Published in Eur J Pharmacol on January 20, 2007
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Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. FASEB J (2008) 1.45
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain. Br J Pharmacol (2008) 1.14
Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6. J Biol Chem (2011) 1.01
Anticancer Properties of PPARalpha-Effects on Cellular Metabolism and Inflammation. PPAR Res (2008) 0.96
The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse. J Cereb Blood Flow Metab (2009) 0.90
Involvement of a Stat3 binding site in inflammation-induced enteric apelin expression. Am J Physiol Gastrointest Liver Physiol (2008) 0.88
A newly identified CG301269 improves lipid and glucose metabolism without body weight gain through activation of peroxisome proliferator-activated receptor alpha and gamma. Diabetes (2011) 0.88
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Establishment of the insulin resistance induced by inflammatory response in 3T3-L1 preadipocytes cell line. Inflammation (2008) 0.79
The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures. PLoS One (2016) 0.77
Regulation of Ketone Body Metabolism and the Role of PPARα. Int J Mol Sci (2016) 0.76
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet (2007) 9.56
A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol (2002) 4.63
Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol (2004) 3.39
IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. Am J Respir Crit Care Med (2008) 2.62
CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia. J Sleep Res (2002) 2.60
Development and characterization of IL-21-producing CD4+ T cells. J Exp Med (2008) 2.34
Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization. Circ Res (2006) 2.31
Total sleep deprivation elevates blood pressure through arterial baroreflex resetting: a study with microneurographic technique. Sleep (2003) 2.17
IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice. J Allergy Clin Immunol (2006) 2.16
Preventive effects of eicosapentaenoic acid on coronary artery disease in patients with peripheral artery disease. Circ J (2010) 2.13
Incremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease. Circ J (2009) 2.01
Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation. Blood (2003) 1.95
Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal. Circ Res (2004) 1.95
A patient with familial amyotrophic lateral sclerosis associated with a new valosin-containing protein (VCP) gene mutation. Rinsho Shinkeigaku (2015) 1.94
Selective granulocyte and monocyte adsorptive apheresis as a first-line treatment for steroid naïve patients with active ulcerative colitis: a prospective uncontrolled study. Dig Dis Sci (2004) 1.92
Is the diagnosis of metabolic syndrome useful for predicting cardiovascular disease in asian diabetic patients? Analysis from the Japan Diabetes Complications Study. Diabetes Care (2005) 1.85
The long-term effects of self-management education for patients with type 2 diabetes on glycemic control: response to Norris et al. Diabetes Care (2002) 1.78
Clinical, autoimmune, and genetic characteristics of adult-onset diabetic patients with GAD autoantibodies in Japan (Ehime Study). Diabetes Care (2002) 1.70
CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration. Arterioscler Thromb Vasc Biol (2010) 1.60
Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy. Biochem Biophys Res Commun (2003) 1.55
Zoledronate has an antitumor effect and induces actin rearrangement in dexamethasone-resistant myeloma cells. Eur J Haematol (2007) 1.52
Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells. Blood (2002) 1.50
Prevalence of metabolic syndrome in the general Japanese population in 2000. J Atheroscler Thromb (2006) 1.50
Bisphenol A affects glucose transport in mouse 3T3-F442A adipocytes. Br J Pharmacol (2004) 1.46
A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet (2010) 1.38
Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling. J Immunol (2006) 1.36
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Mol Cancer Res (2003) 1.32
Adacolumn for selective leukocytapheresis as a non-pharmacological treatment for patients with disorders of the immune system: an adjunct or an alternative to drug therapy? J Clin Apher (2005) 1.30
Long-term outcome of therapeutic neovascularization using peripheral blood mononuclear cells for limb ischemia. Circ Cardiovasc Interv (2009) 1.30
Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: subanalysis of the JELIS trial. Stroke (2008) 1.29
Suppressive effect of EPA on the incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis (2009) 1.28
The effect of statins on mRNA levels of genes related to inflammation, coagulation, and vascular constriction in HUVEC. Human umbilical vein endothelial cells. J Atheroscler Thromb (2002) 1.20
Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator. Arthritis Rheum (2008) 1.18
Targeted disruption of TGF-beta-Smad3 signaling leads to enhanced neointimal hyperplasia with diminished matrix deposition in response to vascular injury. Circ Res (2005) 1.18
Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins. J Atheroscler Thromb (2005) 1.18
Report of the Japan Atherosclerosis Society (JAS) Guideline for Diagnosis and Treatment of Hyperlipidemia in Japanese adults. J Atheroscler Thromb (2002) 1.17
CD4(+)CD25(+) T-cell development is regulated by at least 2 distinct mechanisms. Blood (2002) 1.16
Guidelines for the management of familial hypercholesterolemia. J Atheroscler Thromb (2012) 1.16
Dysadipocytokinemia in werner syndrome and its recovery by treatment with pioglitazone. Diabetes Care (2004) 1.14
Advanced glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytes. Diabetes Res Clin Pract (2006) 1.13
The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load. PLoS One (2009) 1.11
Relationships between plasma fatty acid composition and coronary artery disease. J Atheroscler Thromb (2010) 1.11
T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways. J Allergy Clin Immunol (2007) 1.09
High glucose-induced upregulation of osteopontin is mediated via Rho/Rho kinase pathway in cultured rat aortic smooth muscle cells. Arterioscler Thromb Vasc Biol (2003) 1.08
Methylation silencing of the Apaf-1 gene in acute leukemia. Mol Cancer Res (2005) 1.07
Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation. Blood (2007) 1.05
Serum lipid survey and its recent trend in the general Japanese population in 2000. J Atheroscler Thromb (2005) 1.03
IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-alpha production in mast cells. J Exp Med (2003) 1.03
Toward the realization of a better aged society: messages from gerontology and geriatrics. Geriatr Gerontol Int (2012) 1.02
Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression. J Immunol (2005) 1.02
A retrospective search for predictors of clinical response to selective granulocyte and monocyte apheresis in patients with ulcerative colitis. Dig Dis Sci (2006) 1.02
Non-HDL cholesterol as a measure of atherosclerotic risk. J Atheroscler Thromb (2004) 1.01
Clinical features of familial hypercholesterolemia in Japan in a database from 1996-1998 by the research committee of the ministry of health, labour and welfare of Japan. J Atheroscler Thromb (2004) 1.00
Fc receptor-independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice. Arthritis Rheum (2003) 0.99
Global analysis of RNA expression profile in human vascular cells treated with statins. J Atheroscler Thromb (2004) 0.99
Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism. J Exp Med (2002) 0.98
Hyperglycemia-induced alteration of vascular smooth muscle phenotype. J Diabetes Complications (2002) 0.98
Association of cytosine-adenine repeat polymorphism of the estrogen receptor-beta gene with menopausal symptoms. Gend Med (2005) 0.97
LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration. Circ Res (2004) 0.97
Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation. J Immunol (2008) 0.97
Roles of degree of fat deposition and its localization on VEGF expression in adipocytes. Am J Physiol Endocrinol Metab (2004) 0.97
A secreted soluble form of LR11, specifically expressed in intimal smooth muscle cells, accelerates formation of lipid-laden macrophages. Arterioscler Thromb Vasc Biol (2007) 0.96
Increased circulating malondialdehyde-modified LDL levels in patients with coronary artery diseases and their association with peak sizes of LDL particles. Arterioscler Thromb Vasc Biol (2002) 0.96
Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein(a). J Biol Chem (2002) 0.96
Pitavastatin: efficacy and safety profiles of a novel synthetic HMG-CoA reductase inhibitor. Cardiovasc Drug Rev (2003) 0.96
Diagnosis and management of type I and type V hyperlipoproteinemia. J Atheroscler Thromb (2011) 0.95
Sustained reduction of serum cholesterol in low-dose 6-year simvastatin treatment with minimum side effects in 51,321 Japanese hypercholesterolemic patients. Circ J (2003) 0.95
Revascularization determines volume retention and gene expression by fat grafts in mice. Exp Biol Med (Maywood) (2005) 0.95
Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation. J Immunol (2005) 0.95
Effects of Yoku-kan-san-ka-chimpi-hange on the sleep of normal healthy adult subjects. Psychiatry Clin Neurosci (2002) 0.94
Diazepam reduces both arterial blood pressure and muscle sympathetic nerve activity in human. Neurosci Lett (2004) 0.94
The roles of transforming growth factor-β and Smad3 signaling in adipocyte differentiation and obesity. Biochem Biophys Res Commun (2011) 0.93
Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs. Dev Biol (2003) 0.92
Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan. J Atheroscler Thromb (2008) 0.92
Familial hypercholesterolemia. J Atheroscler Thromb (2013) 0.91
Emergence of fibrocytes showing morphological changes in the inflamed colonic mucosa. Dig Dis Sci (2009) 0.91
Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells. Microvasc Res (2008) 0.90
Age dependence of early symptomatic vertebral fracture with high-dose glucocorticoid treatment for collagen vascular diseases. J Clin Endocrinol Metab (2009) 0.89
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene. J Hum Genet (2003) 0.89
Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. J Clin Lipidol (2013) 0.89
Butyrate reduces colonic paracellular permeability by enhancing PPARgamma activation. Biochem Biophys Res Commun (2002) 0.89
Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice. J Clin Invest (2008) 0.89
Connexin 26-mediated gap junctional intercellular communication suppresses paracellular permeability of human intestinal epithelial cell monolayers. Exp Cell Res (2004) 0.89
Influence of statins on glucose tolerance in patients with type 2 diabetes mellitus: subanalysis of the collaborative study on hypercholesterolemia drug intervention and their benefits for atherosclerosis prevention (CHIBA study). J Atheroscler Thromb (2009) 0.89