Published in Bioorg Med Chem Lett on February 08, 2007
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin Cancer Res (2007) 5.59
Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Stent) Study: a prospective, randomized control trial. Circulation (2009) 4.61
Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discov (2013) 2.93
Association between IVUS findings and adverse outcomes in patients with coronary artery disease: the VIVA (VH-IVUS in Vulnerable Atherosclerosis) Study. JACC Cardiovasc Imaging (2011) 2.43
Sequencing studies in human genetics: design and interpretation. Nat Rev Genet (2013) 2.27
Molecular toolbox for studying diatom biology in Phaeodactylum tricornutum. Gene (2007) 2.05
Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia. Hum Brain Mapp (2006) 2.00
Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain (2003) 1.82
Consensus scoring for ligand/protein interactions. J Mol Graph Model (2002) 1.67
Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression. Mol Cell (2010) 1.55
Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain (2003) 1.55
Global biogeography of SAR11 marine bacteria. Mol Syst Biol (2012) 1.42
Translational crossroads for biomarkers. Clin Cancer Res (2005) 1.38
Evaluation of the Vicorder, a novel cuff-based device for the noninvasive estimation of central blood pressure. J Hypertens (2013) 1.36
Randomized, multicenter, phase II study of CO-101 versus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma: including a prospective evaluation of the role of hENT1 in gemcitabine or CO-101 sensitivity. J Clin Oncol (2013) 1.30
Topacheous gout as a rare cause of spinal stenosis in the lumbar region. Case report. J Neurosurg Spine (2005) 1.29
The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. J Biol Chem (2011) 1.22
Potent and selective mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors. 1. 4-(4-bromo-2-fluorophenylamino)-1- methylpyridin-2(1H)-ones. J Med Chem (2006) 1.22
Pupil diameter covaries with BOLD activity in human locus coeruleus. Hum Brain Mapp (2014) 1.21
Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL. Neurobiol Aging (2008) 1.13
Pregnancy-related Spontaneous Coronary Artery Dissection: Two Case Reports and a Comprehensive Review of Literature. Heart Views (2012) 1.13
Surgical checklists: the human factor. Patient Saf Surg (2013) 1.10
A diffusion tensor magnetic resonance imaging study of frontal cortex connections in very-late-onset schizophrenia-like psychosis. Am J Geriatr Psychiatry (2005) 1.07
Development of drug-resistant herpes simplex virus infection after haploidentical hematopoietic progenitor cell transplantation. Blood (2002) 1.02
Outcome after surgery for Maisonneuve fracture of the fibula. Injury (2004) 0.98
Multiple dental fractures following tongue barbell placement: a case report. Dent Traumatol (2006) 0.97
Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists. Bioorg Med Chem Lett (2004) 0.96
A longitudinal examination of the psychoeducational, neurocognitive, and psychiatric functioning in children with 22q11.2 deletion syndrome. Res Dev Disabil (2013) 0.96
A pilot study to assess whether glucagon-like peptide-1 protects the heart from ischemic dysfunction and attenuates stunning after coronary balloon occlusion in humans. Circ Cardiovasc Interv (2011) 0.96
Thin water layers on CaCO3 particles dispersed in oil with added salts. Langmuir (2009) 0.96
Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties. J Med Chem (2012) 0.96
Patient satisfaction and oral health-related quality of life outcomes of implant overdentures and fixed complete dentures. Int J Oral Maxillofac Implants (2010) 0.95
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids. Bioorg Med Chem Lett (2009) 0.95
Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. Clin Pharmacol Ther (2006) 0.94
A prospective randomised study to compare the utility and outcomes of subdural and subperiosteal drains for the treatment of chronic subdural haematoma. Acta Neurochir (Wien) (2012) 0.94
Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies. Hum Mol Genet (2010) 0.92
Changes in CD4+ T-cell differentiation phenotype during structured treatment interruption in patients with chronic HIV-1 infection. J Acquir Immune Defic Syndr (2003) 0.91
Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-alpha, IL-6 and IL-1 beta: possible relevance to multiple sclerosis. J Neuroimmunol (2003) 0.91
Single-agent inhibition of Chk1 is antiproliferative in human cancer cell lines in vitro and inhibits tumor xenograft growth in vivo. Oncol Res (2011) 0.91
Genioglossus fatigue in obstructive sleep apnea. Respir Physiol Neurobiol (2012) 0.91
Exploring the use of an anti-tick vaccine as a tool for the integrated eradication of the cattle fever tick, Rhipicephalus (Boophilus) annulatus. Vaccine (2012) 0.90
Treatment with an antibody to VLA-1 integrin reduces glomerular and tubulointerstitial scarring in a rat model of crescentic glomerulonephritis. Am J Pathol (2002) 0.90
Extradural haematoma--to evacuate or not? Revisiting treatment guidelines. Clin Neurol Neurosurg (2013) 0.90
Impact of moderate and severe hypodontia and amelogenesis imperfecta on quality of life and self-esteem of adult patients. J Dent (2013) 0.90
Insights into the role of DNA methylation in diatoms by genome-wide profiling in Phaeodactylum tricornutum. Nat Commun (2013) 0.89
Leukocyte telomere length is associated with high-risk plaques on virtual histology intravascular ultrasound and increased proinflammatory activity. Arterioscler Thromb Vasc Biol (2011) 0.89
Benzylic oxidation of gemfibrozil-1-O-beta-glucuronide by P450 2C8 leads to heme alkylation and irreversible inhibition. Chem Res Toxicol (2009) 0.88
3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase. Bioorg Med Chem Lett (2008) 0.88
Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry (2003) 0.88
Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists. Bioorg Med Chem Lett (2004) 0.87
Remote ischaemic pre-conditioning does not attenuate ischaemic left ventricular dysfunction in humans. Eur J Heart Fail (2009) 0.87
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14. Bioorg Med Chem Lett (2005) 0.86
High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme. Structure (2003) 0.86
Potent, selective pyrimidinetrione-based inhibitors of MMP-13. Bioorg Med Chem Lett (2006) 0.86
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones. Bioorg Med Chem Lett (2009) 0.86
Remote ischemic preconditioning stimulus does not reduce microvascular resistance or improve myocardial blood flow in patients undergoing elective percutaneous coronary intervention. Angiology (2008) 0.86
Recurrent intramedullary epidermoid cyst of conus medullaris. BMJ Case Rep (2011) 0.85
The pumping of fluid in cementless cups with holes. J Arthroplasty (2004) 0.84
A long-term follow up of spontaneously healed root fractures later subjected to orthodontic forces - two case reports. Dent Traumatol (2008) 0.84
Engineering autoactivating forms of matrix metalloproteinase-9 and expression of the active enzyme in cultured cells and transgenic mouse brain. Biochemistry (2002) 0.84
Score-based adjustment for confounding by population stratification in genetic association studies. Genet Epidemiol (2010) 0.84
Retransplantation in Alport post-transplant anti-GBM disease. Kidney Int (2004) 0.83
Synthesis, structure-property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y₁₂ receptor. Eur J Med Chem (2013) 0.83
Haplotype Association Mapping Identifies a Candidate Gene Region in Mice Infected With Staphylococcus aureus. G3 (Bethesda) (2012) 0.83
Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase. Bioorg Med Chem Lett (2013) 0.83
Primary coronary microvascular dysfunction and poor coronary collaterals predict post-percutaneous coronary intervention cardiac necrosis. Coron Artery Dis (2009) 0.81
Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA. Bioorg Med Chem Lett (2011) 0.81
Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors. Bioorg Med Chem Lett (2010) 0.80
Tooth agenesis in patients referred to an Irish tertiary care clinic for the developmental dental disorders. J Ir Dent Assoc (2010) 0.80
Diagnostic criteria of vascular dementia in CADASIL. Stroke (2008) 0.80
Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors. Bioorg Med Chem Lett (2009) 0.80
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides. Bioorg Med Chem Lett (2009) 0.80
Non-oxime pyrazole based inhibitors of B-Raf kinase. Bioorg Med Chem Lett (2010) 0.80
Chemokines in allergy. Curr Drug Targets Inflamm Allergy (2002) 0.80
Recurrent 'universal tumour' of the spinal cord. BMJ Case Rep (2012) 0.79
Single unit CAD/CAM restorations: a literature review. J Ir Dent Assoc (2007) 0.79
Neutrophils mediate airway hyperresponsiveness after chlorine-induced airway injury in the mouse. Am J Respir Cell Mol Biol (2015) 0.79
Structure-based generation of viable leads from small combinatorial libraries. Curr Opin Drug Discov Devel (2004) 0.79
Coronary collaterals provide a constant scaffold effect on the left ventricle and limit ischemic left ventricular dysfunction in humans. J Appl Physiol (1985) (2012) 0.79
Clinical failure analysis of contemporary ceramic-on-ceramic total hip replacements. Proc Inst Mech Eng H (2013) 0.78
Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships. Bioorg Med Chem Lett (2011) 0.78
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase. Bioorg Med Chem Lett (2012) 0.78
Correlations between MRS and DTI in cerebral small vessel disease. NMR Biomed (2006) 0.78
Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: rational design and kinase selectivity profile of cell potent type II inhibitors. Bioorg Med Chem Lett (2012) 0.78
Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors. Bioorg Med Chem Lett (2009) 0.78
The enantioselective synthesis of alpha-amino acid derivatives via organoboranes. J Am Chem Soc (2002) 0.78
The sensitivity of lavage analysis by light and analytical electron microscopy in correlating the types of asbestos from a known exposure setting. Inhal Toxicol (2003) 0.78
Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors. J Med Chem (2011) 0.77
Context, culture and (non-verbal) communication affect handover quality. BMJ Qual Saf (2012) 0.77
Stunning and cumulative left ventricular dysfunction occurs late after coronary balloon occlusion in humans insights from simultaneous coronary and left ventricular hemodynamic assessment. JACC Cardiovasc Interv (2010) 0.77
Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors. Bioorg Med Chem Lett (2002) 0.77
Non-oxime inhibitors of B-Raf(V600E) kinase. Bioorg Med Chem Lett (2010) 0.77
Stochastic modelling of cardiac cell structure. Conf Proc IEEE Eng Med Biol Soc (2010) 0.77
Discovery and SAR of spirochromane Akt inhibitors. Bioorg Med Chem Lett (2011) 0.77
Quantitative analysis of asbestos burden in women with mesothelioma. Am J Ind Med (2003) 0.77
Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration. J Med Chem (2009) 0.77
Asbestos burden in cases of mesothelioma from individuals from various regions of the United States. Ultrastruct Pathol (2005) 0.77