Published in Ann N Y Acad Sci on March 29, 2007
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin. Proc Natl Acad Sci U S A (2009) 4.88
Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources? BMC Genomics (2009) 3.08
Comparative genomic characterization of Francisella tularensis strains belonging to low and high virulence subspecies. PLoS Pathog (2009) 1.77
The Francisella pathogenicity island protein PdpD is required for full virulence and associates with homologues of the type VI secretion system. J Bacteriol (2008) 1.71
Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development. Microbiol Mol Biol Rev (2009) 1.59
Identification of genes contributing to the virulence of Francisella tularensis SCHU S4 in a mouse intradermal infection model. PLoS One (2009) 1.58
Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4. Infect Immun (2008) 1.56
Global transcriptional response to mammalian temperature provides new insight into Francisella tularensis pathogenesis. BMC Microbiol (2008) 1.49
A functional genomic yeast screen to identify pathogenic bacterial proteins. PLoS Pathog (2008) 1.46
Burkholderia mallei cluster 1 type VI secretion mutants exhibit growth and actin polymerization defects in RAW 264.7 murine macrophages. Infect Immun (2009) 1.45
Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence. PLoS Pathog (2016) 1.42
Subversion of host recognition and defense systems by Francisella spp. Microbiol Mol Biol Rev (2012) 1.40
Glutathione provides a source of cysteine essential for intracellular multiplication of Francisella tularensis. PLoS Pathog (2008) 1.40
A conserved alpha-helix essential for a type VI secretion-like system of Francisella tularensis. J Bacteriol (2009) 1.36
Salmonella pathogenicity and host adaptation in chicken-associated serovars. Microbiol Mol Biol Rev (2013) 1.27
The Role of the Francisella Tularensis Pathogenicity Island in Type VI Secretion, Intracellular Survival, and Modulation of Host Cell Signaling. Front Microbiol (2010) 1.26
Francisella tularensis genes required for inhibition of the neutrophil respiratory burst and intramacrophage growth identified by random transposon mutagenesis of strain LVS. Infect Immun (2009) 1.25
Interrelationship between dendritic cell trafficking and Francisella tularensis dissemination following airway infection. PLoS Pathog (2008) 1.25
Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages. Infect Immun (2010) 1.23
Type IV pili in Francisella tularensis: roles of pilF and pilT in fiber assembly, host cell adherence, and virulence. Infect Immun (2008) 1.19
Small molecule control of virulence gene expression in Francisella tularensis. PLoS Pathog (2009) 1.17
Comparative review of Francisella tularensis and Francisella novicida. Front Cell Infect Microbiol (2014) 1.16
Macrophage replication screen identifies a novel Francisella hydroperoxide resistance protein involved in virulence. PLoS One (2011) 1.14
Features of sepsis caused by pulmonary infection with Francisella tularensis Type A strain. Microb Pathog (2011) 1.11
Francisella-arthropod vector interaction and its role in patho-adaptation to infect mammals. Front Microbiol (2011) 1.07
Massively parallel delivery of large cargo into mammalian cells with light pulses. Nat Methods (2015) 1.05
Directed screen of Francisella novicida virulence determinants using Drosophila melanogaster. Infect Immun (2010) 1.04
Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs. Infect Immun (2010) 1.04
Characterization and application of a glucose-repressible promoter in Francisella tularensis. Appl Environ Microbiol (2008) 1.04
Regulation of francisella tularensis virulence. Front Microbiol (2011) 1.03
Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challenge. Vaccine (2009) 1.03
Characterization of the pathogenicity island protein PdpA and its role in the virulence of Francisella novicida. Microbiology (2009) 0.99
Targeted gene disruption in Francisella tularensis by group II introns. Methods (2009) 0.98
Whole genome sequencing of the fish pathogen Francisella noatunensis subsp. orientalis Toba04 gives novel insights into Francisella evolution and pathogenecity. BMC Genomics (2012) 0.97
Pivotal role of the Francisella tularensis heat-shock sigma factor RpoH. Microbiology (2009) 0.97
Requirement of the CXXC motif of novel Francisella infectivity potentiator protein B FipB, and FipA in virulence of F. tularensis subsp. tularensis. PLoS One (2011) 0.93
Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice and reveals a unique phenotype for pdpC. Infect Immun (2012) 0.93
Identification of trkH, encoding a potassium uptake protein required for Francisella tularensis systemic dissemination in mice. PLoS One (2010) 0.92
Genotype-phenotype associations in a nonmodel prokaryote. MBio (2012) 0.90
NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis. Mol Microbiol (2012) 0.90
Uncovering the components of the Francisella tularensis virulence stealth strategy. Front Cell Infect Microbiol (2014) 0.90
AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity. Eur J Immunol (2015) 0.89
Identification of T-cell epitopes in Francisella tularensis using an ordered protein array of serological targets. Immunology (2011) 0.88
The Francisella tularensis migR, trmE, and cphA genes contribute to F. tularensis pathogenicity island gene regulation and intracellular growth by modulation of the stress alarmone ppGpp. Infect Immun (2013) 0.88
Host-pathogen interactions and immune evasion strategies in Francisella tularensis pathogenicity. Infect Drug Resist (2014) 0.87
FeoB-mediated uptake of iron by Francisella tularensis. Infect Immun (2013) 0.87
Identification of a dominant CD4 T cell epitope in the membrane lipoprotein Tul4 from Francisella tularensis LVS. Mol Immunol (2009) 0.87
Importance of PdpC, IglC, IglI, and IglG for modulation of a host cell death pathway induced by Francisella tularensis. Infect Immun (2013) 0.86
The RNA chaperone Hfq is important for growth and stress tolerance in Francisella novicida. PLoS One (2011) 0.85
Importance of branched-chain amino acid utilization in Francisella intracellular adaptation. Infect Immun (2014) 0.84
Interaction of Francisella asiatica with tilapia (Oreochromis niloticus) innate immunity. Infect Immun (2010) 0.84
Intra-Vacuolar Proliferation of F. Novicida within H. Vermiformis. Front Microbiol (2011) 0.84
Ubiquitous promoter-localization of essential virulence regulators in Francisella tularensis. PLoS Pathog (2015) 0.84
The Francisella tularensis LVS ΔpdpC mutant exhibits a unique phenotype during intracellular infection. BMC Microbiol (2013) 0.83
IglC and PdpA are important for promoting Francisella invasion and intracellular growth in epithelial cells. PLoS One (2014) 0.81
Use of a capture-based pathogen transcript enrichment strategy for RNA-Seq analysis of the Francisella tularensis LVS transcriptome during infection of murine macrophages. PLoS One (2013) 0.81
Genome sequence and phenotypic analysis of a first German Francisella sp. isolate (W12-1067) not belonging to the species Francisella tularensis. BMC Microbiol (2014) 0.80
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of intracellular growth locus E (IglE) protein from Francisella tularensis subsp. novicida. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.80
Identification of Francisella novicida mutants that fail to induce prostaglandin E(2) synthesis by infected macrophages. Front Microbiol (2013) 0.80
Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth. Cell Host Microbe (2016) 0.78
A broadly applicable approach to T cell epitope identification: application to improving tumor associated epitopes and identifying epitopes in complex pathogens. J Immunol Methods (2011) 0.78
Microinjection of Francisella tularensis and Listeria monocytogenes reveals the importance of bacterial and host factors for successful replication. Infect Immun (2015) 0.78
Host-pathogen o-methyltransferase similarity and its specific presence in highly virulent strains of Francisella tularensis suggests molecular mimicry. PLoS One (2011) 0.78
Dissection of Francisella-Host Cell Interactions in Dictyostelium discoideum. Appl Environ Microbiol (2015) 0.77
Characterization and Vaccine Potential of Membrane Vesicles Produced by Francisella noatunensis sup. orientalis in an Adult Zebrafish Model. Clin Vaccine Immunol (2017) 0.75
Whole genome relationships among Francisella bacteria of diverse origin define new species and provide specific regions for detection. Appl Environ Microbiol (2016) 0.75
High-Quality Draft Genome Sequence of Francisella tularensis subsp. holarctica Strain 08T0073 Isolated from a Wild European Hare. Genome Announc (2017) 0.75
Francisella philomiragia Infection and Lethality in Mammalian Tissue Culture Cell Models, Galleria mellonella, and BALB/c Mice. Front Microbiol (2016) 0.75
Francisella tularensis Susceptibility to Antibiotics: A Comprehensive Review of the Data Obtained In vitro and in Animal Models. Front Cell Infect Microbiol (2017) 0.75
A response regulator promotes Francisella tularensis intramacrophage growth by repressing an anti-virulence factor. Mol Microbiol (2016) 0.75
Strategies Used by Bacteria to Grow in Macrophages. Microbiol Spectr (2016) 0.75
Identification of mechanisms for attenuation of the FSC043 mutant of Francisella tularensis SCHU S4. Infect Immun (2014) 0.75
Francisella tularensis type VI secretion system comes of age. Virulence (2017) 0.75