Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function.

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Factors and networks that underpin early hematopoiesis. Semin Immunol (2011) 1.03

Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo. Proc Natl Acad Sci U S A (2012) 0.88

Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function. J Immunol (2007) 0.87

Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. Cell Rep (2016) 0.79

PAX5 overexpression is not enough to reestablish the mature B-cell phenotype in classical Hodgkin lymphoma. Leukemia (2013) 0.76

Identification of human plasma cells with a lamprey monoclonal antibody. JCI Insight (2016) 0.75

Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature (2007) 5.39

Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. Genes Dev (2004) 3.66

The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity (2012) 3.65

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol (2011) 3.44

Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. Nat Neurosci (2004) 3.26

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16

Pax5: the guardian of B cell identity and function. Nat Immunol (2007) 3.15

Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene. Nat Immunol (2004) 2.90

Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity (2006) 2.64

CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62

Nephric lineage specification by Pax2 and Pax8. Genes Dev (2002) 2.52

Mcl-1 is essential for germinal center formation and B cell memory. Science (2010) 2.42

The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells. Immunity (2011) 2.41

Reversion of B cell commitment upon loss of Pax5 expression. Science (2002) 2.16

Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity (2008) 2.11

Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity (2007) 2.06

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol (2009) 2.05

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol (2009) 1.98

Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development (2005) 1.91

Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol Cell Biol (2006) 1.81

Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes. Nat Immunol (2007) 1.77

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells. Blood (2010) 1.71

Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. Immunity (2009) 1.67

Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow. Blood (2005) 1.58

Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity (2013) 1.56

Transcriptional control of B-cell development. Curr Opin Immunol (2002) 1.51

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis. EMBO J (2012) 1.50

Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity (2002) 1.48

Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene. Immunity (2002) 1.43

Pax5: a master regulator of B cell development and leukemogenesis. Adv Immunol (2011) 1.37

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell (2013) 1.37

Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation. Mol Cell Biol (2006) 1.34

In vitro differentiation of murine embryonic stem cells toward a renal lineage. Differentiation (2007) 1.31

Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors. J Immunol (2004) 1.31

Tissue-specific expression of cre recombinase from the Pax8 locus. Genesis (2004) 1.30

Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors. EMBO J (2003) 1.29

Developmental plasticity of lymphocytes. Curr Opin Immunol (2008) 1.29

Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible. EMBO J (2004) 1.28

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells. EMBO J (2011) 1.22

Differential requirement for Nfil3 during NK cell development. J Immunol (2014) 1.21

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells. Nat Immunol (2013) 1.19

STAT5 in B cell development and leukemia. Curr Opin Immunol (2010) 1.19

B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase. Proc Natl Acad Sci U S A (2010) 1.15

Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. BMC Dev Biol (2010) 1.12

Essential role of EBF1 in the generation and function of distinct mature B cell types. J Exp Med (2012) 1.12

Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes. EMBO Rep (2004) 1.11

The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers. Development (2002) 1.04

Postnatal development of the murine cerebellar cortex: formation and early dispersal of basket, stellate and Golgi neurons. Eur J Neurosci (2006) 1.03

Life beyond cleavage: the case of Ago2 and hematopoiesis. Genes Dev (2007) 0.99

The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction. EMBO J (2006) 0.98

Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation. J Immunol (2013) 0.96

Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region. Development (2005) 0.95

Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus. Blood (2006) 0.95

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice. Blood (2013) 0.94

Regulation of DNA replication within the immunoglobulin heavy-chain locus during B cell commitment. PLoS Biol (2012) 0.92

Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis. Blood (2008) 0.91

Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation. Proc Natl Acad Sci U S A (2012) 0.89

Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age. PLoS One (2011) 0.89

Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function. J Immunol (2007) 0.87

Regulation of GATA-3 expression during CD4 lineage differentiation. J Immunol (2011) 0.86

GABAergic neurons regulate lateral ventricular development via transcription factor Pax5. Genesis (2013) 0.81

Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells. Eur J Immunol (2005) 0.77

B young again. Immunity (2008) 0.76

Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine. J Innate Immun (2016) 0.75

Pillars Article: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999. 401: 556-562. J Immunol (2015) 0.75

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis. Cancer Cell (2016) 0.75