Published in J Phys Chem B on February 28, 2007
Applications of 2D IR spectroscopy to peptides, proteins, and hydrogen-bond dynamics. J Phys Chem B (2009) 1.54
Equilibrium exchange processes of the aqueous tryptophan dipeptide. J Phys Chem B (2009) 0.82
Wide-field subdiffraction imaging by accumulated binding of diffusing probes. Proc Natl Acad Sci U S A (2006) 4.33
Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature (2005) 2.90
Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120. Structure (2008) 2.74
Two-dimensional infrared spectroscopy of the alanine dipeptide in aqueous solution. J Phys Chem B (2005) 2.52
Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins. Proc Natl Acad Sci U S A (2004) 2.44
Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state. PLoS Pathog (2009) 2.34
Oxygen microscopy by two-photon-excited phosphorescence. Chemphyschem (2008) 2.17
Chemical exchange 2D IR of hydrogen-bond making and breaking. Proc Natl Acad Sci U S A (2005) 2.09
Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry (2006) 1.99
Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents. Cancer Biol Ther (2004) 1.71
Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Abeta40. Proc Natl Acad Sci U S A (2008) 1.63
Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase. Proc Natl Acad Sci U S A (2007) 1.61
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J Neurosci (2010) 1.60
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci (2012) 1.60
Applications of 2D IR spectroscopy to peptides, proteins, and hydrogen-bond dynamics. J Phys Chem B (2009) 1.54
Phosphorescent oxygen sensor with dendritic protection and two-photon absorbing antenna. J Am Chem Soc (2005) 1.49
2D IR provides evidence for mobile water molecules in beta-amyloid fibrils. Proc Natl Acad Sci U S A (2009) 1.49
Two-dimensional infrared spectra of the 13C=18O isotopomers of alanine residues in an alpha-helix. J Phys Chem B (2005) 1.47
Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity. PLoS Pathog (2011) 1.47
Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155. J Virol (2004) 1.35
Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors. J Med Chem (2012) 1.29
Dynamics of amide-I modes of the alanine dipeptide in D2O. J Phys Chem B (2005) 1.29
Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. Biochemistry (2009) 1.28
Dual-frequency 2D-IR spectroscopy heterodyned photon echo of the peptide bond. Proc Natl Acad Sci U S A (2003) 1.27
Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy. Proc Natl Acad Sci U S A (2011) 1.27
Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase. Nat Chem (2013) 1.24
Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain. J Virol (2009) 1.23
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. Pharmacol Res (2010) 1.20
Identification of novel inhibitors of dietary lipid absorption using zebrafish. PLoS One (2010) 1.20
The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell Cycle (2005) 1.19
Interactions of halichondrin B and eribulin with tubulin. J Chem Inf Model (2011) 1.19
Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments. Expert Opin Pharmacother (2005) 1.18
Seeing the light: preassembly and ligand-induced changes of the interferon gamma receptor complex in cells. Mol Cell Proteomics (2002) 1.18
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors. J Med Chem (2003) 1.18
2D-IR experiments and simulations of the coupling between amide-I and ionizable side chains in proteins: application to the Villin headpiece. J Phys Chem B (2009) 1.17
Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer. Proc Natl Acad Sci U S A (2006) 1.17
Residue-specific vibrational echoes yield 3D structures of a transmembrane helix dimer. Science (2011) 1.17
Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies. J Med Chem (2012) 1.17
Vibrational coupling, isotopic editing, and beta-sheet structure in a membrane-bound polypeptide. J Am Chem Soc (2004) 1.15
Total syntheses of (+)-lyconadin A and (-)-lyconadin B. J Am Chem Soc (2007) 1.15
2D IR photon echo of azido-probes for biomolecular dynamics. Phys Chem Chem Phys (2010) 1.15
The Two Dimensional Vibrational Echo of a Nitrile Probe of the Villin HP35 Protein. J Phys Chem Lett (2010) 1.15
Energy and electron transfer in enhanced two-photon-absorbing systems with triplet cores. J Phys Chem A (2007) 1.14
Ultrafast vibrational spectroscopy of a degenerate mode of guanidinium chloride. J Phys Chem B (2009) 1.10
Nature of structural inhomogeneities on folding a helix and their influence on spectral measurements. Proc Natl Acad Sci U S A (2004) 1.10
Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice. Clin Cancer Res (2006) 1.09
Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus. J Med Chem (2007) 1.08
Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicol Appl Pharmacol (2009) 1.08
Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors. Exp Neurol (2009) 1.08
Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1. J Med Chem (2008) 1.07
Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening. Bioorg Med Chem (2010) 1.06
Ultrafast relaxation and 2D IR of the aqueous trifluorocarboxylate ion. J Chem Phys (2010) 1.06
Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation. J Med Chem (2010) 1.06
Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization. ACS Med Chem Lett (2013) 1.05
Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau. J Neurochem (2009) 1.05
Identification of a human immunodeficiency virus type 1 envelope glycoprotein variant resistant to cold inactivation. J Virol (2009) 1.05
Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal. J Neurosci (2011) 1.05
Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist. Acc Chem Res (2014) 1.04
Local structure of beta-hairpin isotopomers by FTIR, 2D IR, and ab initio theory. J Phys Chem B (2006) 1.04
Probing lipid vesicles by bimolecular association and dissociation trajectories of single molecules. J Am Chem Soc (2006) 1.04
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells. Mol Pharmacol (2010) 1.03
Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies. J Med Chem (2014) 1.03
2D IR photon echo spectroscopy reveals hydrogen bond dynamics of aromatic nitriles. Chem Phys Lett (2009) 1.03
Human cytosolic extracts stabilize the HIV-1 core. J Virol (2013) 1.03
Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays. Bioorg Med Chem Lett (2007) 1.02
Correlation of the vibrations of the aqueous azide ion with the O-H modes of bound water molecules. J Phys Chem B (2007) 1.02
Tetrazine phototriggers: probes for peptide dynamics. Angew Chem Int Ed Engl (2010) 1.01
Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. Clin Cancer Res (2005) 1.01
Controlled bimolecular collisions allow sub-diffraction limited microscopy of lipid vesicles. Phys Chem Chem Phys (2006) 1.00
Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L. Mol Pharmacol (2008) 1.00
Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg Med Chem Lett (2007) 0.99
Water-induced relaxation of a degenerate vibration of guanidinium using 2D IR echo spectroscopy. J Phys Chem B (2010) 0.99
Identification of arginine residues in peptides by 2D-IR echo spectroscopy. J Phys Chem A (2011) 0.99
Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid. J Virol (2012) 0.98
Techniques: spectroscopy at a stretch. Nature (2005) 0.98
Preassembly and ligand-induced restructuring of the chains of the IFN-gamma receptor complex: the roles of Jak kinases, Stat1 and the receptor chains. Cell Res (2006) 0.98
Carboxylic acid (bio)isosteres in drug design. ChemMedChem (2013) 0.97
A unified synthetic strategy to the Cryptocarya family of natural products exploiting Anion Relay Chemistry (ARC). Org Lett (2013) 0.96
Multicomponent type II anion relay chemistry (ARC): one-pot syntheses of 2,3-disubstituted furans and thiophenes. Org Lett (2009) 0.96
Toward understanding how the lactone moiety of discodermolide affects activity. J Am Chem Soc (2005) 0.96
Some binding-related drug properties are dependent on thermodynamic signature. Chem Biol Drug Des (2011) 0.96
Dynamic structures of aqueous oxalate and the effects of counterions seen by 2D IR. Phys Chem Chem Phys (2012) 0.96
A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin. Biochemistry (2006) 0.95
Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation. J Biol Chem (2013) 0.95
Pyrrolinone-based peptidomimetics. "Let the enzyme or receptor be the judge". Acc Chem Res (2010) 0.94
Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization. Biochemistry (2009) 0.94
Motions of single molecules and proteins in trehalose glass. J Am Chem Soc (2003) 0.94
Comparison of linear and 2D IR spectra in the presence of fast exchange. J Phys Chem B (2006) 0.94
Anthracene-BODIPY cassettes: syntheses and energy transfer. Chemistry (2003) 0.93
An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors. PLoS One (2011) 0.93
Two-dimensional infrared spectroscopy displays signatures of structural ordering in peptide aggregates. Biophys J (2006) 0.92
Two-dimensional infrared spectral signature and hydration of the oxalate dianion. J Chem Phys (2011) 0.92
Three-dimensional structures by two-dimensional vibrational spectroscopy. Acc Chem Res (2012) 0.91
Interactions among the components of the interleukin-10 receptor complex. Biochem Biophys Res Commun (2005) 0.91
Molecular docking of cathepsin L inhibitors in the binding site of papain. J Chem Inf Model (2008) 0.91
Access to the akuammiline family of alkaloids: total synthesis of (+)-scholarisine A. J Am Chem Soc (2012) 0.90
Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies. Bioorg Med Chem Lett (2007) 0.90