Published in Psychopharmacology (Berl) on March 09, 2007
Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol (2007) 3.06
AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine. Neurosci Biobehav Rev (2010) 2.58
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New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiatry (2011) 2.11
Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking. Behav Brain Res (2009) 1.73
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mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats. Neuropsychopharmacology (2008) 1.57
Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl) (2008) 1.49
Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. J Neurosci (2009) 1.47
A shift in the role of glutamatergic signaling in the nucleus accumbens core with the development of an addicted phenotype. Biol Psychiatry (2014) 1.45
Homers regulate drug-induced neuroplasticity: implications for addiction. Biochem Pharmacol (2007) 1.43
Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking. J Neurosci (2008) 1.41
Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell. Eur J Neurosci (2012) 1.39
Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine. J Neurochem (2009) 1.36
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci (2013) 1.35
Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. Curr Drug Abuse Rev (2008) 1.26
Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J mice. Neuropsychopharmacology (2007) 1.25
mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse. Mol Interv (2009) 1.23
Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats. Alcohol Clin Exp Res (2009) 1.23
Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake. Biol Psychiatry (2009) 1.22
Extinction of drug- and withdrawal-paired cues in animal models: relevance to the treatment of addiction. Neurosci Biobehav Rev (2010) 1.19
Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats. Psychopharmacology (Berl) (2009) 1.17
Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction. Eur J Pharmacol (2010) 1.12
Glutamatergic targets for new alcohol medications. Psychopharmacology (Berl) (2013) 1.10
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Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes. Brain Res (2008) 1.09
Extracellular fluctuations of dopamine and glutamate in the nucleus accumbens core and shell associated with lever-pressing during cocaine self-administration, extinction, and yoked cocaine administration. Psychopharmacology (Berl) (2010) 1.08
Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior. J Neurochem (2008) 1.08
Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats. J Neurochem (2010) 1.07
Role of mGluR5 neurotransmission in reinstated cocaine-seeking. Addict Biol (2012) 1.06
mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior. Pharmacol Biochem Behav (2012) 1.05
Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate. Pharmacol Ther (2012) 1.04
Regulation of AMPA receptor trafficking in the nucleus accumbens by dopamine and cocaine. Neurotox Res (2010) 1.01
Psychostimulant-induced neuroadaptations in nucleus accumbens AMPA receptor transmission. Cold Spring Harb Perspect Med (2013) 1.01
Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addict Biol (2014) 0.99
Discrete cue-conditioned alcohol-seeking after protracted abstinence: pattern of neural activation and involvement of orexin₁ receptors. Br J Pharmacol (2011) 0.97
Role of corticostriatal circuits in context-induced reinstatement of drug seeking. Brain Res (2014) 0.96
Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine. Neuropsychopharmacology (2007) 0.94
Region-specific involvement of AMPA/Kainate receptors in Fos protein expression induced by cocaine-conditioned cues. Eur Neuropsychopharmacol (2008) 0.92
Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator. Psychopharmacology (Berl) (2012) 0.92
Striatal signal transduction and drug addiction. Front Neuroanat (2011) 0.91
Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma. J Neurosci (2013) 0.91
Disulfiram stimulates dopamine release from noradrenergic terminals and potentiates cocaine-induced dopamine release in the prefrontal cortex. Psychopharmacology (Berl) (2011) 0.89
Modulation of the endocannabinoid system: vulnerability factor and new treatment target for stimulant addiction. Front Psychiatry (2013) 0.88
Cocaine-related behaviors in mice with deficient gliotransmission. Psychopharmacology (Berl) (2012) 0.88
Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats. Psychopharmacology (Berl) (2009) 0.88
Role of cues and contexts on drug-seeking behaviour. Br J Pharmacol (2014) 0.87
Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in rats. Psychopharmacology (Berl) (2007) 0.86
The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on behavioural responses to nicotine. Psychopharmacology (Berl) (2010) 0.86
The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis. Pharmacol Rev (2016) 0.86
Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking. Addict Biol (2014) 0.85
Interaction of the rostral basolateral amygdala and prelimbic prefrontal cortex in regulating reinstatement of cocaine-seeking behavior. Pharmacol Biochem Behav (2010) 0.85
A double-blind, placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence. Addict Behav (2010) 0.85
Role of a hippocampal SRC-family kinase-mediated glutamatergic mechanism in drug context-induced cocaine seeking. Neuropsychopharmacology (2013) 0.84
The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice. PLoS One (2013) 0.83
Systems level neuroplasticity in drug addiction. Cold Spring Harb Perspect Med (2013) 0.83
The mGluR5 antagonist MTEP dissociates the acquisition of predictive and incentive motivational properties of reward-paired stimuli in mice. Neuropsychopharmacology (2010) 0.83
Impact of mGluR5 during amphetamine-induced hyperactivity and conditioned hyperactivity in differentially reared rats. Psychopharmacology (Berl) (2011) 0.82
Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology (Berl) (2013) 0.81
Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse. Psychopharmacology (Berl) (2016) 0.80
Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse. Front Pharmacol (2014) 0.80
Ventral tegmental area-basolateral amygdala-nucleus accumbens shell neurocircuitry controls the expression of heroin-conditioned immunomodulation. J Neuroimmunol (2011) 0.80
Withdrawal from cocaine self-administration and yoked cocaine delivery dysregulates glutamatergic mGlu5 and NMDA receptors in the rat brain. Neurotox Res (2014) 0.79
Novel RNA modifications in the nervous system: form and function. J Neurosci (2014) 0.78
High-frequency electrical stimulation in the nucleus accumbens of morphine-treated rats suppresses neuronal firing in reward-related brain regions. Med Sci Monit (2011) 0.78
The Dorsal Agranular Insular Cortex Regulates the Cued Reinstatement of Cocaine-Seeking, but not Food-Seeking, Behavior in Rats. Neuropsychopharmacology (2015) 0.77
Bidirectional modulation of cocaine expectancy by phasic glutamate fluctuations in the nucleus accumbens. J Neurosci (2013) 0.77
Reduction of the Morphine Maintenance by Blockade of the NMDA Receptors during Extinction Period in Conditioned Place Preference Paradigm of Rats. Basic Clin Neurosci (2016) 0.77
mGlu receptors and drug addiction. Wiley Interdiscip Rev Membr Transp Signal (2012) 0.76
The metabotropic glutamate 5 receptor is necessary for extinction of cocaine-associated cues. Br J Pharmacol (2016) 0.76
Do specific NMDA receptor subunits act as gateways for addictive behaviors? Genes Brain Behav (2016) 0.75
Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking. J Neurosci (2016) 0.75
Metabotropic and ionotropic glutamate receptors as potential targets for the treatment of alcohol use disorder. Neurosci Biobehav Rev (2017) 0.75
Long-lasting impairment of mGluR5-activated intracellular pathways in the striatum after withdrawal of cocaine self-administration. Int J Neuropsychopharmacol (2016) 0.75
Effects of metabotropic glutamate receptor ligands on male sexual behavior in rats. Neuropharmacology (2012) 0.75
Sign-trackers have elevated myo-inositol in the nucleus accumbens and ventral hippocampus following Pavlovian conditioned approach. J Neurochem (2016) 0.75
Modulatory effects of Ampicillin/Sulbactam on glial glutamate transporters and metabotropic glutamate receptor 1 as well as reinstatement to cocaine-seeking behavior. Behav Brain Res (2017) 0.75
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci (2005) 16.18
The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl) (2002) 9.90
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev (2002) 8.78
From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol (1980) 5.46
Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci (2003) 5.20
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J Neurosci (2001) 5.18
Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens. J Neurosci (2005) 3.99
Neural activity related to drug craving in cocaine addiction. Arch Gen Psychiatry (2001) 3.84
Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J Neurosci (2003) 3.30
Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. J Neurosci (2000) 3.19
Central amygdala ERK signaling pathway is critical to incubation of cocaine craving. Nat Neurosci (2005) 2.90
Selective inactivation of the dorsomedial prefrontal cortex and the basolateral amygdala attenuates conditioned-cued reinstatement of extinguished cocaine-seeking behavior in rats. Psychopharmacology (Berl) (2002) 2.79
Differential control over cocaine-seeking behavior by nucleus accumbens core and shell. Nat Neurosci (2004) 2.52
Cue-induced brain activity changes and relapse in cocaine-dependent patients. Neuropsychopharmacology (2006) 2.32
Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl) (2004) 2.29
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Neural substrates of cocaine-cue associations that trigger relapse. Eur J Pharmacol (2005) 2.15
Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine-seeking behavior. Neuropsychopharmacology (2001) 1.97
Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens. J Neurosci (2002) 1.94
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The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology (Berl) (2003) 1.83
mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology (2004) 1.83
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Dissociation of primary and secondary reward-relevant limbic nuclei in an animal model of relapse. Neuropsychopharmacology (2000) 1.74
Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats. J Neurochem (2003) 1.72
Extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration. Learn Mem (2004) 1.63
Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure. Eur J Neurosci (2001) 1.57
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Glutamatergic mechanisms in addiction. Mol Psychiatry (2003) 1.49
Nicotine potentiation of brain stimulation reward reversed by DH beta E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats. Psychopharmacology (Berl) (2001) 1.47
Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology (Berl) (2004) 1.47
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Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties. Drug Alcohol Depend (2006) 1.33
Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist. Neuropharmacology (2002) 1.24
Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates. J Neurochem (2005) 1.01
Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior in the rat. Psychopharmacology (Berl) (2003) 0.92
Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology (2006) 1.84
mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology (2004) 1.83
The alcohol-preferring AA and alcohol-avoiding ANA rats: neurobiology of the regulation of alcohol drinking. Addict Biol (2006) 1.34
Ionotropic glutamate receptor antagonists modulate cue-induced reinstatement of ethanol-seeking behavior. Alcohol Clin Exp Res (2004) 1.32
Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG. Eur J Pharmacol (2005) 1.24
Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference. Neuropsychopharmacology (2006) 1.16
Glycine receptor expression in the forebrain of male AA/ANA rats. Brain Res (2009) 1.06
Comparison of the effect of the GABAΒ receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in 3 different lines of alcohol-preferring rats. Alcohol Clin Exp Res (2012) 0.98
Effects of melanocortin receptor ligands on ethanol intake and opioid peptide levels in alcohol-preferring AA rats. Brain Res Bull (2002) 0.98
Behavioral profiling of multiple pairs of rats selectively bred for high and low alcohol intake using the MCSF test. Addict Biol (2011) 0.97
Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats. Addict Biol (2011) 0.95
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The multivariate concentric square field test reveals different behavioural profiles in male AA and ANA rats with regard to risk taking and environmental reactivity. Behav Brain Res (2007) 0.91
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Attenuation of cocaine-seeking behaviour by the AMPA/kainate receptor antagonist CNQX in rats. Psychopharmacology (Berl) (2003) 0.82
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Brain regional mu-opioid receptor function in rat lines selected for differences in alcohol preference. Eur J Pharmacol (2002) 0.78
Risperidone reduces limited access alcohol drinking in alcohol-preferring rats. Eur J Pharmacol (2003) 0.77
Extracellular glutamate and GABA in the ventral tegmental area of alcohol-preferring AA and alcohol-avoiding ANA rats treated repeatedly with morphine. Eur J Pharmacol (2006) 0.77
Behavioral consequences of repeated nicotine during adolescence in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol Clin Exp Res (2008) 0.77
Extracellular levels of dopamine in the nucleus accumbens in AA and ANA rats after reverse microdialysis of ethanol into the nucleus accumbens or ventral tegmental area. Alcohol (2003) 0.77
Enhanced morphine-induced ethanol drinking in alcohol-preferring alko alcohol rats sensitized to morphine. Alcohol Clin Exp Res (2006) 0.76
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