Published in Annu Rev Biochem on January 01, 2007
cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev (2010) 3.27
Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation (2010) 2.85
Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis. Br J Pharmacol (2009) 1.89
Advances in targeting cyclic nucleotide phosphodiesterases. Nat Rev Drug Discov (2014) 1.86
Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol (2012) 1.78
Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics. Pharmacol Ther (2009) 1.66
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature (2015) 1.65
Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit. Genes Dev (2010) 1.61
Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells. Am J Physiol Cell Physiol (2011) 1.60
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell (2011) 1.52
PKA: lessons learned after twenty years. Biochim Biophys Acta (2013) 1.52
Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2011) 1.51
Much ado about adenosine: adenosine synthesis and function in regulatory T cell biology. J Immunol (2010) 1.50
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J (2008) 1.50
Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors. Proc Natl Acad Sci U S A (2007) 1.50
The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Br J Pharmacol (2009) 1.46
The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways. Oncogene (2010) 1.45
A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex. Eur J Hum Genet (2008) 1.44
The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations. PLoS One (2010) 1.34
Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes. Proc Natl Acad Sci U S A (2010) 1.33
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. Proc Natl Acad Sci U S A (2009) 1.30
Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs. PLoS Pathog (2011) 1.29
cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Circ Res (2011) 1.29
Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis. Cell Signal (2009) 1.26
Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments. Br J Pharmacol (2012) 1.26
Resveratrol as a calorie restriction mimetic: therapeutic implications. Trends Cell Biol (2012) 1.26
Compartmentalized cyclic adenosine 3',5'-monophosphate at the plasma membrane clusters PDE3A and cystic fibrosis transmembrane conductance regulator into microdomains. Mol Biol Cell (2010) 1.25
cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies. Br J Pharmacol (2009) 1.25
G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem (2015) 1.24
Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Mol Microbiol (2007) 1.20
Conserved expression and functions of PDE4 in rodent and human heart. Basic Res Cardiol (2010) 1.19
Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons. Nat Neurosci (2009) 1.19
Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle. Am J Respir Cell Mol Biol (2008) 1.19
The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth. PLoS One (2011) 1.18
The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3. J Biol Chem (2009) 1.16
The protein kinase A pathway-regulated transcriptome of endometrial stromal fibroblasts reveals compromised differentiation and persistent proliferative potential in endometriosis. Endocrinology (2010) 1.15
Ion channels and signaling in the pituitary gland. Endocr Rev (2010) 1.14
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Arthritis Res Ther (2010) 1.14
PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts. J Biol Chem (2011) 1.13
The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland. Mol Pharmacol (2010) 1.13
Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease. PLoS One (2010) 1.11
Effects of cholesterol depletion on compartmentalized cAMP responses in adult cardiac myocytes. J Mol Cell Cardiol (2010) 1.11
Mechanisms for the modulation of dopamine d(1) receptor signaling in striatal neurons. Front Neuroanat (2011) 1.10
Striatal neurones have a specific ability to respond to phasic dopamine release. J Physiol (2013) 1.10
Cyclic nucleotide signaling in polycystic kidney disease. Kidney Int (2009) 1.09
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J Biol Chem (2009) 1.09
Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. Biochemistry (2008) 1.09
Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit. EMBO J (2009) 1.09
New genes and/or molecular pathways associated with adrenal hyperplasias and related adrenocortical tumors. Mol Cell Endocrinol (2008) 1.08
Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling. J Gen Physiol (2008) 1.08
Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes. J Biol Chem (2009) 1.08
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. J Biol Chem (2011) 1.07
Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2008) 1.07
cAMP and mitochondria. Physiology (Bethesda) (2013) 1.07
Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ Res (2011) 1.07
A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability. J Biol Chem (2009) 1.06
Treating brain tumors with PDE4 inhibitors. Trends Pharmacol Sci (2011) 1.05
Characterization of human cone phosphodiesterase-6 ectopically expressed in Xenopus laevis rods. J Biol Chem (2009) 1.04
Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes. J Mol Cell Cardiol (2010) 1.04
Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro. Br J Pharmacol (2012) 1.03
Cyclic AMP compartments and signaling specificity: role of cyclic nucleotide phosphodiesterases. J Gen Physiol (2014) 1.03
Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase. Proc Natl Acad Sci U S A (2014) 1.03
cAMP signaling in subcellular compartments. Pharmacol Ther (2014) 1.02
Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4. Mol Biol Cell (2009) 1.02
The prenyl-binding protein PrBP/δ: a chaperone participating in intracellular trafficking. Vision Res (2012) 1.02
AKAPs: the architectural underpinnings of local cAMP signaling. J Mol Cell Cardiol (2011) 1.02
Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases. Ther Adv Musculoskelet Dis (2010) 1.02
Rod phosphodiesterase-6 PDE6A and PDE6B subunits are enzymatically equivalent. J Biol Chem (2010) 1.02
Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis. Am J Respir Cell Mol Biol (2014) 1.01
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome. J Cell Biol (2012) 1.01
Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem J (2007) 1.00
Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor. Mol Pharmacol (2008) 1.00
Inhibition of phosphodiesterase-4 decreases ethanol intake in mice. Psychopharmacology (Berl) (2011) 1.00
Phosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination. Mol Cell Proteomics (2010) 0.99
Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia. Mol Psychiatry (2008) 0.99
cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Nat Med (2012) 0.99
Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection. Sci Transl Med (2011) 0.99
Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proc Natl Acad Sci U S A (2010) 0.99
Decreased catalytic activity and altered activation properties of PDE6C mutants associated with autosomal recessive achromatopsia. Hum Mol Genet (2010) 0.98
Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling. Biophys J (2014) 0.98
PdeH, a high-affinity cAMP phosphodiesterase, is a key regulator of asexual and pathogenic differentiation in Magnaporthe oryzae. PLoS Pathog (2010) 0.98
Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6. J Biol Chem (2012) 0.98
MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation. Pigment Cell Melanoma Res (2014) 0.97
cAMP/PKA signaling defects in tumors: genetics and tissue-specific pluripotential cell-derived lesions in human and mouse. Mol Cell Endocrinol (2013) 0.97
Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev (2014) 0.96
Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts. J Biol Chem (2008) 0.95
Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP. Mol Pharmacol (2011) 0.95
Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Proc Natl Acad Sci U S A (2013) 0.95
GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility. Cell Commun Signal (2013) 0.95
Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models. Prog Retin Eye Res (2012) 0.94
PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. PLoS One (2010) 0.94
Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. FASEB J (2011) 0.94
Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species. J Histochem Cytochem (2009) 0.93
Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proc Natl Acad Sci U S A (2013) 0.93
Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D. Mol Cell Biol (2010) 0.93
The role of cGMP signalling in regulating life cycle progression of Plasmodium. Microbes Infect (2012) 0.93
Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. Mol Pharmacol (2007) 0.92
Identification of cytosolic phosphodiesterases in the erythrocyte: a possible role for PDE5. Med Sci Monit (2011) 0.91
Characterization of novel phosphodiesterases in the bovine ovarian follicle. Biol Reprod (2009) 0.91