Published in Alcohol Res Health on January 01, 2006
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. Proc Natl Acad Sci U S A (2007) 2.68
Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Mol Psychiatry (2008) 2.49
Varenicline reduces alcohol self-administration in heavy-drinking smokers. Biol Psychiatry (2009) 2.25
Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats. Neuropsychopharmacology (2010) 1.99
A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Biol Psychiatry (2008) 1.88
A double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence. J Addict Med (2013) 1.47
Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control. Psychopharmacology (Berl) (2011) 1.31
A preliminary investigation of varenicline for heavy drinking smokers. Psychopharmacology (Berl) (2011) 1.27
Acute alcohol action and desensitization of ligand-gated ion channels. Pharmacol Rev (2009) 1.25
The genetic components of alcohol and nicotine co-addiction: from genes to behavior. Curr Drug Abuse Rev (2008) 1.25
Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity. Pharmacol Biochem Behav (2012) 1.13
Synaptic effects induced by alcohol. Curr Top Behav Neurosci (2013) 1.13
Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders. CNS Neurol Disord Drug Targets (2010) 1.06
Differential effects of acute and chronic ethanol exposure on orexin expression in the perifornical lateral hypothalamus. Alcohol Clin Exp Res (2010) 1.01
How can we use our knowledge of alcohol-tobacco interactions to reduce alcohol use? Annu Rev Clin Psychol (2012) 1.01
Varenicline potentiates alcohol-induced negative subjective responses and offsets impaired eye movements. Alcohol Clin Exp Res (2012) 0.93
Drinking motives in female smokers: factor structure, alcohol dependence, and genetic influences. Alcohol Clin Exp Res (2010) 0.84
Varenicline ameliorates ethanol-induced deficits in learning in C57BL/6 mice. Neurobiol Learn Mem (2008) 0.83
Potential therapeutic uses of mecamylamine and its stereoisomers. Pharmacol Biochem Behav (2013) 0.82
Longitudinal associations between smoking cessation medications and alcohol consumption among smokers in the International Tobacco Control Four Country survey. Alcohol Clin Exp Res (2012) 0.81
P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders. Front Neurosci (2014) 0.81
Nicotine administration in the cholinergic basal forebrain increases alcohol consumption in C57BL/6J mice. Alcohol Clin Exp Res (2014) 0.80
Nicotinic acetylcholine receptors are sensors for ethanol in lung fibroblasts. Alcohol Clin Exp Res (2013) 0.80
Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in adrenalectomy/gonadectomy mice. Neuroscience (2010) 0.79
Lifestyle, family history, and risk of idiopathic Parkinson disease: a large Danish case-control study. Am J Epidemiol (2015) 0.79
The predicted impact of reducing the nicotine content in cigarettes on alcohol use. Nicotine Tob Res (2014) 0.78
Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways. Cent Eur J Immunol (2015) 0.78
Unintended consequences of cigarette price changes for alcohol drinking behaviors across age groups: evidence from pooled cross sections. Subst Abuse Treat Prev Policy (2012) 0.78
Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research. Prog Neuropsychopharmacol Biol Psychiatry (2015) 0.77
Nicotine infusion in the wake-promoting basal forebrain enhances alcohol-induced activation of nucleus accumbens. Alcohol Clin Exp Res (2014) 0.77
A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. Int Rev Neurobiol (2016) 0.77
The β2 nicotinic acetylcholine receptor subunit differentially influences ethanol behavioral effects in the mouse. Alcohol (2013) 0.77
Varenicline and cytisine: two nicotinic acetylcholine receptor ligands reduce ethanol intake in University of Chile bibulous rats. Psychopharmacology (Berl) (2013) 0.77
Short-term ethanol exposure causes imbalanced neurotrophic factor allocation in the basal forebrain cholinergic system: a novel insight into understanding the initial processes of alcohol addiction. J Neural Transm (Vienna) (2013) 0.76
Brain regions affected by impaired control modulate responses to alcohol and smoking cues. J Stud Alcohol Drugs (2014) 0.76
Effects of varenicline on ethanol-induced conditioned place preference, locomotor stimulation, and sensitization. Alcohol Clin Exp Res (2014) 0.76
Pharmacotherapy for alcohol use disorder: current and emerging therapies. Harv Rev Psychiatry (2015) 0.76
Synaptic targets: Chronic alcohol actions. Neuropharmacology (2017) 0.75
Inhibition of rat muscle and liver phosphofructokinases by high doses of ethanol. Biochem Res Int (2013) 0.75
Involvement of Purinergic P2X4 Receptors in Alcohol Intake of High-Alcohol-Drinking (HAD) Rats. Alcohol Clin Exp Res (2015) 0.75
Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse. Alcohol Clin Exp Res (2016) 0.75
The clinical utility of the Medication Adherence Questionnaire (MAQ) in an alcohol pharmacotherapy trial. J Subst Abuse Treat (2017) 0.75
Introduction to the special issue "Pharmacotherapies for the treatment of alcohol abuse and dependence" and a summary of patents targeting other neurotransmitter systems. Recent Pat CNS Drug Discov (2012) 0.75
Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants. J Neurosci Res (2007) 1.22
Spatial learning and psychomotor performance of C57BL/6 mice: age sensitivity and reliability of individual differences. Age (Dordr) (2006) 0.90
The alpha7 nicotinic acetylcholine receptor-selective antagonist, methyllycaconitine, partially protects against beta-amyloid1-42 toxicity in primary neuron-enriched cultures. Brain Res (2004) 0.86
The selectively bred high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats differ in sensitivity to nicotine. Alcohol Clin Exp Res (2002) 0.85
Alpha 7 nicotinic acetylcholine receptor-mediated protection against ethanol-induced neurotoxicity. Alcohol (2003) 0.80
alpha7 Nicotinic acetylcholine receptor knockout selectively enhances ethanol-, but not beta-amyloid-induced neurotoxicity. Neurosci Lett (2005) 0.80
Freely accessible water does not decrease consumption of ethanol liquid diets. Alcohol (2003) 0.78
[3H]Ethynylbicycloorthobenzoate ([3H]EBOB) binding in recombinant GABAA receptors. Neurotoxicology (2003) 0.78