1
|
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
|
Nat Genet
|
2008
|
22.35
|
2
|
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
|
Nat Genet
|
2008
|
15.94
|
3
|
Genome-wide association study identifies eight loci associated with blood pressure.
|
Nat Genet
|
2009
|
12.44
|
4
|
LDL-cholesterol concentrations: a genome-wide association study.
|
Lancet
|
2008
|
6.44
|
5
|
Use of recovery biomarkers to calibrate nutrient consumption self-reports in the Women's Health Initiative.
|
Am J Epidemiol
|
2008
|
4.28
|
6
|
Combined effect of health behaviours and risk of first ever stroke in 20,040 men and women over 11 years' follow-up in Norfolk cohort of European Prospective Investigation of Cancer (EPIC Norfolk): prospective population study.
|
BMJ
|
2009
|
3.89
|
7
|
Genetic variation in LIN28B is associated with the timing of puberty.
|
Nat Genet
|
2009
|
3.09
|
8
|
Consumption of vegetables and fruits and risk of breast cancer.
|
JAMA
|
2005
|
3.02
|
9
|
Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition.
|
Am J Clin Nutr
|
2009
|
2.93
|
10
|
Plasma vitamin C level, fruit and vegetable consumption, and the risk of new-onset type 2 diabetes mellitus: the European prospective investigation of cancer--Norfolk prospective study.
|
Arch Intern Med
|
2008
|
2.71
|
11
|
Early age at menarche associated with cardiovascular disease and mortality.
|
J Clin Endocrinol Metab
|
2009
|
2.32
|
12
|
Telomere length in prospective and retrospective cancer case-control studies.
|
Cancer Res
|
2010
|
2.30
|
13
|
Dietary risk factors for the development of inflammatory polyarthritis: evidence for a role of high level of red meat consumption.
|
Arthritis Rheum
|
2004
|
2.19
|
14
|
Depression and ischemic heart disease mortality: evidence from the EPIC-Norfolk United Kingdom prospective cohort study.
|
Am J Psychiatry
|
2008
|
2.14
|
15
|
Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene.
|
Am J Clin Nutr
|
2009
|
2.14
|
16
|
Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study.
|
Am J Clin Nutr
|
2008
|
2.01
|
17
|
Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study.
|
Circulation
|
2004
|
2.00
|
18
|
Biomarker-calibrated energy and protein consumption and increased cancer risk among postmenopausal women.
|
Am J Epidemiol
|
2009
|
1.98
|
19
|
Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
|
Arch Intern Med
|
2010
|
1.88
|
20
|
Cigarette smoking and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium.
|
Am J Epidemiol
|
2009
|
1.87
|
21
|
Adjustments to improve the estimation of usual dietary intake distributions in the population.
|
J Nutr
|
2004
|
1.84
|
22
|
Biomarkers in nutritional epidemiology: applications, needs and new horizons.
|
Hum Genet
|
2009
|
1.68
|
23
|
Diet-induced endogenous formation of nitroso compounds in the GI tract.
|
Free Radic Biol Med
|
2007
|
1.66
|
24
|
Adaptation to social adversity is associated with stroke incidence: evidence from the EPIC-Norfolk prospective cohort study.
|
Stroke
|
2007
|
1.57
|
25
|
Association between type of dietary fish and seafood intake and the risk of incident type 2 diabetes: the European prospective investigation of cancer (EPIC)-Norfolk cohort study.
|
Diabetes Care
|
2009
|
1.53
|
26
|
Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study.
|
Am J Med
|
2004
|
1.50
|
27
|
Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk.
|
Cancer Epidemiol Biomarkers Prev
|
2004
|
1.41
|
28
|
C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003.
|
Atherosclerosis
|
2005
|
1.36
|
29
|
IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.
|
Arterioscler Thromb Vasc Biol
|
2004
|
1.35
|
30
|
Anthropometry, physical activity, and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition.
|
Cancer Epidemiol Biomarkers Prev
|
2006
|
1.32
|
31
|
Red meat enhances the colonic formation of the DNA adduct O6-carboxymethyl guanine: implications for colorectal cancer risk.
|
Cancer Res
|
2006
|
1.32
|
32
|
Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study.
|
J Lipid Res
|
2006
|
1.28
|
33
|
Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study.
|
Hum Mol Genet
|
2009
|
1.28
|
34
|
Urinary sucrose and fructose as biomarkers for sugar consumption.
|
Cancer Epidemiol Biomarkers Prev
|
2005
|
1.26
|
35
|
Relation between self-reported physical functional health and chronic disease mortality in men and women in the European Prospective Investigation into Cancer (EPIC-Norfolk): a prospective population study.
|
Ann Epidemiol
|
2005
|
1.24
|
36
|
Effect of processed and red meat on endogenous nitrosation and DNA damage.
|
Carcinogenesis
|
2009
|
1.19
|
37
|
The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial.
|
Am J Clin Nutr
|
2004
|
1.19
|
38
|
Urine pH is an indicator of dietary acid-base load, fruit and vegetables and meat intakes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk population study.
|
Br J Nutr
|
2007
|
1.19
|
39
|
The effect of correlated measurement error in multivariate models of diet.
|
Am J Epidemiol
|
2004
|
1.19
|
40
|
Plasma phytoestrogens and subsequent breast cancer risk.
|
J Clin Oncol
|
2007
|
1.14
|
41
|
Energy intake at breakfast and weight change: prospective study of 6,764 middle-aged men and women.
|
Am J Epidemiol
|
2007
|
1.13
|
42
|
Use of the predictive sugars biomarker to evaluate self-reported total sugars intake in the Observing Protein and Energy Nutrition (OPEN) study.
|
Cancer Epidemiol Biomarkers Prev
|
2011
|
1.09
|
43
|
Glycated hemoglobin and risk of stroke in people without known diabetes in the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study: a threshold relationship?
|
Stroke
|
2007
|
1.09
|
44
|
Fruit and vegetable consumption and self-reported functional health in men and women in the European Prospective Investigation into Cancer-Norfolk (EPIC-Norfolk): a population-based cross-sectional study.
|
Public Health Nutr
|
2007
|
1.09
|
45
|
Combined work and leisure physical activity and risk of stroke in men and women in the European prospective investigation into Cancer-Norfolk Prospective Population Study.
|
Neuroepidemiology
|
2006
|
1.08
|
46
|
Dietary fish intake and plasma phospholipid n-3 polyunsaturated fatty acid concentrations in men and women in the European Prospective Investigation into Cancer-Norfolk United Kingdom cohort.
|
Am J Clin Nutr
|
2006
|
1.08
|
47
|
Urinary potassium is as reliable as urinary nitrogen for use as a recovery biomarker in dietary studies of free living individuals.
|
J Nutr
|
2006
|
1.08
|
48
|
Serum lipoprotein lipase concentration and risk for future coronary artery disease: the EPIC-Norfolk prospective population study.
|
Arterioscler Thromb Vasc Biol
|
2005
|
1.08
|
49
|
Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165].
|
Breast Cancer Res
|
2004
|
1.07
|
50
|
Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study.
|
Arterioscler Thromb Vasc Biol
|
2005
|
1.06
|
51
|
Measured height loss predicts fractures in middle-aged and older men and women: the EPIC-Norfolk prospective population study.
|
J Bone Miner Res
|
2008
|
1.06
|
52
|
New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acid.
|
Cancer Epidemiol Biomarkers Prev
|
2006
|
1.05
|
53
|
Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population.
|
Inflamm Bowel Dis
|
2008
|
1.04
|
54
|
Serum IGF-I, its major binding protein (IGFBP-3) and epithelial ovarian cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC).
|
Endocr Relat Cancer
|
2007
|
1.02
|
55
|
Healthy lifestyle choices: could sense of coherence aid health promotion?
|
J Epidemiol Community Health
|
2007
|
1.02
|
56
|
Postmenopausal hormone therapy and changes in mammographic density.
|
J Clin Oncol
|
2007
|
1.01
|
57
|
Variations in plasma phytoestrogen concentrations in European adults.
|
J Nutr
|
2007
|
1.01
|
58
|
Implications of gene-environment interaction in studies of gene variants in breast cancer: an example of dietary isoflavones and the D356N polymorphism in the sex hormone-binding globulin gene.
|
Cancer Res
|
2006
|
1.01
|
59
|
Apolipoprotein E gene polymorphism and colorectal cancer: gender-specific modulation of risk and prognosis.
|
Clin Sci (Lond)
|
2003
|
1.01
|
60
|
Measurement of fruit and vegetable consumption with diet questionnaires and implications for analyses and interpretation.
|
Am J Epidemiol
|
2005
|
1.00
|
61
|
Phytoestrogen content of foods of animal origin: dairy products, eggs, meat, fish, and seafood.
|
J Agric Food Chem
|
2008
|
0.99
|
62
|
More acidic dietary acid-base load is associated with reduced calcaneal broadband ultrasound attenuation in women but not in men: results from the EPIC-Norfolk cohort study.
|
Am J Clin Nutr
|
2007
|
0.99
|
63
|
Differences in N-acetylation genotypes between Caucasians and Black South Africans: implications for cancer prevention.
|
Cancer Detect Prev
|
2002
|
0.99
|
64
|
Mastery is associated with cardiovascular disease mortality in men and women at apparently low risk.
|
Health Psychol
|
2010
|
0.99
|
65
|
Modifiable lifestyle behaviors and functional health in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study.
|
Prev Med
|
2006
|
0.98
|
66
|
Detection of malondialdehyde DNA adducts in human colorectal mucosa: relationship with diet and the presence of adenomas.
|
Cancer Epidemiol Biomarkers Prev
|
2002
|
0.98
|
67
|
Habitual fish consumption and risk of incident stroke: the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study.
|
Public Health Nutr
|
2006
|
0.98
|
68
|
Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk.
|
Nutr Cancer
|
2006
|
0.98
|
69
|
Influence of estrogen receptor alpha and progesterone receptor polymorphisms on the effects of hormone therapy on mammographic density.
|
Cancer Epidemiol Biomarkers Prev
|
2006
|
0.96
|
70
|
Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions.
|
Cancer Epidemiol Biomarkers Prev
|
2005
|
0.96
|
71
|
Plasminogen activator inhibitor-1 gene polymorphism and colorectal cancer risk and prognosis.
|
Cancer Lett
|
2003
|
0.96
|
72
|
Mammographic breast density as a biomarker of effects of isoflavones on the female breast.
|
Breast Cancer Res
|
2001
|
0.94
|
73
|
Phytoestrogen content of beverages, nuts, seeds, and oils.
|
J Agric Food Chem
|
2008
|
0.92
|
74
|
Self-reported mental health-related quality of life and mortality in men and women in the European Prospective Investigation into Cancer (EPIC-Norfolk): a prospective population study.
|
Psychosom Med
|
2007
|
0.91
|
75
|
Apolipoprotein E polymorphisms, dietary fat and fibre, and serum lipids: the EPIC Norfolk study.
|
Eur Heart J
|
2007
|
0.91
|
76
|
Optimization of conditions for the enzymatic hydrolysis of phytoestrogen conjugates in urine and plasma.
|
Anal Biochem
|
2005
|
0.90
|
77
|
Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study.
|
Cancer Epidemiol Biomarkers Prev
|
2005
|
0.87
|
78
|
Red meat, dietary nitrosamines, and heme iron and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
|
Cancer Epidemiol Biomarkers Prev
|
2011
|
0.87
|
79
|
No evidence that social stress is associated with breast cancer incidence.
|
Breast Cancer Res Treat
|
2009
|
0.85
|
80
|
Dietary beta-cryptoxanthin and inflammatory polyarthritis: results from a population-based prospective study.
|
Am J Clin Nutr
|
2005
|
0.85
|
81
|
Dietary intake of different types and characteristics of processed meat which might be associated with cancer risk--results from the 24-hour diet recalls in the European Prospective Investigation into Cancer and Nutrition (EPIC).
|
Public Health Nutr
|
2006
|
0.85
|
82
|
Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study.
|
Carcinogenesis
|
2006
|
0.85
|
83
|
Mammographic density using two computer-based methods in an isoflavone trial.
|
Maturitas
|
2008
|
0.85
|
84
|
Phytoestrogen content of cereals and cereal-based foods consumed in the UK.
|
Nutr Cancer
|
2009
|
0.85
|
85
|
MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom).
|
Cancer Causes Control
|
2006
|
0.84
|
86
|
Smoking predicts long-term mortality in stroke: The European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study.
|
Prev Med
|
2006
|
0.84
|
87
|
Is bowel habit linked to colorectal cancer? - Results from the EPIC-Norfolk study.
|
Eur J Cancer
|
2008
|
0.84
|
88
|
Quantification of isoflavones and lignans in serum using isotope dilution liquid chromatography/tandem mass spectrometry.
|
Rapid Commun Mass Spectrom
|
2003
|
0.84
|
89
|
Effect of age on the relationship of occupational social class with prevalence of modifiable cardiovascular risk factors and cardiovascular diseases. A population-based cross-sectional study from European Prospective Investigation into Cancer - Norfolk (EPIC-Norfolk).
|
Gerontology
|
2006
|
0.83
|
90
|
Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men.
|
J Nutr
|
2005
|
0.83
|
91
|
Modest protective effects of isoflavones from a red clover-derived dietary supplement on cardiovascular disease risk factors in perimenopausal women, and evidence of an interaction with ApoE genotype in 49-65 year-old women.
|
J Nutr
|
2004
|
0.83
|
92
|
Detection and quantification of sucrose as dietary biomarker using gas chromatography and liquid chromatography with mass spectrometry.
|
Rapid Commun Mass Spectrom
|
2008
|
0.83
|
93
|
Extraction and quantification of phytoestrogens in foods using automated solid-phase extraction and LC/MS/MS.
|
Anal Chem
|
2007
|
0.82
|
94
|
Isolation of exfoliated colonocytes from human stool as a new technique for colonic cytology.
|
APMIS
|
2002
|
0.81
|
95
|
Physical activity, C-reactive protein levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.
|
Eur J Cardiovasc Prev Rehabil
|
2006
|
0.80
|
96
|
Risk factors for first-ever stroke in the EPIC-Norfolk prospective population-based study.
|
Eur J Cardiovasc Prev Rehabil
|
2008
|
0.80
|
97
|
Respiratory function as a marker of bone health and fracture risk in an older population.
|
J Bone Miner Res
|
2009
|
0.80
|
98
|
Phytoestrogen exposure is associated with circulating sex hormone levels in postmenopausal women and interact with ESR1 and NR1I2 gene variants.
|
Cancer Epidemiol Biomarkers Prev
|
2007
|
0.80
|
99
|
Quantification of isoflavones and lignans in urine using gas chromatography/mass spectrometry.
|
Anal Biochem
|
2003
|
0.79
|
100
|
Obesity indices and self-reported functional health in men and women in the EPIC-Norfolk.
|
Obesity (Silver Spring)
|
2006
|
0.79
|
101
|
Variability in fecal water genotoxicity, determined using the Comet assay, is independent of endogenous N-nitroso compound formation attributed to red meat consumption.
|
Environ Mol Mutagen
|
2006
|
0.79
|
102
|
Physical activity and fibrinogen concentrations in 23,201 men and women in the EPIC-Norfolk population-based study.
|
Atherosclerosis
|
2007
|
0.79
|
103
|
Effect of age and sex on the relationship between different socioeconomic indices and self-reported functional health in the EPIC-Norfolk population-based study.
|
Ann Epidemiol
|
2009
|
0.78
|
104
|
Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop report.
|
Br J Nutr
|
2004
|
0.77
|
105
|
No association between APOE and major depressive disorder in a community sample of 17,507 adults.
|
J Psychiatr Res
|
2009
|
0.77
|
106
|
Optimizing immunoslot blot assays and application to low DNA adduct levels using an amplification approach.
|
Anal Biochem
|
2010
|
0.77
|
107
|
Adduction of human p53 gene by fecal water: an in vitro biomarker of mutagenesis in the human large bowel.
|
Cancer Epidemiol Biomarkers Prev
|
2007
|
0.76
|
108
|
A HMGCR polymorphism is associated with relations between blood pressure and urinary sodium and potassium ratio in the Epic-Norfolk Study.
|
J Am Soc Hypertens
|
2010
|
0.76
|
109
|
[Dietary fibers in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study].
|
Ugeskr Laeger
|
2004
|
0.75
|
110
|
The Short-Form Six-Dimension utility index predicted mortality in the European Prospective Investigation into Cancer-Norfolk prospective population-based study.
|
J Clin Epidemiol
|
2009
|
0.75
|
111
|
A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene ( HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study.
|
Br J Nutr
|
2010
|
0.75
|
112
|
No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial.
|
Cancer Epidemiol Biomarkers Prev
|
2005
|
0.75
|
113
|
Quantitative analysis using gas chromatography/combustion/isotope ratio mass spectrometry and standard addition of intrinsically labelled standards (SAIL)--application to isoflavones in foods.
|
Rapid Commun Mass Spectrom
|
2002
|
0.75
|