Published in Dig Dis Sci on March 30, 2007
Prucalopride in the treatment of chronic constipation in patients from the Asia-Pacific region: a randomized, double-blind, placebo-controlled study. Neurogastroenterol Motil (2012) 2.03
Irritable bowel syndrome: diagnosis and pathogenesis. World J Gastroenterol (2012) 1.32
The serotonin transporter polymorphism (5-HTTLPR): allelic variation and links with depressive symptoms. Depress Anxiety (2010) 1.22
Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol (2012) 1.19
Genetic approaches to functional gastrointestinal disorders. Gastroenterology (2010) 1.18
Genetics of irritable bowel syndrome. Am J Gastroenterol (2008) 0.98
The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies. BMC Gastroenterol (2014) 0.98
Genetic determination of irritable bowel syndrome. World J Gastroenterol (2008) 0.97
The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome. Dig Dis Sci (2009) 0.95
Current insights in to the pathophysiology of Irritable Bowel Syndrome. Gut Pathog (2010) 0.94
A serotonin transporter gene (SLC6A4) polymorphism is associated with reduced risk of irritable bowel syndrome in American and Asian population: a meta-analysis. PLoS One (2013) 0.91
Pharmacogenetics of low dose clonidine in irritable bowel syndrome. Neurogastroenterol Motil (2009) 0.91
The role of peptide YY in gastrointestinal diseases and disorders (review). Int J Mol Med (2012) 0.90
Influence of the serotonin transporter 5HTTLPR polymorphism on symptom severity in irritable bowel syndrome. PLoS One (2013) 0.88
Serotonin in the gastrointestinal tract. Curr Opin Endocrinol Diabetes Obes (2009) 0.87
Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population. BMC Med Genet (2011) 0.87
Genetics and irritable bowel syndrome: from genomics to intermediate phenotype and pharmacogenetics. Dig Dis Sci (2009) 0.87
Review article: biomarkers and personalised therapy in functional lower gastrointestinal disorders. Aliment Pharmacol Ther (2015) 0.87
Association study of serotonin transporter SLC6A4 gene with Chinese Han irritable bowel syndrome. PLoS One (2014) 0.83
Genes and irritable bowel syndrome: is there a link? Curr Gastroenterol Rep (2008) 0.82
Interaction between a serotonin transporter gene promoter region polymorphism and stress predicts depressive symptoms in Chinese adolescents: a multi-wave longitudinal study. BMC Psychiatry (2013) 0.81
Association Between SLC6A4 Serotonin Transporter Gene Lainked Polymorphic Region and ADRA2A -1291C>G and Irritable Bowel Syndrome in Korea. J Neurogastroenterol Motil (2014) 0.80
Genetic epidemiology of irritable bowel syndrome. World J Gastroenterol (2015) 0.79
New paradigm for studying genetic contributions to irritable bowel syndrome. Dig Dis Sci (2012) 0.79
The role of pharmacogenetics in nonmalignant gastrointestinal diseases. Nat Rev Gastroenterol Hepatol (2012) 0.79
Molecular basis of the irritable bowel syndrome. World J Gastroenterol (2014) 0.78
Advances in Medications and Tailoring Treatment for Alcohol Use Disorder. Alcohol Res (2015) 0.78
Gene polymorphisms associated with functional dyspepsia. World J Gastroenterol (2015) 0.77
Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome. PLoS One (2016) 0.77
Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome. World J Gastroenterol (2016) 0.75
Association of Serotonin Transporter Promoter Polymorphism (5HTTLPR) with Microscopic Colitis and Ulcerative Colitis: Time to Be AsSERTive? Dig Dis Sci (2015) 0.75
Serotonin Transporter Gene (SLC6A4) Polymorphism and Mucosal Serotonin Levels in Southeastern Iranian Patients with Irritable Bowel Syndrome. Middle East J Dig Dis (2017) 0.75
Serotonin-Related Gene Variants in Patients with Irritable Bowel Syndrome and Depressive or Anxiety Disorders. Gastroenterol Res Pract (2017) 0.75
Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science (1996) 16.04
Functional bowel disorders and functional abdominal pain. Gut (1999) 7.63
Allelic variation of human serotonin transporter gene expression. J Neurochem (1996) 7.08
Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol Psychiatry (1998) 3.07
Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet (1996) 2.92
Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet (1997) 2.88
Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. Gastroenterology (2002) 2.52
A double-blind, placebo-controlled, randomized study to evaluate the efficacy, safety and tolerability of tegaserod in patients with irritable bowel syndrome. Scand J Gastroenterol (2004) 2.37
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet (1999) 2.16
Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Aliment Pharmacol Ther (2001) 2.04
A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci U S A (1999) 1.86
Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatry (2004) 1.85
Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut (2004) 1.55
Irritable bowel syndrome: epidemiology, natural history, health care seeking and emerging risk factors. Gastroenterol Clin North Am (2005) 1.44
Serotonin transporter gene polymorphism in irritable bowel syndrome. Am J Gastroenterol (2002) 1.40
Population studies of polymorphisms of the serotonin transporter protein gene. Am J Med Genet (1999) 1.40
Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol Psychiatry (1998) 1.23
Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review. Mol Psychiatry (2004) 1.16
Epidemiology of irritable bowel syndrome in Chinese. Dig Dis Sci (2002) 1.12
The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments. Prog Neuropsychopharmacol Biol Psychiatry (2005) 1.10
Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter. Am J Physiol Gastrointest Liver Physiol (2002) 1.08
Subject's Global Assessment of Relief: an appropriate method to assess the impact of treatment on irritable bowel syndrome-related symptoms in clinical trials. J Clin Epidemiol (2003) 1.08
Functional analysis of a novel human serotonin transporter gene promoter in immortalized raphe cells. Brain Res Mol Brain Res (1999) 1.03
[Serotonin transporter gene polymorphism in healthy adults and patients with irritable bowel syndrome]. Korean J Gastroenterol (2004) 0.96
Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder. Psychiatr Genet (2005) 0.94
Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders. Am J Med Genet (1998) 0.94
Genetics and genotypes in irritable bowel syndrome: implications for diagnosis and treatment. Gastroenterol Clin North Am (2005) 0.89
[Serotonin transporter gene polymorphism in irritable bowel syndrome]. Zhonghua Nei Ke Za Zhi (2004) 0.87
Association for serotonin transporter gene variable number tandem repeat polymorphism and schizophrenic disorders. Neuropsychobiology (2002) 0.77
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature (2011) 6.73
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res (2013) 3.50
Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia. Blood (2006) 3.48
Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Genome Res (2006) 2.81
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev (2012) 2.70
Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line. Arterioscler Thromb Vasc Biol (2005) 2.51
Randomized open-label phase II study of decitabine in patients with low- or intermediate-risk myelodysplastic syndromes. J Clin Oncol (2013) 2.42
High-efficiency InGaN-based LEDs grown on patterned sapphire substrates. Opt Express (2011) 2.14
Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia. Blood (2008) 2.04
Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase. Hypertension (2012) 1.92
Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol (2003) 1.82
The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors. Anesthesiology (2008) 1.79
Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1. Structure (2012) 1.77
Recent developments in top-emitting organic light-emitting diodes. Adv Mater (2010) 1.72
Transmembrane protein topology mapping by the substituted cysteine accessibility method (SCAM(TM)): application to lipid-specific membrane protein topogenesis. Methods (2005) 1.69
Spontaneous mammary intraepithelial lesions in dogs--a model of breast cancer. Cancer Epidemiol Biomarkers Prev (2007) 1.56
Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res (2005) 1.55
Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity. Neurosci Lett (2007) 1.53
The Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans. PLoS Genet (2013) 1.52
[Effects of different statin regimens on lipid profile and serum metalloproteinases in patients with coronary heart disease]. Zhonghua Xin Xue Guan Bing Za Zhi (2009) 1.50
Automated reconstruction of neuronal morphology based on local geometrical and global structural models. Neuroinformatics (2011) 1.50
In vitro evaluation of the sealing ability of MTA used for the repair of furcation perforations with and without the use of an internal matrix. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2008) 1.48
Regularized sensitivity encoding (SENSE) reconstruction using Bregman iterations. Magn Reson Med (2009) 1.46
An orthophosphate semiconductor with photooxidation properties under visible-light irradiation. Nat Mater (2010) 1.46
Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res (2006) 1.45
Hepatitis B virus status and the risk of pancreatic cancer: a meta-analysis. Eur J Cancer Prev (2013) 1.43
The role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradation. J Biol Chem (2006) 1.43
Neuroprotective effect on retinal ganglion cells by transpupillary laser irradiation of the optic nerve head. Neurosci Lett (2010) 1.42
HIV prevalence and correlates of unprotected anal intercourse among men who have sex with men, Jinan, China. AIDS Behav (2008) 1.41
Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers. Clin Cancer Res (2008) 1.41
Left atrial dyssynchrony time measured by tissue Doppler imaging to predict atrial fibrillation recurrences after pulmonary vein isolation. Anatol J Cardiol (2014) 1.40
To flip or not to flip: lipid-protein charge interactions are a determinant of final membrane protein topology. J Cell Biol (2008) 1.39
Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation. Cell Res (2012) 1.39
Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact. Epigenetics (2010) 1.37
Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol Cancer Ther (2010) 1.37
Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia. Leuk Res (2009) 1.37
WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther (2009) 1.34
Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53. Cancer Prev Res (Phila) (2008) 1.34
Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence. Aging (Albany NY) (2010) 1.33
Rising HIV prevalence among married and unmarried among men who have sex with men: Jinan, China. AIDS Behav (2009) 1.32
Phosphorylated α-synuclein in Parkinson's disease. Sci Transl Med (2012) 1.29
Diversity of rotavirus strains among children with acute diarrhea in China: 1998-2000 surveillance study. J Clin Microbiol (2002) 1.29
Genome-wide analysis reveals gene expression and metabolic network dynamics during embryo development in Arabidopsis. Plant Physiol (2011) 1.29
The substantial hospitalization burden of influenza in central China: surveillance for severe, acute respiratory infection, and influenza viruses, 2010-2012. Influenza Other Respir Viruses (2013) 1.28
Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii. Phytochemistry (2007) 1.26
Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana. BMC Genomics (2010) 1.23
Which Chinese men who have sex with men miss out on HIV testing? Sex Transm Infect (2011) 1.22
Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors. Cancer (2004) 1.22
Antileukemia activity of the combination of an anthracycline with a histone deacetylase inhibitor. Blood (2006) 1.22
Bioactive novel polyphenols from the fruit of Manilkara zapota (Sapodilla). J Nat Prod (2003) 1.22
Molecular basis of spectral tuning in the red- and green-sensitive (M/LWS) pigments in vertebrates. Genetics (2008) 1.21
Public perceptions of private health care in socialist China. Health Aff (Millwood) (2004) 1.20
Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. J Orthop Res (2007) 1.20
Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension by promoting basilar smooth muscle cell proliferation. Circulation (2012) 1.20
A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in Canavan mice. Mol Ther (2013) 1.19
Monoglucosyldiacylglycerol, a foreign lipid, can substitute for phosphatidylethanolamine in essential membrane-associated functions in Escherichia coli. J Biol Chem (2003) 1.18
Modulation of macrophage activation and programming in immunity. J Cell Physiol (2013) 1.17
A novel mycovirus that is related to the human pathogen hepatitis E virus and rubi-like viruses. J Virol (2008) 1.16
Mapping the knowledge structure of research on patient adherence: knowledge domain visualization based co-word analysis and social network analysis. PLoS One (2012) 1.16
A novel p53/microRNA-22/Cyr61 axis in synovial cells regulates inflammation in rheumatoid arthritis. Arthritis Rheumatol (2014) 1.14
Roles of cyclophilins in cancers and other organ systems. World J Surg (2005) 1.14
NuMA influences higher order chromatin organization in human mammary epithelium. Mol Biol Cell (2006) 1.14
Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia. Blood (2010) 1.14
Stem cells from human-exfoliated deciduous teeth can differentiate into dopaminergic neuron-like cells. Stem Cells Dev (2010) 1.13
Evolutionary dynamics of the interferon-induced transmembrane gene family in vertebrates. PLoS One (2012) 1.13
Intensity-modulated microbend fiber optic sensor for respiratory monitoring and gating during MRI. IEEE Trans Biomed Eng (2013) 1.13
Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20. Mol Immunol (2009) 1.12
Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth. Int J Cancer (2010) 1.12
Bioassay-guided isolation of aldose reductase inhibitors from Artemisia dracunculus. Phytochemistry (2006) 1.12
Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanate. Blood (2010) 1.12
Analysis of polyphenolic antioxidants from the fruits of three pouteria species by selected ion monitoring liquid chromatography-mass spectrometry. J Agric Food Chem (2004) 1.11
Phase II trial of vorinostat with idarubicin and cytarabine for patients with newly diagnosed acute myelogenous leukemia or myelodysplastic syndrome. J Clin Oncol (2012) 1.10
Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res (2008) 1.10
Ectodermal Wnt/β-catenin signaling shapes the mouse face. Dev Biol (2010) 1.10
Oncogenic functions of the transcription factor Nrf2. Free Radic Biol Med (2013) 1.10
An integrated microfluidic array system for evaluating toxicity and teratogenicity of drugs on embryonic zebrafish developmental dynamics. Biomicrofluidics (2011) 1.10
Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother Pharmacol (2008) 1.09
The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy. Clin Cancer Res (2010) 1.08
Viral infection and focal cortical dysplasia. Ann Neurol (2014) 1.08
Quantitative analysis of antiradical phenolic constituents from fourteen edible Myrtaceae fruits. Food Chem (2008) 1.08
A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway. Mol Pharmacol (2009) 1.08
Adaptive diversification of vomeronasal receptor 1 genes in rodents. J Mol Evol (2005) 1.07
MicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6. Tumour Biol (2012) 1.07
Lipid-protein interactions drive membrane protein topogenesis in accordance with the positive inside rule. J Biol Chem (2008) 1.07
Renalase deficiency in heart failure model of rats--a potential mechanism underlying circulating norepinephrine accumulation. PLoS One (2011) 1.07
Bioactive depsides and anthocyanins from jaboticaba (Myrciaria cauliflora). J Nat Prod (2006) 1.07
alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity. Neurosci Lett (2009) 1.07
A metal-based inhibitor of tumor necrosis factor-α. Angew Chem Int Ed Engl (2012) 1.06
Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model. Clin Orthop Relat Res (2008) 1.06
The link between psychosocial factors and functional dyspepsia: an epidemiological study. Chin Med J (Engl) (2002) 1.06
Cyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther (2013) 1.06
Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries. J Acquir Immune Defic Syndr (2005) 1.06