Published in World J Gastroenterol on February 14, 2007
Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. Mol Cancer (2008) 1.31
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers. Gastroenterology (2015) 1.24
Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. BMC Cancer (2009) 1.19
Hypermethylated SFRP2 gene in fecal DNA is a high potential biomarker for colorectal cancer noninvasive screening. World J Gastroenterol (2008) 1.16
Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer. Mol Cancer (2008) 1.11
Promoter hypermethylation of tumour suppressor genes as potential biomarkers in colorectal cancer. Int J Mol Sci (2015) 1.09
Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease. Br J Cancer (2009) 1.08
Advances in epigenetic biomarker research in colorectal cancer. World J Gastroenterol (2014) 1.02
Colorectal carcinoma: nucleosomes, carcinoembryonic antigen and ca 19-9 as apoptotic markers; a comparative study. J Biomed Sci (2011) 0.89
Diagnostic value of stool DNA testing for multiple markers of colorectal cancer and advanced adenoma: a meta-analysis. Can J Gastroenterol (2013) 0.89
DNA methylation: its role in cancer development and therapy. Curr Probl Cancer (2008) 0.88
Methylation of TMEFF2 gene in tissue and serum DNA from patients with non-small cell lung cancer. Mol Cells (2012) 0.86
Accuracy of early detection of colorectal tumours by stool methylation markers: a meta-analysis. World J Gastroenterol (2014) 0.82
Methylation pattern of SFRP1 promoter in stool sample is a potential marker for early detection of colorectal cancer. Adv Biomed Res (2012) 0.80
Methylation of SFRP2 gene as a promising noninvasive biomarker using feces in colorectal cancer diagnosis: a systematic meta-analysis. Sci Rep (2016) 0.79
Study of SFRP1 and SFRP2 methylation status in patients with de novo Acute Myeloblastic Leukemia. Int J Hematol Oncol Stem Cell Res (2015) 0.78
Quantitative profiling of CpG island methylation in human stool for colorectal cancer detection. Int J Colorectal Dis (2012) 0.78
Detection and Clinical Significance of DLC1 Gene Methylation in Serum DNA from Colorectal Cancer Patients. Chin J Cancer Res (2011) 0.77
Analysis of O6-methylguanine-DNA methyltransferase methylation status in sporadic colon polyps. Rep Pract Oncol Radiother (2012) 0.76
Improved amplification efficiency on stool samples by addition of spermidine and its use for non-invasive detection of colorectal cancer. BMC Biotechnol (2015) 0.75
BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas. Cancers (Basel) (2009) 0.75
p33(ING1b) methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. Oncol Lett (2014) 0.75
The Diagnostic Performance of Stool DNA Testing for Colorectal Cancer: A Systematic Review and Meta-Analysis. Medicine (Baltimore) (2016) 0.75
Tumoral tissue specific promoter hypermethylation of distinct tumor suppressor genes in a case with nonsmall cell lung carcinoma: a case report. Lung India (2008) 0.75
DNA methylation assay for colorectal carcinoma. Cancer Biol Med (2017) 0.75
Analysis of DNA Methylation Status in Bodily Fluids for Early Detection of Cancer. Int J Mol Sci (2017) 0.75
Cancer statistics, 2006. CA Cancer J Clin (2006) 30.71
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A (1996) 29.54
Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer (2006) 11.22
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet (2004) 7.78
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res (1999) 6.10
Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene. J Natl Cancer Inst (2005) 3.73
Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas. Am J Clin Pathol (2003) 3.05
Epigenetic changes in colorectal cancer. Cancer Metastasis Rev (2004) 2.35
CpG island methylation in aberrant crypt foci of the colorectum. Am J Pathol (2002) 1.83
Methylation changes in faecal DNA: a marker for colorectal cancer screening? Lancet (2004) 1.80
Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res (2005) 1.59
Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer. Gut (2004) 1.53
HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers. Proc Natl Acad Sci U S A (2001) 1.41
Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer. Clin Gastroenterol Hepatol (2005) 1.27
Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers. Neoplasia (2005) 1.15
Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma. Cancer Res (2002) 1.13
Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer. Cancer Epidemiol Biomarkers Prev (2004) 1.12
Detection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer: a feasibility study. Clin Chem (2004) 1.00
DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients. Int J Cancer (2006) 0.92
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Effect of iodine intake on thyroid diseases in China. N Engl J Med (2006) 5.46
Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res (2002) 4.92
High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice. PLoS One (2011) 3.90
R gene expression induced by a type-III effector triggers disease resistance in rice. Nature (2005) 3.25
The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium. Proc Natl Acad Sci U S A (2002) 3.19
Enterovirus 71 outbreak in the People's Republic of China in 2008. J Clin Microbiol (2009) 2.98
Nitrogen fixation island and rhizosphere competence traits in the genome of root-associated Pseudomonas stutzeri A1501. Proc Natl Acad Sci U S A (2008) 2.70
A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Nat Genet (2010) 2.68
Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum Mol Genet (2009) 2.34
Virome analysis for identification of novel mammalian viruses in bat species from Chinese provinces. J Virol (2012) 2.21
Human cytomegalovirus escapes a naturally occurring neutralizing antibody by incorporating it into assembling virions. Cell Host Microbe (2011) 2.20
d+id' chiral superconductivity in bilayer silicene. Phys Rev Lett (2013) 2.18
Testing the position-effect variegation hypothesis for facioscapulohumeral muscular dystrophy by analysis of histone modification and gene expression in subtelomeric 4q. Hum Mol Genet (2003) 2.15
Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ Res (2006) 1.95
Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse. Development (2005) 1.93
Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer. Cancer Res (2010) 1.74
Imatinib (ST1571) provides only limited selectivity for CML cells and treatment might be complicated by silent BCR-ABL genes. Cancer Biol Ther (2003) 1.73
Complete genome analysis of coxsackievirus A2, A4, A5, and A10 strains isolated from hand, foot, and mouth disease patients in China revealing frequent recombination of human enterovirus A. J Clin Microbiol (2011) 1.71
Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties. J Gen Physiol (2007) 1.68
MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720. Clin Cancer Res (2010) 1.68
The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein. J Biol Chem (2011) 1.68
Genes that escape from X inactivation. Hum Genet (2011) 1.63
Lipid interaction converts prion protein to a PrPSc-like proteinase K-resistant conformation under physiological conditions. Biochemistry (2007) 1.62
A Xanthomonas uridine 5'-monophosphate transferase inhibits plant immune kinases. Nature (2012) 1.60
Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation. Blood (2002) 1.59
Characterization of ST-4821 complex, a unique Neisseria meningitidis clone. Genomics (2007) 1.59
Video-assisted thoracoscopic left cardiac sympathetic denervation: a reliable minimally invasive approach for congenital long-QT syndrome. Ann Thorac Surg (2008) 1.58
Hierarchical MnMoO(4)/CoMoO(4) heterostructured nanowires with enhanced supercapacitor performance. Nat Commun (2011) 1.55
Revisiting the molecular evolutionary history of Shigella spp. J Mol Evol (2006) 1.54
Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a. BMC Genomics (2006) 1.54
The future of biologic coatings for orthopaedic implants. Biomaterials (2013) 1.53
Molecular genetic studies of gene identification for osteoporosis: a 2004 update. J Bone Miner Res (2006) 1.52
Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arterioscler Thromb Vasc Biol (2005) 1.52
{μ-6,6'-Dimeth-oxy-2,2'-[cyclo-hexane-1,2-diylbis(nitrilo-methyl-idyne)]diphenolato}methanol-μ-nitrato-dinitratocopper(II)europium(III). Acta Crystallogr Sect E Struct Rep Online (2010) 1.51
An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity. Oncogene (2005) 1.47
BIK1 interacts with PEPRs to mediate ethylene-induced immunity. Proc Natl Acad Sci U S A (2013) 1.45
Dormancy cycling and persistence of seeds in soil of a cold desert halophyte shrub. Ann Bot (2013) 1.44
Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure. Gut (2009) 1.43
CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. Clin Cancer Res (2010) 1.42
Unbiased parallel detection of viral pathogens in clinical samples by use of a metagenomic approach. J Clin Microbiol (2011) 1.41
Using a standardized follow-up program to improve coronary heart disease secondary prevention. Anatol J Cardiol (2015) 1.39
Climate change and mercury accumulation in Canadian high and subarctic lakes. Environ Sci Technol (2011) 1.39
Escape from X inactivation in mice and humans. Genome Biol (2010) 1.39
Comparison of epidermal growth factor receptor mutation statuses in tissue and plasma in stage I-IV non-small cell lung cancer patients. Respiration (2012) 1.38
Uric acid, hyperuricemia and vascular diseases. Front Biosci (Landmark Ed) (2012) 1.38
Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan. Biomaterials (2009) 1.35
The MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates immunity mediated by a mitogen-activated protein kinase kinase kinase in Arabidopsis. Plant Cell (2012) 1.33
Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system. Kidney Int (2010) 1.32
A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides. Nat Commun (2012) 1.32
Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain. Nat Struct Mol Biol (2010) 1.32
Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. Blood (2007) 1.31
Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res (2010) 1.31
Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology (2010) 1.29
Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition. Blood (2002) 1.29
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol (2006) 1.28
Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes. J Allergy Clin Immunol (2004) 1.27
Video-assisted thoracoscopic surgery is more favorable than thoracotomy for administration of adjuvant chemotherapy after lobectomy for non-small cell lung cancer. World J Surg Oncol (2011) 1.26
NeuronMetrics: software for semi-automated processing of cultured neuron images. Brain Res (2007) 1.25
Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. J Biol Chem (2009) 1.24
Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Blood (2010) 1.24
CD90 (Thy-1)-positive selection enhances osteogenic capacity of human adipose-derived stromal cells. Tissue Eng Part A (2013) 1.23
Video-assisted thoracoscopic surgery lobectomy for lung cancer: the learning curve. World J Surg (2010) 1.23
Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. J Gen Physiol (2012) 1.21
Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B. J Biol Chem (2002) 1.21
Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo. Mol Endocrinol (2008) 1.20
Brain endothelial hemostasis regulation by pericytes. J Cereb Blood Flow Metab (2006) 1.18
Comparison of germination and seed bank dynamics of dimorphic seeds of the cold desert halophyte Suaeda corniculata subsp. mongolica. Ann Bot (2012) 1.17
MicroRNA-21 regulates the migration and invasion of a stem-like population in hepatocellular carcinoma. Int J Oncol (2013) 1.16
LMX1B mutations cause hereditary FSGS without extrarenal involvement. J Am Soc Nephrol (2013) 1.16
Antithyroperoxidase and antithyroglobulin antibodies in a five-year follow-up survey of populations with different iodine intakes. J Clin Endocrinol Metab (2008) 1.16
Robust cell migration and neuronal growth on pristine carbon nanotube sheets and yarns. J Biomater Sci Polym Ed (2007) 1.16
MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells. Tumour Biol (2012) 1.15
Microwave synthesis of fluorescent carbon nanoparticles with electrochemiluminescence properties. Chem Commun (Camb) (2009) 1.15
MicroRNAs 185, 96, and 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition. Mol Cell Biol (2013) 1.14
Histone modification in constitutive heterochromatin versus unexpressed euchromatin in human cells. J Cell Biochem (2004) 1.13
Hyperhomocysteinemia inhibits post-injury reendothelialization in mice. Cardiovasc Res (2005) 1.12
Subunit assembly of N-methyl-d-aspartate receptors analyzed by fluorescence resonance energy transfer. J Biol Chem (2005) 1.12
Surgical treatment of primary palmar hyperhidrosis: a prospective randomized study comparing T3 and T4 sympathicotomy. Eur J Cardiothorac Surg (2009) 1.11
The activity of the Drosophila morphogenetic protein Bicoid is inhibited by a domain located outside its homeodomain. Development (2002) 1.11
Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer. Genome Res (2013) 1.11
Sex-specific responses of Populus cathayana to drought and elevated temperatures. Plant Cell Environ (2008) 1.10
Ebola Virus Outbreak Investigation, Sierra Leone, September 28-November 11, 2014. Emerg Infect Dis (2015) 1.10
Regulation of homocysteine metabolism and methylation in human and mouse tissues. FASEB J (2010) 1.10
Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax. Neoplasia (2009) 1.09
Bioresponsive phosphoester hydrogels for bone tissue engineering. Tissue Eng (2005) 1.09
Subclinical infection with the novel Influenza A (H1N1) virus. Clin Infect Dis (2009) 1.08
1,1'-Dimethyl-4,4'-bipyridinium bis-(tetra-fluorido-borate). Acta Crystallogr Sect E Struct Rep Online (2007) 1.07
Diagnostic accuracy of a questionnaire and simple home monitoring device in detecting obstructive sleep apnoea in a Chinese population at high cardiovascular risk. Respirology (2010) 1.07
Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane. J Biol Chem (2008) 1.06
Mechanism of nano-anatase TiO2 on promoting photosynthetic carbon reaction of spinach: inducing complex of rubisco-rubisco activase. Biol Trace Elem Res (2006) 1.06
Imaginal discs--a new source of chromosomes for genome mapping of the yellow fever mosquito Aedes aegypti. PLoS Negl Trop Dis (2011) 1.04
Is isolated nocturnal hypertension a novel clinical entity? Findings from a Chinese population study. Hypertension (2007) 1.04
Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis. Arthritis Rheumatol (2014) 1.04
Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds. Tissue Eng Part A (2010) 1.04
3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2. Bioorg Med Chem Lett (2004) 1.04
Preferential localization of human origins of DNA replication at the 5'-ends of expressed genes and at evolutionarily conserved DNA sequences. PLoS One (2011) 1.04
Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt. Neoplasia (2009) 1.04
Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury. J Neurotrauma (2008) 1.03
The complete sequence and analysis of the large virulence plasmid pSS of Shigella sonnei. Plasmid (2005) 1.03