Published in Diabetes on March 14, 2007
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia (2012) 2.05
Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab (2010) 1.67
Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol (2014) 1.38
cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem Sci (2010) 1.36
Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB J (2014) 1.20
O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs. Mol Cell Proteomics (2009) 1.13
Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance. J Virol (2012) 1.09
In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS. J Proteome Res (2009) 1.04
Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL. Cell Metab (2010) 0.98
Label-free relative quantification of co-eluting isobaric phosphopeptides of insulin receptor substrate-1 by HPLC-ESI-MS/MS. J Am Soc Mass Spectrom (2010) 0.96
Global IRS-1 phosphorylation analysis in insulin resistance. Diabetologia (2011) 0.93
Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem (2014) 0.92
Increased interaction with insulin receptor substrate 1, a novel abnormality in insulin resistance and type 2 diabetes. Diabetes (2014) 0.84
The identification of raptor as a substrate for p44/42 MAPK. Endocrinology (2011) 0.83
Site-specific phosphorylation of protein phosphatase 1 regulatory subunit 12A stimulated or suppressed by insulin. J Proteomics (2012) 0.83
Gestational protein restriction impairs insulin-regulated glucose transport mechanisms in gastrocnemius muscles of adult male offspring. Endocrinology (2014) 0.82
Insulin resistance and muscle insulin receptor substrate-1 serine hyperphosphorylation. Physiol Rep (2014) 0.80
Insulin-stimulated phosphorylation of protein phosphatase 1 regulatory subunit 12B revealed by HPLC-ESI-MS/MS. Proteome Sci (2012) 0.79
Acute Hepatic Insulin Resistance Contributes to Hyperglycemia in Rats Following Myocardial Infarction. Mol Med (2015) 0.79
Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573. PLoS One (2012) 0.79
Reproducibility of an HPLC-ESI-MS/MS method for the measurement of stable-isotope enrichment of in vivo-labeled muscle ATP synthase beta subunit. PLoS One (2011) 0.77
Endoplasmic reticulum stress impairs insulin receptor signaling in the brains of obese rats. PLoS One (2015) 0.77
High-fat load: mechanism(s) of insulin resistance in skeletal muscle. Int J Obes Suppl (2012) 0.76
Exercise reduces cellular stress related to skeletal muscle insulin resistance. Cell Stress Chaperones (2013) 0.76
Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling. Front Endocrinol (Lausanne) (2017) 0.75
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol (2006) 3.55
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab (2002) 2.98
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes (2004) 2.86
Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem (2006) 2.50
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J Biol Chem (2004) 2.46
Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc Natl Acad Sci U S A (2004) 2.27
Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab (2002) 2.08
Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest (2010) 1.85
Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle. J Biol Chem (2004) 1.69
Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab (2004) 1.67
Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients. Diabetes (2005) 1.57
The Association of Biomolecular Resource Facilities Proteomics Research Group 2006 study: relative protein quantitation. Mol Cell Proteomics (2007) 1.53
Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise. Am J Physiol Endocrinol Metab (2008) 1.53
Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes. Diabetes (2009) 1.52
IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance. Diabetes Care (2006) 1.52
Increased collagen content in insulin-resistant skeletal muscle. Am J Physiol Endocrinol Metab (2005) 1.49
Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. J Neurosci (2004) 1.48
Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects. Metabolism (2004) 1.44
Proteomic analysis identifies in vivo candidate matrix metalloproteinase-9 substrates in the left ventricle post-myocardial infarction. Proteomics (2010) 1.42
Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases. J Biol Chem (2005) 1.42
Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training. Diabetes (2006) 1.41
Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. J Biol Chem (2002) 1.34
Characterization of the human skeletal muscle proteome by one-dimensional gel electrophoresis and HPLC-ESI-MS/MS. Mol Cell Proteomics (2007) 1.31
Complete genomic sequence and mass spectrometric analysis of highly diverse, atypical Bacillus thuringiensis phage 0305phi8-36. Virology (2007) 1.21
LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training. Am J Physiol Endocrinol Metab (2005) 1.20
Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo. Am J Physiol Endocrinol Metab (2008) 1.17
Identification of bovine heart cytochrome c oxidase subunits modified by the lipid peroxidation product 4-hydroxy-2-nonenal. Biochemistry (2002) 1.17
Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria. Am J Physiol Endocrinol Metab (2011) 1.17
Characterization of Pseudomonas chlororaphis myovirus 201varphi2-1 via genomic sequencing, mass spectrometry, and electron microscopy. Virology (2008) 1.16
Photolabeling of cardiolipin binding subunits within bovine heart cytochrome c oxidase. Biochemistry (2006) 1.16
Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence. Proc Natl Acad Sci U S A (2012) 1.15
Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling. Endocrinology (2007) 1.15
The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation. Am J Physiol Lung Cell Mol Physiol (2007) 1.13
Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites. Biochemistry (2005) 1.10
Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients. Diabetes (2003) 1.09
Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS. J Proteomics (2009) 1.09
Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223. Endocrinology (2005) 1.09
Quantification of endocannabinoids in rat biological samples by GC/MS: technical and theoretical considerations. Prostaglandins Other Lipid Mediat (2006) 1.08
Wnt antagonist SFRP1 functions as a secreted mediator of senescence. Mol Cell Biol (2012) 1.06
Comparative study of the skin penetration of protein transduction domains and a conjugated peptide. Pharm Res (2005) 1.05
In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS. J Proteome Res (2009) 1.04
The left ventricle proteome differentiates middle-aged and old left ventricles in mice. J Proteome Res (2008) 1.04
Exercise-induced improvement in vasodilatory function accompanies increased insulin sensitivity in obesity and type 2 diabetes mellitus. J Clin Endocrinol Metab (2006) 1.03
Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration. Diabetes (2007) 1.02
Label-free proteomic identification of endogenous, insulin-stimulated interaction partners of insulin receptor substrate-1. J Am Soc Mass Spectrom (2011) 1.01
Texas 3-step decellularization protocol: looking at the cardiac extracellular matrix. J Proteomics (2013) 1.01
Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease. Free Radic Biol Med (2004) 0.99
Global relationship between the proteome and transcriptome of human skeletal muscle. J Proteome Res (2008) 0.99
Peroxynitrite-induced nitrative and oxidative modifications alter tau filament formation. Biochemistry (2011) 0.98
Specific modification of two tryptophans within the nuclear-encoded subunits of bovine cytochrome c oxidase by hydrogen peroxide. Biochemistry (2004) 0.98
Label-free relative quantification of co-eluting isobaric phosphopeptides of insulin receptor substrate-1 by HPLC-ESI-MS/MS. J Am Soc Mass Spectrom (2010) 0.96
The small heat shock protein, HSPB6, in muscle function and disease. Cell Stress Chaperones (2009) 0.96
In vivo matrix metalloproteinase-7 substrates identified in the left ventricle post-myocardial infarction using proteomics. J Proteome Res (2010) 0.95
Quantification of phosphorylation of insulin receptor substrate-1 by HPLC-ESI-MS/MS. J Am Soc Mass Spectrom (2006) 0.95
Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats. J Appl Physiol (1985) (2002) 0.94
Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase. J Biol Chem (2004) 0.94
A novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model. J Vasc Surg (2010) 0.94
Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts. J Invest Dermatol (2008) 0.94
Glucose response curve and type 2 diabetes risk in Latino adolescents. Diabetes Care (2012) 0.93
Visualization of bacteriophage T3 capsids with DNA incompletely packaged in vivo. J Mol Biol (2008) 0.92
Characterization of the Human Adipocyte Proteome and Reproducibility of Protein Abundance by One-Dimensional Gel Electrophoresis and HPLC-ESI-MS/MS. J Proteome Res (2010) 0.92
Extensive proteolysis of head and inner body proteins by a morphogenetic protease in the giant Pseudomonas aeruginosa phage φKZ. Mol Microbiol (2012) 0.91
Evidence for bacteriophage T7 tail extension during DNA injection. BMC Res Notes (2008) 0.91
Adiponectin inhibits insulin function in primary trophoblasts by PPARα-mediated ceramide synthesis. Mol Endocrinol (2014) 0.90
Identification of phosphorylation sites in insulin receptor substrate-1 by hypothesis-driven high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Anal Chem (2005) 0.89
Protein metabolism in human obesity: a shift in focus from whole-body to skeletal muscle. Obesity (Silver Spring) (2010) 0.89
Effect of exercise on the skeletal muscle proteome in patients with type 2 diabetes. Med Sci Sports Exerc (2013) 0.89
Characterization of lytic Pseudomonas aeruginosa bacteriophages via biological properties and genomic sequences. Appl Microbiol Biotechnol (2012) 0.88
Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action. J Appl Physiol (1985) (2003) 0.88
DNA packaging-associated hyper-capsid expansion of bacteriophage t3. J Mol Biol (2010) 0.88
Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle. Antioxid Redox Signal (2014) 0.88
Proteome of the large Pseudomonas myovirus 201 phi 2-1: delineation of proteolytically processed virion proteins. Mol Cell Proteomics (2010) 0.88
Phosphorylation of connexin 50 by protein kinase A enhances gap junction and hemichannel function. J Biol Chem (2011) 0.88