Published in Cell Cycle on February 19, 2007
Hypothermia and rewarming induce gene expression and multiplication of cells in healthy rat prostate tissue. PLoS One (2015) 1.99
p53-Dependent induction of PVT1 and miR-1204. J Biol Chem (2011) 1.56
Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. Mol Cell Biol (2008) 1.44
Temporal analysis of signaling pathways activated in a murine model of two-kidney, one-clip hypertension. Am J Physiol Renal Physiol (2009) 1.27
Targeting prostate cancer based on signal transduction and cell cycle pathways. Cell Cycle (2008) 1.25
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A (2010) 1.20
Upregulation of p21Waf1/Cip1 expression in vivo by butyrate administration can be chemoprotective or chemopromotive depending on the lipid component of the diet. Carcinogenesis (2008) 1.16
Loss of p53 induces tumorigenesis in p21-deficient mesenchymal stem cells. Neoplasia (2009) 1.09
Serum-nutrient starvation induces cell death mediated by Bax and Puma that is counteracted by p21 and unmasked by Bcl-x(L) inhibition. PLoS One (2011) 1.07
Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ (2009) 1.05
Switching Akt: from survival signaling to deadly response. Bioessays (2009) 1.03
Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy. Br J Pharmacol (2012) 1.00
Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1). Cell Death Differ (2011) 0.91
The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1. Cell Death Dis (2013) 0.89
Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program. Cell Death Dis (2013) 0.88
A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities. PLoS One (2012) 0.88
α-Fucosidase as a novel convenient biomarker for cellular senescence. Cell Cycle (2013) 0.86
EAPP: gatekeeper at the crossroad of apoptosis and p21-mediated cell-cycle arrest. Oncogene (2011) 0.85
p21 as a transcriptional co-repressor of S-phase and mitotic control genes. PLoS One (2012) 0.85
Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. PLoS One (2011) 0.82
Coordination between p21 and DDB2 in the cellular response to UV radiation. PLoS One (2013) 0.78
miR-30e controls DNA damage-induced stress responses by modulating expression of the CDK inhibitor p21WAF1/CIP1 and caspase-3. Oncotarget (2016) 0.77
Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells. PLoS One (2011) 0.77
Simultaneous deletion of p21Cip1/Waf1 and caspase-3 accelerates proliferation and partially rescues the differentiation defects of caspase-3 deficient hematopoietic stem cells. PLoS One (2014) 0.77
Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-γ-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2. Free Radic Biol Med (2016) 0.76
p21(WAF1) modulates drug-induced apoptosis and cell cycle arrest in B-cell precursor acute lymphoblastic leukemia. Cell Cycle (2015) 0.75
Catfish rhamnose-binding lectin induces G0/1 cell cycle arrest in Burkitt's lymphoma cells via membrane surface Gb3. Glycoconj J (2016) 0.75
The selective PI3Kα inhibitor BYL719 as a novel therapeutic option for neuroendocrine tumors: Results from multiple cell line models. PLoS One (2017) 0.75
T-helper-1-cell cytokines drive cancer into senescence. Nature (2013) 4.47
Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell (2003) 3.68
Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell (2005) 2.89
Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Hepatology (2011) 2.49
Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology (2004) 2.41
MicroRNAs play a role in spontaneous recovery from acute liver failure. Hepatology (2014) 2.23
Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol Biol Cell (2002) 2.05
Prorenin receptor is essential for podocyte autophagy and survival. J Am Soc Nephrol (2011) 2.04
Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver. Hepatology (2007) 1.97
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med (2011) 1.81
Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. J Biol Chem (2007) 1.75
Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFα treatment. Gut (2011) 1.75
Cancer stem cell markers in common cancers - therapeutic implications. Trends Mol Med (2008) 1.75
Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J (2003) 1.60
Functional characterization of p53beta and p53gamma, two isoforms of the tumor suppressor p53. Cell Cycle (2009) 1.59
Thioredoxin in human and experimental sepsis. Crit Care Med (2009) 1.51
Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. Mol Cell Biol (2008) 1.44
IκBζ is a transcriptional key regulator of CCL2/MCP-1. J Immunol (2013) 1.41
MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program. Blood (2006) 1.40
Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop. Oncogene (2003) 1.40
New approaches and therapeutics targeting apoptosis in disease. Pharmacol Rev (2005) 1.40
Apoptin, a tumor-selective killer. Biochim Biophys Acta (2009) 1.39
Multiple virulence factors are required for Staphylococcus aureus-induced apoptosis in endothelial cells. Cell Microbiol (2005) 1.35
SOX2 expression associates with stem cell state in human ovarian carcinoma. Cancer Res (2013) 1.34
Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event. Cancer Res (2004) 1.30
Guardians of cell death: the Bcl-2 family proteins. Essays Biochem (2003) 1.28
Non-apoptotic functions of caspases in cellular proliferation and differentiation. Biochem Pharmacol (2003) 1.27
Staphylococcus aureus alpha-toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumour necrosis factor-alpha and the mitochondrial death pathway. Cell Microbiol (2003) 1.26
p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. Cancer Res (2006) 1.26
Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness. FASEB J (2002) 1.24
A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. J Biol Chem (2006) 1.22
Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling. Anesthesiology (2007) 1.21
Caspase activation is associated with spontaneous recovery from acute liver failure. Hepatology (2008) 1.20
S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2. Biochim Biophys Acta (2007) 1.19
The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. J Biol Chem (2007) 1.18
Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. J Biol Chem (2004) 1.16
Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B. J Invest Dermatol (2005) 1.16
Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene (2005) 1.15
Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis. J Cell Biol (2007) 1.14
Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1. FASEB J (2011) 1.14
Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications. J Mol Med (Berl) (2008) 1.12
Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells. J Invest Dermatol (2002) 1.12
RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. J Biol Chem (2010) 1.12
CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function. J Exp Med (2004) 1.12
Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment. Blood (2007) 1.12
The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum. Hepatology (2005) 1.10
Impaired adrenal stress response in Toll-like receptor 2-deficient mice. Proc Natl Acad Sci U S A (2004) 1.09
Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci U S A (2006) 1.08
Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. J Biol Chem (2006) 1.08
Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell (2006) 1.07
Translational approaches targeting the p53 pathway for anti-cancer therapy. Br J Pharmacol (2012) 1.04
Slug/SNAI2 regulates cell proliferation and invasiveness of metastatic prostate cancer cell lines. Tumour Biol (2010) 1.03
Switching Akt: from survival signaling to deadly response. Bioessays (2009) 1.03
MiRNA expression patterns predict survival in glioblastoma. Radiat Oncol (2011) 1.01
Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1. Neoplasia (2012) 1.00
Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox- and Nrf2-independent manner. PLoS One (2013) 0.99
Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis. J Cell Sci (2009) 0.98
Caspase activation is required for antiviral treatment response in chronic hepatitis C virus infection. Hepatology (2006) 0.98
The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway. J Biol Chem (2006) 0.98
Toxoplasma gondii inhibits Fas/CD95-triggered cell death by inducing aberrant processing and degradation of caspase 8. Cell Microbiol (2007) 0.97
Loss of caspase-9 provides genetic evidence for the type I/II concept of CD95-mediated apoptosis. J Biol Chem (2006) 0.97
The role of caspases in cryoinjury: caspase inhibition strongly improves the recovery of cryopreserved hematopoietic and other cells. FASEB J (2002) 0.96
Human skin endothelial cells can express all 10 TLR genes and respond to respective ligands. Clin Vaccine Immunol (2007) 0.96
Ribavirin and alpha interferon enhance death receptor-mediated apoptosis and caspase activation in human hepatoma cells. Antimicrob Agents Chemother (2003) 0.95
Cancer stem cells as targets for cancer therapy: selected cancers as examples. Arch Immunol Ther Exp (Warsz) (2008) 0.95
Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. Blood (2008) 0.95
Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9. Apoptosis (2008) 0.94
Serum biomarkers of cell death for monitoring therapy response of gastrointestinal carcinomas. Eur J Cancer (2010) 0.94
IkappaBzeta expression is regulated by miR-124a. Cell Cycle (2009) 0.93
Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis. J Biol Chem (2005) 0.93
Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway. Oncogene (2005) 0.92
Caspase-10 sensitizes breast carcinoma cells to TRAIL-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner. Mol Cell Biol (2005) 0.92
Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells. J Biol Chem (2002) 0.92
New insights into the molecular pathology of radiation-induced pneumopathy. Radiother Oncol (2011) 0.91
Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold. RNA (2010) 0.91
Cell surface externalization of annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis. J Immunol (2009) 0.91
Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumor cells. Mol Cancer Ther (2013) 0.91
Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing. Mol Cell Biol (2005) 0.91
The proteasome is required for rapid initiation of death receptor-induced apoptosis. Mol Cell Biol (2006) 0.91
Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA. Nucleic Acids Res (2009) 0.90
Redox events in HTLV-1 Tax-induced apoptotic T-cell death. Antioxid Redox Signal (2002) 0.89
IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor. Immunity (2012) 0.89
Induction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation. Cell Signal (2009) 0.89
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway. Oncogene (2004) 0.89