Published in Mol Pharmacol on August 14, 2008
Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction. Circ Res (2009) 1.31
Conserved expression and functions of PDE4 in rodent and human heart. Basic Res Cardiol (2010) 1.19
Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes. Mol Pharmacol (2010) 1.08
Cardiac ankyrins in health and disease. J Mol Cell Cardiol (2009) 1.08
cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3. J Biol Chem (2010) 1.07
Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ Res (2011) 1.07
Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart. Circ Res (2012) 0.95
Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure. J Mol Cell Cardiol (2010) 0.91
The relationship between the MMP system, adrenoceptors and phosphoprotein phosphatases. Br J Pharmacol (2012) 0.91
Defects in cytoskeletal signaling pathways, arrhythmia, and sudden cardiac death. Front Physiol (2012) 0.89
Regulation by phosphodiesterase isoforms of protein kinase A-mediated attenuation of myocardial protein kinase D activation. Basic Res Cardiol (2010) 0.89
Compartmentalization of β-adrenergic signals in cardiomyocytes. Trends Cardiovasc Med (2013) 0.83
Anthrax lethal toxin induces acute diastolic dysfunction in rats through disruption of the phospholamban signaling network. Int J Cardiol (2013) 0.82
Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. PLoS One (2015) 0.75
Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases. Front Pharmacol (2015) 0.75
Influence of phosphodiesterases and cGMP on cAMP generation and on phosphorylation of phospholamban and troponin I by 5-HT4 receptor activation in porcine left atrium. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.75
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem (2007) 5.62
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science (2002) 4.96
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science (2002) 3.46
Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology. Am J Physiol Heart Circ Physiol (2000) 3.32
Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Circ Res (2006) 2.66
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res (2004) 2.58
Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling. J Biol Chem (2002) 2.55
Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation. J Biol Chem (1996) 2.49
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Proc Natl Acad Sci U S A (2003) 2.43
beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. J Biol Chem (2007) 2.42
AKAP signaling complexes: getting to the heart of the matter. Trends Mol Med (2006) 2.29
Seven transmembrane receptors: something old, something new. Acta Physiol (Oxf) (2007) 2.25
cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling. Circ Res (2007) 2.21
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J (2006) 1.99
Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice. Mol Pharmacol (2001) 1.90
Myocyte adrenoceptor signaling pathways. Science (2003) 1.81
PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1. Mol Cell (2002) 1.67
Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proc Natl Acad Sci U S A (2005) 1.65
Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart. Trends Pharmacol Sci (2006) 1.65
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Natl Acad Sci U S A (2006) 1.59
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J (2008) 1.50
Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue. Biochem J (2005) 1.43
Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. Mol Pharmacol (1995) 1.42
Compartmentalization of adenylate cyclase and cAMP signalling. Biochem Soc Trans (2005) 1.32
PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes. Circ Res (2007) 1.22
Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes. J Biol Chem (2007) 1.20
Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death. J Mol Cell Cardiol (2001) 1.18
Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells. Am J Physiol Cell Physiol (2006) 1.17
Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: II. Effects on myocyte contractile processes. Circulation (1997) 1.16
Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor. Am J Physiol Cell Physiol (2005) 1.07
Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors. J Biol Chem (2000) 1.05
Contributions of protein kinase A anchoring proteins to compartmentation of cAMP signaling in the heart. Mol Pharmacol (2002) 0.93
A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes. Biochem Soc Trans (2006) 0.91
Proteomic studies of PP2A-B56gamma1 phosphatase complexes reveal phosphorylation-regulated partners in cardiac local signaling. J Proteome Res (2007) 0.83
Low affinity of beta1-adrenergic receptor for beta-arrestins explains the resistance to agonist-induced internalization. Life Sci (2001) 0.77
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res (2008) 20.59
PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J (2005) 3.10
Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. J Biol Chem (2003) 2.68
Control of the postmating behavioral switch in Drosophila females by internal sensory neurons. Neuron (2009) 2.50
Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature (2012) 2.07
Piezoelectric properties of domain engineered barium titanate single crystals with different volume fractions of domain walls. J Appl Phys (2009) 1.82
Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J (2006) 1.56
Differential expression of microRNAs in mouse liver under aberrant energy metabolic status. J Lipid Res (2009) 1.43
Strengths and limitations of microarray-based phenotype prediction: lessons learned from the IMPROVER Diagnostic Signature Challenge. Bioinformatics (2013) 1.39
Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. Cell Res (2010) 1.33
Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction. Circ Res (2009) 1.31
A clinicopathological analysis of 40 cases of ovarian Sertoli-Leydig cell tumors. Gynecol Oncol (2012) 1.30
Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach. Arthritis Res Ther (2006) 1.27
Preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios as independent predictors of cervical stromal involvement in surgically treated endometrioid adenocarcinoma. Onco Targets Ther (2013) 1.24
The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic. EMBO J (2003) 1.22
Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes. J Biol Chem (2007) 1.20
Weighted frequent gene co-expression network mining to identify genes involved in genome stability. PLoS Comput Biol (2012) 1.19
Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. J Cell Biol (2007) 1.19
Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers. Am J Physiol Lung Cell Mol Physiol (2013) 1.18
Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons. Dev Biol (2008) 1.17
Mechanochemical delivery and dynamic tracking of fluorescent quantum dots in the cytoplasm and nucleus of living cells. Nano Lett (2009) 1.15
Using gene co-expression network analysis to predict biomarkers for chronic lymphocytic leukemia. BMC Bioinformatics (2010) 1.12
In vitro evidence suggests that miR-133a-mediated regulation of uncoupling protein 2 (UCP2) is an indispensable step in myogenic differentiation. J Biol Chem (2008) 1.12
Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes. Mol Pharmacol (2010) 1.08
Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes. J Biol Chem (2009) 1.08
Light-induced structural and functional plasticity in Drosophila larval visual system. Science (2011) 1.07
N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes. Mol Pharmacol (2007) 1.06
Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages. Aging Cell (2011) 1.06
Optimization of piezoelectric properties for [001](c) poled 0.94Pb(Zn(13)Nb(23))O(3)-0.06PbTiO(3) single crystals. Appl Phys Lett (2010) 1.06
PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway. Cell Res (2007) 1.06
Age-related differences in postinfarct left ventricular rupture and remodeling. Am J Physiol Heart Circ Physiol (2008) 1.05
Tumor progression of culture-adapted human embryonic stem cells during long-term culture. Genes Chromosomes Cancer (2008) 1.05
Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes. J Biol Chem (2009) 1.04
Effects of acetazolamide and anordiol on osmotic water permeability in AQP1-cRNA injected Xenopus oocyte. Acta Pharmacol Sin (2004) 1.04
PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells. PLoS One (2009) 1.04
Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris. BMC Med Genomics (2013) 1.04
Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis. Arthritis Res Ther (2009) 1.02
Multiple cranial neuropathy variant of Guillain-Barré syndrome: a case series. Muscle Nerve (2011) 1.02
Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes. Endocrinology (2005) 1.01
Surgical management of chemotherapy-resistant gestational trophoblastic neoplasia. Expert Rev Anticancer Ther (2010) 1.00
Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models. BMC Bioinformatics (2014) 1.00
Clinical parameters predicting therapeutic response to surgical management in patients with chemotherapy-resistant gestational trophoblastic neoplasia. Gynecol Oncol (2009) 0.98
Using Frequent Co-expression Network to Identify Gene Clusters for Breast Cancer Prognosis. Proc Int Joint Conf Bioinforma Syst Biol Intell Comput (2009) 0.97
Cardiomyocytes with disrupted CFTR function require CaMKII and Ca(2+)-activated Cl(-) channel activity to maintain contraction rate. J Physiol (2010) 0.97
Isolated epithelioid trophoblastic tumor of the vagina: a case report and review of the literature. Onco Targets Ther (2013) 0.97
Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation. Peptides (2006) 0.96
PGC-1alpha inhibits oleic acid induced proliferation and migration of rat vascular smooth muscle cells. PLoS One (2007) 0.96
[Diagnosis and management of uterine arteriovenous fistula with massive vaginal bleeding]. Zhonghua Fu Chan Ke Za Zhi (2004) 0.95
Engineering a hollow nanocontainer platform with multifunctional molecular machines for tumor-targeted therapy in vitro and in vivo. ACS Nano (2013) 0.95
Association study of a functional copy number variation in the WWOX gene with risk of gliomas among Chinese people. Int J Cancer (2014) 0.94
Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2. Cell Mol Life Sci (2011) 0.94
Trophoblastic disease review for diagnosis and management: a joint report from the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup. Int J Gynecol Cancer (2014) 0.93
Effectively processing medical term queries on the UMLS Metathesaurus by layered dynamic programming. BMC Med Genomics (2014) 0.93
The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge. J Cell Sci (2011) 0.92
Preferential sites for the integration and disruption of human papillomavirus 16 in cervical lesions. J Clin Virol (2013) 0.92
Dynamin 1-like-dependent mitochondrial fission initiates overactive mitophagy in the hepatotoxicity of cadmium. Autophagy (2013) 0.92
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces chemotactic migration of monocytes via a death receptor 4-mediated RhoGTPase pathway. Mol Immunol (2010) 0.92
Circulating serum trefoil factor 3 (TFF3) is dramatically increased in chronic kidney disease. PLoS One (2013) 0.91
PHB/PHBHHx scaffolds and human adipose-derived stem cells for cartilage tissue engineering. Biomaterials (2009) 0.90
Pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios do not predict survival in patients with cervical cancer treated with neoadjuvant chemotherapy and radical hysterectomy. Chin Med J (Engl) (2013) 0.90
Arrestin orchestrates crosstalk between G protein-coupled receptors to modulate the spatiotemporal activation of ERK MAPK. Circ Res (2009) 0.90
Comparison of human papillomavirus detection and genotyping with four different prime sets by PCR-sequencing. Biomed Environ Sci (2013) 0.90
Comprehensive transcriptome profiling and functional analysis of the frog (Bombina maxima) immune system. DNA Res (2013) 0.89
Mapping QTLs for tissue culture response of mature wheat embryos. Mol Cells (2007) 0.89
Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior. Neuropsychopharmacology (2008) 0.89
Aptamer-based piezoelectric quartz crystal microbalance biosensor array for the quantification of IgE. Biosens Bioelectron (2009) 0.89
Wheat cryptochromes: subcellular localization and involvement in photomorphogenesis and osmotic stress responses. Plant Physiol (2008) 0.89
Neurotoxin-conjugated upconversion nanoprobes for direct visualization of tumors under near-infrared irradiation. Biomaterials (2010) 0.89
The prevalence of autoantibodies against cartilage intermediate layer protein, YKL-39, osteopontin, and cyclic citrullinated peptide in patients with early-stage knee osteoarthritis: evidence of a variety of autoimmune processes. Rheumatol Int (2004) 0.89
The encouraging prognosis of nongestational ovarian choriocarcinoma with lung metastases. J Reprod Med (2014) 0.88
Inhibition of mTOR pathway attenuates migration and invasion of gallbladder cancer via EMT inhibition. Mol Biol Rep (2014) 0.88
Synergistic antitumor effect of AAV-mediated TRAIL expression combined with cisplatin on head and neck squamous cell carcinoma. BMC Cancer (2011) 0.88
Comprehensive analysis of short peptides in sera from patients with IgA nephropathy. Rapid Commun Mass Spectrom (2009) 0.87
Identifying dynamic network modules with temporal and spatial constraints. Pac Symp Biocomput (2009) 0.87
Ad-PUMA sensitizes drug-resistant choriocarcinoma cells to chemotherapeutic agents. Gynecol Oncol (2007) 0.87
MRP4 and CFTR in the regulation of cAMP and β-adrenergic contraction in cardiac myocytes. Eur J Pharmacol (2012) 0.87
Infection with respiratory syncytial virus alters peptidergic innervation in the lower airways of guinea-pigs. Exp Physiol (2008) 0.87
Identification of four serum microRNAs from a genome-wide serum microRNA expression profile as potential non-invasive biomarkers for endometrioid endometrial cancer. Oncol Lett (2013) 0.87
Activation of CFTR trafficking and gating by vasoactive intestinal peptide in human bronchial epithelial cells. J Cell Biochem (2011) 0.86
Pulmonary peptidergic innervation remodeling and development of airway hyperresponsiveness induced by RSV persistent infection. Peptides (2007) 0.86
Regulatory peptides modulate adhesion of polymorphonuclear leukocytes to bronchial epithelial cells through regulation of interleukins, ICAM-1 and NF-kappaB/IkappaB. Acta Biochim Biophys Sin (Shanghai) (2006) 0.86
Involvement of calcium, reactive oxygen species, and ATP in hexavalent chromium-induced damage in red blood cells. Cell Physiol Biochem (2014) 0.86
Downregulation of integrin β4 decreases the ability of airway epithelial cells to present antigens. PLoS One (2012) 0.85
Changes of clinical features in hydatidiform mole: analysis of 113 cases. J Reprod Med (2008) 0.85
Clinicopathological analysis of mullerian adenosarcoma of the uterus. Chin Med J (Engl) (2010) 0.85
Decreased expression of protease-activated receptor 4 in human gastric cancer. Int J Biochem Cell Biol (2011) 0.85
Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients. Cell Res (2010) 0.85
Analysis of the prognosis and related factors for patients with stage IV gestational trophoblastic neoplasia. Int J Gynecol Cancer (2014) 0.84
Ozone stress down-regulates the expression of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial cells. Chem Biol Interact (2008) 0.84
An entropy-based measure for QTL mapping using extreme samples of population. Hum Hered (2007) 0.84
[Association of genetic polymorphisms of serum amyloid protein A1 with plasma high density lipoproteins cholesterol]. Zhonghua Yi Xue Za Zhi (2010) 0.84
Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. ACS Nano (2016) 0.84
Prevalence of major cardiovascular risk factors and adverse risk profiles among three ethnic groups in the Xinjiang Uygur Autonomous Region, China. Lipids Health Dis (2013) 0.83
Fabrication of electrospun poly(L-lactide-co-ε-caprolactone)/collagen nanoyarn network as a novel, three-dimensional, macroporous, aligned scaffold for tendon tissue engineering. Tissue Eng Part C Methods (2013) 0.83
[Evaluation of surgical resection of pulmonary metastasis of trophoblastic tumour]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2003) 0.83
Analysis of clinicopathologic prognostic factors in 9 patients with epithelioid trophoblastic tumor. Int J Gynecol Cancer (2011) 0.83
Gene Co-expression analysis predicts genetic aberration loci associated with colon cancer metastasis. Int J Comput Biol Drug Des (2013) 0.83
Detection of C677T mutation of MTHFR in subject with coronary heart disease by hairpin probe with enzymatic color on microarray. Biosens Bioelectron (2011) 0.83