Published in Cancer Res on March 01, 2007
Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology (2010) 2.31
Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer. PLoS One (2010) 1.43
Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation. Pigment Cell Melanoma Res (2008) 1.37
Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer. Breast Cancer Res Treat (2011) 1.30
Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma. BMC Syst Biol (2010) 1.26
A phase 0 trial of riluzole in patients with resectable stage III and IV melanoma. Clin Cancer Res (2009) 1.24
Serum glutamate levels correlate with Gleason score and glutamate blockade decreases proliferation, migration, and invasion and induces apoptosis in prostate cancer cells. Clin Cancer Res (2012) 1.17
Pathways and therapeutic targets in melanoma. Oncotarget (2014) 1.17
Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice. Proc Natl Acad Sci U S A (2011) 1.12
Recent advances in drug repositioning for the discovery of new anticancer drugs. Int J Biol Sci (2014) 1.12
Targeting Wnt pathways in disease. Cold Spring Harb Perspect Biol (2012) 1.11
Molecular pathways: dysregulated glutamatergic signaling pathways in cancer. Clin Cancer Res (2012) 1.10
Network-guided analysis of genes with altered somatic copy number and gene expression reveals pathways commonly perturbed in metastatic melanoma. PLoS One (2011) 1.09
The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol (2010) 1.07
Chemical-genetic screen identifies riluzole as an enhancer of Wnt/β-catenin signaling in melanoma. Chem Biol (2010) 1.05
Metabotropic glutamate receptors (mGlus) and cellular transformation. Neuropharmacology (2008) 1.02
Riluzole prodrugs for melanoma and ALS: design, synthesis, and in vitro metabolic profiling. Bioorg Med Chem (2012) 1.02
Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. Oncogene (2012) 1.01
Glutamatergic pathway targeting in melanoma: single-agent and combinatorial therapies. Clin Cancer Res (2011) 1.01
Delving into somatic variation in sporadic melanoma. Pigment Cell Melanoma Res (2012) 0.99
G-protein-coupled receptors and melanoma. Pigment Cell Melanoma Res (2008) 0.97
Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications. Int J Biol Sci (2013) 0.96
AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1). Pigment Cell Melanoma Res (2009) 0.95
Altered glutamine metabolism and therapeutic opportunities for lung cancer. Clin Lung Cancer (2013) 0.93
Functional effects of GRM1 suppression in human melanoma cells. Mol Cancer Res (2012) 0.91
Genetics of melanoma. Front Genet (2013) 0.91
Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancer. PLoS One (2011) 0.91
Current State of Animal (Mouse) Modeling in Melanoma Research. Cancer Growth Metastasis (2015) 0.91
The Akt signaling pathway: an emerging therapeutic target in malignant melanoma. Cancer Biol Ther (2011) 0.89
A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS Chem Neurosci (2014) 0.88
Riluzole enhances ionizing radiation-induced cytotoxicity in human melanoma cells that ectopically express metabotropic glutamate receptor 1 in vitro and in vivo. Clin Cancer Res (2011) 0.87
Comprehensive genomic characterization of cutaneous malignant melanoma cell lines derived from metastatic lesions by whole-exome sequencing and SNP array profiling. PLoS One (2013) 0.85
Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1. Bioorg Med Chem Lett (2013) 0.84
Glutamate, a metabolic biomarker of aggressiveness and a potential therapeutic target for prostate cancer. Asian J Androl (2013) 0.84
mGlu Receptors and Cancerous Growth. Wiley Interdiscip Rev Membr Transp Signal (2011) 0.84
(1)H NMR Metabolomics Study of Metastatic Melanoma in C57BL/6J Mouse Spleen. Metabolomics (2014) 0.83
Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer. PLoS One (2014) 0.83
Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain. Sci Rep (2015) 0.82
Metabotropic glutamate receptor-1 contributes to progression in triple negative breast cancer. PLoS One (2014) 0.82
Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes. PLoS One (2013) 0.81
Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget (2014) 0.80
Activation of the glutamate receptor GRM1 enhances angiogenic signaling to drive melanoma progression. Cancer Res (2014) 0.80
Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells. Breast Cancer Res Treat (2015) 0.80
N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg Med Chem Lett (2013) 0.80
Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression. Transl Oncol (2015) 0.79
Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. PLoS Pathog (2014) 0.79
Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism. Neuropharmacology (2015) 0.78
ERBB4 mutation analysis: emerging molecular target for melanoma treatment. Methods Mol Biol (2014) 0.78
Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res (2014) 0.77
Impaired gp100-Specific CD8(+) T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model. J Invest Dermatol (2015) 0.77
Metabotropic glutamate receptors in cancer. Neuropharmacology (2016) 0.77
Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma. PLoS One (2012) 0.77
Two newly identified exons in human GRM1 express a novel splice variant of metabotropic glutamate 1 receptor. Gene (2013) 0.77
Regulation of mGluR1 expression in human melanocytes and melanoma cells. Biochim Biophys Acta (2012) 0.76
Role of the G Protein-Coupled Receptor, mGlu1, in Melanoma Development. Pharmaceuticals (Basel) (2010) 0.76
Exosomes: The Link between GPCR Activation and Metastatic Potential? Front Genet (2016) 0.76
Effect of (S)-3,5-DHPG on microRNA expression in mouse brain. Exp Neurol (2012) 0.76
Biology, Therapy and Implications of Tumor Exosomes in the Progression of Melanoma. Cancers (Basel) (2016) 0.75
Metastatic Melanoma Induced Metabolic Changes in C57BL/6J Mouse Stomach Measured by 1H NMR Spectroscopy. Metabolomics (Los Angel) (2015) 0.75
Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. BMC Evol Biol (2016) 0.75
Genetically engineered mouse models of melanoma. Cancer (2017) 0.75
Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole. PLoS One (2017) 0.75
Triple threat treatment: Exploiting the dependence receptor properties of metabotropic glutamate receptor 1 against melanoma. Mol Cell Oncol (2014) 0.75
PET and SPECT imaging of melanoma: the state of the art. Eur J Nucl Med Mol Imaging (2017) 0.75
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nat Genet (2003) 2.67
Rewired ERK-JNK signaling pathways in melanoma. Cancer Cell (2007) 2.03
Melanoma patients with positive sentinel nodes who did not undergo completion lymphadenectomy: a multi-institutional study. Ann Surg Oncol (2006) 2.00
Phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with metastatic melanoma. Clin Cancer Res (2008) 1.94
Prospective multi-institutional study of reverse transcriptase polymerase chain reaction for molecular staging of melanoma. J Clin Oncol (2006) 1.85
GLI2-mediated melanoma invasion and metastasis. J Natl Cancer Inst (2010) 1.68
Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCepsilon. Cell Signal (2005) 1.50
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A (2008) 1.42
Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation. Pigment Cell Melanoma Res (2008) 1.37
Gender-related differences in outcome for melanoma patients. Ann Surg (2006) 1.32
Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region. Genomics (2003) 1.25
A phase 0 trial of riluzole in patients with resectable stage III and IV melanoma. Clin Cancer Res (2009) 1.24
Differential expression of vascular endothelial growth factor-A isoforms at different stages of melanoma progression. J Am Coll Surg (2003) 1.15
Lessons learned from the Sunbelt Melanoma Trial. J Surg Oncol (2004) 1.15
Factors associated with false-negative sentinel lymph node biopsy in melanoma patients. Ann Surg Oncol (2009) 1.08
Progressive appearance of pigmentation in amelanotic melanoma lesions. Pigment Cell Res (2002) 1.08
Identification and characterization of mouse Rab32 by mRNA and protein expression analysis. Biochim Biophys Acta (2003) 1.07
The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol (2010) 1.07
Sun protection and exposure behaviors among Hispanic adults in the United States: differences according to acculturation and among Hispanic subgroups. BMC Public Health (2012) 1.02
Riluzole prodrugs for melanoma and ALS: design, synthesis, and in vitro metabolic profiling. Bioorg Med Chem (2012) 1.02
Metabotropic glutamate receptors (mGlus) and cellular transformation. Neuropharmacology (2008) 1.02
Psychosocial correlates of sun protection behaviors among U.S. Hispanic adults. J Behav Med (2014) 1.01
Glutamatergic pathway targeting in melanoma: single-agent and combinatorial therapies. Clin Cancer Res (2011) 1.01
Exchange protein directly activated by cyclic AMP increases melanoma cell migration by a Ca2+-dependent mechanism. Cancer Res (2010) 0.98
Linguistic acculturation and skin cancer-related behaviors among Hispanics in the southern and western United States. JAMA Dermatol (2013) 0.98
Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells. Melanoma Res (2007) 0.97
G-protein-coupled receptors and melanoma. Pigment Cell Melanoma Res (2008) 0.97
AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1). Pigment Cell Melanoma Res (2009) 0.95
Detection of mutations in the mitogen-activated protein kinase pathway in human melanoma. Clin Cancer Res (2003) 0.95
Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration. PLoS One (2012) 0.95
Glutamatergic signaling in cellular transformation. Pigment Cell Melanoma Res (2012) 0.94
Skin cancer surveillance behaviors among US Hispanic adults. J Am Acad Dermatol (2012) 0.93
Albumin nanoshell encapsulation of near-infrared-excitable rare-Earth nanoparticles enhances biocompatibility and enables targeted cell imaging. Small (2010) 0.91
Functional effects of GRM1 suppression in human melanoma cells. Mol Cancer Res (2012) 0.91
Genetics of melanoma. Front Genet (2013) 0.91
Enhancement of TPA-induced growth inhibition and apoptosis in myeloid leukemia cells by BAY 11-7082, an NF-kappaB inhibitor. Int J Oncol (2005) 0.90
Inhibitors of inducible nitric oxide synthase expression from Artemisia iwayomogi. Arch Pharm Res (2003) 0.89
Induction of CYP1A1 and CYP1A2 expressions by prototypic and atypical inducers in the human lung. Cancer Lett (2002) 0.88
Comparison of success rates of orthodontic mini-screws by the insertion method. Korean J Orthod (2012) 0.88
Grm5 expression is not required for the oncogenic role of Grm1 in melanocytes. Neuropharmacology (2005) 0.87
Riluzole enhances ionizing radiation-induced cytotoxicity in human melanoma cells that ectopically express metabotropic glutamate receptor 1 in vitro and in vivo. Clin Cancer Res (2011) 0.87
Epac1 promotes melanoma metastasis via modification of heparan sulfate. Pigment Cell Melanoma Res (2011) 0.87
TNF-α increases lipogenesis via JNK and PI3K/Akt pathways in SZ95 human sebocytes. J Dermatol Sci (2011) 0.87
A proposal for soft tissue landmarks for craniofacial analysis using 3-dimensional laser scan imaging. World J Orthod (2006) 0.86
Anti-inflammatory activity of sulfur-containing compounds from garlic. J Med Food (2012) 0.85
Metabotropic glutamate receptor 1 mediates melanocyte transformation via transactivation of insulin-like growth factor 1 receptor. Pigment Cell Melanoma Res (2014) 0.85
Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development. J Mol Med (Berl) (2004) 0.85
Anatomical distribution analysis reveals lack of Langerin+ dermal dendritic cells in footpads and tail of C57BL/6 mice. Exp Dermatol (2014) 0.85
Skin cancer screening among Hispanic adults in the United States: results from the 2010 National Health Interview Survey. Arch Dermatol (2012) 0.84
Garlic (Allium sativum) extract inhibits lipopolysaccharide-induced Toll-like receptor 4 dimerization. Biosci Biotechnol Biochem (2008) 0.84
Effect of multiple-nodal basin drainage on cutaneous melanoma. Arch Surg (2008) 0.84
Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases. Exp Dermatol (2012) 0.84
Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition. Pigment Cell Melanoma Res (2011) 0.84
mGlu Receptors and Cancerous Growth. Wiley Interdiscip Rev Membr Transp Signal (2011) 0.84
Skin self-examination behaviors among individuals diagnosed with melanoma. Melanoma Res (2016) 0.83
Loss of heterozygosity and internal tandem duplication mutations of the CBP gene are frequent events in human esophageal squamous cell carcinoma. Clin Cancer Res (2004) 0.83
[Illness experience of people with chronic hepatitis B in Korea]. Taehan Kanho Hakhoe Chi (2007) 0.83
Multifunctional albumin nanoparticles as combination drug carriers for intra-tumoral chemotherapy. Adv Healthc Mater (2013) 0.82
The EphB4 receptor promotes the growth of melanoma cells expressing the ephrin-B2 ligand. Pigment Cell Melanoma Res (2010) 0.81
Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes. PLoS One (2013) 0.81
U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo. Mol Ther Nucleic Acids (2013) 0.81
Tumor cell and circulating markers in melanoma: diagnosis, prognosis, and management. Curr Oncol Rep (2005) 0.80
A curcuminoid and two sesquiterpenoids from Curcuma zedoaria as inhibitors of nitric oxide synthesis in activated macrophages. Arch Pharm Res (2004) 0.80
Gβγ subunits inhibit Epac-induced melanoma cell migration. BMC Cancer (2011) 0.80
Activation of the glutamate receptor GRM1 enhances angiogenic signaling to drive melanoma progression. Cancer Res (2014) 0.80
Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells. Breast Cancer Res Treat (2015) 0.80
Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling. Pigment Cell Melanoma Res (2014) 0.80
Luteolin inhibits LPS-stimulated inducible nitric oxide synthase expression in BV-2 microglial cells. Planta Med (2006) 0.79
Inhibition of Wnt/β-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells. Phytother Res (2015) 0.79
Surveillance after surgical treatment of melanoma: futility of routine chest radiography. Surgery (2010) 0.79
From existing therapies to novel targets: a current view on melanoma. Front Biosci (2006) 0.79
Suppression of inducible nitric oxide synthase expression by furfuran lignans from flower buds of Magnolia fargesii in BV-2 microglial cells. Phytother Res (2010) 0.79
In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens. Phytother Res (2011) 0.79
In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii. Bioorg Med Chem Lett (2008) 0.79