Metabolome analysis by capillary electrophoresis-mass spectrometry.

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nat Protoc (2011) 4.13

Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach. Nat Protoc (2008) 3.24

Analytical strategies for LC-MS-based targeted metabolomics. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 3.05

The use of metabolomics to dissect plant responses to abiotic stresses. Cell Mol Life Sci (2012) 1.55

Combining genetic diversity, informatics and metabolomics to facilitate annotation of plant gene function. Nat Protoc (2010) 1.51

Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis. Curr Bioinform (2012) 1.31

Capillary electrophoresis with electrospray ionization mass spectrometric detection for single-cell metabolomics. Anal Chem (2009) 1.19

On-line separations combined with MS for analysis of glycosaminoglycans. Mass Spectrom Rev (2009) 1.19

Impact of intestinal microbiota on intestinal luminal metabolome. Sci Rep (2012) 1.18

Metabolomics and its application for non-invasive embryo assessment in IVF. Mol Hum Reprod (2008) 1.06

Postgenomics diagnostics: metabolomics approaches to human blood profiling. OMICS (2013) 1.03

Review: toxicometabolomics. J Appl Toxicol (2013) 1.03

Perspectives on deciphering mechanisms underlying plant heat stress response and thermotolerance. Front Plant Sci (2013) 1.02

Review: Microfluidic applications in metabolomics and metabolic profiling. Anal Chim Acta (2009) 0.99

Capillary electrophoresis in bioanalysis. Anal Chem (2008) 0.98

Metabolomics of a single vacuole reveals metabolic dynamism in an alga Chara australis. Plant Physiol (2011) 0.96

Recent developments in instrumentation for capillary electrophoresis and microchip-capillary electrophoresis. Electrophoresis (2010) 0.95

Diagnosis of gastroenterological diseases by metabolome analysis using gas chromatography-mass spectrometry. J Gastroenterol (2011) 0.94

Metabolic Profiling of Human Blood by High Resolution Ion Mobility Mass Spectrometry (IM-MS). Int J Mass Spectrom (2010) 0.94

Recent advances of metabolomics in plant biotechnology. Plant Biotechnol Rep (2011) 0.93

Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study. Front Syst Neurosci (2013) 0.87

Oxygen-linked modulation of erythrocyte metabolism: state of the art. Blood Transfus (2010) 0.87

Metabolomic effects of xylitol and fluoride on plaque biofilm in vivo. J Dent Res (2011) 0.87

MMMDB: Mouse Multiple Tissue Metabolome Database. Nucleic Acids Res (2011) 0.86

A method for concurrent diazomethane synthesis and substrate methylation in a 96-sample format. Nat Protoc (2010) 0.85

Fermentation of xylose causes inefficient metabolic state due to carbon/energy starvation and reduced glycolytic flux in recombinant industrial Saccharomyces cerevisiae. PLoS One (2013) 0.84

Systematic evaluation of extraction methods for multiplatform-based metabotyping: application to the Fasciola hepatica metabolome. Anal Chem (2012) 0.82

Ultrasensitive sample quantitation via selected reaction monitoring using CITP/CZE-ESI-triple quadrupole MS. Anal Chem (2012) 0.82

An integrated multi-omics study revealed metabolic alterations underlying the effects of coffee consumption. PLoS One (2014) 0.81

Manual therapy ameliorates delayed-onset muscle soreness and alters muscle metabolites in rats. Physiol Rep (2015) 0.79

Metabolite Profiling of Root Exudates of Common Bean under Phosphorus Deficiency. Metabolites (2014) 0.79

Metabolomic assessment of embryo viability. Semin Reprod Med (2014) 0.78

Mass spectrometry as a quantitative tool in plant metabolomics. Philos Trans A Math Phys Eng Sci (2016) 0.77

Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery. PLoS One (2016) 0.76

Hydroxyproline, a serum biomarker candidate for gastric ulcer in rats: a comparison study of metabolic analysis of gastric ulcer models induced by ethanol, stress, and aspirin. Biomark Insights (2014) 0.76

Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells. Am J Cancer Res (2016) 0.75

Separation technique for the determination of highly polar metabolites in biological samples. Metabolites (2012) 0.75

Colonic Absorption of Low-Molecular-Weight Metabolites Influenced by the Intestinal Microbiome: A Pilot Study. PLoS One (2017) 0.75

MassBank: a public repository for sharing mass spectral data for life sciences. J Mass Spectrom (2010) 6.16

Multiple high-throughput analyses monitor the response of E. coli to perturbations. Science (2007) 5.87

Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res (2009) 3.50

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell (2011) 3.00

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell (2013) 2.58

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain (2012) 2.18

Autophagy protects the proximal tubule from degeneration and acute ischemic injury. J Am Soc Nephrol (2011) 2.04

Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics (2009) 2.03

Oncometabolites: linking altered metabolism with cancer. J Clin Invest (2013) 1.78

SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. J Am Soc Nephrol (2009) 1.70

MathDAMP: a package for differential analysis of metabolite profiles. BMC Bioinformatics (2006) 1.68

Analysis of liver metabolism in a rat model of heart failure. Int J Cardiol (2011) 1.68

Visualization of three-way comparisons of omics data. BMC Bioinformatics (2007) 1.66

Simultaneous determination of the main metabolites in rice leaves using capillary electrophoresis mass spectrometry and capillary electrophoresis diode array detection. Plant J (2004) 1.63

Measurement of internal body time by blood metabolomics. Proc Natl Acad Sci U S A (2009) 1.56

Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism. Mol Syst Biol (2009) 1.52

A systematic survey of in vivo obligate chaperonin-dependent substrates. EMBO J (2010) 1.41

Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS. Mol Biosyst (2007) 1.41

Human blood metabolite timetable indicates internal body time. Proc Natl Acad Sci U S A (2012) 1.37

Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure. Circ Heart Fail (2010) 1.35

Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis. Curr Bioinform (2012) 1.31

Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion. Hepatology (2009) 1.29

mTORC1 is essential for leukemia propagation but not stem cell self-renewal. J Clin Invest (2012) 1.27

Metabolomic profiling of uremic solutes in CKD patients. Hypertens Res (2010) 1.26

Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia. Mol Biosyst (2011) 1.24

Roles of hemoglobin Allostery in hypoxia-induced metabolic alterations in erythrocytes: simulation and its verification by metabolome analysis. J Biol Chem (2007) 1.24

Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry. Metabolomics (2012) 1.17

Metabolomics approach for enzyme discovery. J Proteome Res (2006) 1.16

Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway. J Virol (2011) 1.09

Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency. Cell Rep (2013) 1.08

The emerging role of fumarate as an oncometabolite. Front Oncol (2012) 1.08

13C-metabolic flux analysis for batch culture of Escherichia coli and its Pyk and Pgi gene knockout mutants based on mass isotopomer distribution of intracellular metabolites. Biotechnol Prog (2010) 1.06

Prediction of liquid chromatographic retention times of peptides generated by protease digestion of the Escherichia coli proteome using artificial neural networks. J Proteome Res (2006) 1.03

Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation. Tumour Biol (2014) 1.02

Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in Escherichia coli. J Biol Chem (2009) 1.00

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia. Cell Rep (2013) 0.99

HIF-1alpha is necessary to support gluconeogenesis during liver regeneration. Biochem Biophys Res Commun (2009) 0.98

Time-resolved metabolomics reveals metabolic modulation in rice foliage. BMC Syst Biol (2008) 0.97

Evaluation of metabolic alteration in transgenic rice overexpressing dihydroflavonol-4-reductase. Ann Bot (2006) 0.97

Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis. PLoS Pathog (2012) 0.96

In silico modeling and metabolome analysis of long-stored erythrocytes to improve blood storage methods. J Biotechnol (2009) 0.96

Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1. Pharm Res (2010) 0.95

Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy. J Mol Cell Cardiol (2013) 0.95

Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy. Anal Bioanal Chem (2012) 0.94

Degradation of ppGpp by nudix pyrophosphatase modulates the transition of growth phase in the bacterium Thermus thermophilus. J Biol Chem (2009) 0.94

Two atypical L-cysteine-regulated NADPH-dependent oxidoreductases involved in redox maintenance, L-cystine and iron reduction, and metronidazole activation in the enteric protozoan Entamoeba histolytica. J Biol Chem (2010) 0.92

Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis (2013) 0.91

L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease. J Hypertens (2012) 0.90

Metabolic and morphological changes of an oil accumulating trebouxiophycean alga in nitrogen-deficient conditions. Metabolomics (2012) 0.89

Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells. Int J Cancer (2013) 0.88

Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress. Autophagy (2013) 0.88

Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice. Biochem Biophys Res Commun (2011) 0.88

Dynamic simulation and metabolome analysis of long-term erythrocyte storage in adenine-guanosine solution. PLoS One (2013) 0.88

Metabolic profiling of the protozoan parasite Entamoeba invadens revealed activation of unpredicted pathway during encystation. PLoS One (2012) 0.88

Concise review: genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells. Stem Cells (2014) 0.88

Direct measurement of isotopomer of intracellular metabolites using capillary electrophoresis time-of-flight mass spectrometry for efficient metabolic flux analysis. J Chromatogr A (2007) 0.87

Hypotaurine is an Energy-Saving Hepatoprotective Compound against Ischemia-Reperfusion Injury of the Rat Liver. J Clin Biochem Nutr (2010) 0.87

Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact. Am J Pathol (2013) 0.86

Unveiling cellular biochemical reactions via metabolomics-driven approaches. Curr Opin Microbiol (2010) 0.86

Prediction of metabolite identity from accurate mass, migration time prediction and isotopic pattern information in CE-TOFMS data. Electrophoresis (2010) 0.86

Dramatic increase in glycerol biosynthesis upon oxidative stress in the anaerobic protozoan parasite Entamoeba histolytica. PLoS Negl Trop Dis (2012) 0.86

Development of bottom-fermenting saccharomyces strains that produce high SO2 levels, using integrated metabolome and transcriptome analysis. Appl Environ Microbiol (2008) 0.86

MMMDB: Mouse Multiple Tissue Metabolome Database. Nucleic Acids Res (2011) 0.86

Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes. Biochem J (2009) 0.85

Metabolome analysis revealed increase in S-methylcysteine and phosphatidylisopropanolamine synthesis upon L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica. J Biol Chem (2010) 0.85

Large-scale prediction of cationic metabolite identity and migration time in capillary electrophoresis mass spectrometry using artificial neural networks. Anal Chem (2005) 0.85

The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns. Mol Syst Biol (2013) 0.85

Acetaminophen-induced hepatotoxicity in a liver tissue model consisting of primary hepatocytes assembling around an endothelial cell network. Drug Metab Dispos (2011) 0.85

Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice. PLoS One (2013) 0.84

Model-based definition of population heterogeneity and its effects on metabolism in sporulating Bacillus subtilis. J Biochem (2007) 0.84

Transcriptional regulation of organic anion transporting polypeptide SLCO4C1 as a new therapeutic modality to prevent chronic kidney disease. J Pharm Sci (2011) 0.83

Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver. Drug Metab Dispos (2010) 0.83

Metabolomic study of Chilean biomining bacteria Acidithiobacillus ferrooxidans strain Wenelen and Acidithiobacillus thiooxidans strain Licanantay. Metabolomics (2012) 0.83

Sheathless capillary electrophoresis-mass spectrometry with a high-sensitivity porous sprayer for cationic metabolome analysis. Analyst (2012) 0.82

Correlation between sensory evaluation scores of Japanese sake and metabolome profiles. J Agric Food Chem (2010) 0.82

Glycogen is the primary source of glucose during the lag phase of E. coli proliferation. Biochim Biophys Acta (2012) 0.82

Metabolic profiling to identify potential serum biomarkers for gastric ulceration induced by nonsteroid anti-inflammatory drugs. J Proteome Res (2013) 0.82

Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: a metabolomics analysis. Metabolism (2013) 0.81

Application of capillary electrophoresis-mass spectrometry to synthetic in vitro glycolysis studies. Electrophoresis (2004) 0.81

Sex-dependent hepatic transcripts and metabolites in the development of glucose intolerance and insulin resistance in Zucker diabetic fatty rats. J Mol Endocrinol (2011) 0.81

Changes of metabolic profiles in an oral squamous cell carcinoma cell line induced by eugenol. In Vivo (2013) 0.80

Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations. Mitochondrion (2012) 0.80

A metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by capillary electrophoresis with mass spectrometry (CE-MS). Toxins (Basel) (2012) 0.80

Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model. Clin Exp Nephrol (2011) 0.80

Differences in the fatty acid metabolism of visceral adipose tissue in postmenopausal women. Menopause (2014) 0.80

Metabolomic profiling of the response of susceptible and resistant soybean strains to foxglove aphid, Aulacorthum solani Kaltenbach. J Chromatogr B Analyt Technol Biomed Life Sci (2013) 0.79

A yeast metabolite extraction protocol optimised for time-series analyses. PLoS One (2012) 0.79

Positive autoregulation delays the expression phase of mammalian clock gene Per2. PLoS One (2011) 0.79

Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart. Am J Physiol Heart Circ Physiol (2013) 0.79

Time-resolved metabolomics of a novel trebouxiophycean alga using (13)CO2 feeding. J Biosci Bioeng (2013) 0.79

Metabolomic identification of the target of the filopodia protrusion inhibitor glucopiericidin A. Chem Biol (2010) 0.79

Cytotoxic effect of amide derivatives of trifluoromethionine against the enteric protozoan parasite Entamoeba histolytica. Int J Antimicrob Agents (2009) 0.79

Metabolomic profiles and sensory attributes of edamame under various storage duration and temperature conditions. J Agric Food Chem (2010) 0.78

Amino acid analysis by capillary electrophoresis-mass spectrometry. Methods Mol Biol (2012) 0.78

Changes in the charged metabolite and sugar profiles of pasteurized and unpasteurized Japanese sake with storage. J Agric Food Chem (2012) 0.78

A novel mechanism regulates H(2) S and SO(2) production in Saccharomyces cerevisiae. Yeast (2010) 0.77

In vivo role of aldehyde reductase. Biochim Biophys Acta (2012) 0.77

The dynamics of cellular energetics during continuous yeast culture. Conf Proc IEEE Eng Med Biol Soc (2013) 0.77

A medium-chain fatty acid as an alternative energy source in mouse preimplantation development. Sci Rep (2012) 0.77

GTP-dependent RNA 3'-terminal phosphate cyclase from the hyperthermophilic archaeon Pyrococcus furiosus. Genes Cells (2011) 0.77