Published in Toxicol Sci on March 22, 2007
Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat fetal testis in vitro. Environ Health Perspect (2008) 1.14
Of mice and men (and rats): phthalate-induced fetal testis endocrine disruption is species-dependent. Toxicol Sci (2012) 0.97
Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents. PLoS One (2012) 0.96
Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways. Toxicol Sci (2011) 0.93
Optimizing staining protocols for laser microdissection of specific cell types from the testis including carcinoma in situ. PLoS One (2009) 0.88
Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency. Toxicol Sci (2011) 0.86
A controlled challenge study on di(2-ethylhexyl) phthalate (DEHP) in house dust and the immune response in human nasal mucosa of allergic subjects. Environ Health Perspect (2008) 0.85
Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis. PLoS One (2011) 0.85
Laser capture microdissection of embryonic cells and preparation of RNA for microarray assays. Methods Mol Biol (2014) 0.83
Endocrine-disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis. J Cancer Prev (2015) 0.80
Gender-Specific Adverse Effects of Mono-Ethylhexyl Phthalate on Steroidogenesis in Immature Granulosa Cells and Rat Leydig cell Progenitors in vitro. Front Endocrinol (Lausanne) (2011) 0.78
Mechanisms mediating environmental chemical-induced endocrine disruption in the adrenal gland. Front Endocrinol (Lausanne) (2015) 0.76
Experimentally induced testicular dysgenesis syndrome originates in the masculinization programming window. JCI Insight (2017) 0.75
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A (2004) 3.48
Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. J Clin Invest (2008) 2.39
Public health implications of altered puberty timing. Pediatrics (2008) 2.26
Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo. Stem Cells (2008) 2.20
Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate. Hum Reprod (2003) 2.12
Androgen action via testicular peritubular myoid cells is essential for male fertility. FASEB J (2009) 1.64
Abnormal Leydig Cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis. Endocrinology (2004) 1.57
Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds. Endocr Rev (2009) 1.54
Cellular and hormonal disruption of fetal testis development in sheep reared on pasture treated with sewage sludge. Environ Health Perspect (2005) 1.54
Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months. Toxicol Sci (2002) 1.51
The role of androgens in sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor. Endocrinology (2005) 1.36
Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate. Endocrinology (2005) 1.35
Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat. Endocrinology (2008) 1.34
The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice. Mol Endocrinol (2005) 1.34
Role of androgens in fetal testis development and dysgenesis. Endocrinology (2007) 1.27
Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human. Environ Health Perspect (2006) 1.27
Clinical review: Anogenital distance or digit length ratio as measures of fetal androgen exposure: relationship to male reproductive development and its disorders. J Clin Endocrinol Metab (2013) 1.25
Cellular origins of testicular dysgenesis in rats exposed in utero to di(n-butyl) phthalate. Int J Androl (2006) 1.20
Acute and long-term effects of in utero exposure of rats to di(n-butyl) phthalate on testicular germ cell development and proliferation. Endocrinology (2006) 1.17
Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J (2005) 1.14
ERbeta1 and the ERbeta2 splice variant (ERbetacx/beta2) are expressed in distinct cell populations in the adult human testis. J Clin Endocrinol Metab (2002) 1.14
Critical androgen-sensitive periods of rat penis and clitoris development. Int J Androl (2009) 1.10
Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation. Hum Reprod (2010) 1.08
Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development. Endocrinology (2009) 1.07
The war on error. Hum Reprod (2015) 1.07
Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development. PLoS One (2010) 1.05
In utero exposure to di(n-butyl) phthalate and testicular dysgenesis: comparison of fetal and adult end points and their dose sensitivity. Environ Health Perspect (2007) 1.04
Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells. Proc Natl Acad Sci U S A (2014) 1.04
Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor. Endocrinology (2005) 1.03
Phthalate exposure during pregnancy and lower anogenital index in boys: wider implications for the general population? Environ Health Perspect (2005) 1.02
The critical time window for androgen-dependent development of the Wolffian duct in the rat. Endocrinology (2007) 1.01
In utero exposure to low doses of environmental pollutants disrupts fetal ovarian development in sheep. Mol Hum Reprod (2008) 0.99
Evidence that androgens and oestrogens, as well as follicle-stimulating hormone, can alter Sertoli cell number in the neonatal rat. J Endocrinol (2005) 0.98
Sertoli cell development and function in an animal model of testicular dysgenesis syndrome. Biol Reprod (2007) 0.97
Induction of reproductive tract developmental abnormalities in the male rat by lowering androgen production or action in combination with a low dose of diethylstilbestrol: evidence for importance of the androgen-estrogen balance. Endocrinology (2002) 0.96
Exposure to a complex cocktail of environmental endocrine-disrupting compounds disturbs the kisspeptin/GPR54 system in ovine hypothalamus and pituitary gland. Environ Health Perspect (2009) 0.96
Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents. PLoS One (2012) 0.96
Effect of fetal or neonatal exposure to monobutyl phthalate (MBP) on testicular development and function in the marmoset. Hum Reprod (2009) 0.93
Nuclear, chloroplast, and mitochondrial transcript abundance along a maize leaf developmental gradient. Plant Mol Biol (2007) 0.92
Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide. Endocrinology (2006) 0.90
Differential mobility of pigment-protein complexes in granal and agranal thylakoid membranes of C₃ and C₄ plants. Plant Physiol (2012) 0.90
Comparative effects of di(n-butyl) phthalate exposure on fetal germ cell development in the rat and in human fetal testis xenografts. Environ Health Perspect (2014) 0.90
Toxicant-induced leakage of germ cell-specific proteins from seminiferous tubules in the rat: relationship to blood-testis barrier integrity and prospects for biomonitoring. Toxicol Sci (2010) 0.90
Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts. PLoS One (2013) 0.89
Male fertility following childhood cancer: current concepts and future therapies. Asian J Androl (2003) 0.89
Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action. Endocrinology (2015) 0.88
Androgen action via testicular arteriole smooth muscle cells is important for Leydig cell function, vasomotion and testicular fluid dynamics. PLoS One (2010) 0.88
Neonatal coadministration of testosterone with diethylstilbestrol prevents diethylstilbestrol induction of most reproductive tract abnormalities in male rats. J Androl (2003) 0.87
New insights into the role of androgens in wolffian duct stabilization in male and female rodents. Endocrinology (2009) 0.86
Neonatal treatment of rats with diethylstilboestrol (DES) induces stromal-epithelial abnormalities of the vas deferens and cauda epididymis in adulthood following delayed basal cell development. Reproduction (2005) 0.85
Infant feeding with soy formula milk: effects on puberty progression, reproductive function and testicular cell numbers in marmoset monkeys in adulthood. Hum Reprod (2006) 0.85
Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis. Biol Reprod (2002) 0.85
Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat. Endocrinology (2010) 0.85
Systematic evaluation of non-animal test methods for skin sensitisation safety assessment. Toxicol In Vitro (2015) 0.84
The complete chloroplast genome of tall fescue (Lolium arundinaceum; Poaceae) and comparison of whole plastomes from the family Poaceae. Am J Bot (2009) 0.84
Smooth muscle cell-specific knockout of androgen receptor: a new model for prostatic disease. Endocrinology (2011) 0.84
Deletion of androgen receptor in the smooth muscle of the seminal vesicles impairs secretory function and alters its responsiveness to exogenous testosterone and estradiol. Endocrinology (2010) 0.81
Inter-relationship between testicular dysgenesis and Leydig cell function in the masculinization programming window in the rat. PLoS One (2012) 0.81
Bisphenol A exposure and sexual dysfunction in men: editorial commentary on the article 'Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction' Li et al., 2009. Hum Reprod (2009) 0.81
Prostaglandins, masculinization and its disorders: effects of fetal exposure of the rat to the cyclooxygenase inhibitor- indomethacin. PLoS One (2013) 0.80
Perinatal germ cell development and differentiation in the male marmoset (Callithrix jacchus): similarities with the human and differences from the rat. Hum Reprod (2013) 0.80
Exposure to chemical cocktails before or after conception--- the effect of timing on ovarian development. Mol Cell Endocrinol (2013) 0.79
Changes in vascular dynamics of the adult rat testis leading to transient accumulation of seminiferous tubule fluid after administration of a novel 5-hydroxytryptamine (5-HT) agonist. Reprod Toxicol (2002) 0.79
Identification of transcription factors and coactivators affected by dibutylphthalate interactions in fetal rat testes. Toxicol Sci (2013) 0.79
The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development? Int J Androl (2007) 0.79
A plea for risk assessment of endocrine disrupting chemicals. Toxicology (2013) 0.78
Peri-conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal thyroid gland development in sheep. Mol Cell Endocrinol (2013) 0.78
Organotypic cultures of prepubertal mouse testes: a method to study androgen action in sertoli cells while preserving their natural environment. Biol Reprod (2009) 0.77
Perinatal determinants of adult testis size and function. J Clin Endocrinol Metab (2006) 0.77
Pediatrics: endocrine disruption and human health effects--a call to action. Nat Rev Endocrinol (2011) 0.76
Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole. Crit Rev Toxicol (2013) 0.76
Neonatal estrogenic effects upon the male rat pituitary: early gonadotrophin attenuation precedes long-term recovery. Neuromolecular Med (2009) 0.76
An integrated approach for prospectively investigating a mode-of-action for rodent liver effects. Toxicol Appl Pharmacol (2013) 0.75
Low sperm counts may be preventable. Science (2011) 0.75
Science based guidance for the assessment of endocrine disrupting properties of chemicals. Regul Toxicol Pharmacol (2010) 0.75
Guidance on classification for reproductive toxicity under the globally harmonized system of classification and labelling of chemicals (GHS). Crit Rev Toxicol (2013) 0.75
A modular approach to the extended one-generation reproduction toxicity study. The outcome of an ECETOC Task Force and International ECETOC/ECVAM Workshop. Altern Lab Anim (2009) 0.75