Published in J Am Chem Soc on March 27, 2007
Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase. Structure (2010) 2.33
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14
Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol (2009) 1.61
Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins. Prog Nucl Magn Reson Spectrosc (2009) 1.57
Constructing ensembles for intrinsically disordered proteins. Curr Opin Struct Biol (2011) 1.44
How random are intrinsically disordered proteins? A small angle scattering perspective. Curr Protein Pept Sci (2012) 1.37
Intrinsic disorder in measles virus nucleocapsids. Proc Natl Acad Sci U S A (2011) 1.27
Modeling intrinsically disordered proteins with bayesian statistics. J Am Chem Soc (2010) 1.20
Structural characterization of alpha-synuclein in an aggregation prone state. Protein Sci (2009) 1.18
Structural biology by NMR: structure, dynamics, and interactions. PLoS Comput Biol (2008) 1.07
Adaptive Accelerated Molecular Dynamics (Ad-AMD) Revealing the Molecular Plasticity of P450cam. J Phys Chem Lett (2011) 1.07
Quantitative determination of site-specific conformational distributions in an unfolded protein by solid-state nuclear magnetic resonance. J Mol Biol (2009) 1.06
ProtSA: a web application for calculating sequence specific protein solvent accessibilities in the unfolded ensemble. BMC Bioinformatics (2009) 1.01
Multiscale ensemble modeling of intrinsically disordered proteins: p53 N-terminal domain. Biophys J (2011) 0.99
The conformational ensembles of α-synuclein and tau: combining single-molecule FRET and simulations. Biophys J (2012) 0.98
Disease-associated mutations disrupt functionally important regions of intrinsic protein disorder. PLoS Comput Biol (2012) 0.97
Improvement and analysis of computational methods for prediction of residual dipolar couplings. J Magn Reson (2009) 0.95
The effect of a DeltaK280 mutation on the unfolded state of a microtubule-binding repeat in Tau. PLoS Comput Biol (2008) 0.93
What can solid state NMR contribute to our understanding of protein folding? Biophys Chem (2010) 0.91
Competing interactions stabilize pro- and anti-aggregant conformations of human Tau. J Biol Chem (2011) 0.90
A self-consistent description of the conformational behavior of chemically denatured proteins from NMR and small angle scattering. Biophys J (2009) 0.89
A maximum entropy approach to the study of residue-specific backbone angle distributions in α-synuclein, an intrinsically disordered protein. Protein Sci (2014) 0.88
Dynamical coupling of intrinsically disordered proteins and their hydration water: comparison with folded soluble and membrane proteins. Biophys J (2012) 0.87
Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide. J Chem Phys (2013) 0.87
Accelerating chemical reactions: exploring reactive free-energy surfaces using accelerated ab initio molecular dynamics. J Chem Phys (2011) 0.86
Using intramolecular disulfide bonds in tau protein to deduce structural features of aggregation-resistant conformations. J Biol Chem (2012) 0.84
Impact of hydrostatic pressure on an intrinsically disordered protein: a high-pressure NMR study of α-synuclein. Chembiochem (2013) 0.83
CHARMM36m: an improved force field for folded and intrinsically disordered proteins. Nat Methods (2016) 0.83
Local order in the unfolded state: conformational biases and nearest neighbor interactions. Biomolecules (2014) 0.82
Binding of the three-repeat domain of tau to phospholipid membranes induces an aggregated-like state of the protein. Biochim Biophys Acta (2012) 0.82
Structural transitions in tau k18 on micelle binding suggest a hierarchy in the efficacy of individual microtubule-binding repeats in filament nucleation. Protein Sci (2013) 0.81
Challenge of large-scale motion for residual dipolar coupling based analysis of configuration: the case of fibrosterol sulfate A. J Am Chem Soc (2011) 0.80
Finding Our Way in the Dark Proteome. J Am Chem Soc (2016) 0.80
Mechanisms of amyloid formation revealed by solution NMR. Prog Nucl Magn Reson Spectrosc (2015) 0.80
The Effects of Regularly Spaced Glutamine Substitutions on Alpha-Helical Peptide Structures. A DFT/ONIOM Study. Chem Phys Lett (2011) 0.79
Synergistic applications of MD and NMR for the study of biological systems. J Biomed Biotechnol (2012) 0.79
The dynamic duo: combining NMR and small angle scattering in structural biology. Protein Sci (2014) 0.79
A flash in the pan: dissecting dynamic amyloid intermediates using fluorescence. FEBS Lett (2013) 0.78
New opportunities for tensor-free calculations of residual dipolar couplings for the study of protein dynamics. J Biomol NMR (2014) 0.76
A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein. Biochemistry (2014) 0.76
Interconnection of salt-induced hydrophobic compaction and secondary structure formation depends on solution conditions: revisiting early events of protein folding at single molecule resolution. J Biol Chem (2012) 0.76
Integrating solid-state NMR and computational modeling to investigate the structure and dynamics of membrane-associated ghrelin. PLoS One (2015) 0.76
Probing the urea dependence of residual structure in denatured human alpha-lactalbumin. J Biomol NMR (2009) 0.76
Formation, release, and internalization of stable tau oligomers in cells. J Neurochem (2016) 0.75
Signature of an aggregation-prone conformation of tau. Sci Rep (2017) 0.75
Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science (2008) 8.04
Structural characterization of flexible proteins using small-angle X-ray scattering. J Am Chem Soc (2007) 6.53
Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Proc Natl Acad Sci U S A (2005) 3.48
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum Mol Genet (2009) 2.69
Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A (2008) 2.69
Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci (2010) 2.66
Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med (2012) 2.39
VDAC, a multi-functional mitochondrial protein regulating cell life and death. Mol Aspects Med (2010) 2.36
Identification of slow correlated motions in proteins using residual dipolar and hydrogen-bond scalar couplings. Proc Natl Acad Sci U S A (2005) 2.35
A structural model for unfolded proteins from residual dipolar couplings and small-angle x-ray scattering. Proc Natl Acad Sci U S A (2005) 2.28
Mars -- robust automatic backbone assignment of proteins. J Biomol NMR (2004) 2.22
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14
β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons. Ann Neurol (2013) 2.10
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. EMBO J (2009) 2.09
NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA. Proc Natl Acad Sci U S A (2006) 2.05
Exploring multiple timescale motions in protein GB3 using accelerated molecular dynamics and NMR spectroscopy. J Am Chem Soc (2007) 2.04
Atomic model of the type III secretion system needle. Nature (2012) 2.02
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein. J Biol Chem (2008) 1.94
Single-molecule investigation of the interference between kinesin, tau and MAP2c. EMBO J (2002) 1.91
Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs. J Biol Chem (2005) 1.79
The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. J Neurosci (2008) 1.78
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Mol Biol Cell (2002) 1.76
Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings. J Am Chem Soc (2005) 1.75
MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J (2003) 1.75
Global hairpin folding of tau in solution. Biochemistry (2006) 1.69
Model-free analysis of protein backbone motion from residual dipolar couplings. J Am Chem Soc (2002) 1.65
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. J Biol Chem (2004) 1.62
A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA. J Mol Biol (2008) 1.61
Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol (2009) 1.61
Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem (2009) 1.57
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. J Neurosci (2011) 1.57
Toward a unified representation of protein structural dynamics in solution. J Am Chem Soc (2009) 1.55
Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. J Biol Chem (2005) 1.54
Dissociation of amyloid fibrils of alpha-synuclein in supercooled water. Angew Chem Int Ed Engl (2008) 1.51
Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter. Nat Struct Mol Biol (2011) 1.51
Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 1.50
"Lest we forget you--methylene blue...". Neurobiol Aging (2011) 1.50
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons. J Cell Biol (2004) 1.49
Tau protein and tau aggregation inhibitors. Neuropharmacology (2010) 1.48
Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd. EMBO J (2002) 1.48
The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli. J Biol Chem (2003) 1.48
Swimming against the tide: mobility of the microtubule-associated protein tau in neurons. J Neurosci (2007) 1.47
Tau aggregation is driven by a transition from random coil to beta sheet structure. Biochim Biophys Acta (2004) 1.47
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci (2010) 1.46
Weak long-range correlated motions in a surface patch of ubiquitin involved in molecular recognition. J Am Chem Soc (2011) 1.45
A thermodynamic switch modulates abscisic acid receptor sensitivity. EMBO J (2011) 1.44
NMR characterization of long-range order in intrinsically disordered proteins. J Am Chem Soc (2010) 1.43
Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus. J Biol Chem (2008) 1.42
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation. EMBO J (2004) 1.41
Protein conformational flexibility from structure-free analysis of NMR dipolar couplings: quantitative and absolute determination of backbone motion in ubiquitin. Angew Chem Int Ed Engl (2009) 1.38
The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem (2007) 1.37
Structural properties of pore-forming oligomers of alpha-synuclein. J Am Chem Soc (2009) 1.36
Protein refolding is required for assembly of the type three secretion needle. Nat Struct Mol Biol (2010) 1.36
Modulation of kinesin binding by the C-termini of tubulin. EMBO J (2004) 1.35
A thorough dynamic interpretation of residual dipolar couplings in ubiquitin. J Biomol NMR (2006) 1.34
Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation. J Biol Chem (2008) 1.34
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol (2013) 1.34
Self-consistent residual dipolar coupling based model-free analysis for the robust determination of nanosecond to microsecond protein dynamics. J Biomol NMR (2008) 1.33
Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings. Structure (2009) 1.33
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration. EMBO J (2011) 1.32
Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease? ChemMedChem (2008) 1.32
Nucleotide-induced conformations in the neck region of dimeric kinesin. EMBO J (2003) 1.32
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin. EMBO J (2013) 1.31
The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments. Biochemistry (2008) 1.31
Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation. J Biol Chem (2005) 1.30