Published in J Biol Chem on April 03, 2007
Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression. Cancer Res (2008) 2.58
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia. Nat Genet (2013) 2.38
ASD v2.0: updated content and novel features focusing on allosteric regulation. Nucleic Acids Res (2013) 0.94
Structural insights into the inhibition of cytosolic 5'-nucleotidase II (cN-II) by ribonucleoside 5'-monophosphate analogues. PLoS Comput Biol (2011) 0.86
Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP. PLoS One (2014) 0.84
The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis. J Biol Chem (2013) 0.84
Identification of Drosophila and human 7-methyl GMP-specific nucleotidases. J Biol Chem (2012) 0.81
Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila. FEBS J (2014) 0.79
Crystallization and preliminary X-ray analysis of the open form of human ecto-5'-nucleotidase (CD73). Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.76
Expression of bovine cytosolic 5'-nucleotidase (cN-II) in yeast: nucleotide pools disturbance and its consequences on growth and homologous recombination. PLoS One (2013) 0.76
Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs. Pharmacogenet Genomics (2016) 0.75
Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia. BMC Biol (2016) 0.75
Thermofluor-based high-throughput stability optimization of proteins for structural studies. Anal Biochem (2006) 5.05
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proc Natl Acad Sci U S A (2006) 4.45
Protein production and purification. Nat Methods (2008) 3.97
In situ proteolysis for protein crystallization and structure determination. Nat Methods (2007) 3.05
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Science (2013) 2.74
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol Biochem Parasitol (2006) 2.39
A roadmap to generate renewable protein binders to the human proteome. Nat Methods (2011) 2.38
Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution. Science (2006) 2.23
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat Struct Mol Biol (2011) 2.23
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase. Nature (2007) 2.17
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J Biol Chem (2008) 2.12
The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins. Protein Expr Purif (2007) 2.10
Structural basis for molecular recognition and presentation of histone H3 by WDR5. EMBO J (2006) 2.08
Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol (2007) 1.90
The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. J Biol Chem (2008) 1.89
Quantitation of cellular deoxynucleoside triphosphates. Nucleic Acids Res (2009) 1.70
The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells. Proc Natl Acad Sci U S A (2013) 1.61
Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage. Proc Natl Acad Sci U S A (2008) 1.60
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin. Structure (2007) 1.53
The radical site in chlamydial ribonucleotide reductase defines a new R2 subclass. Science (2004) 1.53
p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage. J Biol Chem (2007) 1.52
An efficient strategy for high-throughput expression screening of recombinant integral membrane proteins. Protein Sci (2005) 1.48
Structural basis for recognition by an in vitro evolved affibody. Proc Natl Acad Sci U S A (2003) 1.46
Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances. Mutat Res (2010) 1.39
Origins of mitochondrial thymidine triphosphate: dynamic relations to cytosolic pools. Proc Natl Acad Sci U S A (2003) 1.39
Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem (2008) 1.39
Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-A x-ray data. Proc Natl Acad Sci U S A (2003) 1.38
Mitochondrial DNA depletion and thymidine phosphate pool dynamics in a cellular model of mitochondrial neurogastrointestinal encephalomyopathy. J Biol Chem (2006) 1.35
Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate. Proc Natl Acad Sci U S A (2006) 1.34
Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase. Nat Struct Mol Biol (2004) 1.32
Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters. Nat Struct Mol Biol (2013) 1.31
Mitochondrial deoxynucleotide pools in quiescent fibroblasts: a possible model for mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). J Biol Chem (2005) 1.31
Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature (2013) 1.30
Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3). Structure (2008) 1.23
Enabling IMAC purification of low abundance recombinant proteins from E. coli lysates. Nat Methods (2009) 1.23
Crystal structure of a human mitochondrial deoxyribonucleotidase. Nat Struct Biol (2002) 1.22
Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells. Proc Natl Acad Sci U S A (2012) 1.21
Molecular and structural basis for redox regulation of beta-actin. J Mol Biol (2007) 1.20
A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity. Biochem J (2009) 1.19
Membrane-bound diiron carboxylate proteins. Annu Rev Plant Biol (2003) 1.16
A pilot project to generate affinity reagents to human proteins. Nat Methods (2008) 1.16
Towards proteome scale antibody selections using phage display. N Biotechnol (2009) 1.15
Structure and mechanism of spermidine synthases. Biochemistry (2007) 1.13
Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim. FEBS Lett (2008) 1.13
An allosteric inhibitor of protein arginine methyltransferase 3. Structure (2012) 1.11
Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31. PLoS One (2013) 1.09
Crystal structure of human MTH1 and the 8-oxo-dGMP product complex. FEBS Lett (2011) 1.09
High throughput production of recombinant human proteins for crystallography. Methods Mol Biol (2008) 1.08
Mitochondrial deoxyribonucleotides, pool sizes, synthesis, and regulation. J Biol Chem (2004) 1.08
Crystal structure of the di-iron/radical protein of ribonucleotide reductase from Corynebacterium ammoniagenes. Biochemistry (2002) 1.08
Structural insights into substrate recognition in proton-dependent oligopeptide transporters. EMBO Rep (2013) 1.08
Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases. J Biol Chem (2007) 1.07
Deoxyribonucleotide metabolism in cycling and resting human fibroblasts with a missense mutation in p53R2, a subunit of ribonucleotide reductase. J Biol Chem (2011) 1.06
Colony filtration blot: a new screening method for soluble protein expression in Escherichia coli. Nat Methods (2005) 1.04
Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells. J Biol Chem (2007) 1.03
Engineering membrane protein overproduction in Escherichia coli. Protein Sci (2008) 1.03
Purification, modeling, and analysis of botulinum neurotoxin subtype A5 (BoNT/A5) from Clostridium botulinum strain A661222. Appl Environ Microbiol (2011) 1.02
Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy. Biochem Pharmacol (2003) 1.02
Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus. FEBS J (2009) 1.02
The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain. J Mol Biol (2006) 1.00
The structure of human collapsin response mediator protein 2, a regulator of axonal growth. J Neurochem (2007) 0.99
Structural basis of allele variation of human thiopurine-S-methyltransferase. Proteins (2007) 0.97
Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. J Cell Sci (2012) 0.96
Catalysis within the lipid bilayer-structure and mechanism of the MAPEG family of integral membrane proteins. Curr Opin Struct Biol (2008) 0.96
An efficient and generic strategy for producing soluble human proteins and domains in E. coli by screening construct libraries. Proteins (2006) 0.95
Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A. Proteins (2007) 0.95
Efficiency of hit generation and structural characterization in fragment-based ligand discovery. Curr Opin Chem Biol (2011) 0.94
A high throughput method for the detection of metalloproteins on a microgram scale. Mol Cell Proteomics (2005) 0.94
Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.91
A screening strategy for heterologous protein expression in Escherichia coli with the highest return of investment. Protein Expr Purif (2011) 0.91
High-throughput analytical gel filtration screening of integral membrane proteins for structural studies. Biochim Biophys Acta (2013) 0.91
Arginine 104 is a key catalytic residue in leukotriene C4 synthase. J Biol Chem (2010) 0.91
Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism. Biochemistry (2004) 0.91
Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site. J Biol Chem (2007) 0.91
Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts. Proc Natl Acad Sci U S A (2013) 0.90
The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions. J Biol Chem (2006) 0.90
X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold. FEBS Lett (2004) 0.89
Metabolic interrelations within guanine deoxynucleotide pools for mitochondrial and nuclear DNA maintenance. J Biol Chem (2008) 0.89
A prokaryotic alternative oxidase present in the bacterium Novosphingobium aromaticivorans. FEBS Lett (2003) 0.89
EPR studies of the mitochondrial alternative oxidase. Evidence for a diiron carboxylate center. J Biol Chem (2002) 0.89