Published in Nat Cell Biol on March 11, 2007
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science (2009) 3.96
Mitochondria as sensors and regulators of calcium signalling. Nat Rev Mol Cell Biol (2012) 3.59
EMRE is an essential component of the mitochondrial calcium uniporter complex. Science (2013) 2.39
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter. Cell Metab (2013) 2.15
Crosstalk signaling between mitochondrial Ca2+ and ROS. Front Biosci (Landmark Ed) (2009) 1.96
Ca(2+) transfer from the ER to mitochondria: when, how and why. Biochim Biophys Acta (2009) 1.95
Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Neuroscience (2009) 1.73
SR/ER-mitochondrial local communication: calcium and ROS. Biochim Biophys Acta (2009) 1.73
Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms. Biochim Biophys Acta (2009) 1.67
Dynamic regulation of the mitochondrial proton gradient during cytosolic calcium elevations. J Biol Chem (2011) 1.66
High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling. Cell Calcium (2008) 1.60
Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. J Cell Sci (2008) 1.48
Mitochondria and Ca(2+) signaling: old guests, new functions. Pflugers Arch (2007) 1.47
Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotection. Cardiovasc Res (2008) 1.41
After half a century mitochondrial calcium in- and efflux machineries reveal themselves. EMBO J (2011) 1.38
The on-off switches of the mitochondrial uncoupling proteins. Trends Biochem Sci (2009) 1.37
Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell Commun Signal (2011) 1.33
Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals. Nat Commun (2013) 1.30
Pre-microRNA and mature microRNA in human mitochondria. PLoS One (2011) 1.29
Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways. J Biol Chem (2011) 1.27
Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic β-cells. J Biol Chem (2012) 1.24
The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications. J Physiol (2013) 1.24
Mitochondrial Ca²⁺ homeostasis: mechanism, role, and tissue specificities. Pflugers Arch (2012) 1.23
Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload. J Cell Sci (2008) 1.17
Controlling metabolism and cell death: at the heart of mitochondrial calcium signalling. J Mol Cell Cardiol (2009) 1.17
UCPs--unlikely calcium porters. Nat Cell Biol (2008) 1.17
Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin. PLoS One (2011) 1.16
The molecular era of the mitochondrial calcium uniporter. Nat Rev Mol Cell Biol (2015) 1.14
Calcium signalling: fishing out molecules of mitochondrial calcium transport. Curr Biol (2010) 1.11
Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease. Transl Neurodegener (2012) 1.06
Negative regulation of UCP2 by TGFβ signaling characterizes low and intermediate-grade primary breast cancer. Cell Death Dis (2010) 1.05
The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death. Biochim Biophys Acta (2008) 1.04
Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. FEBS Lett (2010) 1.04
Studying mitochondrial Ca(2+) uptake - a revisit. Mol Cell Endocrinol (2011) 1.03
Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo. J Biol Chem (2011) 1.03
Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse. J Cereb Blood Flow Metab (2008) 1.02
The genomic response of the ipsilateral and contralateral cortex to stroke in aged rats. J Cell Mol Med (2008) 1.02
Vesicular calcium regulates coat retention, fusogenicity, and size of pre-Golgi intermediates. Mol Biol Cell (2010) 1.02
Mitochondria, endothelial cell function, and vascular diseases. Front Physiol (2014) 1.02
Calcium signaling in cardiac mitochondria. J Mol Cell Cardiol (2013) 1.01
Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production. J Biol Chem (2011) 1.00
Characterization of distinct single-channel properties of Ca²⁺ inward currents in mitochondria. Pflugers Arch (2013) 0.99
Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3? Cell Calcium (2008) 0.97
Noninvasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas. Cancer Prev Res (Phila) (2009) 0.96
Role of the transmembrane potential in the membrane proton leak. Biophys J (2010) 0.96
Mitochondrial calcium homeostasis as potential target for mitochondrial medicine. Mitochondrion (2011) 0.96
The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles. J Biol Chem (2013) 0.95
GPR55-dependent and -independent ion signalling in response to lysophosphatidylinositol in endothelial cells. Br J Pharmacol (2010) 0.95
Uncoupling protein 3 adjusts mitochondrial Ca(2+) uptake to high and low Ca(2+) signals. Cell Calcium (2010) 0.95
Molecularly distinct routes of mitochondrial Ca2+ uptake are activated depending on the activity of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). J Biol Chem (2013) 0.95
The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes. Cell Calcium (2011) 0.95
Mitochondrial Ca2+ channels: Great unknowns with important functions. FEBS Lett (2010) 0.95
Endothelial mitochondria--less respiration, more integration. Pflugers Arch (2012) 0.94
Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure. J Am Heart Assoc (2013) 0.94
Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology. Mol Cell Endocrinol (2011) 0.93
Metal acquisition and availability in the mitochondria. Chem Rev (2009) 0.93
Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1. J Gen Physiol (2012) 0.92
Glutaredoxin-2 is required to control proton leak through uncoupling protein-3. J Biol Chem (2013) 0.92
SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death. Mol Biol Cell (2014) 0.92
IP3-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake. J Cell Sci (2014) 0.91
Update on vascular endothelial Ca(2+) signalling: A tale of ion channels, pumps and transporters. World J Biol Chem (2012) 0.91
Ca2+ dynamics in the mitochondria - state of the art. J Mol Cell Cardiol (2011) 0.90
UCP3 translocates lipid hydroperoxide and mediates lipid hydroperoxide-dependent mitochondrial uncoupling. J Biol Chem (2010) 0.89
Perspectives on: SGP symposium on mitochondrial physiology and medicine: molecular identities of mitochondrial Ca2+ influx mechanism: updated passwords for accessing mitochondrial Ca2+-linked health and disease. J Gen Physiol (2012) 0.88
Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice. Exp Gerontol (2008) 0.88
A novel SP1/SP3 dependent intronic enhancer governing transcription of the UCP3 gene in brown adipocytes. PLoS One (2013) 0.88
Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.). Sci Rep (2015) 0.87
Spatiotemporal correlations between cytosolic and mitochondrial Ca(2+) signals using a novel red-shifted mitochondrial targeted cameleon. PLoS One (2012) 0.87
Distinctive characteristics and functions of multiple mitochondrial Ca2+ influx mechanisms. Sci China Life Sci (2011) 0.86
11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction. PLoS One (2012) 0.86
Mitochondrial protein phosphorylation: instigator or target of lipotoxicity? Trends Endocrinol Metab (2009) 0.86
Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. J Immunol (2009) 0.86
Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart. Heart Fail Rev (2015) 0.86
Brown adipose tissue specific lack of uncoupling protein 3 is associated with impaired cold tolerance and reduced transcript levels of metabolic genes. J Comp Physiol B (2007) 0.86
Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane. Pflugers Arch (2013) 0.85
Plasma membrane Ca2+-ATPase isoforms composition regulates cellular pH homeostasis in differentiating PC12 cells in a manner dependent on cytosolic Ca2+ elevations. PLoS One (2014) 0.85
NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state. J Biol Chem (2014) 0.85
Superoxide anion, uncoupling proteins and Alzheimer's disease. J Clin Biochem Nutr (2010) 0.84
Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity. Oncotarget (2015) 0.84
Mitochondrial Ca(2+) uptake pathways. J Bioenerg Biomembr (2016) 0.83
UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondria. Pflugers Arch (2015) 0.82
Mitochondrial uncoupling protein-2 deficiency protects steatotic mouse hepatocytes from hypoxia/reoxygenation. Am J Physiol Gastrointest Liver Physiol (2011) 0.82
Glucose-stimulated single pancreatic islets sustain increased cytosolic ATP levels during initial Ca2+ influx and subsequent Ca2+ oscillations. J Biol Chem (2013) 0.82
UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis. Mol Cell Neurosci (2013) 0.82
Redox homeostasis in pancreatic β cells. Oxid Med Cell Longev (2012) 0.82
Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neurons. PLoS One (2013) 0.80
Multiplex expression cloning of blood-brain barrier membrane proteins. Proteomics (2009) 0.80
Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches. Metabolites (2014) 0.80
Fatty acids do not activate UCP2 in pancreatic beta cells: comparison with UCP1. Pflugers Arch (2008) 0.80
Diversity of mitochondrial Ca²⁺ signaling in rat neonatal cardiomyocytes: evidence from a genetically directed Ca²⁺ probe, mitycam-E31Q. Cell Calcium (2014) 0.79
Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival. J Mol Neurosci (2016) 0.79
Modulation of the matrix redox signaling by mitochondrial Ca(2.). World J Biol Chem (2015) 0.78
MicroRNAs Regulate Mitochondrial Function in Cerebral Ischemia-Reperfusion Injury. Int J Mol Sci (2015) 0.78
Effect of photoperiod on the feline adipose transcriptome as assessed by RNA sequencing. BMC Vet Res (2014) 0.78
The evolutionary trajectory of mitochondrial carrier family during metazoan evolution. BMC Evol Biol (2010) 0.78
The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale. J Biol Chem (2013) 0.78
By Regulating Mitochondrial Ca2+-Uptake UCP2 Modulates Intracellular Ca2. PLoS One (2016) 0.77
UCP2 Modulates Cardioprotective Effects of Ru360 in Isolated Cardiomyocytes during Ischemia. Pharmaceuticals (Basel) (2015) 0.77
PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells. Nat Commun (2016) 0.77
Control mechanisms in mitochondrial oxidative phosphorylation. Neural Regen Res (2013) 0.76
A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20
Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria. J Biol Chem (1982) 12.07
Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci U S A (1983) 7.55
The mitochondrial calcium uniporter is a highly selective ion channel. Nature (2004) 6.97
Circularly permuted green fluorescent proteins engineered to sense Ca2+. Proc Natl Acad Sci U S A (2001) 6.63
Isolation of subcellular organelles. Methods Enzymol (1990) 4.66
Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor. Proc Natl Acad Sci U S A (2004) 4.46
Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc Natl Acad Sci U S A (1999) 4.40
Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med (2004) 3.85
Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab (2005) 3.49
The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol (2005) 3.42
The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J (2000) 3.26
Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem (2000) 2.65
Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci U S A (1996) 2.50
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest (2003) 2.35
Mitochondrial calcium transport: mechanisms and functions. Cell Calcium (2001) 2.03
Mitochondria and Ca(2+)in cell physiology and pathophysiology. Cell Calcium (2001) 1.95
Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes. Proc Natl Acad Sci U S A (2000) 1.92
Sustained Ca2+ transfer across mitochondria is Essential for mitochondrial Ca2+ buffering, sore-operated Ca2+ entry, and Ca2+ store refilling. J Biol Chem (2003) 1.71
The role of mitochondria for Ca2+ refilling of the endoplasmic reticulum. J Biol Chem (2005) 1.43
Slow feedback inhibition of calcium release-activated calcium current by calcium entry. J Biol Chem (1998) 1.35
Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells. Br J Pharmacol (2003) 1.31
Mitochondria efficiently buffer subplasmalemmal Ca2+ elevation during agonist stimulation. J Biol Chem (2003) 1.19
Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women. Diabetes (2002) 1.10
Mitochondrial uncoupling proteins--facts and fantasies. Physiol Res (2004) 1.06
Fluctuations in mitochondrial membrane potential in single isolated brain mitochondria: modulation by adenine nucleotides and Ca2+. Biophys J (2004) 1.04
A new type of non-Ca2+-buffering Apo(a)-based fluorescent indicator for intraluminal Ca2+ in the endoplasmic reticulum. J Biol Chem (2005) 0.96
Intercellular signalling within vascular cells under high D-glucose involves free radical-triggered tyrosine kinase activation. Diabetologia (2003) 0.95
Uncoupling protein-3 sensitizes cells to mitochondrial-dependent stimulus of apoptosis. J Cell Physiol (2004) 0.88
Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map. Gene (1998) 0.86