Published in Mol Cell on January 01, 2002
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol (2008) 3.94
A walk-through of the yeast mating pheromone response pathway. Peptides (2005) 2.47
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem J (2005) 2.19
Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia. Biol Psychiatry (2015) 1.56
Cdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20. Mol Cell Biol (2002) 1.44
An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther (2009) 1.36
Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS One (2009) 1.29
The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK. EMBO J (2004) 1.25
Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer. Biochem Pharmacol (2010) 1.24
Initiation of cytokinesis is controlled through multiple modes of regulation of the Sid2p-Mob1p kinase complex. Mol Cell Biol (2004) 1.21
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts. J Virol (2004) 1.20
GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. Mol Cell Biol (2003) 1.18
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells. Trends Immunol (2013) 1.16
Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Mol Cell Biol (2006) 1.16
Group I and II mammalian PAKs have different modes of activation by Cdc42. EMBO Rep (2012) 1.13
Tumor cell gene expression changes following short-term in vivo exposure to single agent chemotherapeutics are related to survival in multiple myeloma. Clin Cancer Res (2008) 1.13
PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. Mol Biol Cell (2005) 1.12
Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J (2003) 1.12
P21 activated kinases: structure, regulation, and functions. Small GTPases (2014) 1.06
Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk. J Mol Signal (2006) 1.06
CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization. J Biol Chem (2011) 1.05
The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells. J Clin Invest (2009) 1.05
Mitotic exit regulation through distinct domains within the protein kinase Cdc15. Mol Cell Biol (2003) 1.03
Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions. Mol Biol Cell (2004) 1.03
Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1. BMC Immunol (2009) 1.02
Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration. Am J Respir Crit Care Med (2007) 1.01
From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity. J Cell Biol (2009) 1.01
Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp. Biochem J (2007) 1.00
The endocytic adapter E-Syt2 recruits the p21 GTPase activated kinase PAK1 to mediate actin dynamics and FGF signalling. Biol Open (2012) 0.99
Regulation of cardiac excitation and contraction by p21 activated kinase-1. Prog Biophys Mol Biol (2009) 0.99
Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration. J Biol Chem (2009) 0.98
Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo. J Cell Biol (2012) 0.96
Budding yeast PAK kinases regulate mitotic exit by two different mechanisms. J Cell Biol (2003) 0.95
PAK1-Nck regulates cyclin D1 promoter activity in response to prolactin. Mol Endocrinol (2011) 0.94
XPak3 promotes cell cycle withdrawal during primary neurogenesis in Xenopus laevis. EMBO J (2002) 0.94
Regulation of ack-family nonreceptor tyrosine kinases. J Signal Transduct (2011) 0.92
LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation. Mol Cell (2012) 0.91
A new genetically encoded single-chain biosensor for Cdc42 based on FRET, useful for live-cell imaging. PLoS One (2014) 0.90
Dissecting activation of the PAK1 kinase at protrusions in living cells. J Biol Chem (2009) 0.89
p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. Am J Physiol Heart Circ Physiol (2011) 0.89
Analysis of conformational changes during activation of protein kinase Pak2 by amide hydrogen/deuterium exchange. J Biol Chem (2008) 0.88
Roles of P21-activated kinases and associated proteins in epithelial wound healing. Int Rev Cell Mol Biol (2008) 0.85
Mechanisms regulating the protein kinases of Saccharomyces cerevisiae. Eukaryot Cell (2007) 0.85
Untangling the complexity of PAK1 dynamics: The future challenge. Cell Logist (2012) 0.85
Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation. Mol Cell Biol (2002) 0.85
Signaling, Regulation, and Specificity of the Type II p21-activated Kinases. J Biol Chem (2015) 0.84
Improvements to the Kunkel mutagenesis protocol for constructing primary and secondary phage-display libraries. Methods (2012) 0.84
Evidence for a novel mechanism of the PAK1 interaction with the Rho-GTPases Cdc42 and Rac. PLoS One (2013) 0.83
Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix. J Biol Chem (2009) 0.83
Identification of phosphorylation sites in betaPIX and PAK1. J Cell Sci (2007) 0.81
The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity. J Biol Chem (2012) 0.80
Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1. Mol Cell Biol (2012) 0.79
PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis. Oncotarget (2015) 0.79
Protein kinase CK2 phosphorylates and activates p21-activated kinase 1. Mol Biol Cell (2013) 0.78
3D structure analysis of PAKs: A clue to the rational design for affinity reagents and blockers. Cell Logist (2012) 0.78
Antioxidant Treatment and Induction of Autophagy Cooperate to Reduce Desmin Aggregation in a Cellular Model of Desminopathy. PLoS One (2015) 0.78
Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and Rho GTPases. J Biol Chem (2013) 0.77
Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1. PLoS One (2014) 0.77
The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1). J Biol Chem (2015) 0.77
CRK SH3N Domain Diminishes Cell Invasiveness of Non-Small Cell Lung Cancer. Genes Cancer (2013) 0.77
Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio (2015) 0.77
Structural insights into the intertwined dimer of fyn SH2. Protein Sci (2015) 0.76
PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape. J Cell Sci (2015) 0.76
PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta (2015) 0.76
Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling. Front Pharmacol (2013) 0.76
The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Cell Res (2016) 0.75
Republished: tracing PAKs from GI inflammation to cancer. Postgrad Med J (2014) 0.75
Reciprocally coupled residues crucial for protein kinase Pak2 activity calculated by statistical coupling analysis. PLoS One (2010) 0.75
Receptor-stimulated transamidation induces activation of Rac1 and Cdc42 and the regulation of dendritic spines. Neuropharmacology (2017) 0.75
Autophosphorylation Affects Substrate-Binding Affinity of Tobacco Ca2+-Dependent Protein Kinase1. Plant Physiol (2017) 0.75
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature (2011) 11.59
X-ray structure of a protein-conducting channel. Nature (2003) 9.20
Structure of an unliganded simian immunodeficiency virus gp120 core. Nature (2005) 8.30
Structure of the dengue virus envelope protein after membrane fusion. Nature (2004) 7.97
A ligand-binding pocket in the dengue virus envelope glycoprotein. Proc Natl Acad Sci U S A (2003) 7.76
A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. Nature (2007) 5.78
Crystal structure of glycoprotein B from herpes simplex virus 1. Science (2006) 5.57
Intrinsic motions along an enzymatic reaction trajectory. Nature (2007) 5.53
Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature (2005) 5.44
Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction. Proc Natl Acad Sci U S A (2008) 5.33
The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature (2007) 5.08
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science (2005) 4.97
The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol (2005) 4.81
Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol (2008) 4.68
The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment. Nat Struct Mol Biol (2006) 4.62
Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature (2004) 4.48
An atomic model of the interferon-beta enhanceosome. Cell (2007) 4.22
Structure and function of an essential component of the outer membrane protein assembly machine. Science (2007) 3.85
B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol (2012) 3.69
Structure of the human transferrin receptor-transferrin complex. Cell (2004) 3.64
Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. J Virol (2005) 3.58
Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proc Natl Acad Sci U S A (2011) 3.51
XMAP215 is a processive microtubule polymerase. Cell (2008) 3.33
Role of HIV membrane in neutralization by two broadly neutralizing antibodies. Proc Natl Acad Sci U S A (2009) 3.19
Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc Natl Acad Sci U S A (2004) 3.10
The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. EMBO J (2003) 3.10
Molecular organization of the Ndc80 complex, an essential kinetochore component. Proc Natl Acad Sci U S A (2005) 3.01
Beam-induced motion of vitrified specimen on holey carbon film. J Struct Biol (2012) 2.84
Movies of ice-embedded particles enhance resolution in electron cryo-microscopy. Structure (2012) 2.80
RNA synthesis in a cage--structural studies of reovirus polymerase lambda3. Cell (2002) 2.74
Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A (2009) 2.65
Normal cells, but not cancer cells, survive severe Plk1 depletion. Mol Cell Biol (2006) 2.63
Subunit interactions in bovine papillomavirus. Proc Natl Acad Sci U S A (2010) 2.51
Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy. Curr Opin Struct Biol (2011) 2.47
The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site. EMBO J (2002) 2.41
SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J Biol Chem (2005) 2.36
Single-particle kinetics of influenza virus membrane fusion. Proc Natl Acad Sci U S A (2008) 2.32
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science (2008) 2.30
Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A (2004) 2.28
Atomic model of the papillomavirus capsid. EMBO J (2002) 2.27
Structure of the reovirus membrane-penetration protein, Mu1, in a complex with is protector protein, Sigma3. Cell (2002) 2.24
Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol (2006) 2.17
Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure (2008) 2.13
Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein. Structure (2005) 2.13
Transient non-native hydrogen bonds promote activation of a signaling protein. Cell (2009) 2.12
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J Physiol (2004) 2.09
Generation of functional ion-channel tools by E3 targeting. Nat Biotechnol (2005) 2.08
Structural rearrangements in the membrane penetration protein of a non-enveloped virus. Nature (2004) 2.05
Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase. Cardiovasc Res (2006) 2.02
How does radiation damage in protein crystals depend on X-ray dose? Structure (2003) 2.01
Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. EMBO J (2004) 2.01
Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching. Nature (2011) 1.93
Recognition of the centromere-specific histone Cse4 by the chaperone Scm3. Proc Natl Acad Sci U S A (2011) 1.87
MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta. Mol Cancer (2010) 1.87
The SH2 domain: versatile signaling module and pharmaceutical target. Biochim Biophys Acta (2004) 1.86
Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion. Proc Natl Acad Sci U S A (2006) 1.83
Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature (2004) 1.81
Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc Natl Acad Sci U S A (2006) 1.80
Atomic model of an infectious rotavirus particle. EMBO J (2010) 1.79
Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure (2006) 1.76
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. Proc Natl Acad Sci U S A (2002) 1.75
Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch. J Biol Chem (2007) 1.72
High-throughput phosphotyrosine profiling using SH2 domains. Mol Cell (2007) 1.72
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc Natl Acad Sci U S A (2012) 1.70
Structural basis of selective ubiquitination of TRF1 by SCFFbx4. Dev Cell (2010) 1.68
Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab. Science (2009) 1.66
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem (2005) 1.64
Development of heart failure and congenital septal defects in mice lacking endothelial nitric oxide synthase. Circulation (2002) 1.63
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature (2012) 1.62
X-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution. J Mol Biol (2010) 1.61
Organisation of the mouse sinoatrial node: structure and expression of HCN channels. Cardiovasc Res (2006) 1.61
Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction. J Mol Biol (2007) 1.60
Stu2p binds tubulin and undergoes an open-to-closed conformational change. J Cell Biol (2006) 1.57
Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding. Structure (2007) 1.54
Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution. Structure (2005) 1.53
Conduction slowing contributes to spontaneous ventricular arrhythmias in intrinsically active murine RyR2-P2328S hearts. J Cardiovasc Electrophysiol (2012) 1.53
An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain. PLoS One (2010) 1.52
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev (2009) 1.51
The active conformation of the PAK1 kinase domain. Structure (2005) 1.50
Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization. Curr Biol (2004) 1.50
The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell (2010) 1.48
Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell (2003) 1.48
The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency. Nature (2008) 1.48
CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule. Dev Cell (2010) 1.47
Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol (2010) 1.46
Normalization of nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett (2002) 1.46
Restraining the conformation of HIV-1 gp120 by removing a flexible loop. EMBO J (2006) 1.41
Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion. J Cell Biol (2009) 1.41
Molecular structure, function, and dynamics of clathrin-mediated membrane traffic. Cold Spring Harb Perspect Biol (2014) 1.41
Asymmetric optical cryptosystem based on coherent superposition and equal modulus decomposition. Opt Lett (2015) 1.39
Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques. J Mol Biol (2005) 1.38
Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.35
Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate. PLoS Pathog (2010) 1.35
Protein arms in the kinetochore-microtubule interface of the yeast DASH complex. Mol Biol Cell (2007) 1.35
Chinese minimally invasive percutaneous nephrolithotomy: the Guangzhou experience. J Endourol (2009) 1.34
Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain. J Virol (2006) 1.34
Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. Elife (2013) 1.31
Peptides released from reovirus outer capsid form membrane pores that recruit virus particles. EMBO J (2008) 1.30
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J Mol Cell Cardiol (2009) 1.29