PubRank

Geoffrey P Margison

Author PubWeight™ 49.93‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells. Mol Ther 2005 1.82
2 Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature 2009 1.70
3 Mycoplasma infection significantly alters microarray gene expression profiles. Biotechniques 2003 1.66
4 Tumor radiosensitizers--current status of development of various approaches: report of an International Atomic Energy Agency meeting. Int J Radiat Oncol Biol Phys 2006 1.48
5 Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res 2006 1.45
6 Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI. Virol J 2006 1.38
7 Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1. Clin Cancer Res 2005 1.37
8 Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma. J Clin Oncol 2007 1.29
9 Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients. J Clin Invest 2011 1.27
10 O6-Methylguanine-DNA methyltransferase inactivation and chemotherapy. Br Med Bull 2008 1.21
11 A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer. Int J Cancer 2002 1.20
12 Targeting O⁶-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy. Cell Mol Life Sci 2010 1.20
13 Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway. Lancet Oncol 2003 1.12
14 Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells. Carcinogenesis 2007 1.04
15 A novel DNA damage recognition protein in Schizosaccharomyces pombe. Nucleic Acids Res 2006 0.98
16 Inhibition of O6-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli. Nucleic Acids Res 2005 0.97
17 Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4. Mol Ther 2004 0.94
18 Dual repair modulation reverses Temozolomide resistance in vitro. Mol Cancer Ther 2004 0.94
19 Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. Cancer Res 2008 0.92
20 Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model. Int J Cancer 2002 0.90
21 DNA alkylation and repair in the large bowel: animal and human studies. J Nutr 2002 0.90
22 Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT). Nucleic Acids Res 2006 0.90
23 Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. Mol Cell 2012 0.90
24 Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions. Proc Natl Acad Sci U S A 2012 0.89
25 Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria. Am J Pathol 2011 0.89
26 Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide. Hum Gene Ther 2004 0.88
27 Convenient and efficient syntheses of oligodeoxyribonucleotides containing O(6)-(carboxymethyl)guanine and O(6)-(4-oxo-4-(3-pyridyl)butyl)guanine. Nucleosides Nucleotides Nucleic Acids 2012 0.87
28 Elevated N3-methylpurine-DNA glycosylase DNA repair activity is associated with lung cancer. Mutat Res 2012 0.86
29 Reduced MGMT activity in human colorectal adenomas is associated with K-ras GC->AT transition mutations in a population exposed to methylating agents. Carcinogenesis 2004 0.85
30 Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib. Clin Cancer Res 2010 0.85
31 Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase. Int J Cancer 2008 0.84
32 The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase. Nucleic Acids Res 2013 0.83
33 Bladder tumor contains higher N7-methylguanine levels in DNA than adjacent normal bladder epithelium. Cancer Epidemiol Biomarkers Prev 2006 0.83
34 Associations between tissue-specific DNA alkylation, DNA repair and cell proliferation in the colon and colon tumour yield in mice treated with 1,2-dimethylhydrazine. Carcinogenesis 2003 0.83
35 Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis. Mutat Res 2013 0.83
36 The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine. J Gene Med 2006 0.82
37 Heterogeneity of O(6)-alkylguanine-DNA alkyltransferase activity in colorectal cancer: implications for treatment. Oncology 2002 0.81
38 Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. Cancer Prev Res (Phila) 2010 0.81
39 Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase. Mol Cancer Ther 2004 0.80
40 Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer. Int J Cancer 2003 0.79
41 Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O6-methyl-2'-deoxyguanosine and their recognition by MGMT and Atl1. Chem Commun (Camb) 2012 0.78
42 Smoking is associated with a decrease of O6-alkylguanine-DNA alkyltransferase activity in bronchial epithelial cells. Int J Cancer 2006 0.77
43 Dual agent chemoprotection by retroviral co-expression of either MDR1 or MRP1 with the P140K mutant of O6-methylguanine-DNA-methyl transferase. J Gene Med 2006 0.77
44 Lung cancer risk and variation in MGMT activity and sequence. DNA Repair (Amst) 2007 0.77
45 GSTM1 copy number and lung cancer risk. Mutat Res 2009 0.77
46 Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus. Nucleic Acids Res 2012 0.76
47 Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mononuclear cells. Melanoma Res 2011 0.76
48 Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations. Nucleic Acids Res 2013 0.76
49 No association between N7-methyldeoxyguanosine and 8-oxodeoxyguanosine levels in human lymphocyte DNA. Mutat Res 2006 0.75
50 Expression of O-Alkylguanine-DNA Alkyltransferase in Normal and Malignant Bladder Tissue of Egyptian Patients. J Nucleic Acids 2010 0.75
51 Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. Mol Cancer 2014 0.75
52 Topographical study of O(6)-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue. Chem Biol Interact 2013 0.75
53 Towards more specific O6-methylguanine-DNA methyltransferase (MGMT) inactivators. Bioorg Med Chem 2011 0.75
54 The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine. Nucleosides Nucleotides Nucleic Acids 2007 0.75
55 The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine. Org Biomol Chem 2006 0.75