Published in Toxicol Sci on November 22, 2011
Of mice and men (and rats): phthalate-induced fetal testis endocrine disruption is species-dependent. Toxicol Sci (2012) 0.97
Epigenomic programing: a future way to health? Microb Ecol Health Dis (2014) 0.88
A short-term in vivo screen using fetal testosterone production, a key event in the phthalate adverse outcome pathway, to predict disruption of sexual differentiation. Toxicol Sci (2014) 0.81
Dose Addition Models Based on Biologically Relevant Reductions in Fetal Testosterone Accurately Predict Postnatal Reproductive Tract Alterations by a Phthalate Mixture in Rats. Toxicol Sci (2015) 0.80
Simvastatin and dipentyl phthalate lower ex vivo testicular testosterone production and exhibit additive effects on testicular testosterone and gene expression via distinct mechanistic pathways in the fetal rat. Toxicol Sci (2014) 0.79
Nuclear receptors and endocrine disruptors in fetal and neonatal testes: a gapped landscape. Front Endocrinol (Lausanne) (2015) 0.77
Establishing the "Biological Relevance" of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels. Toxicol Sci (2015) 0.76
Maternal cypermethrin exposure during the perinatal period impairs testicular development in C57BL male offspring. PLoS One (2014) 0.76
Xenotransplantation models to study the effects of toxicants on human fetal tissues. Birth Defects Res B Dev Reprod Toxicol (2014) 0.75
Cumulative effects of antiandrogenic chemical mixtures and their relevance to human health risk assessment. Int J Hyg Environ Health (2016) 0.75
Mono-(2-ethylhexyl) phthalate-induced Sertoli cell injury stimulates the production of pro-inflammatory cytokines in Fischer 344 rats. Reprod Toxicol (2017) 0.75
Di-n-Butyl Phthalate Induces Multinucleated Germ Cells in the Rat Fetal Testis Through a Nonproliferative Mechanism. Biol Reprod (2015) 0.75
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ Health Perspect (2004) 5.32
The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci (2000) 3.46
Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci (2000) 3.45
Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol Appl Pharmacol (1999) 3.23
Something from "nothing"--eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environ Sci Technol (2002) 2.93
Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: an antiandrogenic mechanism? Toxicol Sci (1998) 2.53
Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl (2005) 2.48
Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. J Clin Invest (2008) 2.39
Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci (2003) 2.20
Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation. Toxicol Sci (2000) 2.19
Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. Toxicol Sci (2004) 2.15
Study of the testicular effects and changes in zinc excretion produced by some n-alkyl phthalates in the rat. Toxicol Appl Pharmacol (1980) 1.74
trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol (1999) 1.72
Internal phthalate exposure over the last two decades--a retrospective human biomonitoring study. Int J Hyg Environ Health (2007) 1.71
Abnormal Leydig Cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis. Endocrinology (2004) 1.57
Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory rats. Environ Res (2008) 1.55
Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats. Reprod Toxicol (2010) 1.40
Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis. Toxicol Lett (2004) 1.39
Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate. Endocrinology (2005) 1.35
Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat. Endocrinology (2008) 1.34
Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate. Toxicol Sci (2001) 1.33
Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to Di(n-butyl) phthalate. Toxicol Pathol (2003) 1.33
A mixture of the "antiandrogens" linuron and butyl benzyl phthalate alters sexual differentiation of the male rat in a cumulative fashion. Biol Reprod (2004) 1.30
Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis. Toxicology (2006) 1.29
Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate. Toxicol Sci (2003) 1.24
Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. Endocrinology (2003) 1.22
Receptor and nonreceptor-mediated organ-specific toxicity of di(2-ethylhexyl)phthalate (DEHP) in peroxisome proliferator-activated receptor alpha-null mice. Toxicol Pathol (1998) 1.22
A mixture of seven antiandrogens induces reproductive malformations in rats. Int J Androl (2008) 1.21
Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate. Birth Defects Res B Dev Reprod Toxicol (2005) 1.20
Identification of a novel population of adrenal-like cells in the mammalian testis. Dev Biol (2006) 1.18
Peroxisome proliferator-activated receptors: mediators of phthalate ester-induced effects in the male reproductive tract? Toxicol Sci (2004) 1.17
Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats. Toxicology (2008) 1.11
Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. Toxicol Appl Pharmacol (2004) 1.08
Differential effects of phthalates on the testis and the liver. Biol Reprod (2004) 1.06
Differential steroidogenic gene expression in the fetal adrenal gland versus the testis and rapid and dynamic response of the fetal testis to di(n-butyl) phthalate. Biol Reprod (2005) 1.05
Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity. Int J Androl (2010) 1.03
Effects of ammonium perfluorooctanoate on Leydig cell function: in vitro, in vivo, and ex vivo studies. Toxicol Appl Pharmacol (1995) 1.03
Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages. Toxicol Sci (2006) 0.99
Effect of peroxisome proliferators on Leydig cell peripheral-type benzodiazepine receptor gene expression, hormone-stimulated cholesterol transport, and steroidogenesis: role of the peroxisome proliferator-activator receptor alpha. Endocrinology (2002) 0.96
Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates. Toxicol Sci (2010) 0.93
A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): effects on androgenic status, developmental landmarks and testicular histology in male offspring rats. Toxicology (2006) 0.91
Teratogenic phthalate esters and metabolites activate the nuclear receptors PPARs and induce differentiation of F9 cells. Toxicol Appl Pharmacol (2003) 0.90
Mapping gene expression changes in the fetal rat testis following acute dibutyl phthalate exposure defines a complex temporal cascade of responding cell types. Biol Reprod (2007) 0.88
Effect of DI-n-pentyl phthalate treatment on testicular steroidogenic enzymes and cytochrome P-450 in the rat. Toxicol Lett (1983) 0.87
Diisobutyl phthalate impairs the androgen-dependent reproductive development of the male rat. Reprod Toxicol (2008) 0.86
Altered gene expression during rat Wolffian duct development following di(n-butyl) phthalate exposure. Toxicol Sci (2005) 0.84
Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis. Reproduction (2007) 0.81
The direct effect of hepatic peroxisome proliferators on rat Leydig cell function in vitro. Fundam Appl Toxicol (1996) 0.81
Two-generation reproduction studies in Rats fed di-isodecyl phthalate. Reprod Toxicol (2001) 0.79
Prenatal developmental toxicity studies on di-n-heptyl and di-n-octyl phthalates in Sprague-Dawley rats. Reprod Toxicol (2011) 0.79
Effects of in utero exposure to di-n-hexyl phthalate on the reproductive development of the male rat. Reprod Toxicol (2009) 0.78
Public health implications of altered puberty timing. Pediatrics (2008) 2.26
Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. Toxicol Sci (2004) 2.15
A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner. Toxicol Sci (2008) 1.83
Fifteen years after "Wingspread"--environmental endocrine disrupters and human and wildlife health: where we are today and where we need to go. Toxicol Sci (2008) 1.71
Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate. Reprod Toxicol (2002) 1.60
Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals. Int J Androl (2006) 1.57
Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory rats. Environ Res (2008) 1.55
Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol Sci (2003) 1.49
Effects of the androgenic growth promoter 17-beta-trenbolone on fecundity and reproductive endocrinology of the fathead minnow. Environ Toxicol Chem (2003) 1.45
Gestational and lactational exposure to ethinyl estradiol, but not bisphenol A, decreases androgen-dependent reproductive organ weights and epididymal sperm abundance in the male long evans hooded rat. Toxicol Sci (2007) 1.42
Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes. Toxicol Sci (2007) 1.41
Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis. Toxicol Lett (2004) 1.39
Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to Di(n-butyl) phthalate. Toxicol Pathol (2003) 1.33
Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol (2004) 1.28
Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate. Toxicol Sci (2003) 1.24
A mixture of seven antiandrogens induces reproductive malformations in rats. Int J Androl (2008) 1.21
Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate. Birth Defects Res B Dev Reprod Toxicol (2005) 1.20
Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that result in subsequent testicular atrophy. Toxicol Sci (2002) 1.19
Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data. Crit Rev Toxicol (2006) 1.14
Endocrine-disrupting effects of cattle feedlot effluent on an aquatic sentinel species, the fathead minnow. Environ Health Perspect (2004) 1.14
Determination of the di-(2-ethylhexyl) phthalate NOAEL for reproductive development in the rat: importance of the retention of extra animals to adulthood. Toxicol Sci (2010) 1.10
Prenatal testosterone exposure permanently masculinizes anogenital distance, nipple development, and reproductive tract morphology in female Sprague-Dawley rats. Toxicol Sci (2007) 1.10
Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development. Toxicol Pathol (2009) 1.01
Meeting report: moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making. Environ Health Perspect (2008) 0.98
Comparison of five in vitro bioassays to measure estrogenic activity in environmental waters. Environ Sci Technol (2010) 0.98
Identification of metabolites of trenbolone acetate in androgenic runoff from a beef feedlot. Environ Health Perspect (2006) 0.96
Effects of two fungicides with multiple modes of action on reproductive endocrine function in the fathead minnow (Pimephales promelas). Toxicol Sci (2005) 0.94
Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates. Toxicol Sci (2010) 0.93
Late gestational exposure to the fungicide prochloraz delays the onset of parturition and causes reproductive malformations in male but not female rat offspring. Biol Reprod (2005) 0.91
Toxicant-induced hypospadias in the male rat. Adv Exp Med Biol (2004) 0.91
Urinary metabolites of di-n-octyl phthalate in rats. Toxicology (2005) 0.91
Biomarkers of exposure to triclocarban in urine and serum. Toxicology (2011) 0.90
Urinary biomarkers of di-isononyl phthalate in rats. Toxicology (2006) 0.90
Identification of potential biomarkers of exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), an alternative for phthalate plasticizers. J Expo Sci Environ Epidemiol (2012) 0.90
Differential expression of the phthalate syndrome in male Sprague-Dawley and Wistar rats after in utero DEHP exposure. Toxicol Lett (2007) 0.90
Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD(SD)BR rat. Toxicol Sci (2002) 0.89
Pubertal administration of DEHP delays puberty, suppresses testosterone production, and inhibits reproductive tract development in male Sprague-Dawley and Long-Evans rats. Toxicol Sci (2009) 0.89
Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism. Endocrinology (2010) 0.88
Laboratory animal science issues in the design and conduct of studies with endocrine-active compounds. ILAR J (2004) 0.87
Prochloraz inhibits testosterone production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat. Toxicol Sci (2007) 0.86
Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay. Toxicol Sci (2007) 0.86
Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron. Toxicol Sci (2003) 0.86
In utero phthalate effects in the female rat: a model for MRKH syndrome. Toxicol Lett (2013) 0.85
Iprodione delays male rat pubertal development, reduces serum testosterone levels, and decreases ex vivo testicular testosterone production. Toxicol Lett (2007) 0.85
Altered gene expression during rat Wolffian duct development following di(n-butyl) phthalate exposure. Toxicol Sci (2005) 0.84
Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition. Toxicol Sci (2007) 0.84
DNA arrays to monitor gene expression in rat blood and uterus following 17beta-estradiol exposure: biomonitoring environmental effects using surrogate tissues. Toxicol Sci (2002) 0.84
Recombinant expression of aryl hydrocarbon receptor for quantitative ligand-binding analysis. Anal Biochem (2008) 0.83
Hershberger assay to investigate the effects of endocrine-disrupting compounds with androgenic or antiandrogenic activity in castrate-immature male rats. Curr Protoc Toxicol (2005) 0.83
Modeling the interaction of binary and ternary mixtures of estradiol with bisphenol A and bisphenol AF in an in vitro estrogen-mediated transcriptional activation assay (T47D-KBluc). Toxicol Sci (2010) 0.82
In vitro testicular toxicity models: opportunities for advancement via biomedical engineering techniques. ALTEX (2013) 0.82
Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. I: No decrease in epididymal sperm count after a single acute dose. Toxicol Sci (2007) 0.82
Relationships between tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mRNAs, and toxicity in the developing male Wistar(Han) rat. Toxicol Sci (2007) 0.81
Development of a competitive binding assay system with recombinant estrogen receptors from multiple species. Toxicol Lett (2008) 0.81
Use of genomic data in risk assessment case study: II. Evaluation of the dibutyl phthalate toxicogenomic data set. Toxicol Appl Pharmacol (2011) 0.81
Comparison of chemical binding to recombinant fathead minnow and human estrogen receptors alpha in whole cell and cell-free binding assays. Environ Toxicol Chem (2009) 0.81
Urinary and serum metabolites of di-n-pentyl phthalate in rats. Chemosphere (2010) 0.80
Characterization of the androgen-sensitive MDA-kb2 cell line for assessing complex environmental mixtures. Environ Toxicol Chem (2010) 0.80
Effects of in utero linuron exposure on rat Wolffian duct development. Reprod Toxicol (2002) 0.80
Identification of estrogenic compounds emitted from the combustion of computer printed circuit boards in electronic waste. Environ Sci Technol (2007) 0.79
Integrated assessment of runoff from livestock farming operations: Analytical chemistry, in vitro bioassays, and in vivo fish exposures. Environ Toxicol Chem (2014) 0.78
CYP1A2 in a smoking and a non-smoking population; correlation of urinary and salivary phenotypic ratios. Drug Metabol Drug Interact (2004) 0.77
Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone. Reprod Toxicol (2005) 0.77
Interpretation of studies on the developmental reproductive toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring. Food Chem Toxicol (2010) 0.77
Critical evaluation of current developmental toxicity testing strategies: a case of babies and their bathwater. Birth Defects Res B Dev Reprod Toxicol (2011) 0.77
Detection of androgenic activity in emissions from diesel fuel and biomass combustion. Environ Toxicol Chem (2006) 0.77
The biocide tributyltin reduces the accumulation of testosterone as fatty acid esters in the mud snail (Ilyanassa obsoleta). Environ Health Perspect (2003) 0.76
Effects of maternal and lactational exposure to 2-hydroxy-4-methoxybenzone on development and reproductive organs in male and female rat offspring. Birth Defects Res B Dev Reprod Toxicol (2015) 0.76
Cumulative and antagonistic effects of a mixture of the antiandrogens vinclozolin and iprodione in the pubertal male rat. Toxicol Sci (2009) 0.76
Modelling defined mixtures of environmental oestrogens found in domestic animal and sewage treatment effluents using an in vitro oestrogen-mediated transcriptional activation assay (T47D-KBluc). Int J Androl (2012) 0.76
Differences in sensitivity but not selectivity of xenoestrogen binding to alligator versus human estrogen receptor alpha. Environ Toxicol Chem (2010) 0.76
Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 mice. Food Chem Toxicol (2011) 0.75
Macrocyclic architecture: tuning cavity size and shape through maleimide photochemistry. Chemistry (2012) 0.75
A truncation in the aryl hydrocarbon receptor of the CRL:WI(Han) rat does not affect the developmental toxicity of TCDD. Toxicol Sci (2008) 0.75
Beyond equivalence of care in prison pharmacy. Int J Pharm Pract (2014) 0.75