Published in Proc Natl Acad Sci U S A on January 25, 2005
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Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy. J Mol Biol (2009) 2.14
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Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 1.50
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci (2010) 1.46
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Temperature-induced reversible conformational change in the first 100 residues of alpha-synuclein. Protein Sci (2006) 1.14
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E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein. J Mol Biol (2009) 1.05
Tryptophan probes at the alpha-synuclein and membrane interface. J Phys Chem B (2010) 1.05
Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem (2010) 1.04
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Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants. PLoS One (2010) 0.96
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Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation. J Am Chem Soc (2012) 0.95
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Monomeric α-synuclein binds Congo Red micelles in a disordered manner. Biochemistry (2012) 0.95
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Effect of pseudorepeat rearrangement on alpha-synuclein misfolding, vesicle binding, and micelle binding. J Mol Biol (2009) 0.95
Specificity and kinetics of alpha-synuclein binding to model membranes determined with fluorescent excited state intramolecular proton transfer (ESIPT) probe. J Biol Chem (2011) 0.94
NMR determination of pKa values in α-synuclein. Protein Sci (2010) 0.94
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice. Hum Mol Genet (2014) 0.94
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The influence of vesicle size and composition on alpha-synuclein structure and stability. Biophys J (2009) 0.93
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Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments. J Biol Inorg Chem (2006) 0.92
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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PLoS One (2014) 0.92
The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17. Phys Chem Chem Phys (2011) 0.90
Competing interactions stabilize pro- and anti-aggregant conformations of human Tau. J Biol Chem (2011) 0.90
Methionine oxidation stabilizes non-toxic oligomers of alpha-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions. Biochim Biophys Acta (2009) 0.90
Ribosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products. PLoS One (2010) 0.90
The A53T mutation is key in defining the differences in the aggregation kinetics of human and mouse α-synuclein. J Am Chem Soc (2011) 0.90
Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders. ACS Chem Neurosci (2011) 0.90
3D J-resolved NMR spectroscopy for unstructured polypeptides: fast measurement of 3J HNH alpha coupling constants with outstanding spectral resolution. J Biomol NMR (2009) 0.90
Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: implications for the aggregation process. Protein Sci (2006) 0.89
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Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein. J Mol Biol (2011) 0.89
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A maximum entropy approach to the study of residue-specific backbone angle distributions in α-synuclein, an intrinsically disordered protein. Protein Sci (2014) 0.88
Residue-specific fluorescent probes of α-synuclein: detection of early events at the N- and C-termini during fibril assembly. Biochemistry (2011) 0.88
Mechanism of alpha-synuclein oligomerization and membrane interaction: theoretical approach to unstructured proteins studies. Nanomedicine (2008) 0.88
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