Associated with High Histological Grade. J Clin Exp Oncol (2012) 0.76
Intracellular calcium oscillations in strongly metastatic human breast and prostate cancer cells: control by voltage-gated sodium channel activity. Eur Biophys J (2016) 0.75
The influence of sodium on pathophysiology of multiple sclerosis. Neurol Sci (2017) 0.75
Comparison of fluorescence probes for intracellular sodium imaging in prostate cancer cell lines. Eur Biophys J (2016) 0.75
SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer. Nat Commun (2016) 0.75
The role of REST and HDAC2 in epigenetic dysregulation of Nav1.5 and nNav1.5 expression in breast cancer. Cancer Cell Int (2017) 0.75
State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261. Invest New Drugs (2017) 0.75
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature (2011) 11.59
A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. Nature (2007) 5.78
Intrinsic motions along an enzymatic reaction trajectory. Nature (2007) 5.53
The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature (2007) 5.08
Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study. Lancet (2011) 4.73
Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol (2008) 4.68
Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study. Arch Intern Med (2002) 3.83
The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. EMBO J (2003) 3.10
Management of major bleeding complications and emergency surgery in patients on long-term treatment with direct oral anticoagulants, thrombin or factor-Xa inhibitors: proposals of the working group on perioperative haemostasis (GIHP) - March 2013. Arch Cardiovasc Dis (2013) 2.71
Normal cells, but not cancer cells, survive severe Plk1 depletion. Mol Cell Biol (2006) 2.63
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science (2008) 2.30
Transient non-native hydrogen bonds promote activation of a signaling protein. Cell (2009) 2.12
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J Physiol (2004) 2.09
Generation of functional ion-channel tools by E3 targeting. Nat Biotechnol (2005) 2.08
Association of a functional deficit of the BKCa channel, a synaptic regulator of neuronal excitability, with autism and mental retardation. Am J Psychiatry (2006) 2.05
Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase. Cardiovasc Res (2006) 2.02
Prospective evaluation of a rapid nanoparticle-based lateral flow immunoassay (STic Expert(®) HIT) for the diagnosis of heparin-induced thrombocytopenia. Br J Haematol (2014) 2.01
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol Cell (2002) 2.00
MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta. Mol Cancer (2010) 1.87
Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc Natl Acad Sci U S A (2006) 1.80
Pivotal role of the lipid Raft SK3-Orai1 complex in human cancer cell migration and bone metastases. Cancer Res (2013) 1.70
Structural basis of selective ubiquitination of TRF1 by SCFFbx4. Dev Cell (2010) 1.68
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem (2005) 1.64
Development of heart failure and congenital septal defects in mice lacking endothelial nitric oxide synthase. Circulation (2002) 1.63
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature (2012) 1.62
Mapping limbic network organization in temporal lobe epilepsy using morphometric correlations: insights on the relation between mesiotemporal connectivity and cortical atrophy. Neuroimage (2008) 1.61
Organisation of the mouse sinoatrial node: structure and expression of HCN channels. Cardiovasc Res (2006) 1.61
Conduction slowing contributes to spontaneous ventricular arrhythmias in intrinsically active murine RyR2-P2328S hearts. J Cardiovasc Electrophysiol (2012) 1.53
An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain. PLoS One (2010) 1.52
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev (2009) 1.51
Β-adrenergic blockade combined with subcutaneous B-type natriuretic peptide: a promising approach to reduce ventricular arrhythmia in heart failure? Heart (2014) 1.40
Asymmetric optical cryptosystem based on coherent superposition and equal modulus decomposition. Opt Lett (2015) 1.39
Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues. Proc Natl Acad Sci U S A (2010) 1.37
Chinese minimally invasive percutaneous nephrolithotomy: the Guangzhou experience. J Endourol (2009) 1.34
Transmural stretch-dependent regulation of contractile properties in rat heart and its alteration after myocardial infarction. FASEB J (2004) 1.32
A proposed OB-fold with a protein-interaction surface in Candida albicans telomerase protein Est3. Nat Struct Mol Biol (2008) 1.29
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J Mol Cell Cardiol (2009) 1.29
Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells. J Biol Chem (2009) 1.28
N-3 and N-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in Tours, France. Int J Cancer (2002) 1.27
ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer. Proc Natl Acad Sci U S A (2013) 1.26
Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells. Circ Res (2007) 1.26
Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome. PLoS One (2010) 1.25
Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α. Cell Res (2010) 1.23
Involvement of a novel fast inward sodium current in the invasion capacity of a breast cancer cell line. Biochim Biophys Acta (2003) 1.21
Bullous hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin: three cases. J Am Acad Dermatol (2006) 1.19
Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1. Cardiovasc Res (2005) 1.19
Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis. JAMA (2011) 1.19
Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome. Circ Res (2010) 1.18
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Circulation (2011) 1.18
Neuronal nitric oxide synthase protects against myocardial infarction-induced ventricular arrhythmia and mortality in mice. Circulation (2009) 1.18
TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging. Circ Arrhythm Electrophysiol (2011) 1.17
Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node. J Histochem Cytochem (2002) 1.16
Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc Res (2003) 1.16
Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency. Elife (2014) 1.16
CCT chaperonin complex is required for the biogenesis of functional Plk1. Mol Cell Biol (2005) 1.14
SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep (2013) 1.13
Outcome evaluation of the National Cancer Institute career development awards program. J Cancer Educ (2013) 1.12
Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node. Prog Biophys Mol Biol (2007) 1.11
Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth. Circ Res (2009) 1.11
Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. Am J Physiol Heart Circ Physiol (2011) 1.10
Changes in platelet count after cardiac surgery can effectively predict the development of pathogenic heparin-dependent antibodies. Br J Haematol (2005) 1.10
Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice. J Cardiovasc Electrophysiol (2005) 1.10
Downregulation of miR-27a* and miR-532-5p and upregulation of miR-146a and miR-155 in LPS-induced RAW264.7 macrophage cells. Inflammation (2012) 1.09
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. J Mol Cell Cardiol (2011) 1.09
Letter by May et al regarding article, "Use of dabigatran for periprocedural anticoagulation in patients undergoing catheter ablation for atrial fibrillation" by Bassiouny et al. Circ Arrhythm Electrophysiol (2013) 1.09
Environmental and genetic control of arsenic accumulation and speciation in rice grain: comparing a range of common cultivars grown in contaminated sites across Bangladesh, China, and India. Environ Sci Technol (2009) 1.08
MRI atlas of the human hypothalamus. Neuroimage (2011) 1.07
Aesthetic full-perioral reconstruction of burn scar by using a bilateral-pedicled expanded forehead flap. Ann Plast Surg (2009) 1.07
Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium. Am J Physiol Heart Circ Physiol (2004) 1.06
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat Struct Mol Biol (2011) 1.06
Sensitization by docosahexaenoic acid (DHA) of breast cancer cells to anthracyclines through loss of glutathione peroxidase (GPx1) response. Free Radic Biol Med (2008) 1.06
NaV1.5 Na⁺ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia. J Cell Sci (2013) 1.06
Hard and soft micromachining for BioMEMS: review of techniques and examples of applications in microfluidics and drug delivery. Adv Drug Deliv Rev (2004) 1.06
Mapping of reentrant spontaneous polymorphic ventricular tachycardia in a Scn5a+/- mouse model. Am J Physiol Heart Circ Physiol (2011) 1.06
Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation. Nucleic Acids Res (2010) 1.05
High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc (2012) 1.05
Joint injections in patients on antiplatelet or anticoagulant therapy: risk minimization. Joint Bone Spine (2002) 1.05
Identification of SK3 channel as a new mediator of breast cancer cell migration. Mol Cancer Ther (2006) 1.04
Modeling correlated main-chain motions in proteins for flexible molecular recognition. Proteins (2004) 1.04
High-resolution technique for fabricating environmentally sensitive hydrogel microstructures. Langmuir (2004) 1.03
Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex. Structure (2010) 1.03
Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression. PLoS One (2012) 1.02
Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase. Nucleic Acids Res (2008) 1.02
Voltage-gated sodium channels: new targets in cancer therapy? Curr Pharm Des (2006) 1.02
Occurrence and partitioning of cadmium, arsenic and lead in mine impacted paddy rice: Hunan, China. Environ Sci Technol (2009) 1.01
Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA. Proc Natl Acad Sci U S A (2011) 1.00
High-quality ZnO nanowire arrays directly fabricated from photoresists. ACS Nano (2009) 1.00
A novel zinc finger is required for Mcm10 homocomplex assembly. J Biol Chem (2003) 1.00
Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction. J Med Chem (2013) 0.99
DMD-based LED-illumination super-resolution and optical sectioning microscopy. Sci Rep (2013) 0.99
Arsenic shoot-grain relationships in field grown rice cultivars. Environ Sci Technol (2010) 0.99