Published in J Neurosci Res on May 01, 2007
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest (2012) 2.98
The Alzheimer's disease beta-secretase enzyme, BACE1. Mol Neurodegener (2007) 1.81
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis (2009) 1.60
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest (2012) 1.32
The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis. J Neuroinflammation (2011) 1.26
Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation (2010) 1.25
Interactions between APP secretases and inflammatory mediators. J Neuroinflammation (2008) 1.14
A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation. FASEB J (2009) 1.12
BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's disease. Mol Neurodegener (2012) 1.11
Central angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats. PLoS One (2011) 1.08
Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations. J Biol Chem (2012) 1.01
Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway. Biochim Biophys Acta (2014) 1.00
Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. J Neuroinflammation (2012) 0.96
Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1. J Neurosci (2012) 0.95
Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-β generation and inflammatory reactions via inhibition of NF-κB and STAT3 activation in cultured astrocytes and microglial BV-2 cells. J Neuroinflammation (2011) 0.95
MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects. J Biol Chem (2013) 0.93
Beta-secretase: structure, function, and evolution. CNS Neurol Disord Drug Targets (2008) 0.92
Iron and mechanisms of neurotoxicity. Int J Alzheimers Dis (2010) 0.91
The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease. Curr Genomics (2007) 0.90
Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease. Mediators Inflamm (2015) 0.89
Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ1-42-infused mouse model of Alzheimer's disease. Cell Death Dis (2013) 0.87
Nitric oxide in neurodegeneration: potential benefits of non-steroidal anti-inflammatories. Neurosci Bull (2011) 0.87
Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases. Neurobiol Aging (2012) 0.86
Astrocyte signaling and neurodegeneration: new insights into CNS disorders. Prion (2012) 0.86
Is RAGE still a therapeutic target for Alzheimer's disease? Future Med Chem (2012) 0.86
Genetics ignite focus on microglial inflammation in Alzheimer's disease. Mol Neurodegener (2015) 0.85
Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation. Acta Pharmacol Sin (2013) 0.84
Trientine reduces BACE1 activity and mitigates amyloidosis via the AGE/RAGE/NF-κB pathway in a transgenic mouse model of Alzheimer's disease. Antioxid Redox Signal (2013) 0.83
Leptin regulates amyloid β production via the γ-secretase complex. Biochim Biophys Acta (2012) 0.83
Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein. PLoS One (2013) 0.81
Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1. Neurobiol Aging (2008) 0.81
Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer's disease mice model. J Neuroinflammation (2013) 0.81
Interaction of transactive response DNA binding protein 43 with nuclear factor κB in mild cognitive impairment with episodic memory deficits. Acta Neuropathol Commun (2014) 0.80
Transcriptional regulation and its misregulation in Alzheimer's disease. Mol Brain (2013) 0.79
The normal and pathologic roles of the Alzheimer's β-secretase, BACE1. Curr Alzheimer Res (2014) 0.78
Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes. Exp Neurol (2013) 0.78
Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα. Hum Mol Genet (2014) 0.77
CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase. Aging Cell (2015) 0.77
Two novel DNA motifs are essential for BACE1 gene transcription. Sci Rep (2014) 0.76
Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol. Biomol Ther (Seoul) (2014) 0.76
Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1β-stimulated SK-N-SH cells. Eur J Nutr (2015) 0.76
All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of nuclear factor κB (NFκB) signaling. J Biol Chem (2015) 0.75
Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain. J Biol Chem (2016) 0.75
Neuronal Gene Targets of NF-κB and Their Dysregulation in Alzheimer's Disease. Front Mol Neurosci (2016) 0.75
Palmitate Increases β-site AβPP-Cleavage Enzyme 1 Activity and Amyloid-β Genesis by Evoking Endoplasmic Reticulum Stress and Subsequent C/EBP Homologous Protein Activation. J Alzheimers Dis (2017) 0.75
Uncovering the Molecular Mechanism of Actions between Pharmaceuticals and Proteins on the AD Network. PLoS One (2015) 0.75
TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol (2005) 3.92
Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. Science (2014) 3.44
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J (2010) 2.35
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. Proc Natl Acad Sci U S A (2006) 2.17
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med (2008) 2.01
Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch (2007) 1.81
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci U S A (2006) 1.81
Negevirus: a proposed new taxon of insect-specific viruses with wide geographic distribution. J Virol (2012) 1.67
Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia. Am J Physiol Heart Circ Physiol (2008) 1.61
Comparison of the live attenuated yellow fever vaccine 17D-204 strain to its virulent parental strain Asibi by deep sequencing. J Infect Dis (2013) 1.51
IGF-I gene transfer effects on inflammatory elements present after thermal trauma. Am J Physiol Regul Integr Comp Physiol (2003) 1.43
Transcriptional profiling of spinal cord injury-induced central neuropathic pain. J Neurochem (2005) 1.31
Characterization of a novel Negevirus and a novel Bunyavirus isolated from Culex (Culex) declarator mosquitoes in Trinidad. J Gen Virol (2013) 1.26
P2X7 receptor expression after ischemia in the cerebral cortex of rats. J Neuropathol Exp Neurol (2004) 1.21
Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent. Glia (2003) 1.19
NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42. J Biol Chem (2008) 1.19
Protective effects of bone marrow stromal cell transplantation in injured rodent brain: synthesis of neurotrophic factors. J Neurosci Res (2005) 1.16
Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics (2003) 1.13
Human polymorphic variants of the NEIL1 DNA glycosylase. J Biol Chem (2007) 1.10
The transcription factor Yin Yang 1 is an activator of BACE1 expression. J Neurochem (2006) 1.08
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation. J Neurosci (2011) 1.08
Poly(ADP-ribose) polymerase inhibition prevents both apoptotic-like delayed neuronal death and necrosis after H(2)O(2) injury. J Neurochem (2002) 1.06
Gene expression patterns in skeletal muscle of thermally injured children treated with oxandrolone. Ann Surg (2003) 1.04
Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia. Eur J Neurosci (2005) 1.03
Activation of nuclear factor-kappaB signaling pathway by interleukin-1 after hypoxia/ischemia in neonatal rat hippocampus and cortex. J Neurochem (2005) 1.03
Quantification of activated NF-kappaB/RelA complexes using ssDNA aptamer affinity-stable isotope dilution-selected reaction monitoring-mass spectrometry. Mol Cell Proteomics (2011) 1.02
Extracellular superoxide concentration increases following cerebral hypoxia but does not affect cerebral blood flow. Int J Dev Neurosci (2004) 1.01
Human metapneumovirus M2-2 protein inhibits innate cellular signaling by targeting MAVS. J Virol (2012) 1.00
Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways. J Neurosci (2012) 0.97
Decomposition and long-lasting downregulation of extracellular matrix in perineuronal nets induced by focal cerebral ischemia in rats. J Neurosci Res (2005) 0.97
Identification of critical residues required for the mutation avoidance function of human MutY (hMYH) and implications in colorectal cancer. Cancer Lett (2004) 0.97
Kolente virus, a rhabdovirus species isolated from ticks and bats in the Republic of Guinea. J Gen Virol (2013) 0.97
CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133- cells. Lab Invest (2011) 0.97
Mechanisms and effects of seizures in the immature brain. Semin Fetal Neonatal Med (2013) 0.96
Proteomic analysis of hypoxia/ischemia-induced alteration of cortical development and dopamine neurotransmission in neonatal rat. J Proteome Res (2006) 0.96
Nuclear factor-kappaB decoy amelioration of spinal cord injury-induced inflammation and behavior outcomes. J Neurosci Res (2008) 0.96
NH2 terminus of PTB-associated splicing factor binds to the porcine P450scc IGF-I response element. Am J Physiol Endocrinol Metab (2002) 0.96
Bcl-2 family members make different contributions to cell death in hypoxia and/or hyperoxia in rat cerebral cortex. Int J Dev Neurosci (2003) 0.95
Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme. J Neurochem (2005) 0.95
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms. Acta Neuropathol (2011) 0.95
Niakha virus: a novel member of the family Rhabdoviridae isolated from phlebotomine sandflies in Senegal. Virology (2013) 0.94
Gene networks in glucocorticoid-evoked apoptosis of leukemic cells. J Steroid Biochem Mol Biol (2003) 0.94
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms. J Neurosci (2010) 0.94
Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion. J Neurochem (2005) 0.94
Gene expression profile of mouse white adipose tissue during inflammatory stress: age-dependent upregulation of major procoagulant factors. Aging Cell (2013) 0.93
Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo. Neurochem Res (2003) 0.92
Arboretum and Puerto Almendras viruses: two novel rhabdoviruses isolated from mosquitoes in Peru. J Gen Virol (2014) 0.92
Systems approaches to modeling chronic mucosal inflammation. Biomed Res Int (2013) 0.91
Cloning and expression of the rat BACE1 promoter. J Neurosci Res (2003) 0.91
Expression of an IKKgamma splice variant determines IRF3 and canonical NF-kappaB pathway utilization in ssRNA virus infection. PLoS One (2009) 0.90
Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake. Brain Res (2011) 0.90
Pioglitazone protects the myocardium against ischemia-reperfusion injury in eNOS and iNOS knockout mice. Am J Physiol Heart Circ Physiol (2008) 0.89
Debate: "is increasing neuroinflammation beneficial for neural repair?". J Neuroimmune Pharmacol (2006) 0.89
Gene expression analysis in burn wounds of rats. Am J Physiol Regul Integr Comp Physiol (2002) 0.89
Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies. Biochemistry (2011) 0.88
Immortalization and characterization of human myometrial cells from term-pregnant patients using a telomerase expression vector. Mol Hum Reprod (2004) 0.88
Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain. Int J Dev Neurosci (2009) 0.88
Mesoniviruses are mosquito-specific viruses with extensive geographic distribution and host range. Virol J (2014) 0.87
Biphasic changes in the levels of poly(ADP-ribose) polymerase-1 and caspase 3 in the immature brain following hypoxia-ischemia. Int J Dev Neurosci (2005) 0.87
Prenatal hypoxia down regulates the GABA pathway in newborn mice cerebral cortex; partial protection by MgSO4. Int J Dev Neurosci (2007) 0.86
Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. Am J Physiol Endocrinol Metab (2011) 0.86
Bax shuttling after neonatal hypoxia-ischemia: hyperoxia effects. J Neurosci Res (2008) 0.86
First isolation of Aedes flavivirus in the Western Hemisphere and evidence of vertical transmission in the mosquito Aedes (Stegomyia) albopictus (Diptera: Culicidae). Virology (2013) 0.86
BACE1 is a newly discovered protein secreted by the pancreas which cleaves enteropeptidase in vitro. JOP (2009) 0.85
Impaired migration signaling in the hippocampus following prenatal hypoxia. Neuropharmacology (2009) 0.85
Itaya virus, a Novel Orthobunyavirus Associated with Human Febrile Illness, Peru. Emerg Infect Dis (2015) 0.85
Bax shuttling after rotenone treatment of neuronal primary cultures: effects on cell death phenotypes. J Neurosci Res (2009) 0.84
Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. Acta Neuropathol (2010) 0.83
The association of early blood oxygenation with child development in preterm infants with acute respiratory disorders. Int J Dev Neurosci (2007) 0.83
Malpais spring virus is a new species in the genus vesiculovirus. Virol J (2013) 0.82
Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression. Obesity (Silver Spring) (2013) 0.82
IGF-1 controls GLUT3 expression in muscle via the transcriptional factor Sp1. Biochim Biophys Acta (2007) 0.82
Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK. Am J Physiol Gastrointest Liver Physiol (2010) 0.82
Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling. J Neurosci Res (2004) 0.82
Long-term histological outcome after post-hypoxic treatment with 100% or 40% oxygen in a model of perinatal hypoxic-ischemic brain injury. Int J Dev Neurosci (2007) 0.82
Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing. J Biol Chem (2004) 0.82
Effects of NF-kappaB oligonucleotide "decoys" on gene expression in P7 rat hippocampus after hypoxia/ischemia. J Neurosci Res (2004) 0.82
Ginkgolide B revamps neuroprotective role of apurinic/apyrimidinic endonuclease 1 and mitochondrial oxidative phosphorylation against Aβ25-35 -induced neurotoxicity in human neuroblastoma cells. J Neurosci Res (2015) 0.81
Toxicity mediated by soluble oligomers of beta-amyloid(1-42) on cholinergic SN56.B5.G4 cells. J Neurochem (2006) 0.81
Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. Prostaglandins Other Lipid Mediat (2007) 0.81
Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity. Eur J Neurosci (2007) 0.81
Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development. J Biol Chem (2011) 0.81
Fetal origin of adverse pregnancy outcome: the water disinfectant by-product chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal brain. Brain Res Dev Brain Res (2005) 0.81
Prolyl oligopeptidase: a rising star on the stage of neuroinflammation research. CNS Neurol Disord Drug Targets (2011) 0.80
Oxygen resuscitation does not ameliorate neonatal hypoxia/ischemia-induced cerebral edema. J Neurosci Res (2010) 0.80
A decoy oligonucleotide inhibiting nuclear factor-kappaB binding to the IgGkappaB consensus site reduces cerebral injury and apoptosis in neonatal hypoxic-ischemic encephalopathy. J Neurosci Res (2007) 0.80
Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway. J Neuroinflammation (2011) 0.80
Interaction of exogenous liposomal insulin-like growth factor-I cDNA gene transfer with growth factors on collagen expression in acute wounds. Wound Repair Regen (2005) 0.80
Neuronal trauma model: in search of Thanatos. Int J Dev Neurosci (2004) 0.80
Molecular characterization of an inward rectifier channel (IKir) found in avian vestibular hair cells: cloning and expression of pKir2.1. Physiol Genomics (2004) 0.80
Oxygen/glucose deprivation increases the integration of recombinant P2X7 receptors into the plasma membrane of HEK293 cells. Toxicology (2007) 0.79
Cloning, characterization, and expression of the rat relaxin gene. Gene (2003) 0.79
Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins. J Neurochem (2005) 0.79
Bax-an emerging role in ectopic cell death. Int J Dev Neurosci (2009) 0.79