Published in Nat Protoc on January 01, 2006
Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest (2011) 2.25
Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology. Brain (2016) 1.69
Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability. Biol Psychiatry (2014) 1.55
Circadian rhythm. Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing. Science (2014) 1.53
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci (2012) 1.52
Hypoxia-ischemia and therapeutic hypothermia in the neonatal mouse brain--a longitudinal study. PLoS One (2015) 1.50
Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. PLoS Genet (2013) 1.50
The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci (2009) 1.46
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease. Neuron (2017) 1.41
Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. Eur J Neurosci (2008) 1.38
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J (2011) 1.31
Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems. Hum Mol Genet (2012) 1.24
GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction. Transl Psychiatry (2012) 1.21
Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function. Brain Behav (2012) 1.15
Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology. Hum Mol Genet (2011) 1.15
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis (2011) 1.09
Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour? J Exp Biol (2013) 1.08
The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Cell (2011) 1.07
α7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage. Stroke (2011) 1.02
Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury. Nat Commun (2012) 1.00
Mice with reduced NMDA receptor expression: more consistent with autism than schizophrenia? Genes Brain Behav (2012) 1.00
Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes. Autism Res (2013) 0.99
Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions. Glia (2011) 0.99
Modulation of neuronal signal transduction and memory formation by synaptic zinc. Front Behav Neurosci (2011) 0.98
Left-right dissociation of hippocampal memory processes in mice. Proc Natl Acad Sci U S A (2014) 0.97
Direct excitation of parvalbumin-positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition. J Physiol (2014) 0.97
Monoamine oxidase A and A/B knockout mice display autistic-like features. Int J Neuropsychopharmacol (2012) 0.97
Spatial memory and long-term object recognition are impaired by circadian arrhythmia and restored by the GABAAAntagonist pentylenetetrazole. PLoS One (2013) 0.95
Insulin receptor substrate 2 is a negative regulator of memory formation. Learn Mem (2011) 0.94
Cognitive and neural correlates of depression-like behaviour in socially defeated mice: an animal model of depression with cognitive dysfunction. Int J Neuropsychopharmacol (2010) 0.94
Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits. Neuropsychopharmacology (2014) 0.94
Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation (2014) 0.93
Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction. J Clin Invest (2014) 0.92
Prenatal stress induces schizophrenia-like alterations of serotonin 2A and metabotropic glutamate 2 receptors in the adult offspring: role of maternal immune system. J Neurosci (2013) 0.92
Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation. Cereb Cortex (2011) 0.90
HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation. Proc Natl Acad Sci U S A (2014) 0.90
Alcohol binge drinking during adolescence or dependence during adulthood reduces prefrontal myelin in male rats. J Neurosci (2014) 0.89
Prefrontal cortical dysfunction after overexpression of histone deacetylase 1. Biol Psychiatry (2013) 0.89
A New Rabbit Model of Pediatric Traumatic Brain Injury. J Neurotrauma (2015) 0.85
Central CRF system perturbation in an Alzheimer's disease knockin mouse model. Neurobiol Aging (2012) 0.85
The development of spatial behaviour and the hippocampal neural representation of space. Philos Trans R Soc Lond B Biol Sci (2013) 0.84
Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. J Alzheimers Dis (2014) 0.83
GluN1 hypomorph mice exhibit wide-ranging behavioral alterations. Genes Brain Behav (2012) 0.83
Blocking GABA-A receptors in the medial septum enhances hippocampal acetylcholine release and behavior in a rat model of diencephalic amnesia. Pharmacol Biochem Behav (2009) 0.83
Wip1 phosphatase positively modulates dendritic spine morphology and memory processes through the p38MAPK signaling pathway. Cell Adh Migr (2012) 0.83
Aging Research Using Mouse Models. Curr Protoc Mouse Biol (2015) 0.82
Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier. Sci Adv (2015) 0.82
Disrupting the clustering of GABAA receptor α2 subunits in the frontal cortex leads to reduced γ-power and cognitive deficits. Proc Natl Acad Sci U S A (2013) 0.82
Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist. Eur J Neurosci (2013) 0.82
Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice. Biol Psychiatry (2015) 0.81
Long-term consequences of perinatal fatty acid amino hydrolase inhibition. Br J Pharmacol (2014) 0.81
Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice. PLoS One (2012) 0.81
Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury. Behav Brain Res (2014) 0.81
A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice. PLoS One (2016) 0.80
Methyllycaconitine- and scopolamine-induced cognitive dysfunction: differential reversal effect by cognition-enhancing drugs. Pharmacol Res Perspect (2014) 0.79
Genetic dissection of the Down syndrome critical region. Hum Mol Genet (2015) 0.79
Prenatal alcohol exposure and adolescent stress - unmasking persistent attentional deficits in rats. Eur J Neurosci (2014) 0.79
Interleukin17A Promotes Postoperative Cognitive Dysfunction by Triggering β-Amyloid Accumulation via the Transforming Growth Factor-β (TGFβ)/Smad Signaling Pathway. PLoS One (2015) 0.79
HIV protease inhibitors disrupt astrocytic glutamate transporter function and neurobehavioral performance. AIDS (2016) 0.79
Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models. Front Psychiatry (2015) 0.79
Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor. Cell (2015) 0.79
Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion. Cell Rep (2015) 0.79
Effects of postnatal growth restriction and subsequent catch-up growth on neurodevelopment and glucose homeostasis in rats. BMC Physiol (2015) 0.78
Influence of gut microbes on the brain-gut axis (Gut 2011;60:307-317). J Neurogastroenterol Motil (2011) 0.78
Effect of Food Deprivation on a Delayed Nonmatch-to-place T-maze Task. Exp Neurobiol (2013) 0.78
Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse. Neurobiol Dis (2013) 0.77
Effect of sustained postnatal systemic inflammation on hippocampal volume and function in mice. Pediatr Res (2014) 0.77
Deficits in learning and memory in mice with a mutation of the candidate dyslexia susceptibility gene Dyx1c1. Brain Lang (2015) 0.77
Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning. Sci Rep (2015) 0.77
Adjunctive N-acetyl-L-cysteine in treatment of murine pneumococcal meningitis. Antimicrob Agents Chemother (2013) 0.77
Mice repeatedly exposed to Group-A β-Haemolytic Streptococcus show perseverative behaviors, impaired sensorimotor gating, and immune activation in rostral diencephalon. Sci Rep (2015) 0.77
Neuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging. Age (Dordr) (2012) 0.77
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function. Hum Mol Genet (2016) 0.77
Chronic Drinking During Adolescence Predisposes the Adult Rat for Continued Heavy Drinking: Neurotrophin and Behavioral Adaptation after Long-Term, Continuous Ethanol Exposure. PLoS One (2016) 0.77
Down-Regulation of Neuregulin1/ErbB4 Signaling in the Hippocampus Is Critical for Learning and Memory. Mol Neurobiol (2016) 0.77
Developmental alterations in anxiety and cognitive behavior in serotonin transporter mutant mice. Psychopharmacology (Berl) (2014) 0.76
Effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats. Pharmacognosy Res (2014) 0.76
A conceptual and practical guide to the behavioural evaluation of animal models of the symptomatology and therapy of schizophrenia. Cell Tissue Res (2013) 0.76
Sex-dependent behavioral effects and morphological changes in the hippocampus after prenatal invasive interventions in rats: implications for animal models of schizophrenia. Clinics (Sao Paulo) (2010) 0.76
Pharmacological effects of cannabinoids on the reference and working memory functions in mice. Psychopharmacology (Berl) (2012) 0.76
The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Nat Commun (2016) 0.75
Improved Social Interaction, Recognition and Working Memory with Cannabidiol Treatment in a Prenatal Infection (poly I:C) Rat Model. Neuropsychopharmacology (2017) 0.75
Running wheel training does not change neurogenesis levels or alter working memory tasks in adult rats. PeerJ (2017) 0.75
AMPA GluA1-flip targeted oligonucleotide therapy reduces neonatal seizures and hyperexcitability. PLoS One (2017) 0.75
The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. Eur J Neurosci (2017) 0.75
Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome. Mol Brain (2016) 0.75
Baicalein improves behavioral dysfunction induced by Alzheimer's disease in rats. Neuropsychiatr Dis Treat (2016) 0.75
Preparation and implementation of optofluidic neural probes for in vivo wireless pharmacology and optogenetics. Nat Protoc (2017) 0.75
Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects. Elife (2017) 0.75
Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging. Neurobiol Aging (2016) 0.75
Causal Interrogation of Neuronal Networks and Behavior through Virally Transduced Ivermectin Receptors. Front Mol Neurosci (2016) 0.75
Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function. Nat Commun (2016) 0.75
Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome. Nat Commun (2016) 0.75
Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in mice. Neurobiol Learn Mem (2016) 0.75
Efficacy of nonselective optogenetic control of the medial septum over hippocampal oscillations: the influence of speed and implications for cognitive enhancement. Physiol Rep (2016) 0.75
Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice. Neurobiol Dis (2017) 0.75
Pediatric Autoimmune Disorders Associated with Streptococcal Infections and Tourette's Syndrome in Preclinical Studies. Front Neurosci (2016) 0.75
Exploring the Effect of Phyllanthus emblica L. on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Promising Natural Gift for the Mitigation of Alzheimer's Disease. Ann Neurosci (2016) 0.75
Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability In vitro and Spatial Working Memory In vivo. Front Cell Neurosci (2016) 0.75
Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice. Neurobiol Aging (2016) 0.75
Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet (2006) 9.87
Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet (2004) 3.83
Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior. Neuron (2007) 3.67
Genetic and environmental effects on complex traits in mice. Genetics (2006) 3.27
Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell (2007) 3.06
Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biol Psychiatry (2008) 2.66
Assessing nest building in mice. Nat Protoc (2006) 2.56
Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits. Curr Biol (2008) 2.27
A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice. Mamm Genome (2006) 1.96
Digging and marble burying in mice: simple methods for in vivo identification of biological impacts. Nat Protoc (2006) 1.80
Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks. Neuron (2008) 1.78
Effects of cytotoxic hippocampal lesions in mice on a cognitive test battery. Behav Brain Res (2002) 1.73
Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion. Eur J Pharmacol (2009) 1.62
A within-subjects, within-task demonstration of intact spatial reference memory and impaired spatial working memory in glutamate receptor-A-deficient mice. J Neurosci (2003) 1.58
Hippocampal cytotoxic lesion effects on species-typical behaviours in mice. Behav Brain Res (2002) 1.58
Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiol Aging (2010) 1.42
Burrowing in rodents: a sensitive method for detecting behavioral dysfunction. Nat Protoc (2006) 1.39
Anxiolytic effects of cytotoxic hippocampal lesions in rats. Behav Neurosci (2002) 1.36
Housing, husbandry and handling of rodents for behavioral experiments. Nat Protoc (2006) 1.32
Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: evidence for a dual-process memory model. Learn Mem (2009) 1.28
Hippocampal lesions, species-typical behaviours and anxiety in mice. Behav Brain Res (2005) 1.26
Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion. Nat Neurosci (2012) 1.26
Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus. Eur J Neurosci (2009) 1.24
Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: evidence for Wagner's dual-process memory model. Neuropsychologia (2010) 1.22
Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding. FASEB J (2009) 1.15
The role of hippocampal glutamate receptor-A-dependent synaptic plasticity in conditional learning: the importance of spatiotemporal discontiguity. J Neurosci (2004) 1.09
Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity. Nat Neurosci (2011) 1.08
Effects of medial prefrontal cortex cytotoxic lesions in mice. Behav Brain Res (2003) 1.07
Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder? Neuropharmacology (2011) 1.02
Learning impairments of hippocampal-lesioned mice in a paddling pool. Behav Neurosci (2002) 1.01
Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition. Neuropsychopharmacology (2011) 0.94
Appetitive position discrimination in the T-maze. Nat Protoc (2006) 0.89
Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice. Hum Mol Genet (2013) 0.89
A double dissociation between the effects of sub-pyrogenic systemic inflammation and hippocampal lesions on learning. Behav Brain Res (2009) 0.88
Assessing hoarding in mice. Nat Protoc (2006) 0.87
Hippocampal lesioned rats are able to learn a spatial position using non-spatial strategies. Behav Brain Res (2002) 0.82
Hippocampal lesions can enhance discrimination learning despite normal sensitivity to interference from incidental information. Hippocampus (2011) 0.77
Hippocampal scrapie infection impairs operant DRL performance in mice. Behav Brain Res (2005) 0.76
Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice. Behav Brain Res (2011) 0.76