SR/ER-mitochondrial local communication: calcium and ROS.

PubWeight™: 1.73‹?› | Rank: Top 3%

🔗 View Article (PMC 2738971)

Published in Biochim Biophys Acta on June 13, 2009

Authors

György Csordás1, György Hajnóczky

Author Affiliations

1: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Gyorgy.Csordas@jefferson.edu

Articles citing this

Superoxide flashes in mouse skeletal muscle are produced by discrete arrays of active mitochondria operating coherently. PLoS One (2010) 1.44

Integration of ER stress, oxidative stress and the inflammatory response in health and disease. Int J Clin Exp Med (2010) 1.29

Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection. Antioxid Redox Signal (2010) 1.27

Calcium-dependent mitochondrial function and dysfunction in neurons. FEBS J (2010) 1.25

Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice. PLoS One (2013) 1.23

Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet (2013) 1.21

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. Hum Mol Genet (2011) 1.19

Neuronal calcium homeostasis and dysregulation. Antioxid Redox Signal (2010) 1.19

Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome. Trends Immunol (2014) 1.17

Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca²⁺ and reactive oxygen species signaling. J Cell Sci (2013) 1.16

ROS-induced ROS release in vascular biology: redox-redox signaling. Am J Physiol Heart Circ Physiol (2011) 1.11

Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease. J Alzheimers Dis (2010) 1.04

Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons. Eur J Neurosci (2011) 1.02

Regulation of redox signaling by selenoproteins. Biol Trace Elem Res (2010) 1.01

Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis. J Biol Chem (2010) 1.01

Mitochondrial morphology transitions and functions: implications for retrograde signaling? Am J Physiol Regul Integr Comp Physiol (2013) 1.01

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00

Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling. J Biol Chem (2011) 1.00

Cross talk among calcium, hydrogen peroxide, and nitric oxide and activation of gene expression involving calmodulins and calcium-dependent protein kinases in Ulva compressa exposed to copper excess. Plant Physiol (2012) 0.99

α-Synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions. J Biol Chem (2012) 0.98

The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease. Front Aging Neurosci (2014) 0.98

Proteomic analysis of lipid raft-enriched membranes isolated from internal organelles. Biochem Biophys Res Commun (2011) 0.96

Interaction between mitochondria and the endoplasmic reticulum: implications for the pathogenesis of type 2 diabetes mellitus. Exp Diabetes Res (2011) 0.96

Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. Int J Cell Biol (2012) 0.96

Oxidative stress, redox regulation and diseases of cellular differentiation. Biochim Biophys Acta (2014) 0.94

Properties of Ca(2+) transport in mitochondria of Drosophila melanogaster. J Biol Chem (2011) 0.94

Cellular reactive oxygen species inhibit MPYS induction of IFNβ. PLoS One (2010) 0.93

Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species. J Biol Chem (2014) 0.93

Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling. Antioxid Redox Signal (2014) 0.91

Ca2+ dynamics in the mitochondria - state of the art. J Mol Cell Cardiol (2011) 0.90

Heat-shock proteins attenuate SERCA inactivation by the anti-apoptotic protein Bcl-2: possible implications for the ER Ca2+-mediated apoptosis. Biochem J (2012) 0.89

The mitochondrial Na+-Ca2+ exchanger, NCLX, regulates automaticity of HL-1 cardiomyocytes. Sci Rep (2013) 0.88

CGP-37157 inhibits the sarcoplasmic reticulum Ca²+ ATPase and activates ryanodine receptor channels in striated muscle. Mol Pharmacol (2010) 0.88

Mitochondria and chloroplasts shared in animal and plant tissues: significance of communication. Med Sci Monit (2015) 0.87

Cardiac mitochondrial network excitability: insights from computational analysis. Am J Physiol Heart Circ Physiol (2012) 0.86

Copper-induced calcium release from ER involves the activation of ryanodine-sensitive and IP(3)-sensitive channels in Ulva compressa. Plant Signal Behav (2010) 0.85

Pivotal role of mitochondrial Na⁺₋Ca²⁺ exchange in antigen receptor mediated Ca²⁺ signalling in DT40 and A20 B lymphocytes. J Physiol (2011) 0.84

The destiny of Ca(2+) released by mitochondria. J Physiol Sci (2014) 0.84

Mitochondrial DNA damage via augmented oxidative stress regulates endoplasmic reticulum stress and autophagy: crosstalk, links and signaling. PLoS One (2013) 0.84

Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity. Oncotarget (2015) 0.84

Endoplasmic reticulum-plasma membrane junctions: structure, function and dynamics. J Physiol (2016) 0.84

ROS and intracellular ion channels. Cell Calcium (2016) 0.83

Synergistic Interaction of Hypertension and Diabetes in Promoting Kidney Injury and the Role of Endoplasmic Reticulum Stress. Hypertension (2017) 0.82

Obesity and endoplasmic reticulum (ER) stresses. Front Immunol (2012) 0.82

Effect of exercise intensity on unfolded protein response in skeletal muscle of rat. Korean J Physiol Pharmacol (2014) 0.81

The dual role of calcium as messenger and stressor in cell damage, death, and survival. Int J Cell Biol (2010) 0.81

Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication. PLoS One (2014) 0.80

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface. Mol Cell (2016) 0.80

Modulation of intracellular calcium waves and triggered activities by mitochondrial ca flux in mouse cardiomyocytes. PLoS One (2013) 0.80

Novel subcellular localization for α-synuclein: possible functional consequences. Front Neuroanat (2015) 0.80

Targets, trafficking, and timing of cardiac autophagy. Pharmacol Res (2012) 0.80

TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux. J Cell Biol (2016) 0.80

Identification of Leptospira interrogans phospholipase C as a novel virulence factor responsible for intracellular free calcium ion elevation during macrophage death. PLoS One (2013) 0.80

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy. Neurobiol Dis (2014) 0.80

Alginate Oligosaccharide Prevents Acute Doxorubicin Cardiotoxicity by Suppressing Oxidative Stress and Endoplasmic Reticulum-Mediated Apoptosis. Mar Drugs (2016) 0.79

Mitochondria in hypoxic pulmonary vasoconstriction: potential importance of compartmentalized reactive oxygen species signaling. Am J Respir Crit Care Med (2013) 0.78

Mitochondrial Ca(2+) Remodeling is a Prime Factor in Oncogenic Behavior. Front Oncol (2015) 0.78

Pyruvate remediation of cell stress and genotoxicity induced by haloacetic acid drinking water disinfection by-products. Environ Mol Mutagen (2013) 0.78

The mitochondrial Na(+)/Ca(2+) exchanger may reduce high glucose-induced oxidative stress and nucleotide-binding oligomerization domain receptor 3 inflammasome activation in endothelial cells. J Geriatr Cardiol (2015) 0.78

Inhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in guinea pig cardiomyocytes. PLoS One (2014) 0.77

Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes. PLoS One (2015) 0.77

Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop. Sci Rep (2016) 0.77

Regulation and roles of Ca2+ stores in human sperm. Reproduction (2015) 0.77

Targeting microglial K(ATP) channels to treat neurodegenerative diseases: a mitochondrial issue. Oxid Med Cell Longev (2013) 0.77

TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish. RNA Biol (2014) 0.76

Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism. PLoS One (2016) 0.76

Reversal of the Apoptotic Resistance of Non-Small-Cell Lung Carcinoma towards TRAIL by Natural Product Toosendanin. Sci Rep (2017) 0.75

Single-cell resolution of intracellular T cell Ca(2+) dynamics in response to frequency-based H2O2 stimulation. Integr Biol (Camb) (2017) 0.75

Mitochondrial ROS versus ER ROS: Which Comes First in Myocardial Calcium Dysregulation? Front Cardiovasc Med (2016) 0.75

A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun (2017) 0.75

Calcium channel regulator Mid1 links TORC2-mediated changes in mitochondrial respiration to autophagy. J Cell Biol (2016) 0.75

Vitamin C induces apoptosis in AGS cells via production of ROS of mitochondria. Oncol Lett (2016) 0.75

Axonal Endoplasmic Reticulum Ca(2+) Content Controls Release Probability in CNS Nerve Terminals. Neuron (2017) 0.75

PERM Hypothesis: The Fundamental Machinery Able to Elucidate the Role of Xenobiotics and Hormesis in Cell Survival and Homeostasis. Int J Mol Sci (2017) 0.75

H2O2 AUGMENTS CYTOSOLIC CALCIUM IN NUCLEUS TRACTUS SOLITARII NEURONS VIA MULTIPLE VOLTAGE-GATED CALCIUM CHANNELS. Am J Physiol Cell Physiol (2017) 0.75

Articles cited by this

(truncated to the top 100)

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13

Free radicals in the physiological control of cell function. Physiol Rev (2002) 19.62

Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 15.49

Hydroperoxide metabolism in mammalian organs. Physiol Rev (1979) 14.13

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature (2005) 11.22

Calcium signaling. Cell (2007) 11.09

Mitochondrial formation of reactive oxygen species. J Physiol (2003) 10.73

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell (2000) 10.25

Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature (2008) 9.66

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature (2005) 8.51

The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature (1999) 7.85

Decoding of cytosolic calcium oscillations in the mitochondria. Cell (1995) 7.31

AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol (2004) 6.97

The mitochondrial calcium uniporter is a highly selective ion channel. Nature (2004) 6.97

Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol Rev (1999) 6.30

Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science (1993) 6.29

Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med (2000) 6.25

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell (2007) 6.13

Mechanisms by which mitochondria transport calcium. Am J Physiol (1990) 6.06

Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev (2007) 5.95

Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med (2000) 5.90

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature (2004) 5.85

Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol (2006) 5.37

Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem (2002) 5.31

Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci (2006) 5.15

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci U S A (2008) 4.89

Microdomains of intracellular Ca2+: molecular determinants and functional consequences. Physiol Rev (2006) 4.87

Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep (2007) 4.73

Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science (1998) 4.58

Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc Natl Acad Sci U S A (1999) 4.40

Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell (2005) 4.36

Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. J Biol Chem (2005) 4.29

Superoxide flashes in single mitochondria. Cell (2008) 4.08

Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes. J Biol Chem (2003) 3.93

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science (2007) 3.92

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels. J Cell Biol (2006) 3.87

Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion. Biochem J (1989) 3.70

Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol (2007) 3.62

Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation. Science (2003) 3.60

Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes. J Biol Chem (2006) 3.54

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab (2008) 3.52

The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium (2003) 3.38

What is the mitochondrial permeability transition pore? J Mol Cell Cardiol (2009) 3.29

The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J (2006) 3.26

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell (2009) 3.17

S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Nat Med (2004) 3.15

Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit. J Cell Biol (2004) 3.12

PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J (2005) 3.10

Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes. Circ Res (2006) 3.03

Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria. EMBO J (1999) 3.03

Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44. Cell (2005) 2.99

Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J Biol Chem (2002) 2.94

The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control. Antioxid Redox Signal (2006) 2.92

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. Cell (1995) 2.89

On the role of the calcium transport cycle in heart and other mammalian mitochondria. FEBS Lett (1980) 2.85

Integrating cytosolic calcium signals into mitochondrial metabolic responses. EMBO J (1998) 2.82

Membrane transport of hydrogen peroxide. Biochim Biophys Acta (2006) 2.81

VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol (2001) 2.80

Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid Redox Signal (2008) 2.67

The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells. Mol Biol Cell (1999) 2.64

CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol (2008) 2.62

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J Neurosci (2004) 2.57

Calcium, mitochondria and reperfusion injury: a pore way to die. Biochem Soc Trans (2006) 2.57

Glutamate decreases mitochondrial size and movement in primary forebrain neurons. J Neurosci (2003) 2.56

Three-dimensional electron microscopy reveals new details of membrane systems for Ca2+ signaling in the heart. J Cell Sci (2009) 2.49

The Nox family of NAD(P)H oxidases: host defense and beyond. J Biol Chem (2004) 2.48

Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport. Nat Cell Biol (2007) 2.46

Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase. Am J Physiol Cell Physiol (2000) 2.45

Subcellular metabolic transients and mitochondrial redox waves in heart cells. Proc Natl Acad Sci U S A (1998) 2.42

The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions. Cell (2000) 2.41

Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res (2006) 2.39

The organisation and functions of local Ca(2+) signals. J Cell Sci (2001) 2.38

The effect of hyperoxia on superoxide production by lung submitochondrial particles. Arch Biochem Biophys (1982) 2.37

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med (2003) 2.30

Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity. Science (2004) 2.29

Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem (2003) 2.28

A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins. J Biol Chem (1994) 2.22

Mitochondrial calcium uptake from physiological-type pulses of calcium. A description of the rapid uptake mode. J Biol Chem (1995) 2.22

Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease. Cardiovasc Res (2007) 2.17

Peroxisomes and oxidative stress. Biochim Biophys Acta (2006) 2.17

IP3 receptor/Ca2+ channel: from discovery to new signaling concepts. J Neurochem (2007) 2.16

Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores. Nature (1991) 2.16

Modulation of the ryanodine receptor and intracellular calcium. Annu Rev Biochem (2007) 2.14

SERCA pump isoforms: their role in calcium transport and disease. Muscle Nerve (2007) 2.08

Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. J Cell Biol (2002) 2.08

Mitochondria and calcium signaling. Cell Calcium (2005) 2.08

Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age. J Bioenerg Biomembr (1997) 2.06

Mitochondrial matrix phosphoproteome: effect of extra mitochondrial calcium. Biochemistry (2006) 2.06

Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore. Biochim Biophys Acta (2008) 2.05

Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation By electron flow through the respiratory chain complex i. J Biol Chem (1998) 2.01

Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE. J Biol Chem (2004) 1.99

The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria. J Biol Chem (2003) 1.97

Calcium signal transmission between ryanodine receptors and mitochondria. J Biol Chem (2000) 1.97

Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase. J Neurosci (2004) 1.97

Calcium-induced restructuring of nuclear envelope and endoplasmic reticulum calcium stores. Cell (1997) 1.96

Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria. Biochem J (1987) 1.92

Transport of Ca2+ from sarcoplasmic reticulum to mitochondria in rat ventricular myocytes. J Bioenerg Biomembr (2000) 1.87

Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites. J Biol Chem (1996) 1.85

Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. J Neurosci (2000) 1.85

Mitochondria are linked to calcium stores in striated muscle by developmentally regulated tethering structures. Mol Biol Cell (2008) 1.80

Articles by these authors

Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol (2006) 5.37

Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface. Mol Cell (2010) 3.23

Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit. J Cell Biol (2004) 3.12

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase. Proc Natl Acad Sci U S A (2008) 3.04

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Nat Cell Biol (2012) 2.48

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature (2003) 2.22

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter. Cell Metab (2013) 2.15

Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics. EMBO J (2009) 2.11

Ca2+ marks: miniature calcium signals in single mitochondria driven by ryanodine receptors. Proc Natl Acad Sci U S A (2002) 1.72

VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria. EMBO Rep (2009) 1.62

Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130. J Biol Chem (2002) 1.61

High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling. Cell Calcium (2008) 1.60

Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol Cell (2009) 1.58

Ca2+-dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC). J Biol Chem (2006) 1.48

IP3 receptors in cell survival and apoptosis: Ca2+ release and beyond. Apoptosis (2007) 1.45

Mitochondria and endoplasmic reticulum: the lethal interorganelle cross-talk. J Bioenerg Biomembr (2005) 1.39

Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. J Biol Chem (2001) 1.36

Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle. J Biol Chem (2008) 1.28

Plasticity of mitochondrial calcium signaling. J Biol Chem (2003) 1.27

Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. Am J Physiol Cell Physiol (2010) 1.27

Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca²⁺ and reactive oxygen species signaling. J Cell Sci (2013) 1.16

Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling. J Cell Biol (2014) 1.09

Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex. Int J Biochem Cell Biol (2009) 1.09

tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane. EMBO J (2002) 1.08

Bid-induced mitochondrial membrane permeabilization waves propagated by local reactive oxygen species (ROS) signaling. Proc Natl Acad Sci U S A (2012) 1.07

Control of calcium signal propagation to the mitochondria by inositol 1,4,5-trisphosphate-binding proteins. J Biol Chem (2005) 1.07

Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons. Eur J Neurosci (2011) 1.02

Visualization of binding and transcytosis of botulinum toxin by human intestinal epithelial cells. J Pharmacol Exp Ther (2005) 0.98

Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points. Am J Physiol Heart Circ Physiol (2011) 0.95

Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species. J Biol Chem (2014) 0.93

Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology. Mol Cell Endocrinol (2011) 0.93

Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts. BMC Neurosci (2008) 0.92

Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats. Pflugers Arch (2012) 0.91

Uncoupling of ER-mitochondrial calcium communication by transforming growth factor-beta. Am J Physiol Renal Physiol (2008) 0.90

Calcium, mitochondria and apoptosis studied by fluorescence measurements. Methods (2008) 0.90

Switch from ER-mitochondrial to SR-mitochondrial calcium coupling during muscle differentiation. Cell Calcium (2012) 0.82

MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism. Nat Cell Biol (2015) 0.76

Fluorometric methods for detection of mitochondrial membrane permeabilization in apoptosis. Methods Mol Biol (2009) 0.76