Published in J Neurosci on January 16, 2013
Prenatal programming of mental illness: current understanding of relationship and mechanisms. Curr Psychiatry Rep (2015) 0.96
Prenatal stress-induced increases in placental inflammation and offspring hyperactivity are male-specific and ameliorated by maternal antiinflammatory treatment. Endocrinology (2014) 0.95
Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo. Front Cell Neurosci (2015) 0.82
Serotonergic hallucinogens as translational models relevant to schizophrenia. Int J Neuropsychopharmacol (2013) 0.82
Molecular substrates of schizophrenia: homeostatic signaling to connectivity. Mol Psychiatry (2015) 0.82
Preclinical models of antipsychotic drug action. Int J Neuropsychopharmacol (2013) 0.79
Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia. Proc Natl Acad Sci U S A (2014) 0.78
Epigenetic Mechanisms of Serotonin Signaling. ACS Chem Neurosci (2015) 0.77
Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation. Int J Mol Sci (2015) 0.77
Metabotropic Glutamate 2/3 Receptors and Epigenetic Modifications in Psychotic Disorders: A Review. Curr Neuropharmacol (2016) 0.76
Animal Models of Psychosis: Current State and Future Directions. Curr Behav Neurosci Rep (2014) 0.76
Brain in flames - animal models of psychosis: utility and limitations. Neuropsychiatr Dis Treat (2015) 0.76
Does prenatal stress alter the developing connectome? Pediatr Res (2016) 0.76
Group II Metabotropic Glutamate Receptors as Targets for Novel Antipsychotic Drugs. Front Pharmacol (2016) 0.75
The Neurobiological Basis for Social Affiliation in Autism Spectrum Disorder and Schizophrenia. Curr Behav Neurosci Rep (2016) 0.75
Validation of schizophrenia gene expression profile in a preclinical model of maternal infection during pregnancy. Schizophr Res (2017) 0.75
Serotonin and brain function: a tale of two receptors. J Psychopharmacol (2017) 0.75
The role of IL-6 in neurodevelopment after prenatal stress. Brain Behav Immun (2017) 0.75
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science (2008) 20.68
Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature (2008) 20.31
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Common variants conferring risk of schizophrenia. Nature (2009) 10.37
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci (2009) 10.17
Animal models of neuropsychiatric disorders. Nat Neurosci (2010) 5.78
Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am J Med Genet (2000) 5.07
Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci (2009) 4.53
Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature (2008) 4.09
Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci (2007) 4.06
Epigenetic transmission of the impact of early stress across generations. Biol Psychiatry (2010) 3.55
Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry (2004) 3.52
Cognitive impairment in schizophrenia is the core of the disorder. Crit Rev Neurobiol (2000) 3.17
Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol (2001) 3.04
The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J Neurosci (2006) 3.03
Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron (2007) 2.98
Extrapolating brain development from experimental species to humans. Neurotoxicology (2007) 2.73
Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. Arch Gen Psychiatry (2008) 2.69
Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry (2005) 2.60
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell (2011) 2.55
T-maze alternation in the rodent. Nat Protoc (2006) 2.38
Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci U S A (2004) 2.36
Early prenatal stress epigenetically programs dysmasculinization in second-generation offspring via the paternal lineage. J Neurosci (2011) 2.25
Prenatal exposure to maternal stress and subsequent schizophrenia. The May 1940 invasion of The Netherlands. Br J Psychiatry (1998) 2.24
Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. Am J Psychiatry (2004) 2.23
Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr Res (2011) 2.19
Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels. Clin Sci (Lond) (2001) 2.18
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action. Neuroreport (1998) 2.03
Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration. Pediatr Res (2000) 1.77
Serotonin research: contributions to understanding psychoses. Trends Pharmacol Sci (2008) 1.75
In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders. Neurosci Biobehav Rev (2009) 1.74
A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men. Arch Gen Psychiatry (2009) 1.69
A.E. Bennett Research Award. Prenatal rubella, premorbid abnormalities, and adult schizophrenia. Biol Psychiatry (2001) 1.66
The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia. Mol Psychiatry (2006) 1.64
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci (2012) 1.52
A review of the fetal brain cytokine imbalance hypothesis of schizophrenia. Schizophr Bull (2008) 1.49
Sex differences in brain morphology in schizophrenia. Am J Psychiatry (1997) 1.46
Glucocorticoid hormones and early brain development in schizophrenia. Neuropsychopharmacology (2002) 1.46
Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection. Pharmacol Rev (2008) 1.46
The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity. Psychopharmacology (Berl) (2007) 1.36
Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia. Behav Brain Res (2005) 1.36
Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT₂A and mGlu₂ receptors in the adult offspring. J Neurosci (2011) 1.36
Stress as a neuroinflammatory condition in brain: damaging and protective mechanisms. Neurosci Biobehav Rev (2008) 1.34
Psychedelics and schizophrenia. Trends Neurosci (2009) 1.32
Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling. Mol Psychiatry (2007) 1.29
Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications. Mol Psychiatry (2011) 1.23
Acute maternal stress in pregnancy and schizophrenia in offspring: a cohort prospective study. BMC Psychiatry (2008) 1.22
Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia. Biol Psychiatry (2009) 1.22
Gestational stress induces post-partum depression-like behaviour and alters maternal care in rats. Psychoneuroendocrinology (2004) 1.17
Latent effects of prenatal malnutrition on adult health: the example of schizophrenia. Ann N Y Acad Sci (2008) 1.14
Risperidone administered during asymptomatic period of adolescence prevents the emergence of brain structural pathology and behavioral abnormalities in an animal model of schizophrenia. Schizophr Bull (2010) 1.13
Family and twin strategies as a head start in defining prodromes and endophenotypes for hypothetical early-interventions in schizophrenia. Schizophr Res (2001) 1.12
Current outcome in schizophrenia: women vs men. Acta Psychiatr Scand (1986) 1.06
Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia. Pharmacogenomics J (2010) 1.04
The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen. Psychopharmacology (Berl) (2010) 1.04
Group II metabotropic glutamate receptors and schizophrenia. Cell Mol Life Sci (2009) 1.04
The neurodevelopmental basis of sex differences in schizophrenia. Psychol Med (1991) 1.03
Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice. Neuropsychopharmacology (2011) 0.99
Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression. Biol Psychiatry (2010) 0.98
Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain. Mol Pharmacol (2011) 0.97
Prenatal stress has pro-inflammatory consequences on the immune system in adult rats. Psychoneuroendocrinology (2007) 0.92
Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology (2000) 0.92
Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms. Biol Psychiatry (2008) 0.91
Stress during gestation induces lasting effects on emotional reactivity of the dam rat. Behav Brain Res (2004) 0.89
Prenatal stress in the rat alters 5-HT1A receptor binding in the ventral hippocampus. Brain Res (2006) 0.88
Gene expression changes in brains of mice exposed to a maternal virus infection. Neuroreport (2005) 0.87
Validation and pharmacological characterisation of MK-801-induced locomotor hyperactivity in BALB/C mice as an assay for detection of novel antipsychotics. Psychopharmacology (Berl) (2010) 0.87
The role of the HPA axis in psychiatric disorders and CRF antagonists as potential treatments. Arch Pharm (Weinheim) (2006) 0.84
Schizophrenia: treatment targets beyond monoamine systems. Annu Rev Pharmacol Toxicol (2011) 0.83
Changes in pain behavior induced by formalin, substance P, glutamate and pro-inflammatory cytokines in immobilization-induced stress mouse model. Brain Res Bull (2006) 0.83
Symptomatic, familial, perinatal, and social correlates of computerized axial tomography (CAT) changes in schizophrenics and bipolars. J Nerv Ment Dis (1985) 0.81
Sexual dimorphism in corpus callosum and schizophrenia. Schizophr Res (1991) 0.79
Who cares for a stressed brain? The mother, the kid or both? Neurobiol Aging (2003) 0.76
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science (2006) 9.31
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell (2007) 8.99
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron (2005) 5.09
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron (2007) 4.96
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (2010) 3.97
Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A (2007) 3.92
Antidepressant actions of histone deacetylase inhibitors. J Neurosci (2009) 3.17
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature (2012) 3.15
Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01
Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron (2009) 2.97
A standardized protocol for repeated social defeat stress in mice. Nat Protoc (2011) 2.57
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell (2011) 2.55
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (2006) 2.49
Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci U S A (2010) 2.17
IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity. J Neurosci (2011) 2.15
Paternal transmission of stress-induced pathologies. Biol Psychiatry (2011) 2.07
DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment. Eur J Neurosci (2005) 1.95
A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activation. Am J Respir Cell Mol Biol (2005) 1.90
Orexin signaling mediates the antidepressant-like effect of calorie restriction. J Neurosci (2008) 1.76
DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. J Neurosci (2007) 1.74
Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression. Nat Med (2013) 1.70
AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biol Psychiatry (2008) 1.60
Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms. Am J Physiol Lung Cell Mol Physiol (2007) 1.58
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci (2012) 1.52
Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nat Neurosci (2012) 1.50
Role of nucleotides immediately flanking the transcription-regulating sequence core in coronavirus subgenomic mRNA synthesis. J Virol (2005) 1.49
Deletion of exon 4 from human surfactant protein C results in aggresome formation and generation of a dominant negative. J Cell Sci (2003) 1.44
BDNF is a negative modulator of morphine action. Science (2012) 1.41
Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT₂A and mGlu₂ receptors in the adult offspring. J Neurosci (2011) 1.36
Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. J Neurosci (2012) 1.33
Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress. J Neurosci (2010) 1.32
Sex differences in cocaine-induced behavioral responses, pharmacokinetics, and monoamine levels. Neuropharmacology (2004) 1.28
Structural and synaptic plasticity in stress-related disorders. Rev Neurosci (2011) 1.26
Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neurosci Lett (2011) 1.21
Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron (2011) 1.21
Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice. Biol Psychiatry (2009) 1.17
RGS9-2 is a negative modulator of mu-opioid receptor function. J Neurochem (2007) 1.17
Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of chronic antidepressant treatments. Neuropsychopharmacology (2009) 1.14
Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization. Respir Res (2003) 1.05
Group II metabotropic glutamate receptors and schizophrenia. Cell Mol Life Sci (2009) 1.04
Animal models of serotonergic psychedelics. ACS Chem Neurosci (2012) 1.03
Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene. Pediatr Res (2004) 1.02
Cocaine induction of ERK proteins in dorsal striatum of Fischer rats. Brain Res Mol Brain Res (2005) 1.01
Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding. PLoS One (2011) 1.01
Effects of inhibitor of κB kinase activity in the nucleus accumbens on emotional behavior. Neuropsychopharmacology (2012) 1.00
Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem (2012) 1.00
Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. Neuropharmacology (2011) 0.99
p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. J Biol Chem (2006) 0.99
The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice. Am J Physiol Lung Cell Mol Physiol (2002) 0.98
Mechanisms of psychostimulant-induced structural plasticity. Cold Spring Harb Perspect Med (2012) 0.97
Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine. J Neurosci (2011) 0.96
Biosynthesis of surfactant protein C (SP-C). Sorting of SP-C proprotein involves homomeric association via a signal anchor domain. J Biol Chem (2002) 0.96
Flow cytometric analysis of BrdU incorporation as a high-throughput method for measuring adult neurogenesis in the mouse. J Pharmacol Toxicol Methods (2008) 0.95
Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models. Proc Natl Acad Sci U S A (2013) 0.94
The role of D1 and D2 receptors in the cocaine conditioned place preference of male and female rats. Brain Res Bull (2004) 0.92
Validated genomic approach to study differentially expressed genes in complex tissues. Neurochem Res (2002) 0.91
Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine. Neuropsychopharmacology (2012) 0.90
Drug experience epigenetically primes Fosb gene inducibility in rat nucleus accumbens. J Neurosci (2012) 0.90
Insulin receptor substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine. Behav Neurosci (2008) 0.89
Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brain. Synapse (2011) 0.88
Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization. J Neurosci (2013) 0.88
The HIV antiretroviral drug efavirenz has LSD-like properties. Neuropsychopharmacology (2013) 0.88
Progesterone inhibits behavioral responses and estrogen increases corticosterone levels after acute cocaine administration. Pharmacol Biochem Behav (2005) 0.87
Viral-mediated expression of extracellular signal-regulated kinase-2 in the ventral tegmental area modulates behavioral responses to cocaine. Behav Brain Res (2010) 0.87
Stressful experience has opposite effects on dendritic spines in the hippocampus of cycling versus masculinized females. Neurosci Lett (2008) 0.87
Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration. Brain Res Bull (2005) 0.86
Dysregulated 5-HT(2A) receptor binding in postmortem frontal cortex of schizophrenic subjects. Eur Neuropsychopharmacol (2012) 0.86
Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases. J Biol Chem (2009) 0.85
Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics. CNS Neurol Disord Drug Targets (2010) 0.84
Distribution of prolyl endopeptidase activities in rat and human brain. Neurochem Int (2002) 0.84
Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression. ACS Chem Neurosci (2010) 0.83
Efficacy of rifabutin-based triple therapy as second-line treatment to eradicate helicobacter pylori infection. BMC Gastroenterol (2007) 0.83
α₂-Adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims. Biol Psychiatry (2010) 0.82
PTEN knockdown alters dendritic spine/protrusion morphology, not density. J Comp Neurol (2014) 0.82
Disruption of N-linked glycosylation promotes proteasomal degradation of the human ATP-binding cassette transporter ABCA3. Am J Physiol Lung Cell Mol Physiol (2013) 0.82
Effects of acute and chronic social defeat stress are differentially mediated by the dynorphin/kappa-opioid receptor system. Behav Pharmacol (2015) 0.81
Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl) (2012) 0.81
G protein-coupled receptor heterocomplexes in neuropsychiatric disorders. Prog Mol Biol Transl Sci (2013) 0.80
Transcriptional mechanisms: underlying addiction-related structural plasticity. Mol Interv (2010) 0.80
Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice. Mol Pharmacol (2013) 0.80
Surfactant protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses. Respir Res (2005) 0.80
Testosterone plays a limited role in cocaine-induced conditioned place preference and locomotor activity in male rats. Ethn Dis (2008) 0.79
Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice. Neurosci Lett (2013) 0.79