Published in Cancer Res on May 01, 2008
Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol Cancer Ther (2010) 1.37
Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies. PLoS One (2010) 1.34
The Wnt antagonists Frzb-1 and Crescent locally regulate basement membrane dissolution in the developing primary mouth. Development (2009) 1.19
Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinoma. Neoplasia (2008) 1.15
Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells. Invest New Drugs (2010) 1.11
Precise regulation of porcupine activity is required for physiological Wnt signaling. J Biol Chem (2012) 1.02
Animal models of soft-tissue sarcoma. Dis Model Mech (2010) 1.01
Epithelial to Mesenchymal Transition in a Clinical Perspective. J Oncol (2015) 0.99
Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion. PLoS One (2011) 0.95
The decreased metastatic potential of rhabdomyosarcoma cells obtained through MET receptor downregulation and the induction of differentiation. Cell Death Dis (2013) 0.86
Normalization method for transcriptional studies of heterogeneous samples--simultaneous array normalization and identification of equivalent expression. Stat Appl Genet Mol Biol (2009) 0.86
Expression and significance of twist, E-cadherin, and N-cadherin in gastrointestinal stromal tumors. Dig Dis Sci (2012) 0.83
Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function. G3 (Bethesda) (2014) 0.78
ARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cells. BMC Biol (2010) 0.78
Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma. Mol Cancer (2015) 0.77
SOST Inhibits Prostate Cancer Invasion. PLoS One (2015) 0.76
Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma. Clin Cancer Res (2015) 0.75
FRZB up-regulation is correlated with hepatic metastasis and poor prognosis in colon carcinoma patients with hepatic metastasis. Int J Clin Exp Pathol (2015) 0.75
Innovative approaches to establish and characterize primary cultures: an ex vivo 3D system and the zebrafish model. Biol Open (2016) 0.75
FRZB up-regulated in hepatocellular carcinoma bone metastasis. Int J Clin Exp Pathol (2015) 0.75
Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization. PLoS One (2014) 0.75
Met, metastasis, motility and more. Nat Rev Mol Cell Biol (2003) 14.30
Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science (2002) 12.29
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99
Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol (2005) 11.46
Secreted antagonists of the Wnt signalling pathway. J Cell Sci (2003) 8.02
Epithelial-mesenchymal transitions: twist in development and metastasis. Cell (2004) 7.14
Soft-tissue sarcomas in adults. N Engl J Med (2005) 5.97
Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res (2006) 5.90
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem (2007) 3.24
Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell (1997) 3.23
Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity (2007) 2.71
Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell (1997) 2.40
Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer Res (2003) 2.23
Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor). Oncogene (1999) 2.10
Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. Cancer Res (2004) 1.93
The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases. Proc Natl Acad Sci U S A (2002) 1.92
The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo. Cancer Res (2007) 1.90
Wnt/beta-catenin signaling pathway as a novel cancer drug target. Curr Cancer Drug Targets (2004) 1.72
Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. J Biol Chem (1996) 1.70
The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. Oncogene (1995) 1.66
c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase. Oncogene (1991) 1.58
Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res (2005) 1.55
Validation of met as a therapeutic target in alveolar and embryonal rhabdomyosarcoma. Cancer Res (2006) 1.50
Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/beta-catenin signaling. J Biol Chem (2001) 1.47
Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. Int J Cancer (2002) 1.37
Matrix metalloproteinases participate in osteosarcoma invasion. J Surg Res (2005) 1.32
Retrogenic expression of the MET proto-oncogene correlates with the invasive phenotype of human rhabdomyosarcomas. Oncogene (1996) 1.25
Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice. Cancer Res (2007) 1.21
Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. J Orthop Res (2007) 1.20
Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. Int J Cancer (2005) 1.10
MET overexpression turns human primary osteoblasts into osteosarcomas. Cancer Res (2006) 1.09
Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway. Cancer Res (2007) 1.09
Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin. Biochem J (2002) 1.08
Wnt pathway and breast cancer. Front Biosci (2007) 1.08
RNAi mediated MMP-1 silencing inhibits human chondrosarcoma invasion. J Orthop Res (2005) 1.07
Efficacy of Wnt-1 monoclonal antibody in sarcoma cells. BMC Cancer (2005) 1.05
Wnt inhibitory factor inhibits lung cancer cell growth. J Thorac Cardiovasc Surg (2007) 1.03
Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors. Pathol Int (1998) 1.03
APC mutations in synovial sarcoma. J Pathol (2002) 1.00
Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas. Oncogene (2005) 1.00
The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation. Adv Cancer Res (2000) 0.95
Frequent beta-catenin abnormalities in bone and soft-tissue tumors. Jpn J Cancer Res (1999) 0.93
Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma. Gene (2006) 0.92
The functional genetic variant Arg324Gly of frizzled-related protein is associated with colorectal cancer risk. Carcinogenesis (2007) 0.88
Activation of Wnt signaling in the intestinal mucosa of Apc +/min mice does not cause overexpression of the receptor tyrosine kinase Met. Cancer Sci (2006) 0.80
Hypermethylation of the APC promoter but lack of APC mutations in myxoid/round-cell liposarcoma. Int J Cancer (2006) 0.80
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma. Clin Cancer Res (2005) 2.31
p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells. Oncogene (2003) 2.17
Osteosarcoma: basic science and clinical implications. Orthop Clin North Am (2006) 1.80
Recent developments in top-emitting organic light-emitting diodes. Adv Mater (2010) 1.72
Transmembrane protein topology mapping by the substituted cysteine accessibility method (SCAM(TM)): application to lipid-specific membrane protein topogenesis. Methods (2005) 1.69
Mast cell density, angiogenesis, blood clotting, and prognosis in women with advanced ovarian cancer. Gynecol Oncol (2005) 1.63
Spontaneous mammary intraepithelial lesions in dogs--a model of breast cancer. Cancer Epidemiol Biomarkers Prev (2007) 1.56
Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res (2005) 1.55
The Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans. PLoS Genet (2013) 1.52
Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma. Cancer Res (2004) 1.51
Automated reconstruction of neuronal morphology based on local geometrical and global structural models. Neuroinformatics (2011) 1.50
In vitro evaluation of the sealing ability of MTA used for the repair of furcation perforations with and without the use of an internal matrix. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2008) 1.48
Regularized sensitivity encoding (SENSE) reconstruction using Bregman iterations. Magn Reson Med (2009) 1.46
Hepatitis B virus status and the risk of pancreatic cancer: a meta-analysis. Eur J Cancer Prev (2013) 1.43
Neuroprotective effect on retinal ganglion cells by transpupillary laser irradiation of the optic nerve head. Neurosci Lett (2010) 1.42
Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells. Int J Cancer (2004) 1.42
To flip or not to flip: lipid-protein charge interactions are a determinant of final membrane protein topology. J Cell Biol (2008) 1.39
Allograft-prosthesis composite reconstruction of the proximal part of the humerus: functional outcome and survivorship. J Bone Joint Surg Am (2009) 1.38
Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol Cancer Ther (2010) 1.37
Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma. Int J Oncol (2004) 1.35
WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther (2009) 1.34
Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53. Cancer Prev Res (Phila) (2008) 1.34
Analysis of prognostic factors in Ewing sarcoma using a population-based cancer registry. Cancer (2010) 1.33
The association of serotonin transporter genetic polymorphisms and irritable bowel syndrome and its influence on tegaserod treatment in Chinese patients. Dig Dis Sci (2007) 1.32
Diagnosis of gastric glomus tumor by endoscopic ultrasound-guided fine needle aspiration biopsy. A case report with cytologic, histologic and immunohistochemical studies. Acta Cytol (2002) 1.26
The Wnt signaling pathway: implications for therapy in osteosarcoma. Expert Rev Anticancer Ther (2011) 1.23
Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. J Orthop Res (2007) 1.20
Comparison of location of mesh placed transvaginally vs mesh placed abdominally at the time of sacrocolpopexy. Int Urogynecol J (2014) 1.20
A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in Canavan mice. Mol Ther (2013) 1.19
Monoglucosyldiacylglycerol, a foreign lipid, can substitute for phosphatidylethanolamine in essential membrane-associated functions in Escherichia coli. J Biol Chem (2003) 1.18
A novel mycovirus that is related to the human pathogen hepatitis E virus and rubi-like viruses. J Virol (2008) 1.16
Mapping the knowledge structure of research on patient adherence: knowledge domain visualization based co-word analysis and social network analysis. PLoS One (2012) 1.16
Wnt pathway-related gene expression in inflammatory bowel disease. Dig Dis Sci (2007) 1.15
A novel p53/microRNA-22/Cyr61 axis in synovial cells regulates inflammation in rheumatoid arthritis. Arthritis Rheumatol (2014) 1.14
NuMA influences higher order chromatin organization in human mammary epithelium. Mol Biol Cell (2006) 1.14
Giant epidermal inclusion cyst of buttock. Skeletal Radiol (2006) 1.13
Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth. Int J Cancer (2010) 1.12
Feasibility of management of high-grade cervical lesions in a single visit: a randomized controlled trial. JAMA (2005) 1.10
Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. Int J Cancer (2007) 1.09
A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway. Mol Pharmacol (2009) 1.08
Elevated physiologic tumor pressure promotes proliferation and chemosensitivity in human osteosarcoma. Clin Cancer Res (2005) 1.08
Lipid-protein interactions drive membrane protein topogenesis in accordance with the positive inside rule. J Biol Chem (2008) 1.07
Renalase deficiency in heart failure model of rats--a potential mechanism underlying circulating norepinephrine accumulation. PLoS One (2011) 1.07
Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model. Clin Orthop Relat Res (2008) 1.06
Cyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther (2013) 1.06
On-chip temperature gradient interaction chromatography. J Chromatogr A (2005) 1.06
Wnt pathway component LEF1 mediates tumor cell invasion and is expressed in human and murine breast cancers lacking ErbB2 (her-2/neu) overexpression. Int J Oncol (2005) 1.04
New hepatitis E virus genotype in camels, the Middle East. Emerg Infect Dis (2014) 1.03
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Mol Oncol (2012) 1.02
Expression and characterization of the carboxyl esterase Rv3487c from Mycobacterium tuberculosis. Protein Expr Purif (2005) 1.02
Analysis of prognostic factors for patients with chordoma with use of the California Cancer Registry. J Bone Joint Surg Am (2012) 1.01
Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice. PLoS One (2012) 1.01
Overexpression of Aurora-A enhances invasion and matrix metalloproteinase-2 expression in esophageal squamous cell carcinoma cells. Mol Cancer Res (2012) 1.00
Effects of emodin and vitamin C on growth performance, biochemical parameters and two HSP70s mRNA expression of Wuchang bream (Megalobrama amblycephala Yih) under high temperature stress. Fish Shellfish Immunol (2012) 0.98
Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons. J Neurosci (2009) 0.97
Microsatellite instability in Japanese vs European American patients with gastric cancer. Arch Surg (2002) 0.97
AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. J Biol Chem (2003) 0.97
Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Mol Carcinog (2011) 0.97
FSH beta gene mutations in a female with partial breast development and a male sibling with normal puberty and azoospermia. J Clin Endocrinol Metab (2002) 0.97
Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells. Biochem Biophys Res Commun (2004) 0.97
A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma. J Exp Clin Cancer Res (2014) 0.97
Adenovirus-adeno-associated virus hybrid for large-scale recombinant adeno-associated virus production. Hum Gene Ther (2009) 0.97
Rheumatoid arthritis-associated gene-gene interaction network for rheumatoid arthritis candidate genes. BMC Proc (2009) 0.96
Seasonal dynamics of phytoplankton and its relationship with the environmental factors in Dongping Lake, China. Environ Monit Assess (2012) 0.96
Molecular cloning and expression of two HSP70 genes in the Wuchang bream (Megalobrama amblycephala Yih). Fish Shellfish Immunol (2009) 0.95
Dynamic neural responses to cue-reactivity paradigms in heroin-dependent users: an fMRI study. Hum Brain Mapp (2009) 0.94
Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells. Proc Natl Acad Sci U S A (2012) 0.93
Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. J Orthop Res (2011) 0.93
A dominant-negative mutation of HSF2 associated with idiopathic azoospermia. Hum Genet (2012) 0.92
Characterization of the porcine alpha interferon multigene family. Gene (2006) 0.92
Targeted blockade of interleukin-8 abrogates its promotion of cervical cancer growth and metastasis. Mol Cell Biochem (2012) 0.91
Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A (2012) 0.91
Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier. BMC Cancer (2008) 0.91
Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis. Mol Cancer (2013) 0.90
Lycopene enhances docetaxel's effect in castration-resistant prostate cancer associated with insulin-like growth factor I receptor levels. Neoplasia (2011) 0.90
Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line. J Obstet Gynaecol Res (2012) 0.90
Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model. Cancer Prev Res (Phila) (2013) 0.90
Focus on vulnerable populations and promoting equity in health service utilization--an analysis of visitor characteristics and service utilization of the Chinese community health service. BMC Public Health (2014) 0.90
Overexpression of the structural maintenance of chromosome 4 protein is associated with tumor de-differentiation, advanced stage and vascular invasion of primary liver cancer. Oncol Rep (2012) 0.90