Published in EMBO Rep on March 16, 2007
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The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. J Virol (2007) 1.66
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Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways. J Biol Chem (2009) 0.88
New insight into the oncogenic mechanism of the retroviral oncoprotein Tax. Protein Cell (2012) 0.87
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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell (2004) 6.00
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell (2004) 5.08
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature (2003) 3.96
Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines. Cancer Res (1984) 3.67
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The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol (2006) 2.65
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu Rev Immunol (2001) 2.54
Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem (2006) 2.32
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J Biol Chem (2006) 2.19
Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A (2006) 2.19
Activation of NF-kappaB by HTLV-I and implications for cell transformation. Oncogene (2005) 2.10
Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone. J Virol (1999) 1.94
IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. J Biol Chem (1999) 1.92
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Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma. J Biol Chem (1999) 1.82
Negative regulation of JNK signaling by the tumor suppressor CYLD. J Biol Chem (2004) 1.79
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases. Mol Cell Biol (1998) 1.79
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol (2006) 1.70
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NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J Biol Chem (1998) 1.60
IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1. J Biol Chem (1999) 1.57
Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation. Oncogene (2001) 1.23
Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activation. J Virol (1999) 1.05
Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells. J Biol Chem (2006) 0.89
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J Biol Chem (2004) 3.35
Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol (2006) 2.73
Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem (2004) 2.30
Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med (2007) 2.14
The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia. Cancer Cell (2010) 2.09
Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell (2007) 2.05
Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100. J Biol Chem (2002) 1.90
Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol (2009) 1.86
Negative regulation of JNK signaling by the tumor suppressor CYLD. J Biol Chem (2004) 1.79
Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD. J Biol Chem (2008) 1.78
IkappaB kinase is an essential component of the Tpl2 signaling pathway. Mol Cell Biol (2004) 1.76
The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling. Nat Immunol (2012) 1.68
Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. Mol Cell Biol (2005) 1.61
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest (2008) 1.53
The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol (2011) 1.45
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity (2010) 1.31
Distinct signal codes generate dendritic cell functional plasticity. Sci Signal (2010) 1.30
Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK. Blood (2009) 1.29
Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase. J Biol Chem (2006) 1.23
OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature (2013) 1.21
The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50. Sci Signal (2011) 1.18
TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage. Am J Physiol Cell Physiol (2005) 1.16
CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Proc Natl Acad Sci U S A (2014) 1.15
beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870. Cell Signal (2005) 1.09
Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med (2013) 1.08
TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells. Proc Natl Acad Sci U S A (2009) 1.07
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol (2012) 1.05
Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cell Mol Immunol (2012) 1.04
CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. J Immunol (2012) 1.03
Regulation of natural killer T-cell development by deubiquitinase CYLD. EMBO J (2010) 1.01
Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells. J Biol Chem (2007) 1.01
NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation. J Immunol (2009) 1.00
Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proc Natl Acad Sci U S A (2010) 1.00
Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development. Proc Natl Acad Sci U S A (2011) 0.99
RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex. FEBS Lett (2009) 0.99
HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy. J Biol Chem (2012) 0.98
Study of T-cell signaling by somatic cell mutagenesis and complementation cloning. J Immunol Methods (2003) 0.97
Regulation of NF-kappaB2/p100 processing by its nuclear shuttling. Oncogene (2003) 0.95
Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3. Sci Signal (2013) 0.95
Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway. Virology (2005) 0.95
TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. J Exp Med (2013) 0.93
Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells. J Biol Chem (2006) 0.89
Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation. Biochim Biophys Acta (2006) 0.86
TRIM28 mediates chromatin modifications at the TCRα enhancer and regulates the development of T and natural killer T cells. Proc Natl Acad Sci U S A (2012) 0.86
CARMA1 regulation of regulatory T cell development involves modulation of interleukin-2 receptor signaling. J Biol Chem (2010) 0.86
Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium. Cell Signal (2008) 0.84
Regulation of antiviral innate immunity by deubiquitinase CYLD. Cell Mol Immunol (2011) 0.83
S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100. J Biol Chem (2002) 0.82
Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13. Proc Natl Acad Sci U S A (2009) 0.81
A special issue on NF-κB signaling and function. Cell Res (2011) 0.81
Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKβ signaling cascade. Sci Signal (2013) 0.79
The E3 ligase c-Cbl regulates dendritic cell activation. EMBO Rep (2011) 0.78
Immune receptor signaling: from ubiquitination to NF-κB activation. Cell Mol Immunol (2012) 0.75